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Research description

We are studying why there is such extensive overlap, or comorbidity, among mental health problems. One hypothesis is that it might be beneficial to measure this comorbidity via a so-called general factor of psychopathology. This would allow for measuring both general as well as specific mental health problems. To address this issue, we apply multivariate behavior genetic analyses to the Swedish population-based health registers and the Swedish Twin Register.


Current doctoral students

Chen Cen (supervisor)

Laura Ghirardi (co-supervisor)

Monica Siqueiros (co-supervisor)

Yangjun Liu (co-supervisor)


Current research grants (as PI)

Swedish Research Council


Association of Fetal Growth With General and Specific Mental Health Conditions
Pettersson E, Larsson H, D'onofrio B, Almqvist C, Lichtenstein P
JAMA psychiatry 2019;():-

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
Attention Deficit/hyperactivity Disorder Working Group Of The Ipsych-broad-pgc Consortium Autism Spectrum Disorder Working Group Of The Ipsych-broad-pgc Consortium Bipolar Disorder Working Group Of The Pgc Eating Disorder Working Group Of The Pgc Major Depressive Disorder Working Group Of The Pgc Obsessive Compulsive Disorders And Tourette Syndrome Working Group Of The Pgc Schizophrenia Clozuk Substance Use Disorder Working Group Of The Pgc, Pettersson E, Lichtenstein P, Larsson H, Song J, Agrawal A, et al
Psychological medicine 2019;49(7):1166-1173

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
Psychiat Genomics Consortium, Generation Scotland, Arnau-soler A, Macdonald-dunlop E, Adams Mj, Clarke Tk, et al

Identification of common genetic risk variants for autism spectrum disorder
23andme Res Team, Bupgen, Psychiat Genomics Consortium, Grove J, Ripke S, Als Td, et al
NATURE GENETICS 2019;51(3):431-444

Visual Disengagement: Genetic Architecture and Relation to Autistic Traits in the General Population
Siqueiros Sanchez M, Pettersson E, Kennedy Dp, Bölte S, Lichtenstein P, D'onofrio Bm, et al
Journal of autism and developmental disorders 2019;():-

Childhood neurodevelopmental disorders and risk of coercive sexual victimization in childhood and adolescence - a population-based prospective twin study
Ohlsson Gotby V, Lichtenstein P, Långström N, Pettersson E
Journal of child psychology and psychiatry, and allied disciplines 2018;59(9):957-965

Criterion Validity and Utility of the General Factor of Psychopathology in Childhood: Predictive Associations With Independently Measured Severe Adverse Mental Health Outcomes in Adolescence
Pettersson E, Lahey Bb, Larsson H, Lichtenstein P
Journal of the American Academy of Child and Adolescent Psychiatry 2018;57(6):372-383

Genetic and environmental contribution to the overlap between ADHD and ASD trait dimensions in young adults: a twin study
Ghirardi L, Pettersson E, Taylor Mj, Freitag Cm, Franke B, Asherson P, et al
Psychological medicine 2018;():1-9

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Eqtlgen, Major Depressive Disorder Working Group Of The Psychiatric Genomics Consortium, 23andme, Wray Nr, Ripke S, Mattheisen M, et al
Nature genetics 2018;50(5):668-681

The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology
Brikell I, Larsson H, Lu Y, Pettersson E, Chen Q, Kuja-halkola R, et al
Molecular psychiatry 2018;():-

Brief Report: Association Between Autism Spectrum Disorder, Gastrointestinal Problems and Perinatal Risk Factors Within Sibling Pairs
Isaksson J, Pettersson E, Kostrzewa E, Diaz Heijtz R, Bölte S
Journal of autism and developmental disorders 2017;47(8):2621-2627

Childhood attention-deficit/hyperactivity disorder symptoms and the development of adolescent alcohol problems: A prospective, population-based study of Swedish twins
Quinn Pd, Pettersson E, Lundström S, Anckarsäter H, Långström N, Gumpert Ch, et al
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2016;171(7):958-70

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population
Pettersson E, Larsson H, Lichtenstein P
Molecular psychiatry 2016;21(5):717-21

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium
Generation Scotland, Van Den Berg Sm, De Moor Mh, Verweij Kj, Krueger Rf, Luciano M, et al
Behavior genetics 2016;46(2):170-82

The association between childhood autistic traits and adolescent psychotic experiences is explained by general neuropsychiatric problems
Cederlöf M, Pettersson E, Sariaslan A, Larsson H, Östberg P, Kelleher I, et al
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2016;171B(2):153-9

Birth weight as an independent predictor of ADHD symptoms: a within-twin pair analysis
Pettersson E, Sjölander A, Almqvist C, Anckarsäter H, D'onofrio Bm, Lichtenstein P, et al
Journal of child psychology and psychiatry, and allied disciplines 2015;56(4):453-9

Childhood neurodevelopmental problems and adolescent bully victimization: population-based, prospective twin study in Sweden
Törn P, Pettersson E, Lichtenstein P, Anckarsäter H, Lundström S, Hellner Gumpert C, et al
European child & adolescent psychiatry 2015;24(9):1049-59

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder
Genetics Of Personality Consortium, De Moor Mh, Van Den Berg Sm, Verweij Kj, Krueger Rf, Luciano M, et al
JAMA psychiatry 2015;72(7):642-50

A Phenotypic Null Hypothesis for the Genetics of Personality
Turkheimer E, Pettersson E, Horn Ee, Fiske St

Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10
Jonsson L, Zettergren A, Pettersson E, Hovey D, Anckarsäter H, Westberg L, et al
Molecular autism 2014;5(1):55-

Do maladaptive behaviors exist at one or both ends of personality traits?
Pettersson E, Mendle J, Turkheimer E, Horn Ee, Ford Dc, Simms Lj, et al
Psychological assessment 2014;26(2):433-46

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory
Van Den Berg Sm, De Moor Mhm, Mcgue M, Pettersson E, Terracciano A, Verweij Kjh, et al
BEHAVIOR GENETICS 2014;44(4):295-313

Language and mathematical problems as precursors of psychotic-like experiences and juvenile mania symptoms
Cederlöf M, Ostberg P, Pettersson E, Anckarsäter H, Gumpert C, Lundström S, et al
Psychological medicine 2014;44(6):1293-302

Self-Reported Personality Pathology Has Complex Structure and Imposing Simple Structure Degrades Test Information
Pettersson E, Turkheimer E

Approach temperament, anger, and evaluation: resolving a paradox
Pettersson E, Turkheimer E
Journal of personality and social psychology 2013;105(2):285-300

Different neurodevelopmental symptoms have a common genetic etiology
Pettersson E, Anckarsäter H, Gillberg C, Lichtenstein P
Journal of child psychology and psychiatry, and allied disciplines 2013;54(12):1356-65

Modeling daily variation in the affective circumplex: A dynamical systems approach
Pettersson E, Boker Sm, Watson D, Clark La, Tellegen A

The General Factor of Personality and Evaluation
Pettersson E, Turkheimer E, Horn Ee, Menatti Ar

Item selection, evaluation, and simple structure in personality data
Pettersson E, Turkheimer E

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Nobels väg 12A