Erik Näslund

Erik Näslund

Professor/Senior Physician
Telephone: +46852482615
Visiting address: Entrévägen 2, 18257 Danderyd
Postal address: D1 Kliniska vetenskaper, Danderyds sjukhus, D1 KoUr Övre abdominell kirurgisk, 171 77 Stockholm
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Grants

  • Swedish Research Council
    1 January 2024 - 31 December 2027
    Obesity is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). Metabolic and bariatric surgery (MBS) has in several randomized controlled trials (RCT) been shown to be superior to best medical therapy in the treatment of T2D. In the area of CVD, RCT after MBS are lacking. We recently demonstrated in a cohort study that MBS in patients with severe obesity and a previous myocardial infarction (MI) was associated with a 50% reduction in the risk of death and new MI. The aim of this proposal is to confirm this in a nationwide RCT. Using the nationwide SWEDEHEART database we will identify patients with serve obesity and a previous MI. They will be contacted and offered participation. After informed consent the patients will be randomized to MBS or optimized care (including visit with a cardiologist and optimization of secondary preventive measures and referral to dietician/physiotherapist). The primary outcome measure is a major cardiovascular adverse event (MACE). Secondary outcome measures include mortality, new MI, stroke, heart failure and atrial fibrillation. Tertiary outcome measures include health related quality of life and surgical complications. Patients will be followed in the nationwide metabolic surgery register SOReg, the national inpatient register, national cause of death register, the Swedish prescribed drug register, and the Swedish population register. If positive results these can be included in guidelines for MBS.
  • Methylation changes after weight loss and treatment of weight regain after gastric bypass surgery for obesity
    Novo Nordisk Foundation
    1 January 2016 - 1 January 2017
  • Mechanisms behind the resolution of diabetes after gastric bypass surgery for obesity
    Novo Nordisk Foundation
    28 August 2014 - 28 August 2015
  • Mechanisms behind resolution of diabetes and weight loss after gastric bypass surgery for obesity
    Novo Nordisk Foundation
    29 August 2013 - 29 August 2014
  • Mechanisms behind resolution of diabetes and weight loss after gastric bypass surgery for obesity
    Novo Nordisk Foundation
    24 August 2012
  • Mechanisms behind resolution of diabetes and weight loss after gastric bypass surgery for obesity.
    Novo Nordisk Foundation
    26 August 2011

Employments

  • Professor/Senior Physician, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2005-

Degrees and Education

  • Docent, Karolinska Institutet, 1999
  • PhD, Karolinska Institute, 1997
  • University Medical Degree, Karolinska Institutet, 1991

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