Johan Frostegård

About me
Publications
Public outreach and news

About me

Professor of Medicine at the Institute of Environmental Medicine and Head of Unit of Immunology and Chronic Disease. Main research interest is how different types of lipids, mainly phospholipids, activate immune reactions and how these affect atherosclerosis, cardiovascular disease, and inflammation in general. The research is both experimental and clinically oriented.

Articles

Article: SCIENTIFIC REPORTS. 2023;13(1):15011
Antibodies against malondialdehyde among 60-year-olds: prediction of cardiovascular disease
Samal SK; Leander K; Vikstroem M; Griesbaum L; de Faire U; Frostegard J
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:809007
Antibodies Against Phosphorylcholine Among 60-Year-Olds: Clinical Role and Simulated Interactions
Samal SK; Panda PK; Vikstrom M; Leander K; de Faire U; Ahuja R; Frostegard J
Article: SCIENTIFIC REPORTS. 2021;11(1):20246
Antibodies against phosphorylcholine in hospitalized versus non-hospitalized obese subjects
Jujic A; Korduner J; Holm H; Engstrom G; Bachus E; Bhattacharya P; Nilsson PM; Frostegard J; Magnusson M
Article: ACR OPEN RHEUMATOLOGY. 2021;3(9):642-653
Effects of Atorvastatin on T-Cell Activation and Apoptosis in Systemic Lupus Erythematosus and Novel Simulated Interactions With C-Reactive Protein and Interleukin 6
Sun J; Panda PK; Samal SK; Ahuja R; Ajeganova S; Hafstrom I; Liu A; Frostegard J
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):201
Higher levels of anti-phosphorylcholine autoantibodies in early rheumatoid arthritis indicate lower risk of incident cardiovascular events
Ajeganova S; Andersson MLE; Frostegard J; Hafstrom I
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(1):141-156
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases
Vries MR; Ewing MM; Jong RCM; MacArthur MR; Karper JC; Peters EAB; Nordzell M; Karabina SAP; Sexton D; Dahlbom I; Bergman A; Mitchell JR; Frostegard J; Kuiper J; Ninio E; Jukema JW; Pettersson K; Quax PHA
Article: SCIENTIFIC REPORTS. 2021;11(1):12120
Potential natural immunization against atherosclerosis in hibernating bears
Samal SK; Frobert O; Kindberg J; Stenvinkel P; Frostegard J
Article: ARTHRITIS & RHEUMATOLOGY. 2021;73(6):1073-1085
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
Barturen G; Babaei S; Catala-Moll F; Martinez-Bueno M; Makowska Z; Martorell-Marugan J; Carmona-Saez P; Toro-Dominguez D; Carnero-Montoro E; Teruel M; Kerick M; Acosta-Herrera M; Le Lann L; Jamin C; Rodriguez-Ubreva J; Garcia-Gomez A; Kageyama J; Buttgereit A; Hayat S; Mueller J; Lesche R; Hernandez-Fuentes M; Juarez M; Rowley T; White I; Maranon C; Gomes Anjos T; Varela N; Aguilar-Quesada R; Garrancho FJ; Lopez-Berrio A; Rodriguez Maresca M; Navarro-Linares H; Almeida I; Azevedo N; Brandao M; Campar A; Faria R; Farinha F; Marinho A; Neves E; Tavares A; Vasconcelos C; Trombetta E; Montanelli G; Vigone B; Alvarez-Errico D; Li T; Thiagaran D; Blanco Alonso R; Corrales Martinez A; Genre F; Lopez Mejias R; Gonzalez-Gay MA; Remuzgo S; Ubilla Garcia B; Cervera R; Espinosa G; Rodriguez-Pinto I; De Langhe E; Cremer J; Lories R; Belz D; Hunzelmann N; Baerlecken N; Kniesch K; Witte T; Lehner M; Stummvoll G; Zauner M; Aguirre-Zamorano MA; Barbarroja N; Castro-Villegas MC; Collantes-Estevez E; de Ramon E; Diaz Quintero I; Escudero-Contreras A; Fernandez Roldan MC; Jimenez Gomez Y; Jimenez Moleon I; Lopez-Pedrera R; Ortega-Castro R; Ortego N; Raya E; Artusi C; Gerosa M; Meroni PL; Schioppo T; De Groof A; Ducreux J; Lauwerys B; Maudoux A-L; Cornec D; Devauchelle-Pensec V; Jousse-Joulin S; Jouve P-E; Rouviere B; Saraux A; Simon Q; Alvarez M; Chizzolini C; Dufour A; Wynar D; Balog A; Bocskai M; Deak M; Dulic S; Kadar G; Kovacs L; Cheng Q; Gerl V; Hiepe F; Khodadadi L; Thiel S; de Rinaldis E; Rao S; Benschop RJ; Chamberlain C; Dow ER; Ioannou Y; Laigle L; Marovac J; Wojcik J; Renaudineau Y; Borghi MO; Frostegard J; Martin J; Beretta L; Ballestar E; McDonald F; Pers J-O; Alarcon-Riquelme ME
Article: LUPUS SCIENCE AND MEDICINE. 2021;8(1):e000454
Patients with SLE have higher risk of cardiovascular events and mortality in comparison with controls with the same levels of traditional risk factors and intima-media measures, which is related to accumulated disease damage and antiphospholipid syndrome: a case-control study over 10 years
Ajeganova S; Hafstrom I; Frostegard J
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):32
Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms
Frostegard J; Ahmed S; Hafstrom I; Ajeganova S; Rahman M
Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100090
An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases
Bettacchioli E; Le Gaffric C; Mazeas M; Borghi MO; Frostegard J; Barturen G; Makowska Z; Babei S; Lesche R; Meroni PL; Alarcon-Riquelme ME; Renaudineau Y
Article: BMC CARDIOVASCULAR DISORDERS. 2020;20(1):524
C-reactive protein in traditional melanesians on Kitava
Carrera-Bastos P; Fontes-Villalba M; Gurven M; Muskiet FAJ; Akerfeldt T; Lindblad U; Rastam L; Frostegard J; Shapira Y; Shoenfeld Y; Granfeldt Y; Sundquist K; Jonsson T
Article: JOURNAL OF AUTOIMMUNITY. 2020;115:102524
Antiphospholipid autoantibody detection is important in all patients with systemic autoimmune diseases
Marziale A; Bettacchioli E; Picart G; Nafai S; Galinat H; Meroni PL; Frostegard J; Alarcon-Riquelme ME; Renaudineau Y
Article: JOURNAL OF IMMUNOLOGY. 2020;205(8):2109-2116
Antibodies against Phosphorylcholine and Malondialdehyde during the First Two Years of Life
Thiagarajan D; Lundstrom SL; Pershagen G; Malmros CA; Andolf E; Hedman A; Berg O; Oparina N; Frostegard J
Article: SCIENTIFIC REPORTS. 2020;10(1):11010
IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases
Thiagarajan D; Oparina N; Lundstrom S; Zubarev R; Sun J; Alarcon-Riquelme M; Frostegard J
Article: LUPUS. 2020;29(8):825-835
Proprotein convertase subtilisin kexin 9 is associated with disease activity and is implicated in immune activation in systemic lupus erythematosus
Liu A; Rahman M; Hafstrom I; Ajeganova S; Frostegard J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2020;201(1):94-104
Different subclasses and isotypes of antibodies against phosphorylcholine in haemodialysis patients: association with mortality
Samal SK; Qureshi AR; Rahman M; Stenvinkel P; Frostegard J
Article: ACR OPEN RHEUMATOLOGY. 2020;2(6):344-356
Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms
Thiagarajan D; Fiskesund R; Frostegard A; Steen J; Rahman M; Vikstroem M; Lundstroem S; Frostegard J
Article: JOURNAL OF INTERNAL MEDICINE. 2020;287(4):422-434
Phenotypic features of vascular calcification in chronic kidney disease
Dai L; Debowska M; Lukaszuk T; Bobrowski L; Barany P; Soderberg M; Thiagarajan D; Frostegard J; Wennberg L; Lindholm B; Qureshi AR; Waniewski J; Stenvinkel P
Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(3):E753-753
Antibodies against Malondialdehyde in Haemodialysis Patients and Its Association with Clinical Outcomes: Differences between Subclasses and Isotypes
Samal SK; Qureshi AR; Rahman M; Stenvinkel P; Frostegard J
Article: LUPUS SCIENCE AND MEDICINE. 2020;7(1):e000362
Similar progression of carotid intima-media thickness in 7-year surveillance of patients with mild SLE and controls, but this progression is still promoted by dyslipidaemia, lower HDL levels, hypertension, history of lupus nephritis and a higher prednisolone usage in patients
Ajeganova S; Gustafsson T; Lindberg L; Hafstrom I; Frostegard J
Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2019;4(4):480-494
Malondialdehyde Conjugated With Albumin Induces Pro-Inflammatory Activation of T Cells Isolated From Human Atherosclerotic Plaques Both Directly and Via Dendritic Cell-Mediated Mechanism
Rahman M; Steuer J; Gillgren P; Vegvari A; Liu A; Frostegard J
Article: LUPUS. 2018;27(10):1670-1678
Autoantibody profiling reveals four protein candidate autoantigens associated with systemic lupus erythematosus
Frostegard J; Hellstrom C; Nilsson P; Frostegard AG; Ajeganova S
Article: CLINICAL RHEUMATOLOGY. 2018;37(7):1825-1834
Variation in pain related to systemic lupus erythematosus (SLE): a 7-year follow-up study
Waldheim E; Ajeganova S; Bergman S; Frostegard J; Welin E
Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
Chen X; Gustafsson S; Whitington T; Borne Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hagg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engstrom G; Lind L; Karlsson MCI; Pedersen NL; Frostegard J; Magnusson PKE
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):428-433
Association between dietary and metabolic factors and IgM antibodies to phosphorylcholine and malondialdehyde in patients with systemic lupus erythematosus and population-based matched controls
Lourdudoss C; Ajeganova S; Frostegard J
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(2):193-210
PCSK9 plays a novel immunological role in oxidized LDL-induced dendritic cell maturation and activation of T cells from human blood and atherosclerotic plaque
Liu A; Frostegard J
Article: ATHEROSCLEROSIS. 2018;268:36-48
IgM antibodies against phosphorylcholine promote polarization of T regulatory cells from patients with atherosclerotic plaques, systemic lupus erythematosus and healthy donors
Sun J; Lundstrom SL; Zhang B; Zubarev RA; Steuer J; Gillgren P; Rahman M; Ajeganova S; Liu A; Frostegard J
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2017;6(11):e006778
Induction of Dendritic Cell-Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60
Rahman M; Steuer J; Gillgren P; Hayderi A; Liu A; Frostegard J
Article: NATURE COMMUNICATIONS. 2017;8:16021
Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld CD; Ainsworth HC; Graham DSC; Kelly JA; Comeau ME; Marion MC; Howard TD; Ramos PS; Croker JA; Morris DL; Sandling JK; Almlof JC; Acevedo-Vasquez EM; Alarcon GS; Babini AM; Baca V; Bengtsson AA; Berbotto GA; Bijl M; Brown EE; Brunner HI; Cardiel MH; Catoggio L; Cervera R; Cucho-Venegas JM; Dahlqvist SR; D'Alfonso S; Da Silva BM; de la Rua Figueroa I; Doria A; Edberg JC; Endreffy E; Esquivel-Valerio JA; Fortin PR; Freedman BI; Frostegard J; Garcia MA; Garcia de la Torre I; Gilkeson GS; Gladman DD; Gunnarsson I; Guthridge JM; Huggins JL; James JA; Kallenberg CGM; Kamen DL; Karp DR; Kaufman KM; Kottyan LC; Kovacs L; Laustrup H; Lauwerys BR; Li Q-Z; Maradiaga-Cecena MA; Martin J; McCune JM; McWilliams DR; Merrill JT; Miranda P; Moctezuma JF; Nath SK; Niewold TB; Orozco L; Ortego-Centeno N; Petri M; Pineau CA; Pons-Estel BA; Pope J; Raj P; Ramsey-Goldman R; Reveille JD; Russell LP; Sabio JM; Aguilar-Salinas CA; Scherbarth HR; Scorza R; Seldin MF; Sjowall C; Svenungsson E; Thompson SD; Toloza SMA; Truedsson L; Tusie-Luna T; Vasconcelos C; Vila LM; Wallace DJ; Weisman MH; Wither JE; Bhangale T; Oksenberg JR; Rioux JD; Gregersen PK; Syvanen A-C; Ronnblom L; Criswell LA; Jacob CO; Sivils KL; Tsao BP; Schanberg LE; Behrens TW; Silverman ED; Alarcon-Riquelme ME; Kimberly RP; Harley JB; Wakeland EK; Graham RR; Gaffney PM; Vyse TJ
Article: LAKARTIDNINGEN. 2017;114:EH7W
[Small fatty substances may be of great importance in the development of atherosclerosis].
Frostegård J
Article: IMMUNOLOGICAL INVESTIGATIONS. 2017;46(1):59-69
Antibodies against Phosphorylcholine among New Guineans Compared to Swedes: An Aspect of the Hygiene/Missing Old Friends Hypothesis
Frostegard J; Tao W; Rastam L; Lindblad U; Lindeberg S
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(1):131-142
Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus
An J; Briggs TA; Dumax-Vorzet A; Alarcon-Riquelme ME; Belot A; Beresford M; Bruce IN; Carvalho C; Chaperot L; Frostegard J; Plumas J; Rice GI; Vyse TJ; Wiedeman A; Crow YJ; Elkon KB
Article: PLOS ONE. 2017;12(4):e0171195
IgM antibodies to oxidized phosphatidylserine as protection markers in cardiovascular disease among 60-year olds
Frostegard J; Su J; Sing S; Hua X; Vikstrom M; Leander K; Gigante B; de Faire U; Frostegard AG
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(12):e004415
Human IgM Antibodies to Malondialdehyde Conjugated With Albumin Are Negatively Associated With Cardiovascular Disease Among 60-Year-Olds
Thiagarajan D; Frostegard AG; Singh S; Rahman M; Liu A; Vikstrom M; Leander K; Gigante B; Hellenius M-L; Zhang B; Zubarev RA; de Faire U; Lundstrom SL; Frostegard J
Article: LUPUS. 2016;25(14):1602-1609
Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus
Lourdudoss C; Elkan A-C; Hafstrom I; Jogestrand T; Gustafsson T; van Vollenhoven R; Frostegard J
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(9):e003976
Oxidized Low-Density Lipoprotein (OxLDL)-Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let-7c Is Integral to the Effect
Frostegard J; Zhang Y; Sun J; Yan K; Liu A
Article: CLINICAL IMMUNOLOGY. 2016;166:27-37
IgM antibodies against malondialdehyde and phosphorylcholine are together strong protection markers for atherosclerosis in systemic lupus erythematosus: Regulation and underlying mechanisms
Rahman M; Sing S; Golabkesh Z; Fiskesund R; Gustafsson T; Jogestrand T; Frostegard AG; Hafstrom I; Liu A; Frostegard J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(1):242-252
Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA
Zhao J; Giles BM; Taylor RL; Yette GA; Lough KM; Ng HL; Abraham LJ; Wu H; Kelly JA; Glenn SB; Adler AJ; Williams AH; Comeau ME; Ziegler JT; Marion M; Alarcon-Riquelme ME; Alarcon GS; Anaya J-M; Bae S-C; Kim D; Lee H-S; Criswell LA; Freedman BI; Gilkeson GS; Guthridge JM; Jacob CO; James JA; Kamen DL; Merrill JT; Sivils KM; Niewold TB; Petri MA; Ramsey-Goldman R; Reveille JD; Scofield RH; Stevens AM; Vila LM; Vyse TJ; Kaufman KM; Harley JB; Langefeld CD; Gaffney PM; Brown EE; Edberg JC; Kimberly RP; Ulgiati D; Tsao BP; Boackle SA
Article: LUPUS SCIENCE AND MEDICINE. 2016;3(1):e000135
The association between diet and glucocorticoid treatment in patients with SLE.
Lourdudoss C; Hafström I; Frostegård J; van Vollenhoven R
Article: CLINICAL IMMUNOLOGY. 2015;161(2):157-162
Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus
Zhao J; Wu H; Langefeld CD; Kaufman KM; Kelly JA; Bae S-C; Alarcon-Riquelme ME; Alarcon GS; Anaya J-M; Criswell LA; Freedman BI; Kamen DL; Gilkeson GS; Jacob CO; James JA; Merrill JT; Gaffney PM; Sivils KM; Niewold TB; Petri MA; Song ST; Jeong H-J; Ramsey-Goldman R; Reveille JD; Scofield RH; Stevens AM; Boackle SA; Vila LM; Chang D-M; Song YW; Vyse TJ; Harley JB; Brown EE; Edberg JC; Kimberly RP; Hahn BH; Grossman JM; Tsao BP; La Cava A
Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2015;29(8):1152-1158
Coenzyme Q10 and oxidative stress, the association with peripheral sensory neuropathy and cardiovascular disease in type 2 diabetes mellitus
Forsberg E; Xu C; Grunler J; Frostegard J; Tekle M; Brismar K; Karvestedt L
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):84
Bone mineral density and carotid atherosclerosis in systemic lupus erythematosus: a controlled cross-sectional study
Ajeganova S; Gustafsson T; Jogestrand T; Frostegard J; Hafstrom I
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(3):e14
PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6
Oparina NY; Delgado-Vega AM; Martinez-Bueno M; Magro-Checa C; Fernandez C; Ortega Castro R; Pons-Estel BA; D'Alfonso S; Sebastiani GD; Witte T; Lauwerys BR; Endreffy E; Kovacs L; Escudero A; Lopez-Pedrera C; Vasconcelos C; da Silva BM; Frostegard J; Truedsson L; Martin J; Raya E; Ortego-Centeno N; de los Angeles Aguirre M; de Ramon Garrido E; Castillo Palma M-J; Alarcon-Riquelme ME; Kozyrev SV
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2015;35(1):197-205
Induction of Dendritic Cell-Mediated T-Cell Activation by Modified but Not Native Low-Density Lipoprotein in Humans and Inhibition by Annexin A5 Involvement of Heat Shock Proteins
Liu A; Ming JY; Fiskesund R; Ninio E; Karabina S-A; Bergmark C; Frostegard AG; Frostegard J
Article: ATHEROSCLEROSIS. 2014;236(2):394-399
Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men
Gigante B; Leander K; Vikstrom M; Baldassarre D; Veglia F; Strawbridge RJ; McLeod O; Gertow K; Sennblad B; Shah S; Zabaneh D; Humphries SE; Kauhanen JP; Rauramaa R; Smit AJ; Mannarino E; Giral P; Tremoli E; Hamsten A; Frostegard J; De Faire U
Article: ATHEROSCLEROSIS. 2014;235(2):592-598
Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5
Wan M; Hua X; Su J; Thiagarajan D; Frostegard AG; Haeggstrom JZ; Frostegard J
Article: JOURNAL OF IMMUNOLOGY. 2014;192(10):4551-4559
Naturally Occurring Human Phosphorylcholine Antibodies Are Predominantly Products of Affinity-Matured B Cells in the Adult
Fiskesund R; Steen J; Amara K; Murray F; Szwajda A; Liu A; Douagi I; Malmstrom V; Frostegard J
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(4):586-598
Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription
Guthridge JM; Lu R; Sun H; Sun C; Wiley GB; Dominguez N; Macwana SR; Lessard CJ; Kim-Howard X; Cobb BL; Kaufman KM; Kelly JA; Langefeld CD; Adler AJ; Harley ITW; Merrill JT; Gilkeson GS; Kamen DL; Niewold TB; Brown EE; Edberg JC; Petri MA; Ramsey-Goldman R; Reveille JD; Vila LM; Kimberly RP; Freedman BI; Stevens AM; Boackle SA; Criswell LA; Vyse TJ; Behrens TW; Jacob CO; Alarcon-Riquelme ME; Sivils KL; Choi J; Joo YB; Bang S-Y; Lee H-S; Bae S-C; Shen N; Qian X; Tsao BP; Scofield RH; Harley JB; Webb CF; Wakeland EK; James JA; Nath SK; Graham RR; Gaffney PM
Article: PLOS ONE. 2014;9(9):e106584
IgM-Antibodies against Phosphorylcholine in Mothers and Normal or Low Birth Weight Term Newborn Infants
Frostegard AG; Sjoberg BG; Frostegard J; Norman M
Article: PLOS ONE. 2014;9(12):e111764
Antibodies against Native and Oxidized Cardiolipin and Phosphatidylserine and Phosphorylcholine in Atherosclerosis Development
Frostegard AG; Su J; Hua X; Vikstrom M; de Faire U; Frostegard J
Article: JOURNAL OF RHEUMATOLOGY. 2013;40(12):1958-1966
Disease Factors in Early Rheumatoid Arthritis Are Associated with Differential Risks for Cardiovascular Events and Mortality Depending on Age at Onset: A 10-year Observational Cohort Study
Ajeganova S; Andersson MLE; Frostegard J; Hafstrom I
Article: JOURNAL OF RHEUMATOLOGY. 2013;40(11):1856-1864
Low Levels of Antibodies Against Oxidized but not Nonoxidized Cardiolipin and Phosphatidylserine Are Associated with Atherosclerotic Plaques in Systemic Lupus Erythematosus
Su J; Frostegard AG; Hua X; Gustafsson T; Jogestrand T; Hafstrom I; Frostegard J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2013;174(3):441-448
Immunoglobulin (Ig)M antibodies against oxidized cardiolipin but not native cardiolipin are novel biomarkers in haemodialysis patients, associated negatively with mortality
Frostegard AG; Hua X; Su J; Carrero JJ; Heimburger O; Barany P; Stenvinkel P; Frostegard J
Article: LUPUS. 2013;22(11):1118-1127
Health-related quality of life, fatigue and mood in patients with SLE and high levels of pain compared to controls and patients with low levels of pain
Waldheim E; Elkan A-C; Pettersson S; van Vollenhoven R; Bergman S; Frostegard J; Henriksson EW
Article: HUMAN MOLECULAR GENETICS. 2013;22(19):4021-4029
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci
Martin J-E; Assassi S; Diaz-Gallo L-M; Broen JC; Simeon CP; Castellvi I; Vicente-Rabaneda E; Fonollosa V; Ortego-Centeno N; Gonzalez-Gay MA; Espinosa G; Carreira P; Camps M; Sabio JM; D'alfonso S; Vonk MC; Voskuyl AE; Schuerwegh AJ; Kreuter A; Witte T; Riemekasten G; Hunzelmann N; Airo P; Beretta L; Scorza R; Lunardi C; Van Laar J; Chee MM; Worthington J; Herrick A; Denton C; Fonseca C; Tan FK; Arnett F; Zhou X; Reveille JD; Gorlova O; Koeleman BPC; Radstake TRDJ; Vyse T; Mayes MD; Alarcon-Riquelme ME; Martin J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2013;106:72-78
Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine
Domeij H; Hua X; Su J; Backlund A; Yan Z; Frostegard AG; Haeggstrom JZ; Modeer T; Frostegard J
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;167(2):464-469
IgM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes
Caidahl K; Hartford M; Karlsson T; Herlitz J; Pettersson K; de Faire U; Frostegard J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(3):437-444
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups
Kaufman KM; Zhao J; Kelly JA; Hughes T; Adler A; Sanchez E; Ojwang JO; Langefeld CD; Ziegler JT; Williams AH; Comeau ME; Marion MC; Glenn SB; Cantor RM; Grossman JM; Hahn BH; Song YW; Yu C-Y; James JA; Guthridge JM; Brown EE; Alarcon GS; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri MA; Reveille JD; Vila LM; Anaya J-M; Boackle SA; Stevens AM; Freedman BI; Criswell LA; Pons-Estel BA; Lee J-H; Lee J-S; Chang D-M; Scofield RHA; Gilkeson GS; Merrill JT; Niewold TB; Vyse TJ; Bae S-C; Alarcon-Riquelme ME; Jacob CO; Sivils KM; Gaffney PM; Harley JB; Sawalha AH; Tsao BP
Article: LUPUS. 2013;22(2):136-143
Extent and characteristics of self-reported pain in patients with systemic lupus erythematosus
Waldheim E; Elkan A-C; Bergman S; Frostegard J; van Vollenhoven R; Henriksson EW
Article: BMC CARDIOVASCULAR DISORDERS. 2013;13:1
Low levels of IgM antibodies to oxidized cardiolipin increase and high levels decrease risk of cardiovascular disease among 60-year olds: a prospective study
Su J; Hua X; Vikstrom M; Leander K; Gigante B; Hellenius M-L; de Faire U; Frostegard J
Article: PLOS GENETICS. 2013;9(10):e1003870
Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression
Sakurai D; Zhao J; Deng Y; Kelly JA; Brown EE; Harley JB; Bae S-C; Alarcon-Riqueime ME; Edberg JC; Kimberly RP; Ramsey-Goldman R; Petri MA; Reveille JD; Vila LM; Alarcon GS; Kaufman KM; Vyse TJ; Jacob CO; Gaffney PM; Sivils KM; James JA; Kamen DL; Gilkeson GS; Niewold TB; Merrill JT; Scofield RH; Criswell LA; Stevens AM; Boackle SA; Kim J-H; Choi J; Pons-Estel BA; Freedman BI; Anaya J-M; Martin J; Yu CY; Chang D-M; Song YW; Langefeld CD; Chen W; Grossman JM; Cantor RM; Hahn BH; Tsao BP
Article: PLOS GENETICS. 2013;9(2):e1003336
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus
Deng Y; Zhao J; Sakurai D; Kaufman KM; Edberg JC; Kimberly RP; Kamen DL; Gilkeson GS; Jacob CO; Scofield H; Langefeld CD; Kelly JA; Ramsey-Goldman R; Petri MA; Reveille JD; Vila LM; Alarcon GS; Vyse TJ; Pons-Estel BA; Freedman BI; Gaffney PM; Sivils KM; James JA; Gregersen PK; Anaya J-M; Niewold TB; Merrill JT; Criswell LA; Stevens AM; Boackle SA; Cantor RM; Chen W; Grossman JM; Hahn BH; Harley JB; Alarcon-Riquelme ME; Brown EE; Tsao BP
Article: PLOS GENETICS. 2013;9(2):e1003222
Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production
Molineros JE; Maiti AK; Sun C; Looger LL; Han S; Kim-Howard X; Glenn S; Adler A; Kelly JA; Niewold TB; Gilkeson GS; Brown EE; Alarcon GS; Edberg JC; Petri M; Ramsey-Goldman R; Reveille JD; Vila LM; Freedman BI; Tsao BP; Criswell LA; Jacob CO; Moore JH; Vyse TJ; Langefeld CL; Guthridge JM; Gaffney PM; Moser KL; Scofield RH; Alarcon-Riquelme ME; Williams SM; Merrill JT; James JA; Kaufman KM; Kimberly RP; Harley JB; Nath SK
Article: PLOS ONE. 2013;8(8):e69404
PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes
Namjou B; Kim-Howard X; Sun C; Adler A; Chung SA; Kaufman KM; Kelly JA; Glenn SB; Guthridge JM; Scofield RH; Kimberly RP; Brown EE; Alarcon GS; Edberg JC; Kim J-H; Choi J; Ramsey-Goldman R; Petri MA; Reveille JD; Vila LM; Boackle SA; Freedman BI; Tsao BP; Langefeld CD; Vyse TJ; Jacob CO; Pons-Estel B; Niewold TB; Sivils KLM; Merrill JT; Anaya J-M; Gilkeson GS; Gaffney PM; Bae S-C; Alarcon-Riquelme ME; Harley JB; Criswell LA; James JA; Nath SK
Article: LUPUS. 2012;21(13):1405-1411
Diet and fatty acid pattern among patients with SLE: associations with disease activity, blood lipids and atherosclerosis
Elkan A-C; Anania C; Gustafsson T; Jogestrand T; Hafstrom I; Frostegard J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(11):1809-1814
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries
Kim K; Brown EE; Choi C-B; Alarc ME; Kelly JA; Glenn SB; Ojwang JO; Adler A; Lee H-S; Boackle SA; Criswell LA; Alarc GS; Edberg JC; Stevens AM; Jacob CO; Gilkeson GS; Kamen DL; Tsao BP; Anaya J-M; Guthridge JM; Nath SK; Richardson B; Sawalha AH; Kang YM; Shim SC; Suh C-H; Lee S-K; Kim C-S; Merrill JT; Petri M; Ramsey-Goldman R; Vil LM; Niewold TB; Martin J; Pons-Estel BA; Vyse TJ; Freedman BI; Moser KL; Gaffney PM; Williams A; Comeau M; Reveille JD; James JA; Eld RHS; Langefeld CD; Kaufman KM; Harley JB; Kang C; Kimberly RP; Bae S-C
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(11):3695-3705
Association of Two Independent Functional Risk Haplotypes in TNIP1 With Systemic Lupus Erythematosus
Adrianto I; Wang S; Wiley GB; Lessard CJ; Kelly JA; Adler AJ; Glenn SB; Williams AH; Ziegler JT; Comeau ME; Marion MC; Wakeland BE; Liang C; Kaufman KM; Guthridge JM; Alarcon-Riquelme ME; Alarcon GS; Anaya J-M; Bae S-C; Kim J-H; Joo YB; Boackle SA; Brown EE; Petri MA; Ramsey-Goldman R; Reveille JD; Vila LM; Criswell LA; Edberg JC; Freedman BI; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Pons-Estel BA; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Harley JB; Wakeland EK; Moser KL; Montgomery CG; Gaffney PM
Article: GENES AND IMMUNITY. 2012;13(5):380-387
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus
Wang S; Adrianto I; Wiley GB; Lessard CJ; Kelly JA; Adler AJ; Glenn SB; Williams AH; Ziegler JT; Comeau ME; Marion MC; Wakeland BE; Liang C; Kaufman KM; Guthridge JM; Alarcon-Riquelme ME; Alarcon GS; Anaya J-M; Bae S-C; Kim J-H; Joo YB; Boackle SA; Brown EE; Petri MA; Ramsey-Goldman R; Reveille JD; Vila LM; Criswell LA; Edberg JC; Freedman BI; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Pons-Estel BA; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Harley JB; Wakeland EK; Moser KL; Montgomery CG; Gaffney PM
Article: LUPUS. 2012;21(8):815-820
Microcirculation as determined by iontophoresis in SLE-patients and controls
Anania C; Norman M; Heimburger M; Gustafsson T; Jogestrand T; Hafstrom I; Frostegard J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(7):1219-1226
Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein
Delgado-Vega AM; Dozmorov MG; Bernal Quiros M; Wu Y-Y; Martinez-Garcia B; Kozyrev SV; Frostegard J; Truedsson L; de Ramon E; Gonzalez-Escribano MF; Ortego-Centeno N; Pons-Estel BA; D'Alfonso S; Sebastiani GD; Witte T; Lauwerys BR; Endreffy E; Kovacs L; Vasconcelos C; da Silva BM; Wren JD; Martin J; Castillejo-Lopez C; Alarcon-Riquelme ME
Article: JOURNAL OF RHEUMATOLOGY. 2012;39(6):1146-1154
Carotid Atherosclerosis, Disease Measures, Oxidized Low-density Lipoproteins, and Atheroprotective Natural Antibodies for Cardiovascular Disease in Early Rheumatoid Arthritis - An Inception Cohort Study
Ajeganova S; de Faire U; Jogestrand T; Frostegard J; Hafstroem I
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(6):1960-1969
Evaluation of TRAF6 in a large multiancestral lupus cohort
Namjou B; Choi C-B; Harley ITW; Alarcon-Riquelme ME; Kelly JA; Glenn SB; Ojwang JO; Adler A; Kim K; Gallant CJ; Boackle SA; Criswell LA; Kimberly RP; Brown EE; Edberg J; Alarcon GS; Stevens AM; Jacob CO; Gilkeson GS; Kamen DL; Tsao BP; Anaya J-M; Kim E-M; Park S-Y; Sung Y-K; Guthridge JM; Merrill JT; Petri M; Ramsey-Goldman R; Vila LM; Niewold TB; Martin J; Pons-Estel BA; Vyse TJ; Freedman BI; Moser KL; Gaffney PM; Williams AH; Comeau ME; Reveille JD; Kang C; James JA; Scofield RH; Langefeld CD; Kaufman KM; Harley JB; Bae S-C
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(5):694-699
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus
Hughes T; Adler A; Merrill JT; Kelly JA; Kaufman KM; Williams A; Langefeld CD; Gilkeson GS; Sanchez E; Martin J; Boackle SA; Stevens AM; Alarcon GS; Niewold TB; Brown EE; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri M; Reveille JD; Criswell LA; Vila LM; Jacob CO; Gaffney PM; Moser KL; Vyse TJ; Alarcon-Riquelme ME; James JA; Tsao BP; Scofield RH; Harley JB; Richardson BC; Sawalha AH
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;90(4):648-660
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study
Lessard CJ; Adrianto I; Ice JA; Wiley GB; Kelly JA; Glenn SB; Adler AJ; Li H; Rasmussen A; Williams AH; Ziegler J; Comeau ME; Marion M; Wakeland BE; Liang C; Ramos PS; Grundahl KM; Gallant CJ; Alarcon-Riquelme ME; Alarcon GS; Anaya J-M; Bae S-C; Boackle SA; Brown EE; Chang D-M; Cho S-K; Criswell LA; Edberg JC; Freedman BI; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Kim J-H; Martin J; Merrill JT; Niewold TB; Park S-Y; Petri MA; Pons-Estel BA; Ramsey-Goldman R; Reveille JD; Scofield RH; Song YW; Stevens AM; Tsao BP; Vila LM; Vyse TJ; Yu C-Y; Guthridge JM; Kaufman KM; Harley JB; Wakeland EK; Langefeld CD; Gaffney PM; Montgomery CG; Moser KL
Article: GENES AND IMMUNITY. 2012;13(3):268-274
Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
Lofgren SE; Frostegard J; Truedsson L; Pons-Estel BA; D'Alfonso S; Witte T; Lauwerys BR; Endreffy E; Kovacs L; Vasconcelos C; Martins da Silva B; Kozyrev SV; Alarcon-Riquelme ME
Article: GENES AND IMMUNITY. 2012;13(3):232-238
Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
Lin CP; Adrianto I; Lessard CJ; Kelly JA; Kaufman KM; Guthridge JM; Freedman BI; Anaya J-M; Alarcon-Riquelme ME; Pons-Estel BA; Martin J; Glenn S; Adler A; Bae S-C; Park S-Y; Bang S-Y; Song Y-W; Boackle SA; Brown EE; Edberg JC; Alarcon GS; Petri MA; Criswell LA; Ramsey-Goldman R; Reveille JD; Vila LM; Gilkeson GS; Kamen DL; Ziegler J; Jacob CO; Rasmussen A; James JA; Kimberly RP; Merrill JT; Niewold TB; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Moser KL; Harley JB; Gaffney PM; Montgomery CG
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(2):485-492
Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus
Hughes T; Adler A; Kelly JA; Kaufman KM; Williams AH; Langefeld CD; Brown EE; Alarcon GS; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri M; Boackle SA; Stevens AM; Reveille JD; Sanchez E; Martin J; Niewold TB; Vila LM; Scofield RH; Gilkeson GS; Gaffney PM; Criswell LA; Moser KL; Merrill JT; Jacob CO; Tsao BP; James JA; Vyse TJ; Alarcon-Riquelme ME; Harley JB; Richardson BC; Sawalha AH
Article: RESULTS IN IMMUNOLOGY. 2012;2:13-18
IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection marker for atherosclerosis development, particularly in combination with other auto-antibodies against modified LDL.
Fiskesund R; Su J; Bulatovic I; Vikström M; de Faire U; Frostegård J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(1):136-142
Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK
Castillejo-Lopez C; Delgado-Vega AM; Wojcik J; Kozyrev SV; Thavathiru E; Wu Y-Y; Sanchez E; Pollmann D; Lopez-Egido JR; Fineschi S; Dominguez N; Lu R; James JA; Merrill JT; Kelly JA; Kaufman KM; Moser KL; Gilkeson G; Frostegard J; Pons-Estel BA; D'Alfonso S; Witte T; Luis Callejas J; Harley JB; Gaffney PM; Martin J; Guthridge JM; Alarcon-Riquelme ME
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2011;29(6):942-950
Effect of biological therapy on levels of atheroprotective antibodies against phosphorylcholine and apolipoproteins in rheumatoid arthritis: a one-year study
Ajeganova S; Fiskesund R; de Faire U; Hafstrom I; Frostegard J
Article: RHEUMATOLOGY. 2011;50(10):1785-1793
Longitudinal levels of apolipoproteins and antibodies against phosphorylcholine are independently associated with carotid artery atherosclerosis 5 years after rheumatoid arthritis onset-a prospective cohort study
Ajeganova S; Ehrnfelt C; Alizadeh R; Rohani M; Jogestrand T; Hafstrom I; Frostegard J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(10):1752-1757
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus
Sanchez E; Nadig A; Richardson BC; Freedman BI; Kaufman KM; Kelly JA; Niewold TB; Kamen DL; Gilkeson GS; Ziegler JT; Langefeld CD; Alarcon GS; Edberg JC; Ramsey-Goldman R; Petri M; Brown EE; Kimberly RP; Reveille JD; Vila LM; Merrill JT; Anaya J-M; James JA; Pons-Estel BA; Martin J; Park S-Y; Bang S-Y; Bae S-C; Moser KL; Vyse TJ; Criswell LA; Gaffney PM; Tsao BP; Jacob CO; Harley JB; Alarcon-Riquelme ME; Sawalha AH
Article: ATHEROSCLEROSIS. 2011;218(1):117-122
Genetic and environmental regulation of inflammatory CVD biomarkers Lp-PLA₂ and IgM anti-PC
Rahman I; Atout R; Pedersen NL; de Faire U; Frostegard J; Ninio E; Bennet AM; Magnusson PKE
Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(9):2755-2763
Association of PPP2CA Polymorphisms With Systemic Lupus Erythematosus Susceptibility in Multiple Ethnic Groups
Tan W; Sunahori K; Zhao J; Deng Y; Kaufman KM; Kelly JA; Langefeld CD; Williams AH; Comeau ME; Ziegler JT; Marion MC; Bae S-C; Lee JH; Lee J-S; Chang D-M; Song YW; Yu C-Y; Kimberly RP; Edberg JC; Brown EE; Petri MA; Ramsey-Goldman R; Vila LM; Reveille JD; Alarcon-Riquelme ME; Harley JB; Boackle SA; Stevens AM; Scofield RH; Merrill JT; Freedman BI; Anaya J-M; Criswell LA; Jacob CO; Vyse TJ; Niewold TB; Gaffney PM; Moser KL; Gilkeson GS; Kamen DL; James JA; Grossman JM; Hahn BH; Tsokos GC; Tsao BP
Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(6):1689-1697
Fine-Mapping and Transethnic Genotyping Establish IL2/IL21 Genetic Association With Lupus and Localize This Genetic Effect to IL21
Hughes T; Kim-Howard X; Kelly JA; Kaufman KM; Langefeld CD; Ziegler J; Sanchez E; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri M; Reveille JD; Martin J; Brown EE; Vila LM; Alarcon GS; James JA; Gilkeson GS; Moser KL; Gaffney PM; Merrill JT; Vyse TJ; Alarcon-Riquelme ME; Nath SK; Harley JB; Sawalha AH
Article: GENES AND IMMUNITY. 2011;12(4):270-279
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
Namjou B; Kothari PH; Kelly JA; Glenn SB; Ojwang JO; Adler A; Alarcon-Riquelme ME; Gallant CJ; Boackle SA; Criswell LA; Kimberly RP; Brown E; Edberg J; Stevens AM; Jacob CO; Tsao BP; Gilkeson GS; Kamen DL; Merrill JT; Petri M; Goldman RR; Vila LM; Anaya J-M; Niewold TB; Martin J; Pons-Estel BA; Sabio JM; Callejas JL; Vyse TJ; Bae S-C; Perrino FW; Freedman BI; Scofield RH; Moser KL; Gaffney PM; James JA; Langefeld CD; Kaufman KM; Harley JB; Atkinson JP
Article: PLOS GENETICS. 2011;7(5):e1002079
Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility
Zhao J; Wu H; Khosravi M; Cui H; Qian X; Kelly JA; Kaufman KM; Langefeld CD; Williams AH; Comeau ME; Ziegler JT; Marion MC; Adler A; Glenn SB; Alarcon-Riquelme ME; Pons-Estel BA; Harley JB; Bae S-C; Bang S-Y; Cho S-K; Jacob CO; Vyse TJ; Niewold TB; Gaffney PM; Moser KL; Kimberly RP; Edberg JC; Brown EE; Alarcon GS; Petri MA; Ramsey-Goldman R; Vila LM; Reveille JD; James JA; Gilkeson GS; Kamen DL; Freedman BI; Anaya J-M; Merrill JT; Criswell LA; Scofield RH; Stevens AM; Guthridge JM; Chang D-M; Song YW; Park JA; Lee EY; Boackle SA; Grossman JM; Hahn BH; Goodship THJ; Cantor RM; Yu C-Y; Shen N; Tsao BP
Article: NATURE GENETICS. 2011;43(3):253-258
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
Adrianto I; Wen F; Templeton A; Wiley G; King JB; Lessard CJ; Bates JS; Hu Y; Kelly JA; Kaufman KM; Guthridge JM; Alarcon-Riquelme ME; Anaya J-M; Bae S-C; Bang S-Y; Boackle SA; Brown EE; Petri MA; Gallant C; Ramsey-Goldman R; Reveille JD; Vila LM; Criswell LA; Edberg JC; Freedman BI; Gregersen PK; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Park S-Y; Pons-Estel BA; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Harley JB; Moser KL; Webb CF; Humphrey MB; Montgomery CG; Gaffney PM
Article: BMC MUSCULOSKELETAL DISORDERS. 2011;12:13
Low level of physical activity in women with rheumatoid arthritis is associated with cardiovascular risk factors but not with body fat mass - a cross sectional study
Elkan A-C; Hakansson N; Frostegard J; Hafstrom I
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2011;88(1):83-91
Identification of a Systemic Lupus Erythematosus Susceptibility Locus at 11p13 between PDHX and CD44 in a Multiethnic Study
Lessard CJ; Adrianto I; Kelly JA; Kaufman KM; Grundahl KM; Adler A; Williams AH; Gallant CJ; Alarcon-Riquelme ME; Anaya J-M; Bae S-C; Boackle SA; Brown EE; Chang D-M; Criswell LA; Edberg JC; Freedman BI; Gregersen PK; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Park S-Y; Petri MA; Pons-Estel BA; Ramsey-Goldman R; Reveille JD; Song YW; Stevens AM; Tsao BP; Vila LM; Vyse TJ; Yu C-Y; Guthridge JM; Bruner GR; Langefeld CD; Montgomery C; Harley JB; Scofield RH; Gaffney PM; Moser KL
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2011;31(1):95-101
Annexin A5 Therapy Attenuates Vascular Inflammation and Remodeling and Improves Endothelial Function in Mice
Ewing MM; de Vries MR; Nordzell M; Pettersson K; de Boer HC; van Zonneveld AJ; Frostegard J; Jukema JW; Quax PHA
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(11):3404-3414
A 3′-Untranslated Region Variant Is Associated With Impaired Expression of CD226 in T and Natural Killer T Cells and Is Associated With Susceptibility to Systemic Lupus Erythematosus
Lofgren SE; Delgado-Vega AM; Gallant CJ; Sanchez E; Frostegard J; Truedsson L; de Ramon Garrido E; Sabio JM; Gonzalez-Escribano MF; Pons-Estel BA; D'Alfonso S; Witte T; Lauwerys BR; Endreffy E; Kovacs L; Vasconcelos C; da Silva BM; Martin J; Alarcon-Riquelme ME; Kozyrev SV
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39(6):447-453
Anti-apoA-1 IgG and oxidized LDL are raised in rheumatoid arthritis (RA): potential associations with cardiovascular disease and RA disease activity
Vuilleumier N; Bratt J; Alizadeh R; Jogestrand T; Hafstrom I; Frostegard J
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2010;21(2):577-584
Low Levels of Antibodies Against Phosphorylcholine in Alzheimer's Disease
Eriksson UK; Sjoberg BG; Bennet AM; de Faire U; Pedersen NL; Frostegard J
Article: STROKE. 2010;41(4):607-612
Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden
Fiskesund R; Stegmayr B; Hallmans G; Vikstrom M; Weinehall L; de Faire U; Frostegard J
Article: JOURNAL OF AUTOIMMUNITY. 2010;34(2):73-79
Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: Effects on uptake of oxidized LDL in macrophages as a potential mechanism
de Faire U; Su J; Hua X; Frostegard A; Halldin M; Hellenius M-L; Wikstrom M; Dahlbom I; Gronlund H; Frostegard J
Article: ARTHRITIS RESEARCH & THERAPY. 2010;12(6):R214
Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus
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Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39(1):77-83
Effects of anti-cardiolipin antibodies and IVIg on annexin A5 binding to endothelial cells: implications for cardiovascular disease
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Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(11):3454-3460
Low levels of IgM antibodies against phosphorylcholine-A increase mortality risk in patients undergoing haemodialysis
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Article: GENES AND IMMUNITY. 2009;10(5):397-403
Genetic associations of LYN with systemic lupus erythematosus
Lu R; Vidal GS; Kelly JA; Delgado-Vega AM; Howard XK; Macwana SR; Dominguez N; Klein W; Burrell C; Harley IT; Kaufman KM; Bruner GR; Moser KL; Gaffney PM; Gilkeson GS; Wakeland EK; Li Q-Z; Langefeld CD; Marion MC; Divers J; Alarcon GS; Brown EE; Kimberly RP; Edberg JC; Ramsey-Goldman R; Reveille JD; McGwin GJ; Vila LM; Petri MA; Bae S-C; Cho S-K; Bang S-Y; Kim I; Choi C-B; Martin J; Vyse TJ; Merrill JT; Harley JB; Alarcon-Riquelme ME; Nath SK; James JA; Guthridge JM
Article: JOURNAL OF CARDIOVASCULAR RISK. 2009;16(3):382-386
Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden
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Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2009;38(3):184-189
Dyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular disease
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Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men
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Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(2):R37
Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study
Elkan A-C; Hakansson N; Frostegard J; Cederholm T; Hafstrom I
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2008;37(5):352-359
Endothelial function and markers of endothelial activation in relation to cardiovascular disease in systemic lupus erythematosus
Svenungsson E; Cederholm A; Jensen-Urstad K; Fei G-Z; de Faire U; Frostegard J
Article: RHEUMATOLOGY. 2008;47(8):1144-1150
Natural antibodies against phosphorylcholine as potential protective factors in SLE
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Article: CLINICAL SCIENCE. 2008;115(1-2):25-33
Anti-(apolipoprotein A-1) IgGs are associated with high levels of oxidized low-density lipoprotein in acute coronary syndrome
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Article: ARTHRITIS RESEARCH & THERAPY. 2008;10(2):R34
Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis:: a randomized study
Elkan A-C; Sjoberg B; Kolsrud B; Ringertz B; Hafstrom I; Frostegard J
Article: JOURNAL OF RHEUMATOLOGY. 2007;34(9):1810-1816
Effects of low-dose prednisolone on endothelial function, atherosclerosis, and traditional risk factors for atherosclerosis in patients with rheumatoid arthritis -: A randomized study
Hafstrom I; Rohani M; Deneberg S; Wornert M; Jogestrand T; Frostegard J
Article: DRUG NEWS AND PERSPECTIVES. 2007;20(5):321-326
Annexin a5 multitasking: A potentially novel antiatherothrombotic agent?
Cederhohn A; Frostegard J
Article: NUTRITION AND METABOLISM. 2007;4:7
Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea
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Article: NUTRITION AND METABOLISM. 2006;3:39
A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs
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Article: ATHEROSCLEROSIS. 2006;188(1):160-166
Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension
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Article: ATHEROSCLEROSIS. 2006;187(2):408-414
Association of TNF-α serum levels and TNFA promoter polymorphisms with risk of myocardial infarction
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Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2006;38(3):297-306
Systemic lupus-erythematosus:: Deoxyribonuclease 1 in necrotic chromatin disposal
Napirei M; Gültekin A; Kloeckl T; Möröy T; Frostegård J; Mannherz HG
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2006;4(1):77-82
Treatment with combined oral contraceptives induces a rise in serum C-reactive protein in the absence of a general inflammatory response
van Rooijen M; Hansson LO; Frostegård J; Silveira A; Hamsten A; Bremme K
Article: LAKARTIDNINGEN. 2005;102(22):1752-1753
[Non-therapeutic ventilation , organ transplantation and medical ethics].
Frostegård J
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(1):192-200
Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
Frostegård J; Svenungsson E; Wu RH; Gunnarsson I; Lundberg IE; Klareskog L; Hörkko S; Witztum JL
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2005;25(1):198-203
Decreased binding of annexin V to endothelial cells -: A potential mechanism in atherothrombosis of patients with systemic lupus erythematosus
Cederholm A; Svenungsson E; Jensen-Urstad K; Trollmo C; Ulfgren AK; Swedenborg J; Fei GZ; Frostegård J
Article: ATHEROSCLEROSIS. 2004;177(2):409-414
The A-1087IL-10 allele is associated with cardiovascular disease in SLE
Fei GZ; Svenungsson E; Frostegård J; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(9):2869-2876
Platelet-activating factor-acetylhydrolase and other novel risk and protective factors for cardiovascular disease in systemic lupus erythematosus
Cederholm A; Svenungsson E; Stengel D; Fei GZ; Pockley AG; Ninio E; Frostegård J
Article: EUROPEAN HEART JOURNAL. 2004;25(16):1447-1453
Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction
Edfeldt K; Bennet AM; Eriksson P; Frostegård J; Wiman B; Hamsten A; Hansson GK; de Faire U; Yan ZQ
Article: LAKARTIDNINGEN. 2004;101(25):2190-2193
[The new biology. Truth, social construction or something in between?].
Frostegård J
Article: LAKARTIDNINGEN. 2004;101(19):1678-1679
[Immunization--future cure against atherosclerosis?].
Frostegård J
Article: LAKARTIDNINGEN. 2004;101(3):229
[Organ donation and utilitarianism: medical ethics more important than medical efficiency].
Frostegård J
Article: ATHEROSCLEROSIS. 2003;171(2):359-367
Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction
Bennet AM; Prince JA; Fei GZ; Lyrenäs L; Huang YH; Wiman B; Frostegård J; de Faire U
Article: EUROPEAN HEART JOURNAL. 2003;24(23):2099-2107
Risk factors for cardiovascular disease in patients with periodontitis
Buhlin K; Gustafsson A; Pockley AG; Frostegård J; Klinge B
Article: CLINICAL SCIENCE. 2003;105(5):615-620
Circulating oxidized low-density lipoprotein is increased in hypertension
Frostegård J; Wu RH; Lemne C; Thulin T; Witztum JL; De Faire U
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;106(1):143-148
Induction of IL-4 by platelet-activating factor
Huang YH; SchaferElinder L; Owman H; Lorentzen JC; Ronnelid J; Frostegard J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;103(1):61-66
Effects of in vitro hyperthermia on proliferative responses and lymphocyte activity
Huang YH; Haegerstrand A; Frostegard J
Article: HYPERTENSION. 2003;42(3):235-238
Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension
Pockley AG; Georgiades A; Thulin T; de Faire U; Frostegård J
Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):2533-2540
Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor α/tumor necrosis factor receptor system in systemic lupus erythematosus
Svenungsson E; Gunnarsson I; Fei GZ; Lundberg IE; Klareskog L; Frostegård J
Article: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2003;189(2):568-573
Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion
Frostegård J; Wramsby ML; Wu R; Bremme K
Article: ATHEROSCLEROSIS. 2003;169(1):77-85
Oxidised LDL modulates immune-activation by an IL-12 dependent mechanism
Fei GZ; Huang YH; Swedenborg J; Frostegård J
Article: LUPUS. 2003;12(6):454-461
TNF-α:: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease
Svenungsson E; Fei GZ; Jensen-Urstad K; de Faire U; Hamsten A; Frostegård J
Article: JOURNAL OF HYPERTENSION. 2002;20(9):1815-1820
Circulating heat shock protein and heat shock protein antibody levels in established hypertension
Pockley AG; de Faire U; Kiessling R; Lemne C; Thulin T; Frostegård J
Article: LAKARTIDNINGEN. 2002;99(34):3306-3308
[A case report: Myocardial infarction in a 26-year-old man with SLE. Acute coronary syndrome can occur in patients with SLE independently of gender and age].
Lehtihet M; Frostegård J
Article: LUPUS. 2002;11(11):744-752
Cardiac valvular abnormalities are frequent in systemic lupus erythematosus patients with manifest arterial disease
Jensen-Urstad K; Svenungsson E; de Faire U; Silveira A; Witztum JL; Hamsten A; Frostegård J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;116(2):326-331
Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism
Huang YH; Schäfer-Elinder L; Wu R; Claesson HE; Frostegård J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(3):561-566
Antibodies to adult human endothelial cells cross-react with oxidized low-density lipoprotein and β₂- glycoprotein I (β₂-GPI) in systemic lupus erythematosus
Wu R; Svenungsson E; Gunnarsson I; Haegerstrand-Gillis C; Andersson B; Lundberg I; Elinder LS; Frostegård J
Article: LAKARTIDNINGEN. 2001;98(42):4616-4619
[The debate on euthanasia with absurd conclusions].
Frostegård J
Article: CIRCULATION. 2001;104(16):1887-1893
Risk factors for cardiovascular disease in systemic lupus erythematosus
Svenungsson E; Jensen-Urstad K; Heimbürger M; Silveira A; Hamsten A; de Faire U; Witztum JL; Frostegård J
Article: LAKARTIDNINGEN. 2001;98(26-27):3135
[Immunological changes in hypertension and atherosclerosis].
Frostegård J
Article: HYPERTENSION. 2001;37(1):154-159
Antibodies to lysophosphatidylcholine are decreased in borderline hypertension
Wu RH; Lemne C; de Faire U; Frostegård J
Article: ATHEROSCLEROSIS. 2000;153(2):273-282
Induction of early atherosclerosis in CBA/J mice by combination of Trypanosoma cruzi infection and a high cholesterol diet
Sunnemark D; Harris RA; Frostegård J; Örn A
Article: HYPERTENSION. 2000;36(2):303-307
Circulating heat shock protein 60 is associated with early cardiovascular disease
Pockley AG; Wu R; Lemne C; Kiessling R; de Faire U; Frostegård J
Article: GENES AND IMMUNITY. 2000;1(6):380-385
Association analysis with microsatellite and SNP markers does not support the involvement of BCL-2 in systemic lupus erythematosus in Mexican and Swedish patients and their families
Johansson C; Castillejo-López C; Johanneson B; Svenungsson E; Gunnarsson I; Frostegård J; Sturfelt G; Truedsson L; Löfström B; Alcocer-Varela J; Lundberg I; Gyllensten UB; Alarcón-Segovia D; Alarcón-Riquelme ME
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(4):389-397
Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome
Wu R; Lemne C; de Faire U; Frostegård J
Article: ATHEROSCLEROSIS. 1999;145(1):33-43
Cytokine expression in advanced human atherosclerotic plaques:: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines
Frostegård J; Ulfgren AK; Nyberg P; Hedin U; Swedenborg J; Andersson U; Hansson GK
Article: HYPERTENSION. 1999;33(1):53-59
Autoantibodies to OxLDL are decreased in individuals with borderline hypertension
Wu RH; de Faire U; Lemne C; Witztum JL; Frostegård J
Article: LUPUS. 1999;8(2):142-150
Antibodies against lysophosphatidylcholine and oxidized LDL in patients with SLE
Wu R; Svenungsson E; Gunnarsson I; Andersson B; Lundberg I; Elinder LS; Frostegård J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998;48(5):480-484
Cellular and cytokine characterization of vascular inflammation in CBA/J mice chronically infected with Trypanosoma cruzi
Sunnemark D; Frostegård J; Örn A; Harris RA
Article: CIRCULATION. 1998;98(11):1092-1098
Antibodies to endothelial cells in borderline hypertension
Frostegård J; Wu RH; Gillis-Haegerstrand C; Lemne C; de Faire U
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1998;18(4):626-630
Lysophosphatidylcholine is involved in the antigenicity of oxidized LDL
Wu RH; Huang YH; Elinder LS; Frostegård J
Article: JOURNAL OF INTERNAL MEDICINE. 1997;242(4):329-337
The influence of age on low density lipoprotein metabolism: effects of cholestyramine treatment in young and old healthy male subjects
Ericsson S; Berglund L; Frostegard J; Einarsson K; Angelin B
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1997;17(10):2257-2263
Expression of phospholipase A(2) isoforms in human normal and atherosclerotic arterial wall
Elinder LS; Dumitrescu A; Larsson P; Hedin U; Frostegard J; Claesson HE
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1997;17(5):963-968
Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism
Frostegard J; Huang YH; Ronnelid J; SchaferElinder L
Article: HYPERTENSION. 1997;29(1):40-44
Association of serum antibodies to heat-shock protein 65 with borderline hypertension
Frostegard J; Lemne C; Andersson B; vanderZee R; Kiessling R; deFaire U
Article: LAKARTIDNINGEN. 1996;93(17):1603-1604
[Historical perspective of euthanasia. From Hippokrates to Nazi physicians].
Frostegård J
Article: ATHEROSCLEROSIS. 1996;121(1):93-103
Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein
Frostegard J; Kjellman B; Gidlund M; Andersson B; Jindal S; Kiessling R
Article: FREE RADICAL RESEARCH. 1995;23(6):581-592
THE SUSCEPTIBILITY OF LOW-DENSITY-LIPOPROTEIN TO CHEMICAL OXIDATION IS CLOSELY-RELATED TO PRONENESS TO BIOLOGICAL MODIFICATION
FROSTEGARD J; REGNSTROM J; TORNVALL P; HAMSTEN A; NILSSON J
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1995;15(10):1577-1583
OXIDIZED LDL INDUCES ENHANCED ANTIBODY-FORMATION AND MHC CLASS II-DEPENDENT IFN-GAMMA PRODUCTION IN LYMPHOCYTES FROM HEALTHY-INDIVIDUALS
HUANG YH; RONNELID J; FROSTEGARD J
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Editorial comment: JOURNAL OF LIPID RESEARCH. 2023;64(8):100412
Antibodies against oxidation-specific epitopes and risk of acute myocardial infarction
Frostegard J
Review: METABOLITES. 2023;13(6):720
Antibodies against Phosphorylcholine-Implications for Chronic Inflammatory Diseases
Frostegard J
Review: JOURNAL OF INTERNAL MEDICINE. 2023;293(1):48-62
Systemic lupus erythematosus and cardiovascular disease
Frostegard J
Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2022;18(5):525-532
Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation
Frostegard J
Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2022;18(1):67-74
The role of PCSK9 in inflammation, immunity, and autoimmune diseases
Frostegard J
Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2015;11(2):247-253
Prediction and management of cardiovascular outcomes in systemic lupus erythematosus
Frostegard J
Review: FRONTIERS IN ENDOCRINOLOGY. 2013;4:162
Immune mechanisms in atherosclerosis, especially in diabetes type 2.
Frostegård J
Review: LAKARTIDNINGEN. 2013;110(43-44):1931-1934
[The immune system in atherosclerosis. Immunomodulatory or anti-inflammatory treatment that is effective against atherosclerosis and its complications are needed to ensure the hypothesis].
Frostegård J
Review: BMC MEDICINE. 2013;11:117
Immunity, atherosclerosis and cardiovascular disease.
Frostegård J
Editorial comment: JOURNAL OF RHEUMATOLOGY. 2012;39(12):2233-2234
Atherosclerosis and Cardiovascular Disease in Rheumatoid Arthritis
Frostegard J
Review: CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY. 2012;42(2):154-163
Geographical Differences in Autoantibodies and Anti-infectious Agents Antibodies Among Healthy Adults
Shapira Y; Katz B-SP; Gilburd B; Barzilai O; Ram M; Blank M; Lindeberg S; Frostegard J; Anaya J-M; Bizzaro N; Jara LJ; Damoiseaux J; Shoenfeld Y; Levin NA
Review: ARTHRITIS RESEARCH & THERAPY. 2011;13(3):225
Cardiovascular co-morbidity in patients with rheumatic diseases
Frostegard J
Editorial comment: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2010;30(5):892-893
Rheumatic Diseases Insights Into Inflammation and Atherosclerosis
Frostegard J
Corrigendum: GENES AND IMMUNITY. 2010;11(1):98
Genetic associations of LYN with systemic lupus erythematosus (vol 10, pg 397, 2009)
Lu R; Vidal GS; Kelly JA; Delgado-Vega AM; Howard XK; Macwana SR; Dominguez N; Klein W; Burrell C; Harley IT; Kaufman KM; Bruner GR; Moser KL; Gaffney PM; Gilkeson GS; Wakeland EK; Li Q-Z; Langefeld CD; Marion MC; Divers J; Alarcon GS; Brown EE; Kimberly RP; Edberg JC; Ramsey-Goldman R; Reveille JD; McGwin GJ; Vila LM; Petri MA; Bae S-C; Cho S-K; Bang S-Y; Kim I; Choi CB; Martin J; Vyse TJ; Merrill JT; Harley JB; Alarcon-Riquelme ME; Nath SK; James JA; Guthridge JM
Review: CLINICAL IMMUNOLOGY. 2010;134(1):47-54
Low level natural antibodies against phosphorylcholine: A novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
Frostegard J
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1173:675-682
Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea
Agmon-Levin N; Bat-sheva PK; Barzilai O; Ram M; Lindeberg S; Frostegard J; Shoenfeld Y
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1173:292-300
Natural Antibodies against Phosphorylcholine in Cardiovascular Disease
de Faire U; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):62
ANNEXIN A5 INHIBITS LYSOPHOSPHATIDYLCHOLINE INDUCED MMP-9 PRODUCTION; IMPLICATIONS FOR SLE AND CARDIOVASCULAR DISEASE
Domeij H; Modeer T; Gilburd B; Svenungsson E; Shoenfeld Y; Frostegard J
Published conference paper: LUPUS. 2008;17(5):364-367
Systemic lupus erythematosus and cardiovascular disease
Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):78
LOW LEVELS OF ANTIBODIES AGAINST PHOSPHORYLCHOLINE PREDICT DEVELOPMENT OF ATHEROSCLEROSIS
Frostegard J; Sjoberg B; Su J; Gronlund H; Dahlbom I; Hedblad B; Berglund G; de Faire U
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):78
IGM ANTIBODIES AGAINST PHOSPHOCHOLINE PROTECTION FACTORS FOR ATHEROSCLEROSIS IN PATIENTS WITH HYPERTENSION AND INHIBIT UPTAKE OF OXIDIZED LDL IN MACROPHAGES
Su J; Gronlund H; Cederholm A; Hua X; Georgiades A; Dahlbom I; de Faire U; Frostegard J
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1108:96-103
Annexin A5 as a novel player in prevention of atherothrombosis in SLE and in the general population
Cederholm A; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):29
Decreased annexin A5 binding to endothelium is associated with cardiovascular disease in systemic lupus erythematosus and inhibited by IVIG
Cederholm A; Von Landenberg P; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):299
Dyslipidemia in SLE-related cardiovascular disease:: Paradoxical lipid pattern and antibodies against apo A1 and lipoprotein lipase
Hua X; Su J; Svenungsson E; Cederholm A; Frostegård J
Letter: JOURNAL OF INTERNAL MEDICINE. 2005;258(6):585-586
High iron stores and cardiovascular disease in systemic lupus erythematosus -: reply
Frostegård J
Editorial comment: HEART. 2005;91(9):1124-1126
Heat shock proteins in cardiovascular disease and the prognostic value of heat shock protein related measurements
Pockley AG; Frostegård J
Review: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2005;25(9):1776-1785
Atherosclerosis in patients with autoimmune disorders
Frostegård J
Review: JOURNAL OF INTERNAL MEDICINE. 2005;257(6):485-495
SLE, atherosclerosis and cardiovascular disease
Frostegård J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2005;6(1):90
Anti-HDL antibodies and lipoprotein characteristics in SLE-related cardiovascular disease
Su J; Cederholm A; Hurt-Camejo E; Svenungsson E; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2005;6(1):65-66
Lipid-peroxidation is enhanced in sle patients and associated with arterial and renal disease manifestations
Frostegard J; Svenungsson E; Wu R; Gunnarsson I; Lundberg I; Klareskog L; Hörkkö S; Witztum J
Published conference paper: IMMUNOBIOLOGY. 2005;210(10):761-768
Annexin A5 in cardiovascular disease and systemic lupus erythematosus
Cederholm A; Frostegård J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S53
Endothelial function and activation in women with systemic lupus erythematosus
Svenungsson E; Cederholm A; Jensen-Urstad K; Fei G-Z; Frostegard J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S51-S52
Decreased binding of annexin V to endothelial cells:: a novel mechanism of atherothrombosis in patients with systemic lupus erythematosus
Cederholm A; Svenungsson E; Jensen-Urstad K; Trollmo C; Ulfgren A-K; Swedenborg J; Fei G-Z; Frostegard J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S45
Non-traditional risk and protective factors for cardiovascular disease in systemic lupus erythematosus
Cederholm A; Svenungsson E; Stengel D; Fei G-Z; Pockley AG; Ninio E; Frostegard J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S40
Anti-high-density lipoprotein antibodies and lipoprotein characteristics in systemic lupus erythematosus-related cardiovascular disease
Su J; Cederholm A; Hurt-Camejo E; Svenungsson E; Frostegard J
Letter: EUROPEAN HEART JOURNAL. 2004;25(15):1366
Cardiovascular disease, periodontitis and the monocyte relationship:: Reply
Buhlin K; Gustafsson A; Frostegård J; Klinge B; Pockley AG
Letter: HYPERTENSION. 2004;43(4):E18-E19
Response:: Is low-heat shock protein 70 a primary or a secondary event in the development of atherosclerosis?
Pockley AG; Georgiades A; Thulin T; de Faire U; Frostegård J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):317
TNF-alpha, dyslipoproteinemia and LDL oxidation are risk factors for CVD in SLE
Svenungsson E; Fei GZ; Gunnarsson I; Lundberg IE; Wu R; Witztum JL; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):315-316
Novel immunological risk factors for atherosclerosis
Frostegard J; Pockley AG; Georgiades A; Thulin T; Wu R; De Faire U
Review: AUTOIMMUNITY REVIEWS. 2002;1(4):233-237
Autoimmunity, oxidized LDL and cardiovascular disease.
Frostegård J
Review: LAKARTIDNINGEN. 1998;95(19):2203-2206
[Atherosclerosis not caused by overindulgence only. Infection may be a risk factor for cardiovascular disease].
Schäfer Elinder L; Frostegård J
Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):283
Cytokine-stimulatory properties of phospholipids and oxidized LDL are mediated by the PAF receptor
Elinder LS; Huang YH; Frostegard J
Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):284
Oxidised LDL induced T cell proliferation; LDL from patients with coronary artery disease inhibited the effect of oxidised LDL
Wu RH; Frostegard J; Giscombe R; Hamsten A; Holm G; Nilsson J; Lefvert AK
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