J-Sebastian Muehlboeck

About me
Publications
Public outreach and news

About me

Neuroimaging research since 2005
Data and solutions architect
Software developer
Psychology MSc (Focus on statistics and I/O)
Interests:
* Big data
* Efficient data management and automated processing in Neuroimaging
* Machine learning
* Cloud (MaaS, SaaS)

Articles

Article: PARKINSONISM AND RELATED DISORDERS. 2024;121:106047
Putaminal T1/T2-weighted ratio is increased in PSP compared to PD and healthy controls, a multi-cohort study
Sjostrom H; van Westen D; Hall S; Tjerkaski J; Westman E; Muehlboeck S; Hansson O; Svenningsson P; Granberg T
Article: HUMAN BRAIN MAPPING. 2024;45(4):e26618
In vivo microstructural heterogeneity of white matter and cognitive correlates in aging using tissue compositional analysis of diffusion magnetic resonance imaging
Badji A; Cedres N; Muehlboeck J-S; Khan W; Dhollander T; Barroso J; Ferreira D; Westman E
Article: NEUROBIOLOGY OF AGING. 2023;129:41-49
Comparing three neuropsychological subgrouping approaches in subjective and mild cognitive impairment from a naturalistic multicenter study
Rennie A; Ekman U; Wallert J; Muehlboeck J-S; Eriksdotter M; Wahlund L-O; Ferreira D; Westman E
Article: FRONTIERS IN AGING NEUROSCIENCE. 2023;15:1303036
A deep learning model for brain age prediction using minimally preprocessed T1w images as input
Dartora C; Marseglia A; Martensson G; Rukh G; Dang J; Muehlboeck J-S; Wahlund L-O; Moreno R; Barroso J; Ferreira D; Schioth HB; Westman E
Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2022;8(4):20552173221144230
Association between brain volume and disability over time in multiple sclerosis
Moridi T; Stawiarz L; McKay KA; Ineichen BV; Ouellette R; Ferreira D; Muehlboeck J-S; Westman E; Kockum I; Olsson T; Piehl F; Hillert J; Manouchehrinia A; Granberg T
Article: NATURE COMMUNICATIONS. 2022;13(1):4566
Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer's disease
Poulakis K; Pereira JB; Muehlboeck J-S; Wahlund L-O; Smedby O; Volpe G; Masters CL; Ames D; Niimi Y; Iwatsubo T; Ferreira D; Westman E
Article: NEUROLOGY. 2022;99(4):e323-e333
Neuropathologic Features of Antemortem Atrophy-Based Subtypes of Alzheimer Disease
Mohanty R; Ferreira D; Frerich S; Muehlboeck J-S; Grothe MJ; Westman E
Article: AGING. 2021;13(16):19963-19977
The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline
Cedres N; Diaz-Galvan P; Diaz-Flores L; Muehlboeck J-S; Molina Y; Barroso J; Westman E; Ferreira D
Article: AGING. 2021;13(10):13430-13442
Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
Wallert J; Rennie A; Ferreira D; Muehlboeck J-S; Wahlund L-O; Westman E; Ekman U
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:644611
Functional Connectivity and Compensation of Phonemic Fluency in Aging
Mohanty R; Gonzalez-Burgos L; Diaz-Flores L; Muehlboeck J-S; Barroso J; Ferreira D; Westman E
Article: NEUROIMAGE. 2020;211:116607
Cholinergic white matter pathways make a stronger contribution to attention and memory in normal aging than cerebrovascular health and nucleus basalis of Meynert
Nemy M; Cedres N; Grothe MJ; Muehlboeck J-S; Lindberg O; Nedelska Z; Stepankova O; Vyslouzilova L; Eriksdotter M; Barroso J; Teipel S; Westman E; Ferreira D
Article: BMC GERIATRICS. 2020;20(1):93
The MemClin project: a prospective multi memory clinics study targeting early stages of cognitive impairment
Ekman U; Ferreira D; Muehlboeck J-S; Wallert J; Rennie A; Eriksdotter M; Wahlund L-O; Westman E
Article: NEURODEGENERATIVE DISEASES. 2020;20(4):153-164
Brain Atrophy Subtypes and the ATN Classification Scheme in Alzheimer's Disease
Cedres N; Ekman U; Poulakis K; Shams S; Cavallin L; Muehlboeck S; Granberg T; Wahlund L-O; Ferreira D; Westman E
Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa192
Comparison of subtyping methods for neuroimaging studies in Alzheimer's disease: a call for harmonization
Mohanty R; Martensson G; Poulakis K; Muehlboeck J-S; Rodriguez-Vieitez E; Chiotis K; Grothe MJ; Nordberg A; Ferreira D; Westman E
Article: FRONTIERS IN NEUROSCIENCE. 2020;14:15
Shape Information Improves the Cross-Cohort Performance of Deep Learning-Based Segmentation of the Hippocampus
Brusini I; Lindberg O; Muehlboeck J-S; Smedby O; Westman E; Wang C
Article: NEUROIMAGE: CLINICAL. 2019;23:101872
AVRA: Automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks
Martensson G; Ferreira D; Cavallin L; Muehlboeck J-S; Wahlund L-O; Wang C; Westman E
Article: FRONTIERS IN AGING NEUROSCIENCE. 2018;10:439
Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease
Boccardi V; Westman E; Pelini L; Lindberg O; Muehlboeck J-S; Simmons A; Tarducci R; Floridi P; Chiarini P; Soininen H; Kloszewska I; Tsolaki M; Vellas B; Spenger C; Wahlund L-O; Lovestone S; Mecocci P
Article: HIPPOCAMPUS. 2017;27(6):653-667
The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals
Ferreira D; Hansson O; Barroso J; Molina Y; Machado A; Andres Hernandez-Cabrera J; Muehlboeck J-S; Stomrud E; Nagga K; Lindberg O; Ames D; Kalpouzos G; Fratiglioni L; Backman L; Graff C; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Ahlstrom H; Lind L; Larsson E-M; Wahlund L-O; Simmons A; Westman E
Article: SCIENTIFIC REPORTS. 2017;7:46263
Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications
Ferreira D; Verhagen C; Andres Hernandez-Cabrera J; Cavallin L; Guo C-J; Ekman U; Muehlboeck J-S; Simmons A; Barroso J; Wahlund L-O; Westman E
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2017;56(3):1159-1174
A Multi-Cohort Study of ApoE ε4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease
Khan W; Giampietro V; Banaschewski T; Barker GJ; Bokde ALW; Buechel C; Conrod P; Flor H; Frouin V; Garavan H; Gowland P; Heinz A; Ittermann B; Lemaitre H; Nees F; Paus T; Pausova Z; Rietschel M; Smolka MN; Stroehle A; Gallinat J; Vellas B; Soininen H; Kloszewska I; Tsolaki M; Mecocci P; Spenger C; Villemagne VL; Masters CL; Muehlboeck J-S; Backman L; Fratiglioni L; Kalpouzos G; Wahlund L-O; Schumann G; Lovestone S; Williams SCR; Westman E; Simmons A
Article: NEUROIMAGE: CLINICAL. 2017;16:418-428
Monitoring disease progression in mild cognitive impairment: Associations between atrophy patterns, cognition, APOE and amyloid
Falahati F; Ferreira D; Muehlboeck J-S; Eriksdotter M; Simmons A; Wahlund L-O; Westman E
Article: BRAIN TOPOGRAPHY. 2015;28(5):746-759
Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease in Two Independent Cohorts
Khan W; Westman E; Jones N; Wahlund L-O; Mecocci P; Vellas B; Tsolaki M; Koszewska I; Soininen H; Spenger C; Lovestone S; Muehlboeck J-S; Simmons A
Article: JOURNAL OF INTERNAL MEDICINE. 2015;278(3):277-290
Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment
Ferreira D; Cavallin L; Larsson E-M; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Simmons A; Wahlund L-O; Westman E
Article: NEUROIMAGE. 2015;115:64-75
Alterations in cortical thickness development in preterm-born individuals: Implications for high-order cognitive functions.
Nam KW; Castellanos N; Simmons A; Froudist-Walsh S; Allin MP; Walshe M; Murray RM; Evans A; Muehlboeck J-S; Nosarti C
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2015;45(3):851-864
Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts
Khondoker M; Newhouse S; Westman E; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Dobson R; Simmons A
Article: PLOS ONE. 2015;10(8):e0134368
A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease
Khan W; Aguilar C; Kiddle SJ; Doyle O; Thambisetty M; Muehlboeck S; Sattlecker M; Newhouse S; Lovestone S; Dobson R; Giampietro V; Westman E; Simmons A
Article: FRONTIERS IN NEUROINFORMATICS. 2014;7:49
The HiveDB image data management and analysis framework
Muehlboeck J-S; Westman E; Simmons A
Article: FRONTIERS IN AGING NEUROSCIENCE. 2014;6:145
Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort
Aguilar C; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Wahlund L-O; Simmons A; Westman E
Article: JOURNAL OF INTERNAL MEDICINE. 2013;273(6):602-621
Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol
Mangialasche F; Westman E; Kivipelto M; Muehlboeck J-S; Cecchetti R; Baglioni M; Tarducci R; Gobbi G; Floridi P; Soininen H; Kloszewska I; Tsolaki M; Vellas B; Spenger C; Lovestone S; Wahlund L-O; Simmons A; Mecocci P
Article: PSYCHIATRY RESEARCH. 2013;212(2):89-98
Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment
Aguilar C; Westman E; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Spenger C; Simmons A; Wahlund L-O
Article: JOURNAL OF INTERNAL MEDICINE. 2013;273(4):396-409
An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment
Spulber G; Simmons A; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Spenger C; Lovestone S; Wahlund L-O; Westman E
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2013;33(3):755-766
Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease
Velayudhan L; Proitsi P; Westman E; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Spenger C; Hodges A; Powell J; Lovestone S; Simmons A
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA. 2013;3(1):446-458
CERAD Neuropsychological Total Scores Reflect Cortical Thinning in Prodromal Alzheimer's Disease.
Paajanen T; Hänninen T; Aitken A; Hallikainen M; Westman E; Wahlund L-O; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Spenger C; Lovestone S; Simmons A; Soininen H; AddNeuroMed Consortium
Article: BRAIN TOPOGRAPHY. 2013;26(1):9-23
Regional Magnetic Resonance Imaging Measures for Multivariate Analysis in Alzheimer's Disease and Mild Cognitive Impairment
Westman E; Aguilar C; Muehlboeck J-S; Simmons A
Article: NEURORADIOLOGY. 2012;54(9):929-938
Education increases reserve against Alzheimer's disease-evidence from structural MRI analysis
Liu Y; Julkunen V; Paajanen T; Westman E; Wahlund L-O; Aitken A; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Spenger C; Lovestone S; Simmons A; Soininen H
Article: NEUROIMAGE. 2012;62(1):229-238
Combining MRI and CSF measures for classification of Alzheimer's disease and prediction of mild cognitive impairment conversion
Westman E; Muehlboeck J-S; Simmons A
Article: NEUROIMAGE. 2011;58(3):818-828
AddNeuroMed and ADNI: Similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America
Westman E; Simmons A; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Weiner MW; Lovestone S; Spenger C; Wahlund L-O
Article: NEUROBIOLOGY OF AGING. 2011;32(7):1198-1206
Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study
Liu Y; Paajanen T; Zhang Y; Westman E; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H
Article: NEUROIMAGE. 2011;54(2):1178-1187
Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls
Westman E; Simmons A; Zhang Y; Muehlboeck J-S; Tunnard C; Liu Y; Collins L; Evans A; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Spenger C; Wahlund L-O
Article: PLOS ONE. 2011;6(7):e22506
Sensitivity and Specificity of Medial Temporal Lobe Visual Ratings and Multivariate Regional MRI Classification in Alzheimer's Disease
Westman E; Cavallin L; Muehlboeck J-S; Zhang Y; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Spenger C; Lovestone S; Simmons A; Wahlund L-O
Article: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2011;26(1):75-82
The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease : experience from the first 24 months
Simmons A; Westman E; Muehlboeck S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Wahlund L-O; Soininen H; Lovestone S; Evans A; Spenger C
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2010;21(4):1141-1151
Differences in Cortical Thickness in Healthy Controls, Subjects with Mild Cognitive Impairment, and Alzheimer's Disease Patients: A Longitudinal Study
Julkunen V; Niskanen E; Koikkalainen J; Herukka S-K; Pihlajamaki M; Hallikainen M; Kivipelto M; Muehlboeck S; Evans AC; Vanninen R; Soininen H
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2010;21(3):947-966
Effect of APOE ε4 Allele on Cortical Thicknesses and Volumes: The AddNeuroMed Study
Liu Y; Paajanen T; Westman E; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Proitsi P; Powell J; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H
Article: NEUROBIOLOGY OF AGING. 2010;31(8):1375-1385
Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease
Liu Y; Paajanen T; Zhang Y; Westman E; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H
Article: ARCHIVES OF GENERAL PSYCHIATRY. 2010;67(7):739-748
Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease
Thambisetty M; Simmons A; Velayudhan L; Hye A; Campbell J; Zhang Y; Wahlund L-O; Westman E; Kinsey A; Guntert A; Proitsi P; Powell J; Causevic M; Killick R; Lunnon K; Lynham S; Broadstock M; Choudhry F; Howlett DR; Williams RJ; Sharp SI; Mitchelmore C; Tunnard C; Leung R; Foy C; O'Brien D; Breen G; Furney SJ; Ward M; Kloszewska I; Mecocci P; Soininen H; Tsolaki M; Vellas B; Hodges A; Murphy DGM; Parkins S; Richardson JC; Resnick SM; Ferrucci L; Wong DF; Zhou Y; Muehlboeck S; Evans A; Francis PT; Spenger C; Lovestone S
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2010;30(3):229-237
APOE ε2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes
Liu Y; Paajanen T; Westman E; Zhang Y; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Proitsi P; Powell J; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2009;28(5):404-412
Cortical Thickness Analysis to Detect Progressive Mild Cognitive Impairment: A Reference to Alzheimer's Disease
Julkunen V; Niskanen E; Muehlboeck S; Pihlajamaki M; Kononen M; Hallikainen M; Kivipelto M; Tervo S; Vanninen R; Evans A; Soininen H
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Letter: JOURNAL OF INTERNAL MEDICINE. 2021;290(2):473-476
Neurofilament light chain as a marker for cortical atrophy in multiple sclerosis without radiological signs of disease activity
Ineichen BV; Moridi T; Ewing E; Ouellette R; Manouchehrinia A; Stawiarz L; Ferreira D; Muehlboeck SJ; Kuhle J; Westman E; Leppert D; Hillert J; Olsson T; Kockum I; Piehl F; Granberg T
Published conference paper: NEURODEGENERATIVE DISEASES. 2016;16(1-2):77-86
Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations
Orellana C; Ferreira D; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Simmons A; Wahlund L-O; Westman E
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1180:47-55
MRI Measures of Alzheimer's Disease and the AddNeuroMed Study
Simmons A; Westman E; Muehlboeck S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Wahlund L-O; Soininen H; Lovestone S; Evans A; Spenger C
Published conference paper: BEHAVIOR RESEARCH METHODS. 2003;35(2):255-258
Animated diagrams in teaching statistics.
Wender KF; Muehlboeck JS

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