Jacob Grünler

About me
Publications
Public outreach and news

Research

Jacob Grünler is responsible for studies on inflammatory processes in
development of atherosclerosis in diabetics especially the effect of
antioxidants, like coenzyme Q10 and vitamin E.
These involves studies of cytokine production, studied in human blood
monocytes, lymfocytes and urine samples, animal models and HPLC-methodology,
flow-cytometry, cell culture studies.
He is also responsible for the laboratory environmental issues, animal
housing and ethic applications.
Research group Growth and metabolism [1]
*Selected publications*
[pubmed:19057015]
[pubmed:15153069]
[pubmed:15038955]
[pubmed:14670990]
[pubmed:10437779]
[1] http://default/node/2970

Articles

Article: EMBO REPORTS. 2024;25(4):1752-1772
Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia
Zhao A; Jiang H; Palomares AR; Larsson A; He W; Grunler J; Zheng X; Wallberg KAR; Catrina S-B; Deng Q
Article: MBIO. 2022;13(5):e0108622-e01022
High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages
Teran G; Li H; Catrina S-B; Liu R; Brighenti S; Zheng X; Grunler J; Nylen S; Carow B; Rottenberg ME
Article: ELIFE. 2022;11:e70714
Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes
Zheng X; Narayanan S; Xu C; Eliasson Angelstig S; Grunler J; Zhao A; Di Toro A; Bernardi L; Mazzone M; Carmeliet P; Del Sole M; Solaini G; Forsberg EA; Zhang A; Brismar K; Schiffer TA; Rajamand Ekberg N; Botusan IR; Palm F; Catrina S-B
Article: ISCIENCE. 2021;24(5):102494
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
Zhang J; Teran G; Popa M; Madapura H; Ladds MJGW; Lianoudaki D; Grunler J; Arsenian-Henriksson M; McCormack E; Rottenberg ME; Catrina S-B; Lain S; Darekar S
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(3):659-671
miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
Li D; Peng H; Qu L; Sommar P; Wang A; Chu T; Li X; Bi X; Liu Q; Serezal IG; Rollman O; Lohcharoenkal W; Zheng X; Angelstig SE; Grunler J; Pivarcsi A; Sonkoly E; Catrina S-B; Xiao C; Stahle M; Mi Q-S; Zhou L; Landen NX
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):768
HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism
Narayanan S; Angelstig SE; Xu C; Grunler J; Zhao A; Zhu W; Landen NX; Stahle M; Zhang J; Ivan M; Maltesen RG; Botusan IR; Ekberg NR; Zheng X; Catrina S-B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(14):6985-6994
Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes
Zheng X; Narayanan S; Sunkari VG; Eliasson S; Botusan IR; Grunler J; Catrina AI; Radtke F; Xu C; Zhao A; Ekberg NR; Lendahl U; Catrina S-B
Article: PLOS ONE. 2018;13(3):e0193084
Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate
Botusan IR; Zheng X; Narayanan S; Grunler J; Sunkari VG; Calissendorff FS; Ansurudeen I; Illies C; Svensson J; Jansson J-O; Ohlsson C; Brismar K; Catrina S-B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638
MicroRNA-132 with Therapeutic Potential in Chronic Wounds
Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grunler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrstrom M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Stahle M; Landen NX
Article: BBA CLINICAL. 2015;4:14-20
Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients.
Montano SJ; Grünler J; Nair D; Tekle M; Fernandes AP; Hua X; Holmgren A; Brismar K; Ungerstedt JS
Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2015;29(8):1152-1158
Coenzyme Q10 and oxidative stress, the association with peripheral sensory neuropathy and cardiovascular disease in type 2 diabetes mellitus
Forsberg E; Xu C; Grunler J; Frostegard J; Tekle M; Brismar K; Karvestedt L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(8):3008-3026
MicroRNA-132 enhances transition from inflammation to proliferation during wound healing
Li D; Wang A; Liu X; Meisgen F; Gruenler J; Botusan IR; Narayanan S; Erikci E; Li X; Blomqvist L; Du L; Pivarcsi A; Sonkoly E; Chowdhury K; Catrina S-B; Stahle M; Landen NX
Article: GROWTH HORMONE AND IGF RESEARCH. 2015;25(1):34-40
Effects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts
Brandt K; Grunler J; Brismar K; Wang J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2014;177(2):478-482
Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity
Brauner H; Luthje P; Grunler J; Ekberg NR; Dallner G; Brismar K; Brauner A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):690-695
Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db^-/db^- mouse, a type 2 diabetes model
Shi T-JS; Zhang M-D; Zeberg H; Nilsson J; Grunler J; Liu S-X; Xiang Q; Persson J; Fried KJ; Catrina SB; Watanabe M; Arhem P; Brismar K; Hokfelt TGM
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2011;27(5):470-479
Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes
Savu O; Sunkari VG; Botusan IR; Gruenler J; Nikoshkov A; Catrina S-B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(49):19426-19431
Stabilization of HIF-1α is critical to improve wound healing in diabetic mice
Botusan IR; Sunkari VG; Savu O; Catrina AI; Grunler J; Lindberg S; Pereira T; Yla-Herttuala S; Poellinger L; Brismar K; Catrina S-B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(30):21024-21035
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants
Skorupinska-Tudek K; Poznanski J; Wojcik J; Bienkowski T; Szostkiewicz I; Zelman-Femiak M; Bajda A; Chojnacki T; Olszowska O; Grunler J; Meyer O; Rohmer M; Danikiewicz W; Swiezewska E
Article: BRITISH JOURNAL OF CANCER. 2005;92(8):1467-1474
Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival
Catrina SB; Lewitt M; Massambu C; Dricu A; Grünler J; Axelson M; Biberfeld P; Brismar K
Article: BIOCHEMICAL JOURNAL. 2004;382(Pt 2):519-526
Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ
Forsgren M; Attersand A; Lake S; Grünler J; Swiezewska E; Dallner G; Climent CL
Article: ENDOCRINOLOGY. 2004;145(3):1137-1143
Gender-specific pattern of insulin-like growth factor-binding protein-3 protease activity in mouse thyroid
Wang J; Grünler J; Lewitt MS
Article: ANALYTICAL BIOCHEMISTRY. 2001;297(2):137-143
Separation and quantitation of phospholipids and their ether analogues by high-performance liquid chromatography
Guan ZZ; Grünler J; Piao SF; Sindelar PJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(36):33297-33300
A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.
Stenmark P; Grünler J; Mattsson J; Sindelar PJ; Nordlund P; Berthold DA
Article: FEBS LETTERS. 1999;455(3):233-237
Subcellular distribution of farnesyl protein transferase in rat liver.
Grünler J; Parmryd I
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1998;353(2):191-198
Phosphorylation of farnesol in rat liver microsomes:: Properties of farnesol kinase and farnesyl phosphate kinase
Bentinger M; Grünler J; Peterson E; Swiezewska E; Dallner G
Article: FEBS LETTERS. 1995;358(3):230-232
ESTIMATION OF DOLICHOL AND CHOLESTEROL-SYNTHESIS IN MICROSOMES AND PEROXISOMES ISOLATED FROM RAT-LIVER
GRUNLER J; OLSSON JM; DALLNER G
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All other publications

Editorial comment: ENDOCRINE. 2014;46(2):347-350
Selective blockade of estrogen receptor beta improves wound healing in diabetes
Sunkari VG; Botusan IR; Savu O; Grunler J; Zheng X; Gustafsson J-A; Brismar K; Catrina S-B
Published conference paper: AMINO ACIDS. 2012;43(1):127-134
Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes
Ansurudeen I; Sunkari VG; Grunler J; Peters V; Schmitt CP; Catrina S-B; Brismar K; Forsberg EA
Meeting abstract: CHEMISTRY AND PHYSICS OF LIPIDS. 2008;154:S41-S42
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants
Skorupinska-Tudek K; Poznanski J; Wojcik J; Bienkowski T; Szostkiewicz I; Zelman-Femiak M; Bajda A; Chojnacki T; Olszowska O; Grunler J; Meyer O; Rohmer M; Danikiewicz W; Swiezewska E
Review: METHODS IN ENZYMOLOGY. 2004;378:3-17
Investigation of regulatory mechanisms in coenzyme Q metabolism
Grünler J; Dallner G

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