Johanna Lanner
About me
Associate Professor of Physiology and principal investigator for the Molecular Muscle Physiology and Pathophysiology laboratory at the Department of Physiology and Pharmacology.
Research
Chronic (non-communicable) diseases including rheumatoid arthritis, diabetes, cardiovascular disease and cancer often develop secondary muscle complications. These muscle complications (including weakness and fatigue) may even be the overshadowing symptoms since ordinary daily activities require extensive effort which reduces the quality of life for afflicted patients, and also contribute to increased mortality risk.
My research centers on muscles capacity to generate force and processes that provides the muscle with energy, particularly focusing on calcium regulation, redox signaling, and mitochondrial function. Over the years, my research has explored the intricate mechanisms underlying muscle dysfunction in chronic diseases that exhibit a component of systemic inflammation. My work has led to valuable insights into the interplay between cellular processes impact on overall muscle health.
- Research in the Molecular Muscle Physiology and Pathophysiology laboratory aims to improve our molecular understanding of muscle dysfunction including weakness and fatigue.
- We are also involved in developing novel therapeutic interventions to improve muscle function.
In the Molecular Muscle Physiology and Pathophysiology laboratory we have created an interdisciplinary and translational niche for making ground-breaking research on the causes of muscle function and dysfunction. This includes human patients and healthy subjects, as well as preclinical models, which are used together with functional analyses (e.g. live imaging, muscle contraction, cellular respirometry), ultrastructural analyses (e.g. electron microscopy, near super-resolution imaging), in vivo assessments (e.g. muscle strength, indirect calorimetry) and multi-omics analyses. This approach allows us to bridge gaps between disciplines, foster creativity and innovation.
Articles
- Article: MOLECULAR METABOLISM. 2024;82:101912
- Journal article: ELIFE. 2024;12
- Article: ELIFE. 2024;12:rp87592
- Article: CIRCULATION RESEARCH. 2023;133(3):255-270
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(11):102515
- Article: ACTA PHYSIOLOGICA. 2022;236(3):e13869
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2022;13(5):2551-2561
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2022;13(2):1151-1163
- Article: THE FASEB JOURNAL. 2021;35(12):e22010
- Article: CELL METABOLISM. 2021;33(11):2215-2230.e8
- Article: SCIENCE ADVANCES. 2021;7(43):eabi9654
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2021;12(5):1232-1248
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2021;320(4):E691-E701
- Journal article: CURRENT OPINION IN PHYSIOLOGY. 2020;17:124-137
- Article: JOURNAL OF PHYSIOLOGY. 2020;598(4):773-787
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2019;317(6):C1304-C1312
- Article: SKELETAL MUSCLE. 2019;9(1):26
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(8):1904-1924
- Article: NATURE COMMUNICATIONS. 2019;10(1):2767
- Article: JOURNAL OF PHYSIOLOGY. 2019;597(12):3133-3146
- Article: THE JOURNAL OF GENERAL PHYSIOLOGY. 2019;151(4):567-577
- Article: JCI INSIGHT. 2019;4(9):126347
- Article: ELIFE. 2018;7:e41044
- Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1111
- Article: JOURNAL OF PHYSIOLOGY. 2017;595(24):7413-7426
- Article: PHYSIOLOGICAL REPORTS. 2017;5(11):e13261
- Article: PLOS ONE. 2017;12(6):e0179925
- Article: PLOS ONE. 2017;12(2):e0169146
- Article: PHYSIOLOGY AND BEHAVIOR. 2017;168:55-61
- Article: THE FASEB JOURNAL. 2016;30(12):3929-3941
- Article: BASIC RESEARCH IN CARDIOLOGY. 2016;111(3):34
- Article: PLOS ONE. 2016;11(12):e0167090
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15492-15497
- Article: HUMAN MOLECULAR GENETICS. 2015;24(23):6580-6587
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(10):1907-1914
- Article: JOURNAL OF PHYSIOLOGY. 2015;593(2):457-472
- Journal article: SKELETAL MUSCLE. 2015;5:4
- Article: SKELETAL MUSCLE. 2015;5:26
- Article: SKELETAL MUSCLE. 2015;5:20
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(37):25556-25570
- Article: CARDIOVASCULAR RESEARCH (CVR). 2014;103(1):90-99
- Article: PLOS ONE. 2014;9(8):e104731
- Article: NATURE MEDICINE. 2012;18(2):244-251
- Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2012;740:217-234
- Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2010;2(11):a003996
- Journal article: BIOPHYSICAL JOURNAL. 2010;98(3):714a
- Article: THE FASEB JOURNAL. 2009;23(6):1728-1738
- Article: MUSCLE AND NERVE. 2009;39(5):674-682
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2007;293(3):C1154-C1159
- Article: DIABETES. 2007;56(4):1136-1142
- Article: CARDIOVASCULAR RESEARCH (CVR). 2007;73(2):376-385
- Article: DIABETES. 2006;55(7):2077-2083
- Article: BMC CELL BIOLOGY. 2004;5:7
- Article: ACTA CRYSTALLOGRAPHICA SECTION E: CRYSTALLOGRAPHIC COMMUNICATIONS. 2001;57:i85-i86
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All other publications
- Review: MOLECULAR ASPECTS OF MEDICINE. 2024;97:101260
- Preprint: BIORXIV. 2023
- Preprint: BIORXIV. 2023;BIORXIV
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839.1-83839
- Editorial comment: THE JOURNAL OF GENERAL PHYSIOLOGY. 2023;155(2):e202213224
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Preprint: SSRN ELECTRONIC JOURNAL. 2022
- Preprint: BIORXIV. 2021
- Review: CLINICAL SCIENCE. 2020;134(21):2835-2850
- Review: REDOX BIOLOGY. 2020;35:101480
- Conference publication: ACTA PHYSIOLOGICA. 2019;227:79
- Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;128:s106
- Review: EBIOMEDICINE. 2017;23:12-19
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:29
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:20-21
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:17
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17
- Editorial comment: JOURNAL OF DIABETES RESEARCH. 2017;2017:7485738-3
- Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186
- Review: JOURNAL OF PHYSIOLOGY. 2016;594(18):5149-5160
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:7
- Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):598A-599A
- Editorial comment: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2015;308(9):C697-C698
- Conference publication: THE FASEB JOURNAL. 2015;29
- Conference publication: ACTA PHYSIOLOGICA. 2014;211:57
- Conference publication: ACTA PHYSIOLOGICA. 2014;211:58
- Conference publication: ACTA PHYSIOLOGICA. 2014;211:76
- Meeting abstract: BIOPHYSICAL JOURNAL. 2014;106(2):728A
- Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):105A-106A
- Book chapter: NANOTECHNOLOGY AND NANOMEDICINE IN DIABETES. 2012;p. 98-119
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a43-A44
- Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):364A
- Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):511A
- Conference publication: JOURNAL OF PHYSIOLOGICAL SCIENCES. 2009;59:240
- Thesis / dissertation: 2008
- Review: CURRENT OPINION IN PHARMACOLOGY. 2008;8(3):339-345
- Conference publication: THE FASEB JOURNAL. 2008;22:1226.5
- Conference publication: BIOPHYSICAL JOURNAL. 2007;:622A-623A
- Conference publication: BIOPHYSICAL JOURNAL. 2005;88(1):301A
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Grants
- Swedish Research Council1 January 2023 - 31 December 2027
Employments
- Senior Lecturer, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-
Degrees and Education
- Docent, Karolinska Institutet, 2020
- Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2008