- 2003 Master of Science in Engineering Biology, Umeå University, Umeå.
- 2008 PhD in Biotechnology, Royal Institute of Technology, Stockholm.
- 2009-2013 Postdoc, Karolinska Institutet, Stockholm.
- 2013-2017 Assistant Professor, Karolinska Institutet, Stockholm.
I am heading the Cancer Genomics team at MEB. The team consists currently of two bioinformaticians, three research engineers and one postdoc. The team has a translational focus, with the goal to pursue clinically relevant research questions. We have developed an informatics infrastructure consisting of in-house developed- and publically available tools to enable live processing of sequencing based data.
The Cancer Genomics team is responsible for targeted sequencing in a prospective clinical trial investigating the effect of adjuvant aspirin treatment of PI3K mutated localized colorectal cancer. Patient inclusion was initiated in the fall 2016 and during the first year 542 colorectal cancers were profiled with two weeks turnover. Reports with randomization information is being sent on a weekly basis to a national network of 27 participating hospitals. The trial will run until approximately 4000 study participants have been included.
We are conducting large studies in prostate cancer where genomic profiling is used to address tumor grading, prognostication at diagnosis and optimization of treatment in the metastatic setting.
We have developed a targeted circulating tumour DNA-based profile that enables us to detect:
- Mutations, amplifications and genomic rearrangements in the androgen receptor.
- Mutations, genomic rearrangements and amplifications/deletions in key genes involved in prostate cancer.
- DNA-repair deficiency.
- Microsatellite instable and hypermutated cancers.
We are currently preparing to enable live profiling of circulating tumor DNA in metastatic prostate cancer in a clinical trial setting. The goal is to initiate the clinical trial (ProBio-II) during the fall 2018.
The Cancer Genomics team is part of a larger research environment with 20-25 persons focused on different aspects of prostate cancer, which is lead by Henrik Grönberg.
I am teaching whenever I get the chance. I am currently co-responsible for the course "Biobanking as a resource for biomedical research".
Comprehensive Profiling of the Androgen Receptor in Liquid Biopsies from Castration-resistant Prostate Cancer Reveals Novel Intra-AR Structural Variation and Splice Variant Expression Patterns
European urology 2017;72(2):192-200
Corrigendum to "Integration of Copy Number and Transcriptomics Provides Risk Stratification in Prostate Cancer: A Discovery and Validation Cohort Study" [EBioMedicine 2 (9) (2015) 1133-1144]
Genetic profile of ductal adenocarcinoma of the prostate
Human pathology 2017;69():1-7
Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes
Clinical cancer research : an official journal of the American Association for Cancer Research 2017;23(10):2584-2592
Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors
European urology 2017;72(1):22-31
Validation of risk stratification models in acute myeloid leukemia using sequencing-based molecular profiling
Determining breast cancer histological grade from RNA-sequencing data
Breast cancer research : BCR 2016;18(1):48-
Gene regulatory mechanisms underpinning prostate cancer susceptibility
Nature genetics 2016;48(4):387-97
Large-scale evaluation of SLC18A2 in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels
Molecular oncology 2016;10(6):825-37
Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers
Scientific reports 2016;6():38037-
The In Vitro Stability of Circulating Tumour DNA
PloS one 2016;11(12):e0168153-
Exome sequencing of contralateral breast cancer identifies metastatic disease
Breast cancer research and treatment 2015;151(2):319-24
Prostate cancer screening in men aged 50-69 years (STHLM3): a prospective population-based diagnostic study
The Lancet. Oncology 2015;16(16):1667-76
The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
Scientific reports 2015;5():13426-
Tracking the origin of metastatic prostate cancer
European urology 2015;67(5):819-22
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding
Nature genetics 2014;46(2):126-35
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
NEW ENGLAND JOURNAL OF MEDICINE 2014;371(26):2477-87
Evaluation of exome sequencing to estimate tumor burden in plasma
PloS one 2014;9(8):e104417-
Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy
Clinical cancer research : an official journal of the American Association for Cancer Research 2014;20(8):2169-81
Immunohistochemical profile of ductal adenocarcinoma of the prostate
Virchows Archiv : an international journal of pathology 2014;465(5):559-65
Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo
BREAST CANCER RESEARCH 2014;16(4):R72-
Exome sequencing of prostate cancer supports the hypothesis of independent tumour origins
European urology 2013;63(2):347-53
Genetic markers associated with early cancer-specific mortality following prostatectomy
The mitochondrial and autosomal mutation landscapes of prostate cancer
European urology 2013;63(4):702-8
Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients
ARTHRITIS AND RHEUMATISM 2010;62(1):44-52
Signal pathways JNK and NF-kappa B, identified by global gene expression profiling, are involved in regulation of TNF alpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts
BMC GENOMICS 2010;:241-
The plasticity of the mammalian transcriptome
Automation of cDNA Synthesis and Labelling Improves Reproducibility
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY 2009;:396808-
Extremely Different Behaviours in High and Low Body Weight Lines of Chicken are Associated with Differential Expression of Genes Involved in Neuronal Plasticity
JOURNAL OF NEUROENDOCRINOLOGY 2009;21(3):208-16
Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles
ANNALS OF THE RHEUMATIC DISEASES 2009;68(5):736-43
Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients - a prospective clinical study
ARTHRITIS RESEARCH & THERAPY 2008;10(2):R33-
Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics
MOLECULAR & CELLULAR PROTEOMICS 2007;6(1):125-32
Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients
ARTHRITIS RESEARCH & THERAPY 2006;8(6):R179-
Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology
ARTHRITIS RESEARCH & THERAPY 2006;8(2):R47-
Nobels väg 12A