Johanna Sandling Johansson

Journal article: LUPUS SCIENCE & MEDICINE. 2023;10(2):e000926

B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus

Hedenstedt A; Reid S; Sayadi A; Eloranta M-L; Skoglund E; Bolin K; Frodlund M; Lerang K; Joensen A; Rantapaeae-Dahlqvist S; Bengtsson AA; Rudin A; Molberg O; Sjoewall C; Sandling JK; Leonard D

Article: EBIOMEDICINE. 2023;96:104804

Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies

Leclair V; Galindo-Feria AS; Rothwell S; Krystufkova O; Zargar SS; Mann H; Diederichsen LP; Andersson H; Klein M; Tansley S; Ronnblom L; Lindblad-Toh K; Syvanen A-C; Wahren-Herlenius M; Sandling JK; McHugh N; Lamb JA; Vencovsky J; Chinoy H; Holmqvist M; Bianchi M; Padyukov L; Lundberg IE; Diaz-Galloc L-M

Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023;189(2):235-241

Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison's disease

Lundtoft C; Eriksson D; Bianchi M; Aranda-Guillen M; Landegren N; Rantapaa-Dahlqvist S; Soderkvist P; Meadows JRS; Bensing S; Pielberg GR; Lindblad-Toh K; Ronnblom L; Kampe O

Article: LUPUS SCIENCE & MEDICINE. 2022;9(1):e000752

Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease

Yavuz S; Pucholt P; Sandling JK; Bianchi M; Leonard D; Bolin K; Imgenberg-Kreuz J; Eloranta M-L; Kozyrev SV; Lanata CM; Jonsen A; Bengtsson AA; Sjowall C; Svenungsson E; Gunnarsson I; Rantapaa-Dahlqvist S; Nititham J; Criswell LA; Lindblad-Toh K; Ronnblom L

Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(11):1842-1850

Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjogren's Syndrome

Lundtoft C; Sjowall C; Rantapaa-Dahlqvist S; Bengtsson AA; Jonsen A; Pucholt P; Wu YL; Lundstrom E; Eloranta M-L; Gunnarsson I; Baecklund E; Jonsson R; Hammenfors D; Forsblad-d'Elia H; Eriksson P; Mandl T; Bucher S; Norheim KB; Johnsen SJA; Omdal R; Kvarnstrom M; Wahren-Herlenius M; Truedsson L; Nilsson B; Kozyrev SV; Bianchi M; Lindblad-Toh K; Yu C-Y; Nordmark G; Sandling JK; Svenungsson E; Leonard D; Ronnblom L

Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(8):1440-1450

Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases

Lundtoft C; Pucholt P; Martin M; Bianchi M; Lundstrom E; Eloranta M-L; Sandling JK; Sjowall C; Jonsen A; Gunnarsson I; Rantapaa-Dahlqvist S; Bengtsson AA; Leonard D; Baecklund E; Jonsson R; Hammenfors D; Forsblad-d'Elia H; Eriksson P; Mandl T; Bucher SM; Norheim KB; Johnsen SJA; Omdal R; Kvarnstrom M; Wahren-Herlenius M; Notarnicola A; Andersson H; Molberg O; Diederichsen LP; Almlof J; Syvanen A-C; Kozyrev SV; Lindblad-Toh K; Nilsson B; Blom AM; Lundberg IE; Nordmark G; Diaz-Gallo LM; Svenungsson E; Ronnblom L

Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(2):342-352

Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort

Bianchi M; Kozyrev SV; Notarnicola A; Hultin Rosenberg L; Karlsson A; Pucholt P; Rothwell S; Alexsson A; Sandling JK; Andersson H; Cooper RG; Padyukov L; Tjarnlund A; Dastmalchi M; Meadows JRS; Pyndt Diederichsen L; Molberg O; Chinoy H; Lamb J; Ronnblom L; Lindblad-Toh K; Lundberg IE

Journal article: NATURE GENETICS. 2022;54(1):18-29

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

Hawe JS; Wilson R; Schmid KT; Zhou L; Lakshmanan LN; Lehne BC; Kuehnel B; Scott WR; Wielscher M; Yew YW; Baumbach C; Lee DP; Marouli E; Bernard M; Pfeiffer L; Matias-Garcia PR; Autio MI; Bourgeois S; Herder C; Karhunen V; Meitinger T; Prokisch H; Rathmann W; Roden M; Sebert S; Shin J; Strauch K; Zhang W; Tan WLW; Hauck SM; Merl-Pham J; Grallert H; Barbosa EGV; Illig T; Peters A; Paus T; Pausova Z; Deloukas P; Foo RSY; Jarvelin M-R; Kooner JS; Loh M; Heinig M; Gieger C; Waldenberger M; Chambers JC

Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(9):1183-1189

Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus

Reid S; Hagberg N; Sandling JK; Alexsson A; Pucholt P; Sjowall C; Lerang K; Jonsen A; Gunnarsson I; Syvanen A-C; Troldborg AM; Voss A; Bengtsson AA; Molberg O; Jacobsen S; Svenungsson E; Ronnblom L; Leonard D

Article: GENES AND IMMUNITY. 2021;22(3):194-202

Variants in BANK1 are associated with lupus nephritis of European ancestry

Bolin K; Imgenberg-Kreuz J; Leonard D; Sandling JK; Alexsson A; Pucholt P; Haarhaus ML; Almlof JC; Nititham J; Jonsen A; Sjowall C; Bengtsson AA; Rantapaa-Dahlqvist S; Svenungsson E; Gunnarsson I; Syvanen A-C; Lerang K; Troldborg A; Voss A; Molberg O; Jacobsen S; Criswell L; Ronnblom L; Nordmark G

Article: RHEUMATOLOGY. 2021;60(2):837-848

Genetic and clinical basis for two distinct subtypes of primary Sjogren's syndrome

Thorlacius GE; Hultin-Rosenberg L; Sandling JK; Bianchi M; Imgenberg-Kreuz J; Pucholt P; Theander E; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Norheim KB; Johnsen SJA; Hammenfors D; Skarstein K; Jonsson MV; Baecklund E; Aqrawi LA; Jensen JL; Palm O; Morris AP; Meadows JRS; Rantapaa-Dahlqvist S; Mandl T; Eriksson P; Lind L; Omdal R; Jonsson R; Lindblad-Toh K; Ronnblom L; Wahren-Herlenius M; Nordmark G

Article: FRONTIERS IN IMMUNOLOGY. 2021;12:702037

DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjogren's Syndrome

Imgenberg-Kreuz J; Sandling JK; Norheim KB; Johnsen SJA; Omdal R; Syvanen A-C; Svenungsson E; Ronnblom L; Eloranta M-L; Nordmark G

Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2021;29(1):184-193

Contributions of de novo variants to systemic lupus erythematosus

Almlof JC; Nystedt S; Mechtidou A; Leonard D; Eloranta M-L; Grosso G; Sjowall C; Bengtsson AA; Jonsen A; Gunnarsson I; Svenungsson E; Ronnblom L; Sandling JK; Syvanen A-C

Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(1):109-117

Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing

Sandling JK; Pucholt P; Rosenberg LH; Farias FHG; Kozyrev SV; Eloranta M-L; Alexsson A; Bianchi M; Padyukov L; Bengtsson C; Jonsson R; Omdal R; Lie BA; Massarenti L; Steffensen R; Jakobsen MA; Lillevang ST; Lerang K; Molberg O; Voss A; Troldborg A; Jacobsen S; Syvanen A-C; Jonsen A; Gunnarsson I; Svenungsson E; Rantapaa-Dahlqvist S; Bengtsson AA; Sjowall C; Leonard D; Lindblad-Toh K; Ronnblom L

Article: PLOS GENETICS. 2020;16(10):e1009199

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

Lundtoft C; Pucholt P; Imgenberg-Kreuz J; Carlsson-Almlof J; Eloranta M-L; Syvanen A-C; Nordmark G; Sandling JK; Kockum I; Olsson T; Ronnblom L; Hagberg N

Article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(3):363-369

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

Reid S; Alexsson A; Frodlund M; Morris D; Sandling JK; Bolin K; Svenungsson E; Jonsen A; Bengtsson C; Gunnarsson I; Rodriguez VI; Bengtsson A; Arve S; Rantapaa-Dahlqvist S; Eloranta M-L; Syvanen A-C; Sjowall C; Vyse TJ; Ronnblom L; Leonard D

Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):60

Sex differences in clinical presentation of systemic lupus erythematosus

Sepulveda JIR; Bolin K; Mofors J; Leonard D; Svenungsson E; Jonsen A; Bengtsson C; Nordmark G; Dahlqvist SR; Bengtsson AA; Ronnblom L; Sjowall C; Gunnarsson I; Wahren-Herlenius M; Zickert A; Bjork A; Jonsen A; Sjowali C; Enocsson H; Wettero J; Eriksson P; Thorlacius GE; Lundberg IE; Sanding JK; SeNiveda JIR; Lindblad-Toh K; Ronnblom L; Padyukov L; Hultin-Rosenberg L; Eloranta M-L; Dahiqvist SR

Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(10):1363-1370

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist L; Jevnikar Z; Riise R; Oberg L; Rhedin M; Leonard D; Yrlid L; Jackson S; Mattsson J; Nanda S; Cohen P; Knebel A; Arthur S; Thorn K; Svenungsson E; Jonsen A; Gunnarsson I; Tandre K; Alexsson A; Kastbom A; Rantapaa-Dahlqvist S; Eloranta M-L; Syvanen A-C; Bengtsson A; Johansson P; Sandling JK; Sjowall C; Ronnblom L; Collins B; Vaarala O

Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27(3):432-441

A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts

Farias FHG; Dahlqvist J; Kozyrev SV; Leonard D; Wilbe M; Abramov SN; Alexsson A; Pielberg GR; Hansson-Hamlin H; Andersson G; Tandre K; Bengtsson AA; Sjowall C; Svenungsson E; Gunnarsson I; Rantapaa-Dahlqvist S; Syvanen A-C; Sandling JK; Eloranta M-L; Ronnblom L; Lindblad-Toh K

Article: HUMAN GENETICS. 2019;138(2):141-150

Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus

Almlof JC; Nystedt S; Leonard D; Eloranta M-L; Grosso G; Sjowall C; Bengtsson AA; Jonsen A; Gunnarsson I; Svenungsson E; Ronnblom L; Sandling JK; Syvanen A-C

Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients

Idborg H; Zandian A; Ossipova E; Wigren E; Preger C; Mobarrez F; Checa A; Sohrabian A; Pucholt P; Sandling JK; Fernandes-Cerqueira C; Ronnelid J; Oke V; Grosso G; Kvarnstrom M; Larsson A; Wheelock CE; Syvanen A-C; Ronnblom L; Kultima K; Persson H; Graslund S; Gunnarsson I; Nilsson P; Svenungsson E; Jakobsson P-J

Journal article: FRONTIERS IN IMMUNOLOGY. 2019;10:1686

Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome

Imgenberg-Kreuz J; Almlof JC; Leonard D; Sjowall C; Syvanen A-C; Ronnblom L; Sandling JK; Nordmark G

Journal article: CLINICAL IMMUNOLOGY. 2018;196:12-20

Epigenetic alterations in primary Sjogren's syndrome - an overview

Imgenberg-Kreuz J; Sandling JK; Nordmark G

Journal article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):238

Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Hjorton K; Hagberg N; Israelsson E; Jinton L; Berggren O; Sandling JK; Thorn K; Mo J; Eloranta M-L; Ronnblom L

Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(7):1063-1069

Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis

Leonard D; Svenungsson E; Dahlqvist J; Alexsson A; Arlestig L; Taylor KE; Sandling JK; Bengtsson C; Frodlund M; Jonsen A; Eketjall S; Jensen-Urstad K; Gunnarsson I; Sjowall C; Bengtsson AA; Eloranta M-L; Syvanen A-C; Rantapaa-Dahlqvist S; Criswell LA; Ronnblom L

Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2018;87(5):e12662

Transcription profiling of peripheral B cells in antibody-positive primary Sjogren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature

Imgenberg-Kreuz J; Sandling JK; Bjork A; Nordlund J; Kvarnstrom M; Eloranta M-L; Ronnblom L; Wahren-Herlenius M; Syvanen A-C; Nordmark G

Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(5):736-743

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus

Imgenberg-Kreuz J; Almlof JC; Leonard D; Alexsson A; Nordmark G; Eloranta M-L; Rantapaa-Dahlqvist S; Bengtsson AA; Jonsen A; Padyukov L; Gunnarsson I; Svenungsson E; Sjowall C; Ronnblom L; Syvanen A-C; Sandling JK

Article: MOLECULAR PSYCHIATRY. 2018;23(2):422-433

A DNA methylation biomarker of alcohol consumption

Liu C; Marioni RE; Hedman AK; Pfeiffer L; Tsai P-C; Reynolds LM; Just AC; Duan Q; Boer CG; Tanaka T; Elks CE; Aslibekyan S; Brody JA; Kuehnel B; Herder C; Almli LM; Zhi D; Wang Y; Huan T; Yao C; Mendelson MM; Joehanes R; Liang L; Love S-A; Guan W; Shah S; Mcrae AF; Kretschmer A; Prokisch H; Strauch K; Peters A; Visscher PM; Wray NR; Guo X; Wiggins KL; Smith AK; Binder EB; Ressler KJ; Irvin MR; Absher DM; Hernandez D; Ferrucci L; Bandinelli S; Lohman K; Ding J; Trevisi L; Gustafsson S; Sandling JH; Stolk L; Uitterlinden AG; Yet I; Castillo-Fernandez JE; Spector TD; Schwartz JD; Vokonas P; Lind L; Li Y; Fornage M; Arnett DK; Wareham NJ; Sotoodehnia N; Ong KK; van Meurs JBJ; Conneely KN; Baccarelli AA; Deary IJ; Bell JT; North KE; Liu Y; Waldenberger M; London SJ; Ingelsson E; Levy D

Article: BIOLOGY OF SEX DIFFERENCES. 2017;8(1):25

Long-term follow-up in primary Sjogren's syndrome reveals differences in clinical presentation between female and male patients

Sepulveda JIR; Kvarnstrom M; Eriksson P; Mandl T; Norheim KB; Johnsen SJ; Hammenfors D; Jonsson MV; Skarstein K; Brun JG; Ronnblom L; Forsblad-d'Elia H; Bucher SM; Baecklund E; Theander E; Omdal R; Jonsson R; Nordmark G; Wahren-Herlenius M

Article: SCIENTIFIC REPORTS. 2017;7(1):6236

Novel risk genes for systemic lupus erythematosus predicted by random forest classification

Almlof JC; Alexsson A; Imgenberg-Kreuz J; Sylwan L; Backlin C; Leonard D; Nordmark G; Tandre K; Eloranta M-L; Padyukov L; Bengtsson C; Jonsen A; Dahlqvist SR; Sjowall C; Bengtsson AA; Gunnarsson I; Svenungsson E; Ronnblom L; Sandling JK; Syvanen A-C

Article: NATURE COMMUNICATIONS. 2017;8:16021

Transancestral mapping and genetic load in systemic lupus erythematosus

Langefeld CD; Ainsworth HC; Graham DSC; Kelly JA; Comeau ME; Marion MC; Howard TD; Ramos PS; Croker JA; Morris DL; Sandling JK; Almlof JC; Acevedo-Vasquez EM; Alarcon GS; Babini AM; Baca V; Bengtsson AA; Berbotto GA; Bijl M; Brown EE; Brunner HI; Cardiel MH; Catoggio L; Cervera R; Cucho-Venegas JM; Dahlqvist SR; D'Alfonso S; Da Silva BM; de la Rua Figueroa I; Doria A; Edberg JC; Endreffy E; Esquivel-Valerio JA; Fortin PR; Freedman BI; Frostegard J; Garcia MA; Garcia de la Torre I; Gilkeson GS; Gladman DD; Gunnarsson I; Guthridge JM; Huggins JL; James JA; Kallenberg CGM; Kamen DL; Karp DR; Kaufman KM; Kottyan LC; Kovacs L; Laustrup H; Lauwerys BR; Li Q-Z; Maradiaga-Cecena MA; Martin J; McCune JM; McWilliams DR; Merrill JT; Miranda P; Moctezuma JF; Nath SK; Niewold TB; Orozco L; Ortego-Centeno N; Petri M; Pineau CA; Pons-Estel BA; Pope J; Raj P; Ramsey-Goldman R; Reveille JD; Russell LP; Sabio JM; Aguilar-Salinas CA; Scherbarth HR; Scorza R; Seldin MF; Sjowall C; Svenungsson E; Thompson SD; Toloza SMA; Truedsson L; Tusie-Luna T; Vasconcelos C; Vila LM; Wallace DJ; Weisman MH; Wither JE; Bhangale T; Oksenberg JR; Rioux JD; Gregersen PK; Syvanen A-C; Ronnblom L; Criswell LA; Jacob CO; Sivils KL; Tsao BP; Schanberg LE; Behrens TW; Silverman ED; Alarcon-Riquelme ME; Kimberly RP; Harley JB; Wakeland EK; Graham RR; Gaffney PM; Vyse TJ

Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(4):910-920

Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma

Roos L; Sandling JK; Bell CG; Glass D; Mangino M; Spector TD; Deloukas P; Bataille V; Bell JT

Journal article: NATURE. 2017;541(7635):81-86

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Wahl S; Drong A; Lehne B; Loh M; Scott WR; Kunze S; Tsai P-C; Ried JS; Zhang W; Yang Y; Tan S; Fiorito G; Franke L; Guarrera S; Kasela S; Kriebel J; Richmond RC; Adamo M; Afzal U; Ala-Korpela M; Albetti B; Ammerpohl O; Apperley JF; Beekman M; Bertazzi PA; Black SL; Blancher C; Bonder M-J; Brosch M; Carstensen-Kirberg M; de Craen AJM; de Lusignan S; Dehghan A; Elkalaawy M; Fischer K; Franco OH; Gaunt TR; Hampe J; Hashemi M; Isaacs A; Jenkinson A; Jha S; Kato N; Krogh V; Laffan M; Meisinger C; Meitinger T; Mok ZY; Motta V; Ng HK; Nikolakopoulou Z; Nteliopoulos G; Panico S; Pervjakova N; Prokisch H; Rathmann W; Roden M; Rota F; Rozario MA; Sandling JK; Schafmayer C; Schramm K; Siebert R; Slagboom PE; Soininen P; Stolk L; Strauch K; Tai E-S; Tarantini L; Thorand B; Tigchelaar EF; Tumino R; Uitterlinden AG; van Duijn C; van Meurs JBJ; Vineis P; Wickremasinghe AR; Wijmenga C; Yang T-P; Yuan W; Zhernakova A; Batterham RL; Smith GD; Deloukas P; Heijmans BT; Herder C; Hofman A; Lindgren CM; Milani L; van der Harst P; Peters A; Illig T; Relton CL; Waldenberger M; Jaervelin M-R; Bollati V; Soong R; Spector TD; Scott J; McCarthy MI; Elliott P; Bell JT; Matullo G; Gieger C; Kooner JS; Grallert H; Chambers JC

Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2017;10(1):e001487

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies

Hedman AK; Mendelson MM; Marioni RE; Gustafsson S; Joehanes R; Irvin MR; Zhi D; Sandling JK; Yao C; Liu C; Liang L; Huan T; McRae AF; Demissie S; Shah S; Starr JM; Cupples LA; Deloukas P; Spector TD; Sundstrom J; Krauss RM; Arnett DK; Deary IJ; Lind L; Levy D; Ingelsson E

Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(11):2029-2036

Genome-wide DNA methylation analysis in multiple tissues in primary Sjogren's syndrome reveals regulatory effects at interferon-induced genes

Imgenberg-Kreuz J; Sandling JK; Almlof JC; Nordlund J; Signer L; Norheim KB; Omdal R; Ronnblom L; Eloranta M-L; Syvanen A-C; Nordmark G

Journal article: BMC MEDICAL GENOMICS. 2016;9(1):59

Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells

Morin A; Kwan T; Ge B; Letourneau L; Ban M; Tandre K; Caron M; Sandling JK; Carlsson J; Bourque G; Laprise C; Montpetit A; Syvanen A-C; Ronnblom L; Sawcer SJ; Lathrop MG; Pastinen T

Journal article: RHEUMATOLOGY. 2016;55(6):1074-1082

Epigenome-wide DNA methylation patterns associated with fatigue in primary Sjogren's syndrome

Norheim KB; Imgenberg-Kreuz J; Jonsdottir K; Janssen EAM; Syvanen A-C; Sandling JK; Nordmark G; Omdal R

Article: HUMAN MOLECULAR GENETICS. 2015;24(15):4464-4479

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

Demerath EW; Guan W; Grove ML; Aslibekyan S; Mendelson M; Zhou Y-H; Hedman AK; Sandling JK; Li L-A; Irvin MR; Zhi D; Deloukas P; Liang L; Liu C; Bressler J; Spector TD; North K; Li Y; Absher DM; Levy D; Arnett DK; Fornage M; Pankow JS; Boerwinkle E

Article: NATURE COMMUNICATIONS. 2015;6:7211

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Allum F; Shao X; Guenard F; Simon M-M; Busche S; Caron M; Lambourne J; Lessard J; Tandre K; Hedman AK; Kwan T; Ge B; Ronnblom L; McCarthy MI; Deloukas P; Richmond T; Burgess D; Spector TD; Tchernof A; Marceau S; Lathrop M; Vohl M-C; Pastinen T; Grundberg E

Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2015;8(2):334-342

DNA Methylation of Lipid-Related Genes Affects Blood Lipid Levels

Pfeiffer L; Wahl S; Pilling LC; Reischl E; Sandling JK; Kunze S; Holdt LM; Kretschmer A; Schramm K; Adamski J; Klopp N; Illig T; Hedman AK; Roden M; Hernandez DG; Singleton AB; Thasler WE; Grallert H; Gieger C; Herder C; Teupser D; Meisinger C; Spector TD; Kronenberg F; Prokisch H; Melzer D; Peters A; Deloukas P; Ferrucci L; Waldenberger M

Journal article: NEUROLOGY. 2014;83(8):678-685

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

Kilarski LL; Achterberg S; Devan WJ; Traylor M; Malik R; Lindgren A; Pare G; Sharma P; Slowik A; Thijs V; Walters M; Worrall BB; Sale MM; Algra A; Kappelle LJ; Wijmenga C; Norrving B; Sandling JK; Roennblom L; Goris A; Franke A; Sudlow C; Rothwell PM; Levi C; Holliday EG; Fornage M; Psaty B; Gretarsdottir S; Thorsteinsdottir U; Seshadri S; Mitchell BD; Kittner S; Clarke R; Hopewell JC; Bis JC; Boncoraglio GB; Meschia J; Ikram MA; Hansen BM; Montaner J; Thorleifsson G; Stefanson K; Rosand J; de Bakker PIW; Farrall M; Dichgans M; Markus HS; Bevan S

Journal article: LANCET. 2014;383(9933):1990-1998

DNA methylation and body-mass index: a genome-wide analysis

Dick KJ; Nelson CP; Tsaprouni L; Sandling JK; Aissi D; Wahl S; Meduri E; Morange P-E; Gagnon F; Grallert H; Waldenberger M; Peters A; Erdmann J; Hengstenberg C; Cambien F; Goodall AH; Ouwehand WH; Schunkert H; Thompson JR; Spector TD; Gieger C; Tregout D-A; Deloukas P; Samani NJ

Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2013;93(5):876-890

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Grundberg E; Meduri E; Sandling JK; Hedman AK; Keildson S; Buil A; Busche S; Yuan W; Nisbet J; Sekowska M; Wilk A; Barrett A; Small KS; Ge B; Caron M; Shin S-Y; Lathrop M; Dermitzakis ET; McCarthy MI; Spector TD; Bell JT; Deloukas P

Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2013;21(9):994-999

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Wang C; Ahlford A; Jarvinen TM; Nordmark G; Eloranta M-L; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jonsen A; Bengtsson AA; Truedsson L; Eriksson C; Rantapaa-Dahlqvist S; Sjowall C; Julkunen H; Criswell LA; Graham RR; Behrens TW; Kere J; Ronnblom L; Syvanen A-C; Sandling JK

Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2013;6(3):255-263

Coronary Heart Disease in Systemic Lupus Erythematosus Is Associated With Interferon Regulatory Factor-8 Gene Variants

Leonard D; Svenungsson E; Sandling JK; Berggren O; Jonsen A; Bengtsson C; Wang C; Jensen-Urstad K; Granstam S-O; Bengtsson AA; Gustafsson JT; Gunnarsson I; Rantapaa-Dahlqvist S; Nordmark G; Eloranta M-L; Syvanen A-C; Ronnblom L

Article: GENES AND IMMUNITY. 2013;14(4):217-222

Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility

Wang C; Ahlford A; Laxman N; Nordmark G; Eloranta M-L; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jonsen A; Bengtsson AA; Truedsson L; Rantapaa-Dahlqvist S; Sjowall C; Sandling JK; Ronnblom L; Syvanen A-C

Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(6):1018-1025

HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus

Lundstrom E; Gustafsson JT; Jonsen A; Leonard D; Zickert A; Elvin K; Sturfelt G; Nordmark G; Bengtsson AA; Sundin U; Kallberg H; Sandling JK; Syvanen A-C; Klareskog L; Gunnarsson I; Ronnblom L; Padyukov L; Svenungsson E

Article: PLOS ONE. 2013;8(12):e84450

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis

Bolin K; Sandling JK; Zickert A; Jonsen A; Sjowall C; Svenungsson E; Bengtsson AA; Eloranta M-L; Ronnblom L; Syvanen A-C; Gunnarsson I; Nordmark G

Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(1):96-103

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4

Wang C; Sandling JK; Hagberg N; Berggren O; Sigurdsson S; Karlberg O; Ronnblom L; Eloranta M-L; Syvanen A-C

Journal article: GENE. 2012;504(2):220-225

Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma

Wang C; Rose-Zerilli MJ; Koppelman GH; Sandling JK; Holloway JW; Postma DS; Holgate ST; Bours V; Syvanen A-C; Dideberg V

Article: JOURNAL OF RHEUMATOLOGY. 2011;38(10):2130-2132

Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control Studies

Wang C; Kokkonen H; Sandling JK; Johansson M; Seddighzadeh M; Padyukov L; Rantapaa-Dahlqvist S; Syvanen A-C

Article: AMERICAN JOURNAL OF KIDNEY DISEASES. 2011;57(6):863-872

Fetal, Developmental, and Parental Influences on Cystatin C in Childhood: The Uppsala Family Study

Nitsch D; Sandling JK; Byberg L; Larsson A; Tuvemo T; Syvanen A-C; Koupil I; Leon DA

Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(4):479-484

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Sandling JK; Garnier S; Sigurdsson S; Wang C; Nordmark G; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jonsen A; Bengtsson AA; Truedsson L; Eriksson C; Rantapaa-Dahlqvist S; Malarstig A; Strawbridge RJ; Hamsten A; Criswell LA; Graham RR; Behrens TW; Eloranta M-L; Alm G; Ronnblom L; Syvanen A-C

Journal article: PLOS GENETICS. 2011;7(2):e1001307

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

Sovio U; Mook-Kanamori DO; Warrington NM; Lawrence R; Briollais L; Palmer CNA; Cecil J; Sandling JK; Syvanen A-C; Kaakinen M; Beilin LJ; Millwood IY; Bennett AJ; Laitinen J; Pouta A; Molitor J; Smith GD; Ben-Shlomo Y; Jaddoe VWV; Palmer LJ; Pennell CE; Cole TJ; McCarthy MI; Jarvelin M-R; Timpson NJ

Article: ANNALS OF THE RHEUMATIC DISEASES. 2010;69(5):834-840

A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus

Svenungsson E; Gustafsson J; Leonard D; Sandling J; Gunnarsson I; Nordmark G; Jonsen A; Bengtsson AA; Sturfelt G; Rantapaa-Dahlqvist S; Elvin K; Sundin U; Garnier S; Simard JF; Sigurdsson S; Padyukov L; Syvanen A-C; Ronnblom L

Article: ANNALS OF THE RHEUMATIC DISEASES. 2010;69(5):883-886

Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort

Hellquist A; Sandling JK; Zucchelli M; Koskenmies S; Julkunen H; D'Amato M; Garnier S; Syvanen A-C; Kere J

Article: NATURE GENETICS. 2009;41(11):1228-1U93

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Gateva V; Sandling JK; Hom G; Taylor KE; Chung SA; Sun X; Ortmann W; Kosoy R; Ferreira RC; Nordmark G; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jonsen A; Bengtsson AA; Rantapaa-Dahlqvist S; Baechler EC; Brown EE; Alarcon GS; Edberg JC; Ramsey-Goldman R; McGwin GJ; Reveille JD; Vila LM; Kimberly RP; Manzi S; Petri MA; Lee A; Gregersen PK; Seldin MF; Ronnblom L; Criswell LA; Syvanen A-C; Behrens TW; Graham RR

Article: JOURNAL OF MEDICAL GENETICS. 2008;45(6):362-369

Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations

Kristjansdottir G; Sandling JK; Bonetti A; Roos IM; Milani L; Wang C; Gustafsdottir SM; Sigurdsson S; Lundmark A; Tienari PJ; Koivisto K; Elovaara I; Pirttila T; Reunanen M; Peltonen L; Saarela J; Hillert J; Olsson T; Landegren U; Alcina A; Fernandez O; Leyva L; Guerrero M; Lucas M; Izquierdo G; Matesanz F; Syvanen A-C

Article: HUMAN MOLECULAR GENETICS. 2008;17(6):872-881

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

Sigurdsson S; Goering HHH; Kristjansdottir G; Milani L; Nordmark G; Sandling JK; Eloranta M-L; Feng D; Sangster-Guity N; Gunnarsson I; Svenungsson E; Sturfelt G; Joensen A; Truedsson L; Barnes BJ; Alm G; Roennblom L; Syvaenen A-C

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