Jeroen Goos
Research Specialist
E-mail: jeroen.goos@ki.se
Visiting address: BioClinicum J5:20, Akademiska Stråket 1, Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 Neuro Holmin Goos, 171 77 Stockholm
Part of:
- Department of Clinical Neuroscience
- Division of Neuro
- Neuroradiology – Staffan Holmin's research group
Research
- The focus of my research group lies with the development of new tools for the
molecular imaging and treatment of patients with cancer. We use synthetic
molecules, but also biological compounds, that are labelled with radioactive
isotopes to specifically target the sites in the body where tumours are
located. Some of these isotopes can be detected using diagnostic imaging
devices (e.g. PET), whereas other isotopes are more suited for the delivery
of therapeutic doses of radioactivity that kill the tumour cells.
Our first research line aims at developing minimally invasive, nuclear
treatment strategies for patients that suffer from brain cancer. We are
using natural peptides and bispecific antibodies that are capable to
cross the blood-brain barrier (BBB) and then specifically bind to tumour
tissue.
In our second research line, we are developing new (radio)chemistry to
improve current pretargeting strategies. The pretargeting strategy
attempts to decrease radioactive doses to healthy tissues by injecting the
targeting vector (e.g. an antibody) and radioactive ligand separately, which
then ligate within the target tissue. By optimising the chemical and
physiological properties of both, the radioactive doses to healthy
tissues can significantly be reduced.
In our third research line, we use imaging isotopes to track immune cells in
the human body during immune cell therapy.
Articles
- Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108801Zafar I; Li K; Zammit J; Palm KP; Davydova M; Varshney M; Lu L; Tran T; Bergstrom T; Swartling FJ; Lewis J; Holmin S; Goos J
- Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108673Friberger I; Tran T; Lu L; Milton S; Samen E; Goos J; Carlsten M; Holmin S
- Article: EJNMMI RESEARCH. 2023;13(1):73Friberger I; Nilsson JNN; Lu L; Siikanen J; Ardenfors O; Milton S; Samen E; Goos JACM; Carlsten M; Holmin S; Tran TAA
- Article: MOLECULAR IMAGING AND BIOLOGY. 2021;23(6):952-962Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samen E; Carlsten M; Holmin S; Tran TA
- Article: ONCOIMMUNOLOGY. 2020;9(1):1832761Nugteren S; Goos JACM; Delis-van Diemen PM; Simons-Oosterhuis Y; Lindenbergh-Kortleve DJ; van Haaften DH; Sanders J; Meijer GA; Fijneman RJA; Samsom JN
- Article: POLYMER CHEMISTRY. 2020;11(35):5681-5692Leiske MN; Mahmoud AM; Warne NM; Goos JACM; Pascual S; Montembault V; Fontaine L; Davis TP; Whittaker MR; Kempe K
- Journal article: MACROMOLECULAR RAPID COMMUNICATIONS. 2020;41(11)Goos JACM; Davydova M; Lengkeek N; Greguric I; Whittaker MR; Quinn JF; Baell JB; Lewis JS; Davis TP
- Article: MACROMOLECULAR RAPID COMMUNICATIONS. 2020;41(11):e2000061Goos JACM; Davydova M; Lengkeek N; Greguric I; Whittaker MR; Quinn JF; Baell JB; Lewis JS; Davis TP
- Article: NUCLEAR MEDICINE AND BIOLOGY. 2020;84-85:63-72Goos JACM; Davydova M; Dilling TR; Cho A; Cornejo MA; Gupta A; Price WS; Puttick S; Whittaker MR; Quinn JF; Davis TP; Lewis JS
- Article: THERANOSTICS. 2020;10(2):567-584Goos JACM; Cho A; Carter LM; Dilling TR; Davydova M; Mandleywala K; Puttick S; Gupta A; Price WS; Quinn JF; Whittaker MR; Lewis JS; Davis TP
- Article: JOURNAL OF NUCLEAR MEDICINE. 2019;60(11):1569-1578Pereira PMR; Mandleywala K; Ragupathi A; Carter LM; Goos JACM; Janjigian YY; Lewis JS
- Article: BRITISH JOURNAL OF CANCER. 2016;115(12):1565-1574den Uil SH; Coupe VMH; Linnekamp JF; van den Broek E; Goos JACM; Diemen PMD-V; Belt EJT; van Grieken NCT; Scott PM; Vermeulen L; Medema JP; Bril H; Stockmann HBAC; Cormier RT; Meijer GA; Fijneman RJA
- Journal article: CANCER RESEARCH. 2016;76(14_Supplement):3125den Uil SH; Coupe VMH; Linnekamp JF; van den Broek E; Goos JACM; Delis-van Diemen PM; Belt EJT; van Grieken NCT; Scott PM; Vermeulen L; Medema JP; Bril H; Stockmann HBAC; Cormier RT; Meijer GA; Fijneman RJ
- Article: ONCOTARGET. 2016;7(2):2123-2134Goos JACM; Coupe VMH; van de Wiel MA; Diosdado B; Delis-Van Diemen PM; Hiemstra AC; de Cuba EMV; Belien JAM; van Oordt CWM-VDH; Geldof AA; Meijer GA; Hoekstra OS; Fijneman RJA
- Article: ANNALS OF SURGERY. 2016;263(1):138-145Goos JACM; de Cuba EMV; Coupe VMH; Diosdado B; Delis-Van Diemen PM; Karga C; Belien JAM; van Oordt CWM-VDH; Geldof AA; Meijer GA; Hoekstra OS; Fijneman RJA
- Article: NUCLEAR MEDICINE AND BIOLOGY. 2016;43(1):63-72Goos JACM; Verbeek J; Geldof AA; Hiernstra AC; van de Wiel MA; Adamzek KA; Delis-Van Diemen PM; Stroud SG; Bradley DP; Meijer GA; Hoekstra OS; Fijneman RJA; Windhorst AD
- Article: ONCOTARGET. 2015;6(28):26278-26290Lenos K; Goos JACM; Vuist IM; den Uil SH; Delis-van Diemen PM; Belt EJT; Stockmann HBAC; Bril H; de Wit M; Carvalho B; Giblett S; Pritchard CA; Meijer GA; van Kooyk Y; Fijneman RJA; van Vliet SJ
- Article: BRITISH JOURNAL OF CANCER. 2014;111(4):749-755Goos JACM; Hiemstra AC; Coupe VMH; Diosdado B; Kooijman W; Delis-Van Diemen PM; Karga C; Belien JAM; van Oordt CWM-VDH; Geldof AA; Meijer GA; Hoekstra OS; Fijneman RJA
- Article: ONCOGENE. 2014;33(29):3861-3868Than BLN; Goos JACM; Sarver AL; O'Sullivan MG; Rod A; Starr TK; Fijneman RJA; Meijer GA; Zhao L; Zhang Y; Largaespada DA; Scott PM; Cormier RT
- Article: BRITISH JOURNAL OF CANCER. 2013;109(9):2445-2452Goos JACM; Coupe VMH; Diosdado B; Diemen PMD-V; Karga C; Belien JAM; Carvalho B; van den Tol MP; Verheul HMW; Geldof AA; Meijer GA; Hoekstra OS; Fijneman RJA
- Article: BRITISH JOURNAL OF CANCER. 2013;109(6):1636-1647Snoeren N; Emmink BL; Koerkamp MJG; van Hooff SR; Goos JACM; van Houdt WJ; de Wit M; Prins AM; Piersma SR; Pham TV; Belt EJ; Bril H; Stockmann HB; Meijer GA; van Hillegersberg R; Holstege FC; Jimenez CR; Fijneman RJA; Kranenburg OW; Rinkes IHMB
- Journal article: CANCER RESEARCH. 2013;73(8_Supplement):1151Goos JACM; Coupé VMH; Diosdado B; Delis-van Diemen PM; Karga C; Beliën JAM; Carvalho B; van den Tol MP; Verheul HMW; Geldof AA; Meijer GA; Hoekstra OS; Fijneman RJA
- Article: MACROMOLECULAR RAPID COMMUNICATIONS. 2013;34(2):156-162Vo C-D; Cadman CJ; Donno R; Goos JACM; Tirelli N
- Article: ZEITSCHRIFT FUR KRISTALLOGRAPHIE-CRYSTALLINE MATERIALS. 2012;227(11):739-743Goos JACM; Vo CD; Dey A; van den Hoogen CJ; Lousberg NJHGM; Hendrix MMRM; Tirelli N; de With G; Sommerdijk NAJM
- Article: AMERICAN JOURNAL OF SURGICAL PATHOLOGY. 2011;35(7):937-948Magnusson K; de Wit M; Brennan DJ; Johnson LB; Mcgee SF; Lundberg E; Naicker K; Klinger R; Kampf C; Asplund A; Wester K; Gry M; Bjartell A; Gallagher WM; Rexhepaj E; Kilpinen S; Kallioniemi O-P; Belt E; Goos J; Meijer G; Birgisson H; Glimelius B; Borrebaeck CAK; Navani S; Uhlen M; O'Connor DP; Jirstrom K; Ponten F
- Journal article: CANCER RESEARCH. 2011;71(8_Supplement):5217Goos JACM; Fijneman RJA; Geldof AA; Group DP; Meijer GA; Hoekstra OS
- Article: SCIENCE. 2009;323(5920):1455-1458Pouget EM; Bomans PHH; Goos JACM; Frederik PM; de With G; Sommerdijk NAJM
- Show more
All other publications
- Corrigendum: MOLECULAR IMAGING AND BIOLOGY. 2022;24(3):510Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samen E; Carlsten M; Holmin S; Tran TA
- Book chapter: HANDBOOK OF RADIOPHARMACEUTICALS. 2020;p. 535-570Goos JACM; Keinänen O; Zeglis BM; Lewis JS
- Preprint: BIORXIV. 2020Oni TE; Bautista C; Merrill JR; Goos JACM; Rivera KD; Miyabayashi K; Biffi G; Garcia L; Plenker D; Patel H; Elyada E; Samaritano M; Yu KH; Pappin DJ; Goggins MG; Hruban RH; Lewis JS; Lyons SK; Yeh JT; Tuveson DA
- Review: FRONTIERS IN PHARMACOLOGY. 2018;9:831Chang D; Lim M; Goos JACM; Qiao R; Ng YY; Mansfeld FM; Jackson M; Davis TP; Kavallaris M
- Conference publication: CANCER RESEARCH. 2015;75(15_Supplement):3419Goos JACM; de Cuba EMV; Coupe VMH; Diosdado B; Delis-van Diemen PM; Karga C; Belien JAM; Menke - Van der Houven van Oordt CW; Geldof AA; Meijer GA; Hoekstra OS; Fijneman RJA
- Conference publication: CANCER RESEARCH. 2014;74(19_Supplement):2853Goos JACM; Hiemstra AC; Coupé VMH; Diosdado B; Kooijman W; Diemen PMD-V; Karga C; Beliën JAM; Oordt CWM-VDHV; Geldof AA; Meijer GA; Hoekstra OS; Fijneman RJA
- Conference publication: CANCER RESEARCH. 2014;74(19_Supplement):112Verbeek J; Goos JA; Geldof AA; Hiemstra AC; Hoekstra OS; Meijer GA; Stroud S; Bradley D; Fijneman RJ; Windhorst AD
Grants
- Swedish Research Council1 January 2022 - 31 December 2025One in three children with brain cancer dies before reaching adulthood. Standard therapy involves opening of the skull for physical removal of the tumour. This highly invasive treatment comes with significant risks. Moreover, an incomplete resection will lead to relapse and decreased survival. My aim is to develop an innovative, minimally invasive therapy approach that effectively and selectively delivers radiotherapeutic agents to brain tumours, with minimal side effects.My team (one PhD student and one postdoc) will design a new class of bispecific monoclonal antibodies (month 1-24) and use a peptide from scorpion venom (month 1-18) for the delivery of therapeutic radionuclides across the blood-brain barrier (BBB). A pretargeting strategy will be employed to reduce radioactive doses to healthy tissues (month 1-48).This proposal uniquely integrates recent advances in radiology, oncology, chemistry and molecular biology into innovative research designs and novel treatment strategies. The proposed strategy will limit side effects with a substantial chance of significant tumour reduction or complete tumour elimination. The newly designed methodologies and agents could lead to breakthroughs in key applications of fundamental, preclinical and clinical interest and change the way we approach illnesses of the brain. The feasibility of the suggested approach is supported by preliminary data. This proposal will open up new fields of research in the basic and (pre)clinical setting.
Employments
- Research Specialist, Department of Clinical Neuroscience, Karolinska Institutet, 2025-
- Assistant Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2019-2025