Johannes Lieslehto

About me
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About me

Combining a foundation in forensic psychiatry and psychopharmacology with both academic and clinical perspectives, my primary academic pursuit revolves around leveraging artificial intelligence in psychiatry. My focus is on enhancing diagnostic accuracy, tailoring treatments and predicting risk. I am also interested in the possibility to alleviate clinician workload through large language models.

Articles

Journal article: PSYCHIATRY RESEARCH. 2024;339:116012

Dopamine D2 receptor antagonism of antipsychotics and the risk of death due to choking.

Luykx JJ; Tanskanen A; Lähteenvuo M; Manu P; Correll CU; Hasan A; Lieslehto J; Taipale H; Tiihonen J
Article: WORLD PSYCHIATRY. 2024;23(2):276-284

Real-world effectiveness of antidepressants, antipsychotics and their combinations in the maintenance treatment of psychotic depression. Evidence from within-subject analyses of two nationwide cohorts.

Taipale H; Lieslehto J; Lähteenvuo M; Hamina A; Tanskanen A; Mittendorfer-Rutz E; Paljärvi T; Solmi M; Cipriani A; Correll CU; Tiihonen J
Journal article: PSYCHIATRY RESEARCH-NEUROIMAGING. 2024;339:111790

The contribution of first-episode illness characteristics and cumulative antipsychotic usage to progressive structural brain changes over a long-term follow-up in schizophrenia.

Konttajärvi T; Haapea M; Huhtaniska S; Björnholm L; Miettunen J; Isohanni M; Penttilä M; Murray GK; Koponen H; Vernon AC; Jääskeläinen E; Lieslehto J
Article: JAMA NETWORK OPEN. 2024;7(3):e240640

Development and Validation of a Machine Learning-Based Model of Mortality Risk in First-Episode Psychosis.

Lieslehto J; Tiihonen J; Lähteenvuo M; Leucht S; Correll CU; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Article: SCHIZOPHRENIA BULLETIN. 2023;49(6):1568-1578

Effects of Substance Use and Antisocial Personality on Neuroimaging-Based Machine Learning Prediction of Schizophrenia.

Taipale M; Tiihonen J; Korhonen J; Popovic D; Vaurio O; Lähteenvuo M; Lieslehto J
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2023;33(Supplement_2):ckad160.1496

Subjective and objective measurements of nurses’ stress and recovery

Rantanen N; Sanmark E; Oksanen L-M; Lieslehto J; Myllymäki T; Geneid A; Lallukka T
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2023;147(6):603-613

Association of pharmacological treatments and real-world outcomes in borderline personality disorder.

Lieslehto J; Tiihonen J; Lähteenvuo M; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Article: JAMA NETWORK OPEN. 2023;6(6):e2317130

Comparative Effectiveness of Pharmacotherapies for the Risk of Attempted or Completed Suicide Among Persons With Borderline Personality Disorder.

Lieslehto J; Tiihonen J; Lähteenvuo M; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Journal article: BIOLOGICAL PSYCHIATRY. 2023;93(2):167-177

Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis.

Fiorito AM; Aleman A; Blasi G; Bourque J; Cao H; Chan RCK; Chowdury A; Conrod P; Diwadkar VA; Goghari VM; Guinjoan S; Gur RE; Gur RC; Kwon JS; Lieslehto J; Lukow PB; Meyer-Lindenberg A; Modinos G; Quarto T; Spilka MJ; Shivakumar V; Venkatasubramanian G; Villarreal M; Wang Y; Wolf DH; Yun J-Y; Fakra E; Sescousse G
Journal article: NEUROSCIENCE APPLIED. 2023;2:102444

Machine learning model to estimate mortality risk after the first episode of bipolar disorder

Lieslehto J; Tiihonen J; Lähteenvuo M; Kautzky A; Akhtar A; Ármannsdóttir B; Leucht S; Correll C; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Journal article: NEUROSCIENCE APPLIED. 2023;2:103017

Comparative real-world effectiveness of antipsychotics for relapse prevention in schizophrenia-spectrum disorders

Hamina A; Taipale H; Lieslehto J; Lähteenvuo M; Tanskanen A; Mittendorfer-Rutz E; Tiihonen J
Journal article: NEUROSCIENCE APPLIED. 2023;2:103032

Leveraging machine learning for personalized pharmacotherapy to prevent future relapse in first-episode psychosis: a risk-based approach in real-world nationwide datasets

Lieslehto J; Tiihonen J; Lähteenvuo M; Leucht S; Correll C; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Journal article: FRONTIERS IN PSYCHIATRY. 2023;14:1001085

Patterns of risk-Using machine learning and structural neuroimaging to identify pedophilic offenders.

Popovic D; Wertz M; Geisler C; Kaufmann J; Lähteenvuo M; Lieslehto J; Witzel J; Bogerts B; Walter M; Falkai P; Koutsouleris N; Schiltz K
Journal article: NEUROSCIENCE APPLIED. 2023;2:103088

Real-world effectiveness of antidepressants and antipsychotics in treatment of psychotic depression

Taipale H; Lieslehto J; Lähteenvuo M; Hamina A; Mittendorfer-Rutz E; Paljärvi T; Tiihonen J
Journal article: INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH. 2022;35(6):707-718

Mental well-being of healthcare workers in 2 hospital districts during the first wave of the COVID-19 pandemic in Finland: a cross-sectional study.

Rantanen N; Lieslehto J; Oksanen L-MAH; Oksanen SA; Anttila V-J; Lehtonen L; Geneid A; Sanmark E
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2022;32(Supplement_3):ckac130.145

Mental well-being of healthcare workers in two hospital districts with differing COVID-19 incidence

Rantanen N; Lieslehto J; Oksanen L-M; Oksanen; Anttila V-J; Lehtonen L; Geneid A; Sanmark E
Journal article: SCIENTIFIC REPORTS. 2022;12(1):8055

A machine learning approach to predict resilience and sickness absence in the healthcare workforce during the COVID-19 pandemic.

Lieslehto J; Rantanen N; Oksanen L-MAH; Oksanen SA; Kivimäki A; Paju S; Pietiäinen M; Lahdentausta L; Pussinen P; Anttila V-J; Lehtonen L; Lallukka T; Geneid A; Sanmark E
Article: SCHIZOPHRENIA BULLETIN. 2022;48(3):655-663

Primary Nonadherence to Antipsychotic Treatment Among Persons with Schizophrenia.

Lieslehto J; Tiihonen J; Lähteenvuo M; Tanskanen A; Taipale H
Journal article: NEUROSCIENCE APPLIED. 2022;1:100845

Real-world effectiveness of pharmacological treatments of borderline personality disorder – a nationwide cohort study

Lieslehto J; Tiihonen J; Lähteenvuo M; Mittendorfer-Rutz E; Tanskanen A; Taipale H
Journal article: BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2021;6(7):692-705

Early Adversity and Emotion Processing From Faces: A Meta-analysis on Behavioral and Neurophysiological Responses.

Saarinen A; Keltikangas-Järvinen L; Jääskeläinen E; Huhtaniska S; Pudas J; Tovar-Perdomo S; Penttilä M; Miettunen J; Lieslehto J
Journal article: NPJ SCHIZOPHRENIA. 2021;7(1):32

The progression of disorder-specific brain pattern expression in schizophrenia over 9 years.

Lieslehto J; Jääskeläinen E; Kiviniemi V; Haapea M; Jones PB; Murray GK; Veijola J; Dannlowski U; Grotegerd D; Meinert S; Hahn T; Ruef A; Isohanni M; Falkai P; Miettunen J; Dwyer DB; Koutsouleris N
Journal article: SCIENTIFIC REPORTS. 2020;10(1):21559

The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies.

Tuovinen T; Kananen J; Rajna Z; Lieslehto J; Korhonen V; Rytty R; Mattila H; Huotari N; Raitamaa L; Helakari H; Elseoud AA; Krüger J; LeVan P; Tervonen O; Hennig J; Remes AM; Nedergaard M; Kiviniemi V
Journal article: SCHIZOPHRENIA BULLETIN. 2020;46(Supplement_1):s290-s291

T157. THE COURSE OF SCHIZOPHRENIA-RELATED NEURAL FINGERPRINTS OVER NINE YEARS - A LONGITUDINAL POPULATION-BASED MACHINE LEARNING STUDY

Lieslehto J; Jääskeläinen E; Miettunen J; Isohanni M; Dwyer D; Koutsouleris N
Journal article: SCHIZOPHRENIA RESEARCH. 2020;216:14-23

Structural and functional alterations in the brain gray matter among first-degree relatives of schizophrenia patients: A multimodal meta-analysis of fMRI and VBM studies.

Saarinen AIL; Huhtaniska S; Pudas J; Björnholm L; Jukuri T; Tohka J; Granö N; Barnett JH; Kiviniemi V; Veijola J; Hintsanen M; Lieslehto J
Journal article: SCHIZOPHRENIA RESEARCH. 2020;216:339-346

Symptomatic psychosis risk and physiological fluctuation in functional MRI data.

Saarinen A; Lieslehto J; Kiviniemi V; Häkli J; Tuovinen T; Hintsanen M; Veijola J
Journal article: PSYCHIATRY RESEARCH-NEUROIMAGING. 2020;297:111031

The relationship of genetic susceptibilities for psychosis with physiological fluctuation in functional MRI data.

Saarinen A; Lieslehto J; Kiviniemi V; Tuovinen T; Veijola J; Hintsanen M
Journal article: PSYCHIATRY RESEARCH-NEUROIMAGING. 2019;292:54-61

Brain response to facial expressions in adults with adolescent ADHD.

Lindholm P; Lieslehto J; Nikkinen J; Moilanen I; Hurtig T; Veijola J; Miettunen J; Kiviniemi V; Ebeling H
Journal article: INTERNATIONAL JOURNAL OF OBESITY. 2019;43(10):1995-2006

Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts.

Verdejo-Román J; Björnholm L; Muetzel RL; Torres-Espínola FJ; Lieslehto J; Jaddoe V; Campos D; Veijola J; White T; Catena A; Nikkinen J; Kiviniemi V; Järvelin M-R; Tiemeier H; Campoy C; Sebert S; El Marroun H
Journal article: SCHIZOPHRENIA BULLETIN. 2019;45(4):835-845

Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood.

Lieslehto J; Kiviniemi VJ; Nordström T; Barnett JH; Murray GK; Jones PB; Paus T; Veijola J
Journal article: INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH. 2019;78(1):1571382

Psychiatric research in the Northern Finland Birth Cohort 1986 - a systematic review.

Miettunen J; Haapea M; Björnholm L; Huhtaniska S; Juola T; Kinnunen L; Lehtiniemi H; Lieslehto J; Rautio N; Nordström T
Journal article: HUMAN BRAIN MAPPING. 2017;38(9):4470-4478

Early adversity and brain response to faces in young adulthood.

Lieslehto J; Kiviniemi V; Mäki P; Koivukangas J; Nordström T; Miettunen J; Barnett JH; Jones PB; Murray GK; Moilanen I; IMAGEN; Paus T; Veijola J
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All other publications

Preprint: MEDRXIV. 2022

Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-based fMRI Meta-analysis

Fiorito AM; Aleman A; Blasi G; Bourque J; Cao H; Chan RCK; Chowdury A; Conrod P; Diwadkar VA; Goghari VM; Guinjoan S; Gur RE; Gur RC; Kwon JS; Lieslehto J; Lukow PB; Meyer-Lindenberg A; Modinos G; Quarto T; Spilka MJ; Shivakumar V; Venkatasubramanian G; Villarreal M; Wang Y; Wolf DH; Yun J-Y; Fakra E; Sescousse G
Review: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL. 2021;36(2)

Medication management of antipsychotic treatment in schizophrenia-A narrative review

Isohanni M; Jaaskelainen E; Miller BJ; Hulkko A; Tiihonen J; Moeller H-J; Hartikainen S; Huhtaniska S; Lieslehto J

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