Ellen Viveka Iacobaeus

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Articles

Article: NEUROLOGY. 2024;102(6):e208051
Clinical Characteristics and Long-Term Outcomes of Late-Onset Multiple Sclerosis A Swedish Nationwide Study
Mouresan EF; Mentesidou E; Berglund A; Mckay KA; Hillert J; Iacobaeus E
Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2024;95(2):125-133
Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
Silfverberg T; Zjukovskaja C; Ljungman P; Nahimi A; Ahlstrand E; Dreimane A; Einarsdottir S; Fagius J; Iacobaeus E; Hagglund H; Lange N; Lenhoff S; Lycke J; Mellergard J; Piehl F; Svenningsson A; Tolf A; Cherif H; Carlson K; Burman J
Article: JOURNAL OF CLINICAL MEDICINE. 2024;13(2):355
Relapses and Serious Infections in Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab: A Swedish Single-Center Study
Carlsson O; Jonsson DI; Brundin L; Iacobaeus E
Article: LEUKEMIA. 2023;37(4):888-900
Cognitive impairments correlate with increased central nervous system immune activation after allogeneic haematopoietic stem cell transplantation
Boberg E; Kadri N; Hagey DWW; Schwieler L; El Andaloussi S; Erhardt S; Iacobaeus E; Le Blanc K
Article: PLOS ONE. 2023;18(1):e0280376
Inventory study of an early pandemic COVID-19 cohort in South-Eastern Sweden, focusing on neurological manifestations
Ahmadpour D; Kristoffersson A; Fredrikson M; Huang-Link Y; Eriksson A; Iacobaeus E; Landtblom A-M; Haghighi S
Article: VACCINES. 2022;10(12):2046
Fatal Acute Hemorrhagic Encephalomyelitis and Antiphospholipid Antibodies following SARS-CoV-2 Vaccination: A Case Report
Kits A; Pantalone MR; Illies C; Antovic A; Landtblom A-M; Iacobaeus E
Article: BONE MARROW TRANSPLANTATION. 2022;57(3):360-369
Reduced prefrontal cortex and sympathetic nervous system activity correlate with fatigue after aHSCT
Boberg E; Iacobaeus E; Greenfield MS; Wang Y; Msghina M; Le Blanc K
Article: LAKARTIDNINGEN. 2020;117:20129
Multipel skleros och covid-19 – kunskapen ännu begränsad.
Iacobaeus E; Burman J; Landtblom A-M
Article: JOURNAL OF CLINICAL MEDICINE. 2019;8(12):E2102-2102
Short and Long Term Clinical and Immunologic Follow up after Bone Marrow Mesenchymal Stromal Cell Therapy in Progressive Multiple Sclerosis-A Phase I Study
Iacobaeus E; Kadri N; Lefsihane K; Boberg E; Gavin C; Andren AT; Lilja A; Brundin L; Le Blanc K
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2249
The Complement System Is Essential for the Phagocytosis of Mesenchymal Stromal Cells by Monocytes
Gavin C; Meinke S; Heldring N; Heck KA; Achour A; Iacobaeus E; Le Blanc K; Kadri N; Hoglund P
Article: IMMUNOLOGY AND CELL BIOLOGY. 2018;96(8):820-830
Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis
Iacobaeus E; Douagi I; Jitschin R; Marcusson-Stahl M; Andren AT; Gavin C; Lefsihane K; Davies LC; Mougiakakos D; Kadri N; Le Blanc K
Article: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2018;44(4):404-416
Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro
Bridel C; Koel-Simmelink MJA; Peferoen L; Troletti CD; Durieux S; Gorter R; Nutma E; Gami P; Iacobaeus E; Brundin L; Kuhle J; Vrenken H; Killestein J; Piersma SR; Pham TV; De Vries HE; Amor S; Jimenez CR; Teunissen CE
Article: NEUROLOGY. 2018;90(6):e498-e506
The national incidence of PML in Sweden, 1988-2013
Iacobaeus E; Burkill S; Bahmanyar S; Hakim R; Bystrom C; Fored M; Olsson T; Brundin L; Montgomery S
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2017;6(10):1840-1851
Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination
Iacobaeus E; Sugars RV; Andren AT; Alm JJ; Qian H; Frantzen J; Newcombe J; Alkass K; Druid H; Bottai M; Roytta M; Le Blanc K
Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2017;8:111-126
Consensus guidelines for lumbar puncture in patients with neurological diseases.
Engelborghs S; Niemantsverdriet E; Struyfs H; Blennow K; Brouns R; Comabella M; Dujmovic I; van der Flier W; Frölich L; Galimberti D; Gnanapavan S; Hemmer B; Hoff E; Hort J; Iacobaeus E; Ingelsson M; Jan de Jong F; Jonsson M; Khalil M; Kuhle J; Lleó A; de Mendonça A; Molinuevo JL; Nagels G; Paquet C; Parnetti L; Roks G; Rosa-Neto P; Scheltens P; Skårsgard C; Stomrud E; Tumani H; Visser PJ; Wallin A; Winblad B; Zetterberg H; Duits F; Teunissen CE
Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2014;85(10):1116-1121
Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience
Burman J; Iacobaeus E; Svenningsson A; Lycke J; Gunnarsson M; Nilsson P; Vrethem M; Fredrikson S; Martin C; Sandstedt A; Uggla B; Lenhoff S; Johansson J-E; Isaksson C; Hagglund H; Carlson K; Fagius J
Article: MULTIPLE SCLEROSIS JOURNAL. 2013;19(13):1802-1809
Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis
Teunissen C; Menge T; Altintas A; Alvarez-Cermeno JC; Bertolotto A; Berven FS; Brundin L; Comabella M; Degn M; Deisenhammer F; Fazekas F; Franciotta D; Frederiksen JL; Galimberti D; Gnanapavan S; Hegen H; Hemmer B; Hintzen R; Hughes S; Iacobaeus E; Kroksveen AC; Kuhle J; Richert J; Tumani H; Villar LM; Drulovic J; Dujmovic I; Khalil M; Bartos A
Article: LUPUS. 2013;22(3):307-311
Analysis of JC virus DNA in NPSLE patients treated with different immunomodulatory agents
Iacobaeus E; Hopia L; Khademi M; Lunden M; Hammarin A-L; Svenungsson E; Andersson M
Article: PLOS ONE. 2011;6(5):e19138
The Expression of VEGF-A Is Down Regulated in Peripheral Blood Mononuclear Cells of Patients with Secondary Progressive Multiple Sclerosis
Iacobaeus E; Amoudruz P; Strom M; Khademi M; Brundin L; Hillert J; Kockum I; Malmstrom V; Olsson T; Tham E; Piehl F
Article: MULTIPLE SCLEROSIS JOURNAL. 2011;17(3):335-343
Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course
Khademi M; Kockum I; Andersson ML; Iacobaeus E; Brundin L; Sellebjerg F; Hillert J; Piehl F; Olsson T
Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2009;80(10):1110-1115
Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosis
Vogt MHJ; Teunissen CE; Iacobaeus E; Heijnen DAM; Breij ECW; Olsson T; Brundin L; Killestein J; Dijkstra CD
Article: NEUROLOGY. 2009;72(15):1322-1329
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis
Teunissen CE; Iacobaeus E; Khademi M; Brundin L; Norgren N; Koel-Simmelink MJA; Schepens M; Bouwman F; Twaalfhoven HAM; Blom HJ; Jakobs C; Dijkstra CD
Article: MULTIPLE SCLEROSIS JOURNAL. 2009;15(1):28-35
Analysis of cerebrospinal fluid and cerebrospinal fluid cells from patients with multiple sclerosis for detection of JC virus DNA
Iacobaeus E; Ryschkewitsch C; Gravell M; Khademi M; Wallstrom E; Olsson T; Brundin L; Major EO
Article: NATURE GENETICS. 2007;39(9):1108-1113
Variation in interleukin 7 receptor a chain (IL7R) influences risk of multiple sclerosis
Lundmark F; Duvefelt K; Iacobaeus E; Kockum I; Wallstroem E; Khademi M; Oturai A; Ryder LP; Saarela J; Harbo HF; Celius EG; Salter H; Olsson T; Hillert J
Article: GENETICS. 2005;170(1):283-289
Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis
Sheng JR; Jagodic M; Dahlman I; Becanovic K; Nohra R; Marta M; Iacobaeus E; Olsson T; Wallström E
Article: JOURNAL OF NEUROIMMUNOLOGY. 2001;116(2):168-177
Curative effects of recombinant human interleukin-6 in DA rats with protracted relapsing experimental allergic encephalomyelitis
Di Marco R; Khademi M; Wallstrom E; Iacobaeus E; Salvaggio A; Caracappa S; Papoian R; Nicoletti F; Olsson T
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All other publications

Review: EUROPEAN JOURNAL OF NEUROLOGY. 2024;31(7):e16284
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis
Hagbohm C; Ouellette R; Flanagan EP; Jonsson DI; Piehl F; Banwell B; Wickstroem R; Iacobaeus E; Granberg T; Ineichen BV
Preprint: BIORXIV. 2024
ATF4 orchestrates IL-1α-induced senescence in adult neural stem cells
Neumann S; Thelin EP; Sankavaram SR; Persson S; Fonseca L; Moruzzi N; Iacobaeus E; Bergsland M; Popova E; Bader M; Svensson M; Espinosa A; Covacu R; Brundin L
Conference publication: 2024;:a17-a18
O15 B cell, T cell, cytotoxic/NK cell, and mitochondrial gene dysregulation patterns separate neuropsychiatric systemic lupus erythematosus patients into two distinct subgroups with differential anticipated response to targeted therapies
Lindblom J; Nikolopoulos D; Toro-Domínguez D; Carnero-Montoro E; Borghi MO; Castillo J; Iacobaeus E; Enman Y; Mohan C; Beretta L; Alarcón-Riquelme ME; Barturen G; Parodis I
Preprint: PREPRINTS.ORG. 2023
Relapses and Serious Infections In Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab: A Swedish Cohort Study
Carlsson O; Jonsson DI; Brundin L; Iacobaeus E
Review: CELLULAR & MOLECULAR IMMUNOLOGY. 2023;20(6):613-625
Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Kadri N; Amu S; Iacobaeus E; Boberg E; Le Blanc K
Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):37
HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR TREATMENT OF MULTIPLE SCLEROSIS IN SWEDEN: AN OBSERVATIONAL COHORT STUDY
Silfverberg T; Zjukovskaja C; Iacobaeus E; Ljungman P; Einarsdottir S; Carlson K; Burman J
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:622-623
Frequency of severe infections and correlation with immune markers in patients with neuromyelitis optica spectrum disorders treated with rituximab: a Swedish cohort study
Carlsson O; Jonsson DI; Brundin L; Iacobaeus E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:850-851
Enlarged perivascular spaces are larger and more frequent in MOG plus NMOSD
Jonsson DI; Ouellette R; Coello RD; Ineichen B; Hagbohm C; Wardlaw J; Valdes-Hernandez M; Brundin L; Iacobaeus E; Granberg T
Conference publication: 2022;:a29.1-a2a29
PO.1.12 Transcriptome profiling and autoimmunity-related serological markers identify TP53 and C3aR as drug targets in neuropsychiatric systemic lupus erythematosus
Lindblom J; Toro-Domínguez D; Carnero-Montoro E; Borghi M; Castillo J; Iacobaeus E; Enman Y; Repsilber D; Mohan C; Alarcón-Riquelme M; Barturen G; Parodis I
Review: MULTIPLE SCLEROSIS JOURNAL. 2022;28(9):1424-1456
The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021
Tur C; Dubessy A-L; Otero-Romero S; Amato MP; Derfuss T; Di Pauli F; Iacobaeus E; Mycko M; Abboud H; Achiron A; Bellinvia A; Boyko A; Casanova J-L; Clifford D; Dobson R; Farez MF; Filippi M; Fitzgerald KC; Fonderico M; Gouider R; Hacohen Y; Hellwig K; Hemmer B; Kappos L; Ladeira F; Lebrun-Frenay C; Louapre C; Magyari M; Mehling M; Oreja-Guevara C; Pandit L; Papeix C; Piehl F; Portaccio E; Ruiz-Camps I; Selmaj K; Simpson-Yap S; Siva A; Sorensen PS; Sormani MP; Trojano M; Vaknin-Dembinsky A; Vukusic S; Weinshenker B; Wiendl H; Winkelmann A; Rodas MIZ; Tintore M; Stankoff B
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:326
TRANSCRIPTOME PROFILING AND AUTOIMMUNITY-RELATED SEROLOGICAL MARKERS IDENTIFY TP53 AND C3AR AS DRUG TARGETS IN NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
Lindblom J; Toro-Dominguez D; Borghi MO; Iacobaeus E; Enman Y; Repsilber D; Mohan C; Alarcon-Riquelme M; Barturen G; Parodis I
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):126-127
Neurological follow up and management of disease reactivation following aHSCT
Iacobaeus E
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:4417-4418
Transcriptome Profiling and Autoimmunity-related Serological Markers Identify Tumour Protein P53 and Complement C3a Receptor 1 as Drug Targets in Neuropsychiatric Systemic Lupus Erythematosus
Lindblom J; Toro-Dominguez D; Carnero-Montoro E; Orietta Borghi M; Castillo J; Iacobaeus E; Enman Y; Mohan C; Alarcon-Riquelme M; Barturen G; Parodis I
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):326
Autologous hematopoietic stem cell transplantation in relapsing remitting multiple sclerosis patients:. single centre experience
Mavromati S; Brundin L; Iacobaeus E
Review: THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS. 2022;15:17562864211066751
Smouldering multiple sclerosis: the 'real MS'.
Giovannoni G; Popescu V; Wuerfel J; Hellwig K; Iacobaeus E; Jensen MB; García-Domínguez JM; Sousa L; De Rossi N; Hupperts R; Fenu G; Bodini B; Kuusisto H-M; Stankoff B; Lycke J; Airas L; Granziera C; Scalfari A
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):169-170
Clinical characteristics and disability progression in late-onset MS
Mouresan EF; Mentesidou E; Berglund A; Hillert J; Mckay KA; Iacobaeus E
Review: ACTA NEUROLOGICA SCANDINAVICA. 2021;144(3):229-235
Multiple sclerosis and COVID-19: The Swedish experience
Landtblom A-M; Berntsson SG; Bostrom I; Iacobaeus E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):356
Comprehensive phenotypic and functional analyses of peripheral blood monocytes during MS disease progression
Iacobaeus E; Kadri N; Gavin C; Le Blanc K
Review: MULTIPLE SCLEROSIS JOURNAL. 2020;26(9):1352458520925369-1044
Aggressive multiple sclerosis (1): Towards a definition of the phenotype
Iacobaeus E; Arrambide G; Amato MP; Derfuss T; Vukusic S; Hemmer B; Tintore M; Brundin L
Review: MULTIPLE SCLEROSIS JOURNAL. 2020;26(9):1352458520924595-1063
Aggressive multiple sclerosis (2): Treatment
Arrambide G; Iacobaeus E; Amato MP; Derfuss T; Vukusic S; Hemmer B; Brundin L; Tintore M
Letter: HAEMATOLOGICA. 2020;105(6):e310-e314
Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation
Boberg E; Kadri N; Winterling J; Davies LC; Bjorklund A; Msghina M; Iacobaeus E; Le Blanc K
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2020;26(3_SUPPL):137-138
Clinical characteristics and outcome of late onset multiple sclerosis
Iacobaeus E; Berglund A; Mckay K; Brundin L; Hillert J
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:533-534
Immunological and clinical follow up after autologous bone-marrow mesenchymal stromal cell therapy in progressive multiple sclerosis: a phase I clinical study
Iacobaeus E; Kadri N; Lefsihane K; Boberg E; Gavin C; Lilja A; Brundin L; Le Blanc K
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2017;23:944
The national incidence of PML in Sweden, 1988-2013
Iacobaeus E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):285
Thymic function predicts response to mesenchymal stromal cell treatment in chronic GVHD
Boberg E; von Bahr L; Heldring N; Afram G; Iacobaeus E; Modin C; Garming-Legert K; Ljungman P; Sugars R; Davies L; Kadri N; Le Blanc K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):335
Functional shift of myeloid-derived suppressor cells during Multiple Sclerosis disease course
Iacobaeus E; Douagi I; Jitschin R; Andren AT; Gavin C; Lefsihane K; Davies L; Olsson T; Mougiakakos D; Kadri N; Le Blanc K
Conference publication: BLOOD. 2017;130
Thymic Function Predicts Response to Mesenchymal Stromal Cell Treatment in Chronic GvHD: A Phase II Clinical Study
Boberg E; Von Bahr L; Heldring N; Afram G; Iacobaeus E; Lindstrom C; Garming-Legert K; Ljungman P; Sugars R; Davies L; Kadri N; Le Blanc K
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2016;25:496-497
Pharmacological Treatments Preceding Diagnosis Of Progressive Multifocal Leukencephalopathy
Burkill S; Iacobaeus E; Bahmanyar S; Brundin L; Fored M; Olsson T; Montgomery S
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2016;25:99
Comorbid Diseases Preceding Diagnosis of Progressive Multifocal Leukencephalopathy
Iacobaeus E; Burkill S; Bahmanyar S; Brundin L; Fored M; Olsson T; Montgomery S
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2016;22:155
Immunohistochemical characterization of mesenchymal perivascular stem/stromal cells in multiple sclerosis and healthy brain tissue
Iacobaeus E; Sugars RV; Tornqvist AA; Alm JJ; Alkass K; Druid H; Roytta M; Le Blanc K
Letter: JOURNAL OF RHEUMATOLOGY. 2012;39(6):1299-1303
Progressive Multifocal Leukoencephalopathy in a Patient with Polymyositis: Case Report and Literature Review
Dastmalchi M; Laki J; Lundberg IE; Iacobaeus E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2011;17:S119
Altered monocyte phenotype with decreased vascular endothelial growth factor-A in progressive multiple sclerosis
Iacobaeus E; Tham E; Khademi M; Olsson T; Piehl F
Thesis / dissertation: 2010
Establishment and applications of a multiple sclerosis biobank : analysis of biomarkers and therapeutic complications in MS
Iacobaeus, Ellen
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Employments

Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2024-2025
Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, Karolinska Institutet, 2021
Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2010
University Medical Degree, Karolinska Institutet, 2001

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