Johanna Lanner

Johanna Lanner

Senior Lecturer | Docent
Telephone: +46852482373
Visiting address: Solnavägen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Molekylär muskelfysiologi och patofysiologi, 171 77 Stockholm

About me

  • Associate Professor of Physiology and principal investigator for the 

  • Molecular Muscle Physiology and Pathophysiology laboratory at the
    Department of Physiology and Pharmacology.

     

  • I thrive in collaborative environments, valuing diverse perspectives and leveraging collective expertise. This can be witnessed in my lab in regards of composition of the lab, and how we work together and embark on research questions.

Research

  • Chronic (non-communicable) diseases including rheumatoid arthritis, diabetes, cardiovascular disease and cancer often develop secondary muscle complications. These muscle complications (including weakness and fatigue) may even be the overshadowing symptoms since ordinary daily activities require extensive effort which reduces the quality of life for afflicted patients, and also contribute to increased mortality risk.

     

  • My research centers on muscles capacity to generate force and processes that provides the muscle with energy, particularly focusing on calcium regulation, redox signaling, and mitochondrial function. Over the years, my research has explored the intricate mechanisms underlying muscle dysfunction in chronic diseases that exhibit a component of systemic inflammation. My work has led to valuable insights into the interplay between cellular processes impact on overall muscle health.

     

  • Research in the Molecular Muscle Physiology and Pathophysiology laboratory aims to improve our molecular understanding of muscle dysfunction including weakness and fatigue.  

  • We are also involved in developing novel therapeutic interventions to improve muscle function.

     

  • In the Molecular Muscle Physiology and Pathophysiology laboratory we have created an interdisciplinary and translational niche for making ground-breaking research on the causes of muscle function and dysfunction. This includes human patients and healthy subjects, as well as preclinical models, which are used together with functional analyses (e.g. live imaging, muscle contraction, cellular respirometry), ultrastructural analyses (e.g. electron microscopy, near super-resolution imaging), in vivo assessments (e.g. muscle strength, indirect calorimetry) and multi-omics analyses. This approach allows us to bridge gaps between disciplines, foster creativity and innovation.

Articles

All other publications

Grants

Employments

  • Senior Lecturer, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-

Degrees and Education

  • Docent, Karolinska Institutet, 2020
  • Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2008

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