Ellen Viveka Iacobaeus

Publications
CV
Public outreach and news

Articles

Article: NEUROLOGY. 2024;102(6):e208051

Clinical Characteristics and Long-Term Outcomes of Late-Onset Multiple Sclerosis: A Swedish Nationwide Study.

Mouresan EF; Mentesidou E; Berglund A; McKay KA; Hillert J; Iacobaeus E
Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2024;95(2):125-133

Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study

Silfverberg T; Zjukovskaja C; Ljungman P; Nahimi A; Ahlstrand E; Dreimane A; Einarsdottir S; Fagius J; Iacobaeus E; Hagglund H; Lange N; Lenhoff S; Lycke J; Mellergard J; Piehl F; Svenningsson A; Tolf A; Cherif H; Carlson K; Burman J
Article: JOURNAL OF CLINICAL MEDICINE. 2024;13(2):355

Relapses and Serious Infections in Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab: A Swedish Single-Center Study

Carlsson O; Jonsson DI; Brundin L; Iacobaeus E
Article: LEUKEMIA. 2023;37(4):888-900

Cognitive impairments correlate with increased central nervous system immune activation after allogeneic haematopoietic stem cell transplantation

Boberg E; Kadri N; Hagey DWW; Schwieler L; El Andaloussi S; Erhardt S; Iacobaeus E; Le Blanc K
Article: PLOS ONE. 2023;18(1):e0280376

Inventory study of an early pandemic COVID-19 cohort in South-Eastern Sweden, focusing on neurological manifestations

Ahmadpour D; Kristoffersson A; Fredrikson M; Huang-Link Y; Eriksson A; Iacobaeus E; Landtblom A-M; Haghighi S
Article: VACCINES. 2022;10(12):2046

Fatal Acute Hemorrhagic Encephalomyelitis and Antiphospholipid Antibodies following SARS-CoV-2 Vaccination: A Case Report

Kits A; Pantalone MR; Illies C; Antovic A; Landtblom A-M; Iacobaeus E
Article: BONE MARROW TRANSPLANTATION. 2022;57(3):360-369

Reduced prefrontal cortex and sympathetic nervous system activity correlate with fatigue after aHSCT

Boberg E; Iacobaeus E; Greenfield MS; Wang Y; Msghina M; Le Blanc K
Article: LAKARTIDNINGEN. 2020;117:20129

Multipel skleros och covid-19 – kunskapen ännu begränsad.

Iacobaeus E; Burman J; Landtblom A-M
Article: JOURNAL OF CLINICAL MEDICINE. 2019;8(12):E2102-2102

Short and Long Term Clinical and Immunologic Follow up after Bone Marrow Mesenchymal Stromal Cell Therapy in Progressive Multiple Sclerosis-A Phase I Study

Iacobaeus E; Kadri N; Lefsihane K; Boberg E; Gavin C; Andren AT; Lilja A; Brundin L; Le Blanc K
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2249

The Complement System Is Essential for the Phagocytosis of Mesenchymal Stromal Cells by Monocytes

Gavin C; Meinke S; Heldring N; Heck KA; Achour A; Iacobaeus E; Le Blanc K; Kadri N; Hoglund P
Article: IMMUNOLOGY AND CELL BIOLOGY. 2018;96(8):820-830

Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis

Iacobaeus E; Douagi I; Jitschin R; Marcusson-Stahl M; Andren AT; Gavin C; Lefsihane K; Davies LC; Mougiakakos D; Kadri N; Le Blanc K
Article: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2018;44(4):404-416

Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro

Bridel C; Koel-Simmelink MJA; Peferoen L; Troletti CD; Durieux S; Gorter R; Nutma E; Gami P; Iacobaeus E; Brundin L; Kuhle J; Vrenken H; Killestein J; Piersma SR; Pham TV; De Vries HE; Amor S; Jimenez CR; Teunissen CE
Article: NEUROLOGY. 2018;90(6):e498-e506

The national incidence of PML in Sweden, 1988-2013

Iacobaeus E; Burkill S; Bahmanyar S; Hakim R; Bystrom C; Fored M; Olsson T; Brundin L; Montgomery S
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2017;6(10):1840-1851

Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination

Iacobaeus E; Sugars RV; Andren AT; Alm JJ; Qian H; Frantzen J; Newcombe J; Alkass K; Druid H; Bottai M; Roytta M; Le Blanc K
Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2017;8:111-126

Consensus guidelines for lumbar puncture in patients with neurological diseases.

Engelborghs S; Niemantsverdriet E; Struyfs H; Blennow K; Brouns R; Comabella M; Dujmovic I; van der Flier W; Frölich L; Galimberti D; Gnanapavan S; Hemmer B; Hoff E; Hort J; Iacobaeus E; Ingelsson M; Jan de Jong F; Jonsson M; Khalil M; Kuhle J; Lleó A; de Mendonça A; Molinuevo JL; Nagels G; Paquet C; Parnetti L; Roks G; Rosa-Neto P; Scheltens P; Skårsgard C; Stomrud E; Tumani H; Visser PJ; Wallin A; Winblad B; Zetterberg H; Duits F; Teunissen CE
Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2014;85(10):1116-1121

Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience

Burman J; Iacobaeus E; Svenningsson A; Lycke J; Gunnarsson M; Nilsson P; Vrethem M; Fredrikson S; Martin C; Sandstedt A; Uggla B; Lenhoff S; Johansson J-E; Isaksson C; Hagglund H; Carlson K; Fagius J
Article: MULTIPLE SCLEROSIS JOURNAL. 2013;19(13):1802-1809

Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis

Teunissen C; Menge T; Altintas A; Alvarez-Cermeno JC; Bertolotto A; Berven FS; Brundin L; Comabella M; Degn M; Deisenhammer F; Fazekas F; Franciotta D; Frederiksen JL; Galimberti D; Gnanapavan S; Hegen H; Hemmer B; Hintzen R; Hughes S; Iacobaeus E; Kroksveen AC; Kuhle J; Richert J; Tumani H; Villar LM; Drulovic J; Dujmovic I; Khalil M; Bartos A
Article: LUPUS. 2013;22(3):307-311

Analysis of JC virus DNA in NPSLE patients treated with different immunomodulatory agents

Iacobaeus E; Hopia L; Khademi M; Lunden M; Hammarin A-L; Svenungsson E; Andersson M
Article: PLOS ONE. 2011;6(5):e19138

The Expression of VEGF-A Is Down Regulated in Peripheral Blood Mononuclear Cells of Patients with Secondary Progressive Multiple Sclerosis

Iacobaeus E; Amoudruz P; Strom M; Khademi M; Brundin L; Hillert J; Kockum I; Malmstrom V; Olsson T; Tham E; Piehl F
Article: MULTIPLE SCLEROSIS JOURNAL. 2011;17(3):335-343

Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course

Khademi M; Kockum I; Andersson ML; Iacobaeus E; Brundin L; Sellebjerg F; Hillert J; Piehl F; Olsson T
Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2009;80(10):1110-1115

Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosis

Vogt MHJ; Teunissen CE; Iacobaeus E; Heijnen DAM; Breij ECW; Olsson T; Brundin L; Killestein J; Dijkstra CD
Article: NEUROLOGY. 2009;72(15):1322-1329

Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis

Teunissen CE; Iacobaeus E; Khademi M; Brundin L; Norgren N; Koel-Simmelink MJA; Schepens M; Bouwman F; Twaalfhoven HAM; Blom HJ; Jakobs C; Dijkstra CD
Article: MULTIPLE SCLEROSIS JOURNAL. 2009;15(1):28-35

Analysis of cerebrospinal fluid and cerebrospinal fluid cells from patients with multiple sclerosis for detection of JC virus DNA

Iacobaeus E; Ryschkewitsch C; Gravell M; Khademi M; Wallstrom E; Olsson T; Brundin L; Major EO
Article: NATURE GENETICS. 2007;39(9):1108-1113

Variation in interleukin 7 receptor a chain (IL7R) influences risk of multiple sclerosis

Lundmark F; Duvefelt K; Iacobaeus E; Kockum I; Wallstroem E; Khademi M; Oturai A; Ryder LP; Saarela J; Harbo HF; Celius EG; Salter H; Olsson T; Hillert J
Article: GENETICS. 2005;170(1):283-289

Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis

Sheng JR; Jagodic M; Dahlman I; Becanovic K; Nohra R; Marta M; Iacobaeus E; Olsson T; Wallström E
Article: JOURNAL OF NEUROIMMUNOLOGY. 2001;116(2):168-177

Curative effects of recombinant human interleukin-6 in DA rats with protracted relapsing experimental allergic encephalomyelitis

Di Marco R; Khademi M; Wallstrom E; Iacobaeus E; Salvaggio A; Caracappa S; Papoian R; Nicoletti F; Olsson T
Show more

All other publications

Review: EUROPEAN JOURNAL OF NEUROLOGY. 2024;31(7):e16284

Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis

Hagbohm C; Ouellette R; Flanagan EP; Jonsson DI; Piehl F; Banwell B; Wickstroem R; Iacobaeus E; Granberg T; Ineichen BV
Preprint: BIORXIV. 2024

ATF4 orchestrates IL-1α-induced senescence in adult neural stem cells

Neumann S; Thelin EP; Sankavaram SR; Persson S; Fonseca L; Moruzzi N; Iacobaeus E; Bergsland M; Popova E; Bader M; Svensson M; Espinosa A; Covacu R; Brundin L
Conference publication: 2024;:a17-a18

O15 B cell, T cell, cytotoxic/NK cell, and mitochondrial gene dysregulation patterns separate neuropsychiatric systemic lupus erythematosus patients into two distinct subgroups with differential anticipated response to targeted therapies

Lindblom J; Nikolopoulos D; Toro-Domínguez D; Carnero-Montoro E; Borghi MO; Castillo J; Iacobaeus E; Enman Y; Mohan C; Beretta L; Alarcón-Riquelme ME; Barturen G; Parodis I
Preprint: PREPRINTS.ORG. 2023

Relapses and Serious Infections In Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab: A Swedish Cohort Study

Carlsson O; Jonsson DI; Brundin L; Iacobaeus E
Review: CELLULAR & MOLECULAR IMMUNOLOGY. 2023;20(6):613-625

Current perspectives on mesenchymal stromal cell therapy for graft versus host disease

Kadri N; Amu S; Iacobaeus E; Boberg E; Le Blanc K
Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):37

HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR TREATMENT OF MULTIPLE SCLEROSIS IN SWEDEN: AN OBSERVATIONAL COHORT STUDY

Silfverberg T; Zjukovskaja C; Iacobaeus E; Ljungman P; Einarsdottir S; Carlson K; Burman J
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:622-623

Frequency of severe infections and correlation with immune markers in patients with neuromyelitis optica spectrum disorders treated with rituximab: a Swedish cohort study

Carlsson O; Jonsson DI; Brundin L; Iacobaeus E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:850-851

Enlarged perivascular spaces are larger and more frequent in MOG plus NMOSD

Jonsson DI; Ouellette R; Coello RD; Ineichen B; Hagbohm C; Wardlaw J; Valdes-Hernandez M; Brundin L; Iacobaeus E; Granberg T
Conference publication: 2022;:a29.1-a2a29

PO.1.12 Transcriptome profiling and autoimmunity-related serological markers identify TP53 and C3aR as drug targets in neuropsychiatric systemic lupus erythematosus

Lindblom J; Toro-Domínguez D; Carnero-Montoro E; Borghi M; Castillo J; Iacobaeus E; Enman Y; Repsilber D; Mohan C; Alarcón-Riquelme M; Barturen G; Parodis I
Review: MULTIPLE SCLEROSIS JOURNAL. 2022;28(9):1424-1456

The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021

Tur C; Dubessy A-L; Otero-Romero S; Amato MP; Derfuss T; Di Pauli F; Iacobaeus E; Mycko M; Abboud H; Achiron A; Bellinvia A; Boyko A; Casanova J-L; Clifford D; Dobson R; Farez MF; Filippi M; Fitzgerald KC; Fonderico M; Gouider R; Hacohen Y; Hellwig K; Hemmer B; Kappos L; Ladeira F; Lebrun-Frenay C; Louapre C; Magyari M; Mehling M; Oreja-Guevara C; Pandit L; Papeix C; Piehl F; Portaccio E; Ruiz-Camps I; Selmaj K; Simpson-Yap S; Siva A; Sorensen PS; Sormani MP; Trojano M; Vaknin-Dembinsky A; Vukusic S; Weinshenker B; Wiendl H; Winkelmann A; Rodas MIZ; Tintore M; Stankoff B
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:326

TRANSCRIPTOME PROFILING AND AUTOIMMUNITY-RELATED SEROLOGICAL MARKERS IDENTIFY TP53 AND C3AR AS DRUG TARGETS IN NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS

Lindblom J; Toro-Dominguez D; Borghi MO; Iacobaeus E; Enman Y; Repsilber D; Mohan C; Alarcon-Riquelme M; Barturen G; Parodis I
Review: THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS. 2022;15:17562864211066751-175628642110667

Smouldering multiple sclerosis: the 'real MS'.

Giovannoni G; Popescu V; Wuerfel J; Hellwig K; Iacobaeus E; Jensen MB; García-Domínguez JM; Sousa L; De Rossi N; Hupperts R; Fenu G; Bodini B; Kuusisto H-M; Stankoff B; Lycke J; Airas L; Granziera C; Scalfari A
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):126-127

Neurological follow up and management of disease reactivation following aHSCT

Iacobaeus E
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:4417-4418

Transcriptome Profiling and Autoimmunity-related Serological Markers Identify Tumour Protein P53 and Complement C3a Receptor 1 as Drug Targets in Neuropsychiatric Systemic Lupus Erythematosus

Lindblom J; Toro-Dominguez D; Carnero-Montoro E; Orietta Borghi M; Castillo J; Iacobaeus E; Enman Y; Mohan C; Alarcon-Riquelme M; Barturen G; Parodis I
Review: ACTA NEUROLOGICA SCANDINAVICA. 2021;144(3):229-235

Multiple sclerosis and COVID-19: The Swedish experience

Landtblom A-M; Berntsson SG; Bostrom I; Iacobaeus E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):356

Comprehensive phenotypic and functional analyses of peripheral blood monocytes during MS disease progression

Iacobaeus E; Kadri N; Gavin C; Le Blanc K
Review: MULTIPLE SCLEROSIS JOURNAL. 2020;26(9):1352458520925369-1044

Aggressive multiple sclerosis (1): Towards a definition of the phenotype

Iacobaeus E; Arrambide G; Amato MP; Derfuss T; Vukusic S; Hemmer B; Tintore M; Brundin L
Review: MULTIPLE SCLEROSIS JOURNAL. 2020;26(9):1352458520924595-1063

Aggressive multiple sclerosis (2): Treatment

Arrambide G; Iacobaeus E; Amato MP; Derfuss T; Vukusic S; Hemmer B; Brundin L; Tintore M
Letter: HAEMATOLOGICA. 2020;105(6):e310-e314

Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation

Boberg E; Kadri N; Winterling J; Davies LC; Bjorklund A; Msghina M; Iacobaeus E; Le Blanc K
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2020;26(3_SUPPL):137-138

Clinical characteristics and outcome of late onset multiple sclerosis

Iacobaeus E; Berglund A; Mckay K; Brundin L; Hillert J
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:533-534

Immunological and clinical follow up after autologous bone-marrow mesenchymal stromal cell therapy in progressive multiple sclerosis: a phase I clinical study

Iacobaeus E; Kadri N; Lefsihane K; Boberg E; Gavin C; Lilja A; Brundin L; Le Blanc K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):285

Thymic function predicts response to mesenchymal stromal cell treatment in chronic GVHD

Boberg E; von Bahr L; Heldring N; Afram G; Iacobaeus E; Modin C; Garming-Legert K; Ljungman P; Sugars R; Davies L; Kadri N; Le Blanc K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):335

Functional shift of myeloid-derived suppressor cells during Multiple Sclerosis disease course

Iacobaeus E; Douagi I; Jitschin R; Andren AT; Gavin C; Lefsihane K; Davies L; Olsson T; Mougiakakos D; Kadri N; Le Blanc K
Conference publication: BLOOD. 2017;130

Thymic Function Predicts Response to Mesenchymal Stromal Cell Treatment in Chronic GvHD: A Phase II Clinical Study

Boberg E; Von Bahr L; Heldring N; Afram G; Iacobaeus E; Lindstrom C; Garming-Legert K; Ljungman P; Sugars R; Davies L; Kadri N; Le Blanc K
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2016;25:496-497

Pharmacological Treatments Preceding Diagnosis Of Progressive Multifocal Leukencephalopathy

Burkill S; Iacobaeus E; Bahmanyar S; Brundin L; Fored M; Olsson T; Montgomery S
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2016;25:99

Comorbid Diseases Preceding Diagnosis of Progressive Multifocal Leukencephalopathy

Iacobaeus E; Burkill S; Bahmanyar S; Brundin L; Fored M; Olsson T; Montgomery S
Letter: JOURNAL OF RHEUMATOLOGY. 2012;39(6):1299-1303

Progressive Multifocal Leukoencephalopathy in a Patient with Polymyositis: Case Report and Literature Review

Dastmalchi M; Laki J; Lundberg IE; Iacobaeus E
Thesis / dissertation: 2010

Establishment and applications of a multiple sclerosis biobank : analysis of biomarkers and therapeutic complications in MS

Iacobaeus, Ellen
Show more

Employments

Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2024-2025
Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, Karolinska Institutet, 2021
Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2010
University Medical Degree, Karolinska Institutet, 2001

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI