Johannes Lieslehto

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About me

Combining a foundation in forensic psychiatry and psychopharmacology with both academic and clinical perspectives, my primary academic pursuit revolves around leveraging artificial intelligence in psychiatry. My focus is on enhancing diagnostic accuracy, tailoring treatments and predicting risk. I am also interested in the possibility to alleviate clinician workload through large language models.

Articles

Article: ECLINICALMEDICINE. 2025;81:103108
Machine learning-based mortality risk assessment in first-episode bipolar disorder: a transdiagnostic external validation study
Lieslehto J; Tiihonen J; Lahteenvuo M; Kautzky A; Akhtar A; Armannsdottir B; Leucht S; Correll CU; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Article: PSYCHOLOGICAL MEDICINE. 2024;54(16):1-11
Labor market marginalization in individuals with bipolar disorder: a Swedish nationwide register-based sibling comparison study
Armannsdottir B; Taipale H; Akhtar A; Kautzky A; Bjorkenstam E; Lieslehto J; Tiihonen J; Amin R; Mittendorfer-Rutz E
Article: JAMA NETWORK OPEN. 2024;7(10):e2438358
Comparative Effectiveness of Antipsychotics in Patients With Schizophrenia Spectrum Disorder
Hamina A; Taipale H; Lieslehto J; Laehteenvuo M; Tanskanen A; Mittendorfer-Rutz E; Tiihonen J
Article: PSYCHIATRY RESEARCH. 2024;339:116012
Dopamine D2 receptor antagonism of antipsychotics and the risk of death due to choking
Luykx JJ; Tanskanen A; Lahteenvuo M; Manu P; Correll CU; Hasan A; Lieslehto J; Taipale H; Tiihonen J
Article: WORLD PSYCHIATRY. 2024;23(2):276-284
Real-world effectiveness of antidepressants, antipsychotics and their combinations in the maintenance treatment of psychotic depression. Evidence from within-subject analyses of two nationwide cohorts
Taipale H; Lieslehto J; Laehteenvuo M; Hamina A; Tanskanen A; Mittendorfer-Rutz E; Paljaervi T; Solmi M; Cipriani A; Correll CU; Tiihonen J
Article: PSYCHIATRY RESEARCH-NEUROIMAGING. 2024;339:111790
The contribution of first-episode illness characteristics and cumulative antipsychotic usage to progressive structural brain changes over a long-term follow-up in schizophrenia
Konttajarvi T; Haapea M; Huhtaniska S; Bjornholm L; Miettunen J; Isohanni M; Penttila M; Murray GK; Koponen H; Vernon AC; Jaaskelainen E; Lieslehto J
Article: JAMA NETWORK OPEN. 2024;7(3):e240640
Development and Validation of a Machine Learning-Based Model of Mortality Risk in First-Episode Psychosis
Lieslehto J; Tiihonen J; Laehteenvuo M; Leucht S; Correll CU; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Journal article: NEUROSCIENCE APPLIED. 2024;3:104425
Individualized machine learning-based mortality risk assessment in first-episode bipolar disorder: a transdiagnostic external validation study
Lieslehto J; Tiihonen J; Lähteenvuo M; Kautzky A; Akhtar A; Ármannsdóttir B; Leucht S; Correll C; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Article: SCHIZOPHRENIA BULLETIN. 2023;49(6):1568-1578
Effects of Substance Use and Antisocial Personality on Neuroimaging-Based Machine Learning Prediction of Schizophrenia
Taipale M; Tiihonen J; Korhonen J; Popovic D; Vaurio O; Lahteenvuo M; Lieslehto J
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2023;33(Supplement_2):ckad160.1496
Subjective and objective measurements of nurses’ stress and recovery
Rantanen N; Sanmark E; Oksanen L-M; Lieslehto J; Myllymäki T; Geneid A; Lallukka T
Article: JAMA NETWORK OPEN. 2023;6(6):e2317130
Comparative Effectiveness of Pharmacotherapies for the Risk of Attempted or Completed Suicide Among Persons With Borderline Personality Disorder
Lieslehto J; Tiihonen J; Lahteenvuo M; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2023;147(6):603-613
Association of pharmacological treatments and real-world outcomes in borderline personality disorder
Lieslehto J; Tiihonen J; Lahteenvuo M; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Article: BIOLOGICAL PSYCHIATRY. 2023;93(2):167-177
Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis.
Fiorito AM; Aleman A; Blasi G; Bourque J; Cao H; Chan RCK; Chowdury A; Conrod P; Diwadkar VA; Goghari VM; Guinjoan S; Gur RE; Gur RC; Kwon JS; Lieslehto J; Lukow PB; Meyer-Lindenberg A; Modinos G; Quarto T; Spilka MJ; Shivakumar V; Venkatasubramanian G; Villarreal M; Wang Y; Wolf DH; Yun J-Y; Fakra E; Sescousse G
Journal article: NEUROSCIENCE APPLIED. 2023;2:102444
Machine learning model to estimate mortality risk after the first episode of bipolar disorder
Lieslehto J; Tiihonen J; Lähteenvuo M; Kautzky A; Akhtar A; Ármannsdóttir B; Leucht S; Correll C; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Journal article: NEUROSCIENCE APPLIED. 2023;2:103032
Leveraging machine learning for personalized pharmacotherapy to prevent future relapse in first-episode psychosis: a risk-based approach in real-world nationwide datasets
Lieslehto J; Tiihonen J; Lähteenvuo M; Leucht S; Correll C; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Journal article: NEUROSCIENCE APPLIED. 2023;2:103017
Comparative real-world effectiveness of antipsychotics for relapse prevention in schizophrenia-spectrum disorders
Hamina A; Taipale H; Lieslehto J; Lähteenvuo M; Tanskanen A; Mittendorfer-Rutz E; Tiihonen J
Article: FRONTIERS IN PSYCHIATRY. 2023;14:1001085
Patterns of risk-Using machine learning and structural neuroimaging to identify pedophilic offenders.
Popovic D; Wertz M; Geisler C; Kaufmann J; Lähteenvuo M; Lieslehto J; Witzel J; Bogerts B; Walter M; Falkai P; Koutsouleris N; Schiltz K
Journal article: NEUROSCIENCE APPLIED. 2023;2:103088
Real-world effectiveness of antidepressants and antipsychotics in treatment of psychotic depression
Taipale H; Lieslehto J; Lähteenvuo M; Hamina A; Mittendorfer-Rutz E; Paljärvi T; Tiihonen J
Article: INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH. 2022;35(6):707-718
Mental well-being of healthcare workers in 2 hospital districts during the first wave of the COVID-19 pandemic in Finland: a cross-sectional study.
Rantanen N; Lieslehto J; Oksanen L-MAH; Oksanen SA; Anttila V-J; Lehtonen L; Geneid A; Sanmark E
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2022;32(Supplement_3):ckac130.145
Mental well-being of healthcare workers in two hospital districts with differing COVID-19 incidence
Rantanen N; Lieslehto J; Oksanen L-M; Oksanen; Anttila V-J; Lehtonen L; Geneid A; Sanmark E
Article: SCIENTIFIC REPORTS. 2022;12(1):8055
A machine learning approach to predict resilience and sickness absence in the healthcare workforce during the COVID-19 pandemic.
Lieslehto J; Rantanen N; Oksanen L-MAH; Oksanen SA; Kivimäki A; Paju S; Pietiäinen M; Lahdentausta L; Pussinen P; Anttila V-J; Lehtonen L; Lallukka T; Geneid A; Sanmark E
Article: SCHIZOPHRENIA BULLETIN. 2022;48(3):655-663
Primary Nonadherence to Antipsychotic Treatment Among Persons with Schizophrenia
Lieslehto J; Tiihonen J; Lahteenvuo M; Tanskanen A; Taipale H
Journal article: NEUROSCIENCE APPLIED. 2022;1:100845
Real-world effectiveness of pharmacological treatments of borderline personality disorder – a nationwide cohort study
Lieslehto J; Tiihonen J; Lähteenvuo M; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Article: BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2021;6(7):692-705
Early Adversity and Emotion Processing From Faces: A Meta-analysis on Behavioral and Neurophysiological Responses.
Saarinen A; Keltikangas-Järvinen L; Jääskeläinen E; Huhtaniska S; Pudas J; Tovar-Perdomo S; Penttilä M; Miettunen J; Lieslehto J
Article: NPJ SCHIZOPHRENIA. 2021;7(1):32
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years.
Lieslehto J; Jääskeläinen E; Kiviniemi V; Haapea M; Jones PB; Murray GK; Veijola J; Dannlowski U; Grotegerd D; Meinert S; Hahn T; Ruef A; Isohanni M; Falkai P; Miettunen J; Dwyer DB; Koutsouleris N
Journal article: SCIENTIFIC REPORTS. 2020;10(1):21559
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies.
Tuovinen T; Kananen J; Rajna Z; Lieslehto J; Korhonen V; Rytty R; Mattila H; Huotari N; Raitamaa L; Helakari H; Elseoud AA; Krüger J; LeVan P; Tervonen O; Hennig J; Remes AM; Nedergaard M; Kiviniemi V
Journal article: SCHIZOPHRENIA BULLETIN. 2020;46(Supplement_1):s290-s291
T157. THE COURSE OF SCHIZOPHRENIA-RELATED NEURAL FINGERPRINTS OVER NINE YEARS - A LONGITUDINAL POPULATION-BASED MACHINE LEARNING STUDY
Lieslehto J; Jääskeläinen E; Miettunen J; Isohanni M; Dwyer D; Koutsouleris N
Journal article: SCHIZOPHRENIA RESEARCH. 2020;216:339-346
Symptomatic psychosis risk and physiological fluctuation in functional MRI data.
Saarinen A; Lieslehto J; Kiviniemi V; Häkli J; Tuovinen T; Hintsanen M; Veijola J
Article: SCHIZOPHRENIA RESEARCH. 2020;216:14-23
Structural and functional alterations in the brain gray matter among first-degree relatives of schizophrenia patients: A multimodal meta-analysis of fMRI and VBM studies.
Saarinen AIL; Huhtaniska S; Pudas J; Björnholm L; Jukuri T; Tohka J; Granö N; Barnett JH; Kiviniemi V; Veijola J; Hintsanen M; Lieslehto J
Journal article: PSYCHIATRY RESEARCH-NEUROIMAGING. 2020;297:111031
The relationship of genetic susceptibilities for psychosis with physiological fluctuation in functional MRI data.
Saarinen A; Lieslehto J; Kiviniemi V; Tuovinen T; Veijola J; Hintsanen M
Journal article: PSYCHIATRY RESEARCH-NEUROIMAGING. 2019;292:54-61
Brain response to facial expressions in adults with adolescent ADHD.
Lindholm P; Lieslehto J; Nikkinen J; Moilanen I; Hurtig T; Veijola J; Miettunen J; Kiviniemi V; Ebeling H
Article: INTERNATIONAL JOURNAL OF OBESITY. 2019;43(10):1995-2006
Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts.
Verdejo-Román J; Björnholm L; Muetzel RL; Torres-Espínola FJ; Lieslehto J; Jaddoe V; Campos D; Veijola J; White T; Catena A; Nikkinen J; Kiviniemi V; Järvelin M-R; Tiemeier H; Campoy C; Sebert S; El Marroun H
Journal article: SCHIZOPHRENIA BULLETIN. 2019;45(4):835-845
Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood
Lieslehto J; Kiviniemi VJ; Nordstrom T; Barnett JH; Murray GK; Jones PB; Paus T; Veijola J
Journal article: INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH. 2019;78(1):1571382
Psychiatric research in the Northern Finland Birth Cohort 1986-a systematic review
Miettunen J; Haapea M; Bjornholm L; Huhtaniska S; Juola T; Kinnunen L; Lehtiniemi H; Lieslehto J; Rautio N; Nordstrom T
Journal article: HUMAN BRAIN MAPPING. 2017;38(9):4470-4478
Early Adversity and Brain Response to Faces in Young Adulthood
Lieslehto J; Kiviniemi V; Maki P; Koivukangas J; Nordstrom T; Miettunen J; Barnett JH; Jones PB; Murray GK; Moilanen I; Paus T; Veijola J
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All other publications

Preprint: MEDRXIV. 2022
Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-based fMRI Meta-analysis
Fiorito AM; Aleman A; Blasi G; Bourque J; Cao H; Chan RCK; Chowdury A; Conrod P; Diwadkar VA; Goghari VM; Guinjoan S; Gur RE; Gur RC; Kwon JS; Lieslehto J; Lukow PB; Meyer-Lindenberg A; Modinos G; Quarto T; Spilka MJ; Shivakumar V; Venkatasubramanian G; Villarreal M; Wang Y; Wolf DH; Yun J-Y; Fakra E; Sescousse G
Review: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL. 2021;36(2)
Medication management of antipsychotic treatment in schizophrenia-A narrative review
Isohanni M; Jaaskelainen E; Miller BJ; Hulkko A; Tiihonen J; Moeller H-J; Hartikainen S; Huhtaniska S; Lieslehto J

Grants

Improving long-term outcomes of patients with severe mental disorder and comorbid cannabis use disorder
Swedish Research Council
1 January 2025 - 31 December 2027
Pathways to adverse health development and increased healthcare consumption in patients with autism spectrum disorders – the role of individual factors and pharmacological treatment
Swedish Research Council
1 January 2025 - 31 December 2027

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