Jonathan Mak

About me
Publications
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About me

I completed my PhD in epidemiology at the Department of Medical Epidemiology and Biostatistics in November 2023. My research focus centers around frailty in older adults, specifically exploring its underlying causes and consequences. I am also passionate about enhancing the care and treatment of frail patients within clinical settings.

Since 2020, I have been affiliated to the National Graduate School on Ageing and Health (SWEAH, https://www.sweah.lu.se/en/).

Research

The overall goal of my doctoral project was to pave the way towards a better management of frailty in older adults. Through analyzing extensive registry-based and clinical datasets, my PhD research aimed to gain understanding into the quantitative genetics, epigenetics, and metabolic biomarkers of frailty. Additionally, I have been developing electronic frailty scores that could facilitate risk stratification and inform clinical decisions within hospital settings.

Link to my PhD thesis: http://hdl.handle.net/10616/48773

Articles

Journal article: NUTRIENTS. 2024;16(20):3536
Phenome-Wide Analysis of Coffee Intake on Health over 20 Years of Follow-Up Among Adults in Hong Kong Osteoporosis Study
Mak JKL; Chau Y-P; Tan KC-B; Kung AW-C; Cheung C-L
Journal article: OSTEOPOROSIS AND SARCOPENIA. 2024;10(3):114-118
Foot and knee deformities in relation to functional limitations and incident osteoarthritis: A prospective cohort study
Mak JKL; Tan KCB; Wong JSH; Chung MMH; Cheung C-L
Article: GEROSCIENCE. 2024;:1-18
Biological aging of different blood cell types
Marttila S; Rajic S; Ciantar J; Mak JKL; Junttila IS; Kummola L; Hagg S; Raitoharju E; Kananen L
Article: ECLINICALMEDICINE. 2024;73:102689
Comparative effectiveness of glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, and sulfonylureas on the risk of dementia in older individuals with type 2 diabetes in Sweden: an emulated trial study
Tang B; Sjolander A; Wastesson JW; Maura G; Blotiere P-O; Szilcz M; Mak JKL; Qin C; Alvarsson M; Religa D; Johnell K; Hagg S
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2024;39(6):667-678
Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility
Wei Y; Hagg S; Mak JKL; Tuomi T; Zhan Y; Carlsson S
Article: AGING CELL. 2024;23(6):e14135
Epigenome-wide analysis of frailty: Results from two European twin cohorts
Mak JKL; Skovgaard AC; Nygaard M; Kananen L; Reynolds CA; Wang Y; Kuja-Halkola R; Karlsson IK; Pedersen NL; Hagg S; Soerensen M; Jylhava J
Article: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. 2024;95(5):481-484
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank
Mak JKL; McMurran CE; Hagg S
Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2023;11(12):e2255
Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population
Li X; Ploner A; Wang Y; Mak JKL; Lu Y; Magnusson PKE; Jylhava J; Hagg S
Article: BRAIN. 2023;146(12):4891-4902
Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings
Mcmurran CE; Wang Y; Mak JKL; Karlsson IK; Tang B; Ploner A; Pedersen NL; Hagg S
Article: AGING CELL. 2023;22(8):e13868
Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses
Mak JKL; Kananen L; Qin C; Kuja-Halkola R; Tang B; Lin J; Wang Y; Jaaskelainen T; Koskinen S; Lu Y; Magnusson PKE; Hagg S; Jylhava J
Article: BRITISH JOURNAL OF CANCER. 2023;129(1):94-103
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
Mak JKL; McMurran CE; Kuja-Halkola R; Hall P; Czene K; Jylhaevae J; Haegg S
Article: GEROSCIENCE. 2023;45(3):2051-2064
Can frailty scores predict the incidence of cancer? Results from two large population-based studies
Mak JKL; Kuja-Halkola R; Wang Y; Haegg S; Jylhaevae J
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(2):333-341
Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age
Mak JKL; Kuja-Halkola R; Bai G; Hassing LB; Pedersen NL; Hagg S; Jylhava J; Reynolds CA
Article: PLOS ONE. 2023;18(3):e0283344
Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden
Kananen L; Hong X; Annetorp M; Mak JKL; Jylhava J; Eriksdotter M; Hagg S; Religa D
Article: GERONTOLOGY. 2023;69(4):396-405
Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study
Mak JKL; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Bostrom A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Olsson M; Cederholm T; Hagg S; Religa D; Jylhava J
Article: GERONTOLOGY. 2023;69(12):1385-1393
Is Frailty Different in Younger Adults Compared to Old? Prevalence, Characteristics, and Risk Factors of Early-Life and Late-Life Frailty in Samples from Sweden and UK
Bai G; Wang Y; Mak JKL; Ericsson M; Hagg S; Jylhava J
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2311-2319
Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden
Mak JKL; Hagg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Bostrom A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Olsson M; Cederholm T; Jylhava J; Religa D
Article: AGING. 2021;13(13):16990-17023
Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education
Mak JKL; Reynolds CA; Hagg S; Li X; Ericsson M; Pedersen NL; Jylhava J; Kuja-Halkola R
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(5):1128-1139
Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: The effect of sampling
Mak JKL; Kuja-Halkola R; Wang Y; Hagg S; Jylhava J
Article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2020;75(4):jech-2020-214728-342
Deprivation is associated with anxiety and stress. A population-based longitudinal household survey among Chinese adults in Hong Kong
Chung RY-N; Marmot M; Mak JK-L; Gordon D; Chan D; Chung GK-K; Wong H; Wong SYS
Article: AMERICAN BEHAVIORAL SCIENTIST, THE. 2020;64(6):802-822
Physical and Mental Health of Live-In Female Migrant Domestic Workers: A Randomly Sampled Survey in Hong Kong
Chung RY-N; Mak JK-L
Article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2020;74(2):164-172
Housing affordability effects on physical and mental health: household survey in a population with the world's greatest housing affordability stress
Chung RY-N; Chung GK-K; Gordon D; Mak JK-L; Zhang L-F; Chan D; Lai FTT; Wong H; Wong SY-S
Article: WOMEN AND BIRTH. 2019;32(3):e427-e431
Gestational diabetes and postnatal depressive symptoms: A prospective cohort study in Western China
Mak JKL; Lee AH; Ngoc MP; Tang L; Pan X-F; Binns CW; Sun X
Article: MENTAL HEALTH AND PHYSICAL ACTIVITY. 2019;16:54-59
Physical activity during early pregnancy and antenatal depression: A prospective cohort study
Mak JKL; Lee AH; Ngoc MP; Tang L; Pan X-F; Xu Z-P; Binns CW; Sun X
Article: BIRTH. 2019;46(1):166-172
Gestational diabetes incidence and delivery outcomes in Western China: A prospective cohort study
Mak JKL; Lee AH; Ngoc MP; Pan X-F; Tang L; Binns CW; Sun X
Article: NUTRITION JOURNAL. 2018;17(1):107
Dietary patterns during pregnancy and risk of gestational diabetes: a prospective cohort study in Western China
Mak JKL; Ngoc MP; Lee AH; Tang L; Pan X-F; Binns CW; Sun X
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All other publications

Review: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(10):glad251
Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age
Mak JKL; Karlsson IK; Tang B; Wang Y; Pedersen NL; Hagg S; Jylhava J; Reynolds CA
Preprint: BIORXIV. 2024
Biological aging of different blood cell types
Marttila S; Rajić S; Ciantar J; Mak JKL; Junttila I; Kummola L; Hägg S; Raitoharju E; Kananen L
Thesis / dissertation: 2023
Genetics and biomarkers of frailty : towards individualized management of the frailty syndrome
Mak, Ka Long Jonathan
Editorial comment: AGING. 2023;15(11):4571-4573
Automated frailty scores: towards clinical implementation
Mak JKL; Religa D; Jylhava J
Review: CLINICAL INTERVENTIONS IN AGING. 2023;18:2171-2183
Use of Electronic Medical Records (EMR) in Gerontology: Benefits, Considerations and a Promising Future
Bednorz A; Mak JKL; Jylhaevae J; Religa D
Preprint: MEDRXIV. 2021
Using an electronic frailty index to predict adverse outcomes in geriatric COVID-19 patients: data from the Stockholm GeroCovid study
Mak J; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Hägg S; Religa D; Jylhävä J
Preprint: MEDRXIV. 2021
Development of an electronic frailty index for hospitalized geriatric patients in Sweden
Mak J; Hägg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Jylhävä J; Religa D
Preprint: MEDRXIV. 2020
Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education
Mak J; Reynolds C; Hägg S; Li X; Ericsson M; Pedersen N; Jylhävä J; Kuja-Halkola R
Preprint: MEDRXIV. 2020
Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: the effect of sampling
Mak J; Kuja-Halkola R; Wang Y; Hägg S; Jylhävä J

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