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About me

In 2000, I received my Pharm.D. degree from the University of Lisbon, Portugal. During the same year, I enrolled in a doctoral program at the Karolinska Institute. My masters and doctoral studies focused on how oxygen levels mediate protein degradation of the hypoxia-inducible factors. These studies culminated in a Licentiate in 2005, and subsequently a Ph.D. in 2009, both in Cell and Molecular Biology.


Following my Ph.D., I continued at the Karolinska Institute as a postdoctoral fellow at the department of Clinical Neurosciences. During my postdoc, I investigated the cellular and molecular mechanisms involved in neovascular age-related macular degeneration, a particularly incident sight-threatening disease. My research elucidated a central role for hypoxia-inducible factor-1alpha in this disease.

Research description

Since 2012, I have been assigned as Head of Molecular and Cellular Research at St Erik Eye Hospital, affiliated to the Karolinska Institute. My present research is centered on cell-based and gene therapy strategies to target the hypoxia-inducible factors as potential therapeutic agents in ocular vascular diseases.


Cell sheet biofabrication by co-administration of mesenchymal stem cells secretome and vitamin C on thermoresponsive polymer
Shotorbani Bb, André H, Barzegar A, Zarghami N, Salehi R, Alizadeh E
Journal of materials science. Materials in medicine 2018;29(11):170-

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
Locri F, Aronsson M, Beaujean O, Kvanta A, André H
Journal of visualized experiments : JoVE 2018;(133):-

The Different Facades of Retinal and Choroidal Endothelial Cells in Response to Hypoxia
Alizadeh E, Mammadzada P, André H
International journal of molecular sciences 2018;19(12):-

A novel in vivo model of puncture-induced iris neovascularization
Beaujean O, Locri F, Aronsson M, Kvanta A, André H
PloS one 2017;12(6):e0180235-

Efficacy of a Fatty Acids Dietary Supplement in a Polyethylene Glycol-Induced Mouse Model of Retinal Degeneration
Cammalleri M, Dal Monte M, Locri F, Lardner E, Kvanta A, Rusciano D, et al
Nutrients 2017;9(10):-

Gene Transfer of Prolyl Hydroxylase Domain 2 Inhibits Hypoxia-inducible Angiogenesis in a Model of Choroidal Neovascularization
Takei A, Ekström M, Mammadzada P, Aronsson M, Yu M, Kvanta A, et al
Scientific reports 2017;7():42546-

Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy
Petrus-reurer S, Bartuma H, Aronsson M, Westman S, Lanner F, André H, et al
Investigative ophthalmology & visual science 2017;58(2):1314-1322

Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis
Mammadzada P, Gudmundsson J, Kvanta A, André H
Acta ophthalmologica 2016;94(8):805-814

The Urokinase Receptor-Derived Peptide UPARANT Mitigates Angiogenesis in a Mouse Model of Laser-Induced Choroidal Neovascularization
Cammalleri M, Dal Monte M, Locri F, Lista L, Aronsson M, Kvanta A, et al
Investigative ophthalmology & visual science 2016;57(6):2600–2611-

Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model
Plaza Reyes A, Petrus-reurer S, Antonsson L, Stenfelt S, Bartuma H, Panula S, et al
Stem cell reports 2016;6(1):9-17

Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model
André H, Tunik S, Aronsson M, Kvanta A
Investigative ophthalmology & visual science 2015;56(11):6591-604

In Vivo Imaging of Subretinal Bleb-Induced Outer Retinal Degeneration in the Rabbit
Bartuma H, Petrus-reurer S, Aronsson M, Westman S, Andre H, Kvanta A

HIF-1 alpha and HIF-2 alpha induce angiogenesis and improve muscle energy recovery
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, et al

Identification of an Alternative Mechanism of Degradation of the Hypoxia-inducible Factor-1 alpha
Andre H, Pereira Ts

Stabilized HIF-1 alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer
Pajusola K, Kunnapuu J, Vuorikoski S, Soronen J, Andre H, Pereira T, et al
FASEB JOURNAL 2005;19(8):1365-7

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