Heela Sarlus

About me
Publications
CV
Public outreach and news

About me

I have a strong research interest in understanding the role of innate immune responses in the brain in the context of neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis with the aim to identify novel therapeutic targets for
these diseases.

Teaching

Teaching biochemistry in Scandinavian Chiropractor institute, Stockholm,

Articles

Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;121:43-55
Bacterial peptidoglycan signalling in microglia: Activation by MDP via the NF-κB/MAPK pathway
Spielbauer J; Glotfelty EJ; Sarlus H; Harris RA; Heijtz RD; Karlsson TE
Article: METALLOMICS. 2024;16(5):mfae019
Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro
Min J-H; Sarlus H; Harris RA
Journal article: TRANSPLANTATION. 2023;107(10):49
Human Amnion Epithelial Cells reduce disease progression in a mouse model for multiple sclerosis
Sarlus H; Zhu K; Guo Y; Balasingh VJ; Min J-H; Cuesta IB; Bencina S; Harris R; Gramignoli R
Article: ACTA PHARMACOLOGICA SINICA. 2023;44(4):766-779
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function
Sun J-X; Zhu K-Y; Wang Y-M; Wang D-J; Zhang M-Z; Sarlus H; Benito-Cuesta I; Zhao X-Q; Zou Z-F; Zhong Q-Y; Feng Y; Wu S; Wang Y-Q; Harris RA; Wang J
Article: EMBO REPORTS. 2022;23(7):e54499
Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation
Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Min J-H; Benito-Cuesta I; Lund H; Amor S; Wang J; Zhang X-M; Kutter C; Guerreiro-Cacais AO; Hogberg B; Harris RA
Article: ACTA BIOMATERIALIA. 2022;142:36-48
Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype
Samanta S; Rangasami VK; Sarlus H; Samal JRK; Evans AD; Parihar VS; Varghese OP; Harris RA; Oommen OP
Article: HEARING RESEARCH. 2022;415:108395
Differential effects of noise exposure between substrains of CBA mice
Versteegh CPC; Tserga EM; Fontana J; Moreno-Paublete R; Sarlus H; Zisiadis G-AR; Cederroth C; Canlon B
Article: EMBO JOURNAL. 2021;40(24):e108662
Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology
Kummer MP; Ising C; Kummer C; Sarlus H; Griep A; Vieira-Saecker A; Schwartz S; Halle A; Bruckner M; Handler K; Schultze JL; Beyer M; Latz E; Heneka MT
Journal article: ALZHEIMERS & DEMENTIA. 2021;17(S3)
Proliferating microglia exhibit unique transcriptomal and functional alterations in Alzheimer’s disease
Villacampa N; Sarlus H; Martorell P; Slutzkin I; Mcmanus RM; Beyer M; Segal E; Heneka MT
Article: CELL REPORTS. 2021;36(13):109758
A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma
Milon B; Shulman ED; So KS; Cederroth CR; Lipford EL; Sperber M; Sellon JB; Sarlus H; Pregernig G; Shuster B; Song Y; Mitra S; Orvis J; Margulies Z; Ogawa Y; Shults C; Depireux DA; Palermo AT; Canlon B; Burns J; Elkon R; Hertzano R
Article: NEUROSCIENCE. 2020;448:14-27
Chronic Airway Allergy Induces Pro-Inflammatory Responses in the Brain of Wildtype Mice but Not 3xTgAD Mice
Sarlus H; Codita A; Wang X; Cedazo-Minguez A; Schultzberg M; Oprica M
Article: FASEB JOURNAL. 2020;34(10):13978-13992
Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea
Tserga E; Moreno-Paublete R; Sarlus H; Bjorn E; Guimaraes E; Goritz C; Cederroth CR; Canlon B
Article: JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA. 2019;146(5):3960-3966
Impact of noise exposure on the circadian clock in the auditory system
Fontana JM; Tserga E; Sarlus H; Canlon B; Cederroth C
Article: CURRENT BIOLOGY. 2019;29(15):2477-2487.e6
Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
Cederroth CR; Park J-S; Basinou V; Weger BD; Tserga E; Sarlus H; Magnusson AK; Kadri N; Gachon F; Canton B
Article: JOURNAL OF ALZHEIMERS DISEASE. 2015;48(2):495-505
Influence of Allergy on Immunoglobulins and Amyloid-β in the Cerebrospinal Fluid of Patients with Alzheimer's Disease
Sarlus H; Eyjolfsdottir H; Eriksdotter M; Oprica M; Schultzberg M
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_8):p336
P1‐093: ALLERGY INCREASES BDNF AND DECREASES INFLAMMATORY PROTEINS IN 3XTGAD MICE
Sarlus H; Codita A; Minguez AC; Oprica M; Schultzberg M
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:99
Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses
Sarlus H; Wang X; Cedazo-Minguez A; Schultzberg M; Oprica M
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(10):2401-2412
Allergy influences the inflammatory status of the brain and enhances tau-phosphorylation
Sarlus H; Hoglund CO; Karshikoff B; Wang X; Lekander M; Schultzberg M; Oprica M

All other publications

Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2024;17:1408159
Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS
Min J-H; Sarlus H; Harris RA
Preprint: BIORXIV. 2023
Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord
Zhu K; Min J-H; Joshua V; Liu Y; Pieber M; Suerth V; Sarlus H; Harris R; Lund H
Preprint: BIORXIV. 2021
Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation
Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Lund H; Amor S; Wang J; Zhang X; Kutter C; Guerreiro Cacais AO; Högberg B; Harris R
Preprint: SSRN ELECTRONIC JOURNAL. 2021
Interpenetrating Gallol Functionalized Tissue Adhesive Hyaluronic Acid Hydrogel Polarizes Macrophages to an Immunosuppressive Phenotype
Samanta S; Rangasami VK; Sarlus H; Samal JRK; Evans AD; Parihar VS; Varghese OP; Harris RA; Oommen OP
Review: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):217
Microglial replacement therapy: a potential therapeutic strategy for incurable CSF1R-related leukoencephalopathy
Han J; Sarlus H; Wszolek ZK; Karrenbauer VD; Harris RA
Review: HEARING RESEARCH. 2019;377:53-60
Circadian integration of inflammation and glucocorticoid actions: Implications for the cochlea
Sarlus H; Fontana JM; Tserga E; Meltser I; Cederroth CR; Canlon B
Review: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(9):3240-3249
Microglia in Alzheimer's disease
Sarlus H; Heneka MT

Employments

Research Specialist, Department of Clinical Neuroscience, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2015

About me

Teaching

Articles

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Degrees and Education

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