Ismael Valladolid Acebes
About me
As a leading researcher at Karolinska Institutet, I specialize in the complex signal transduction mechanisms of pancreatic beta-cells, a critical area for diabetes research. My work focuses on how glucose metabolism influences insulin secretion and how various receptor-operated signaling pathways maintain beta-cell function under physiological conditions. This research contributes to novel therapeutic strategies aimed at improving insulin regulation in diabetes. Collaborating with international labs, I am committed to advancing our understanding of cellular signaling in diabetes, fostering innovation, and contributing to the pharmaceutical industry’s search for effective treatments.
Research
My research interests center on the molecular pathways governing pancreatic beta-cell function, particularly in the context of diabetes. I explore how intracellular signaling networks influence beta-cell survival, proliferation, and insulin secretion, with a strong emphasis on understanding metabolic and environmental stressors that contribute to beta-cell dysfunction. By combining preclinical models, translational approaches, and clinical insights, my work aims to uncover novel therapeutic targets for diabetes treatment. I collaborate with leading international laboratories to bridge the gap between basic science and clinical application, focusing on innovative strategies to enhance insulin sensitivity and beta-cell regeneration. My research offers a unique opportunity to accelerate the development of cutting-edge therapies that could transform the treatment of diabetes and benefit the pharmaceutical industry.
Teaching
As a passionate educator in the fields of obesity, diabetes, and neuroscience, my teaching philosophy centers on integrating cutting-edge research with practical applications to enhance student learning. I strive to create an engaging and dynamic learning environment where students can explore the complex interplay between metabolic disorders and neurological processes.
In my courses, I emphasize the importance of understanding the biological mechanisms underlying obesity and diabetes, and how these conditions intersect with neurological health. By incorporating the latest scientific advancements and real-world case studies, I aim to provide students with a comprehensive understanding of these critical areas. My approach is to foster critical thinking and encourage students to apply theoretical knowledge to practical problems, preparing them for careers in research, clinical practice, and beyond.
Through interactive lectures, hands-on experiments, and collaborative projects, I guide students in exploring the multifaceted nature of obesity and diabetes. My goal is to empower them with the skills and knowledge needed to contribute meaningfully to this evolving field. I am committed to mentoring students and supporting their academic and professional growth, helping them to develop a deep and nuanced understanding of the complex interactions between metabolic and neurological health.
By staying at the forefront of research and continuously updating my teaching materials, I ensure that students receive the most relevant and impactful education. My dedication to these subjects reflects my belief in their importance for advancing scientific knowledge and improving public health outcomes.
Articles
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2024;12:1380564Lipovsek S; Dolensek J; Daris B; Valladolid-Acebes I; Vajs T; Leitinger G; Stozer A; Skelin Klemen M
- Article: CELLULAR SIGNALLING. 2023;102:110535Ma J; Liu Y; Valladolid-Acebes I; Recio-Lopez P; Peng G; Li J; Berggren P-O; Juntti-Berggren L; Tong N
- Article: BIOFACTORS. 2023;49(1):153-172Recio-Lopez P; Valladolid-Acebes I; Hadwiger P; Hossbach M; Krampert M; Prata C; Berggren P-O; Juntti-Berggren L
- Article: LIFE SCIENCE ALLIANCE. 2022;5(12):e202201505Moruzzi N; Valladolid-Acebes I; Kannabiran SA; Bulgaro S; Burtscher I; Leibiger B; Leibiger IB; Berggren P-O; Brismar K
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;23(1):62Recio-Lopez P; Valladolid-Acebes I; Berggren P-O; Juntti-Berggren L
- Article: SCIENCE ADVANCES. 2021;7(30):eabg5733Adori C; Daraio T; Kuiper R; Barde S; Horvathova L; Yoshitake T; Ihnatko R; Valladolid-Acebes I; Vercruysse P; Wellendorf AM; Gramignoli R; Bozoky B; Kehr J; Theodorsson E; Cancelas JA; Mravec B; Jorns C; Ellis E; Mulder J; Uhlen M; Bark C; Hokfelt T
- Article: ANTIOXIDANTS. 2021;10(7):1070Dallner G; Bentinger M; Hussain S; Sinha I; Yang J; Schwank-Xu C; Zheng X; Swiezewska E; Brismar K; Valladolid-Acebes I; Tekle M
- Article: METABOLITES. 2021;11(6):387Leibiger B; Moede T; Valladolid-Acebes I; Paschen M; Visa M; Leibiger IB; Berggren P-O
- Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021;25(10):4800-4813Moruzzi N; Lazzeri-Barcelo F; Valladolid-Acebes I; Moede T; Paschen M; Leibiger B; Berggren P-O; Leibiger IB
- Article: SCIENCE ADVANCES. 2021;7(11):eabc2931Valladolid-Acebes I; Avall K; Recio-Lopez P; Moruzzi N; Bryzgalova G; Bjornholm M; Krook A; Alonso EF; Ericsson M; Landfors F; Nilsson SK; Berggren P-O; Juntti-Berggren L
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(4):1813Mir-Coll J; Moede T; Paschen M; Neelakandhan A; Valladolid-Acebes I; Leibiger B; Biernath A; Ammala C; Leibiger IB; Yesildag B; Berggren P-O
- Article: NEUROPHARMACOLOGY. 2020;170:108070Narvaez M; Andrade-Talavera Y; Valladolid-Acebes I; Fredriksson M; Siegele P; Hernandez-Sosa A; Fisahn A; Fuxe K; Borroto-Escuela DO
- Article: ROYAL SOCIETY OPEN SCIENCE. 2020;7(1):191171Grubelnik V; Markovic R; Lipovsek S; Leitinger G; Gosak M; Dolensek J; Valladolid-Acebes I; Berggren P-O; Stozer A; Perc M; Marhl M
- Article: DIABETOLOGIA. 2019;62(1):123-135Sevillano J; Gracia Sanchez-Alonso M; Zapateria B; Calderon M; Alcala M; Limones M; Pita J; Gramage E; Vicente-Rodriguez M; Horrillo D; Medina-Gomez G; Jesus Obregon M; Viana M; Valladolid-Acebes I; Herradon G; Pilar Ramos-Alvarez M
- Article: FASEB JOURNAL. 2019;33(1):204-218Paschen M; Moede T; Valladolid-Acebes I; Leibiger B; Moruzzi N; Jacob S; Garcia-Prieto CF; Brismar K; Leibiger IB; Berggren P-O
- Article: NEUROSCIENCE LETTERS. 2018;674:75-80Daraio T; Valladolid-Acebes I; Brismar K; Bark C
- Article: SCIENTIFIC REPORTS. 2017;7(1):7744Daraio T; Bombek LK; Gosak M; Valladolid-Acebes I; Klemen MS; Refai E; Berggren P-O; Brismar K; Rupnik MS; Bark C
- Article: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2017;29(1):13-26Al-Qahtani SM; Bryzgalova G; Valladolid-Acebes I; Korach-Andre M; Dahlman-Wright K; Efendic S; Berggren P-O; Portwood N
- Journal article: ADIPOCYTE. 2016;5(3):318-325Valladolid-Acebes I; Daraio T; Brismar K; Hokfelt T; Bark C
- Article: EUROPEAN JOURNAL OF NUTRITION. 2016;55(4):1615-1622Ibias J; Miguens M; del Rio D; Valladolid-Acebes I; Stucchi P; Ambrosio E; Martin M; Morales L; Ruiz-Gayo M; Del Olmo N
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(31):E4326-E4335Valladolid-Acebes I; Daraio T; Brismar K; Harkany T; Oegren SO; Hoekfelt TGM; Bark C
- Article: NEUROREPORT. 2014;25(11):819-822Cano V; Valladolid-Acebes I; Hernández-Nuño F; Merino B; Del Olmo N; Chowen JA; Ruiz-Gayo M
- Article: NEUROBIOLOGY OF LEARNING AND MEMORY. 2013;106:18-25Valladolid-Acebes I; Fole A; Martín M; Morales L; Cano MV; Ruiz-Gayo M; Del Olmo N
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;302(4):E396-E402Valladolid-Acebes I; Merino B; Principato A; Fole A; Barbas C; Lorenzo MP; García A; Del Olmo N; Ruiz-Gayo M; Cano V
- Article: ENDOCRINOLOGY. 2012;153(2):690-699Stucchi P; Gil-Ortega M; Merino B; Guzmán-Ruiz R; Cano V; Valladolid-Acebes I; Somoza B; Le Gonidec S; Argente J; Valet P; Chowen JA; Fernández-Alfonso M; Ruiz-Gayo M
- Article: PLOS ONE. 2012;7(5):e36139Morales L; Del Olmo N; Valladolid-Acebes I; Fole A; Cano V; Merino B; Stucchi P; Ruggieri D; López L; Alguacil LF; Ruiz-Gayo M
- Article: NEUROBIOLOGY OF LEARNING AND MEMORY. 2011;95(1):80-85Valladolid-Acebes I; Stucchi P; Cano V; Fernández-Alfonso MS; Merino B; Gil-Ortega M; Fole A; Morales L; Ruiz-Gayo M; Del Olmo N
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All other publications
- Review: BIOMEDICINES. 2024;12(11):2422Valladolid-Acebes I
- Conference publication: ACTA PHYSIOLOGICA. 2024;240:26-27Dolensek J; Klemen MS; Kopecky J; Paradiz E; Kercmar LJ; Bombek LK; Pohorec V; Rupnik MS; Valladolid-Acebes I; Stozer A
- Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S220-S221Ballesteros-Pla C; Sevillano J; Sanchez-Alonso M; Limones M; Pita J; Pizarro Delgado J; Izquierdo A; Gomez GM; Valladolid-Acebes I; Herradon G; Alvarez MR
- Review: SEMINARS IN LIVER DISEASE. 2023;43(02):149-162Adori M; Bhat S; Gramignoli R; Valladolid-Acebes I; Bengtsson T; Uhlen M; Adori C
- Book chapter: ELECTRON MICROSCOPY. 2022;p.Skelin Klemen M; Dolenšek J; Valladolid-Acebes I; Stožer A; Lipovšek S
- Conference publication: DIABETOLOGIA. 2021;64(SUPPL 1):96-97Recio-Lopez P; Berggren P-O; Juntti-Berggren L; Valladolid-Acebes I
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(2):932Valladolid-Acebes I; Berggren P-O; Juntti-Berggren L
- Conference publication: DIABETOLOGIA. 2019;62:S122Moruzzi N; Valladolid-Acebes I; Paschen M; Moede T; Leibiger B; Berggren P-O; Leibiger IB
- Conference publication: DIABETOLOGIA. 2019;62:S71-S72Valladolid-Acebes I; Recio-Lopez P; Berggren P-O; Juntti-Berggren L
- Conference publication: DIABETOLOGIA. 2019;62:S293-S294Recio-Lopez P; Berggren P-O; Juntti-Berggren L; Valladolid-Acebes I
- Book chapter: CO-IMMUNOPRECIPITATION METHODS FOR BRAIN TISSUE: NEUROMETHODS. 2019;p. 123-135Borroto-Escuela DO; Narvaez M; Zannoni M; Contri C; Crespo-Ramírez M; di Palma M; Ambrogini P; Borroto-Escuela DY; Brito I; Pita-Rodríguez M; Valladolid-Acebes I; de la Mora MP; Fuxe K
- Book chapter: RECEPTOR-RECEPTOR INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM: NEUROMETHODS. 2018;p. 15-23Narvaez M; Corrales F; Brito I; Valladolid-Acebes I; Fuxe K; Borroto-Escuela DO
- Book chapter: RECEPTOR-RECEPTOR INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM: NEUROMETHODS. 2018;p. 299-315Borroto-Escuela DO; Narvaez M; Valladolid-Acebes I; Shumilov K; Di Palma M; Wydra K; Schaefer T; Reyes-Resina I; Navarro G; Mudó G; Filip M; Sartini S; Friedland K; Schellekens H; Beggiato S; Ferraro L; Tanganelli S; Franco R; Belluardo N; Ambrogini P; Pérez de la Mora M; Fuxe K
- Book chapter: RECEPTOR-RECEPTOR INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM: NEUROMETHODS. 2018;p. 283-298Brito I; Narvaez M; Savelli D; Shumilov K; Di Palma M; Sartini S; Skieterska K; Van Craenenbroeck K; Valladolid-Acebes I; Zaldivar-Oro R; Filip M; Cuppini R; Rivera A; Liu F; Ambrogini P; Pérez de la Mora M; Fuxe K; Borroto-Escuela DO
- Conference publication: ACTA PHYSIOLOGICA. 2017;221:82Dolensek J; Valladolid-Acebes I; Gosak M; Klemen MS; Bombek LK; Pohorec V; Berggren PO; Brismar K; Stozer A; Rupnik MS
- Conference publication: ACTA PHYSIOLOGICA. 2017;221:14Daraio T; Bombek LK; Gosak M; Valladolid-Acebes I; Klemen MS; Refai E; Berggren PO; Brismar K; Rupnik MS; Bark C
- Conference publication: DIABETOLOGIA. 2015;58:S293-S294Ansurudeen I; Daraio T; Kolonelou C; Bark C; Brismar K; Valladolid-Acebes I
- Conference publication: ACTA PHYSIOLOGICA. 2014;211:69Valladolid-Acebes I; Daraio T; Brismar K; Ogren SO; Hokfelt T; Bark IC