Felix Grassmann

Felix Grassmann

Affiliated to Research
Visiting address: Nobels väg 12a, 17165 Solna
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Czene, 171 77 Stockholm
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About me

  • I am a Researcher at the Department of Medical Epidemiology and
    Biostatistics. My research focuses on the genetic architecture of risk and
    prognosis of inherited diseases.

Research

  • The main aspect of my research is to understand the genetic architecture of
    inherited diseases and how genetics influences disease severity and
    progression. While it is important to identify the precise genetic mechanism
    and pathway underlying disease risk and to shed light on the missing
    heritability, this knowledge alone will not be sufficient to effectively
    eliminate the burden of genetically determined diseases. Therefore, my
    research aims to understand the involvement of genetic factors in the
    consequence of diseases, particularly for diseases with limited or without
    treatment options since understanding the genetics of disease severity and
    progression is a potent method to identify novel targets for treatment. In
    addition, I am interested in understanding how diseases are genetically
    related in order to shed further light on the underlying genetic architecture
    and to potentially identify novel treatment options, since a shared genetic
    basis can point to shared treatment opportunities. Finally, my research
    focuses on alternative and less explored genetic markers such as somatic
    mosaicism of sex chromosomes, which are currently emerging as an important
    marker for both risk and severity of diseases and may have important
    implications for risk prediction and disease management.

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