Dina Medina-Vera

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Articles

Journal article: FRONTIERS IN PHARMACOLOGY. 2026;17:1850815
Adolescent stress and alcohol are associated with CX₃CR1-linked endocrine-cardiac signatures and anxiety-like behavior in mice
Medina-Vera D; Martin-Chaves L; Sanchez-Marin L; Diaz-Ottaviano M; Gavito AL; Pozo-Vilumbrales B; Beltran-Camacho L; Popova O; Romero-Cuevas M; Fernandez B; Rodriguez-Capitan J; Rodriguez de Fonseca F; Jimenez-Navarro MF; Serrano A; Pavon-Moron FJ
Article: BRAIN BEHAVIOR AND IMMUNITY. 2026;134:106463
Prenatal-lactational alcohol exposure induces sex-specific CX3CL1/CX3CR1 dysregulation linked to neuroendocrine imbalance and cardiovascular risk
Medina-Vera D; Garcia-Baos A; Medrano M; Martin-Chaves L; Rodriguez-Capitan J; de Fonseca FR; Serrano A; Jimenez-Navarro M; Valverde O; Pavon-Moron FJ
Journal article: PLOS ONE. 2025;20(11):e0336509
New insights into the molecular biology of Alzheimer's-like cerebral amyloidosis achieved through multi-omics approaches (vol 20, e0330859, 2025)
Campanelli L; Sendoya JM; Brody S; Galeano P; Do Carmo S; Cuello AC; Castano EM; Gonzales-Jimenez A; Verheul-Campos J; Medina-Vera D; De Fonseca FR; Wernersson R; Morelli L
Journal article: PLOS ONE. 2025;20(9):e0330859
New insights into the molecular biology of Alzheimer's-like cerebral amyloidosis achieved through multi-omics approaches
Campanelli L; Sendoya JM; Brody S; Galeano P; Do Carmo S; Cuello AC; Castano EM; Gonzales-Jimenez A; Verheul J; Medina-Vera D; de Fonseca FR; Wernersson R; Morelli L
Journal article: NEUROPHARMACOLOGY. 2025;275:110503
"Maladaptive stress-coping behavior in CX3CR1-deficient mice: Impact of adolescent stress and alcohol exposure on neuroimmune responses and inflammation"
Medina-Vera D; Martin-Chaves L; Sanchez-Marin L; Diaz-Ottaviano M; Gavito AL; Popova O; Sanchez-Quintero MJ; Rodriguez-Capitan J; de Fonseca FR; Jimenez-Navarro MF; Serrano A; Pavon-Moron FJ
Journal article: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2025;141:111482
Sex-specific dysregulation of the CX₃CL1/CX₃CR1 Axis following cocaine exposure: Translational evidence for a potential biomarker of abstinence
Porras-Perales O; Sanchez-Marin L; Medina-Vera D; Flores-Lopez M; Martin-Chaves L; Boccalon M; Requena-Ocana N; Garcia-Marchena N; Reviriego R; Santin LJ; Martin-Fardon R; Jimenez-Navarro M; de Fonseca FR; Serrano A; Pavon-Moron FJ
Journal article: SCIENTIFIC REPORTS. 2025;15(1):21887
Distinct cardiac troponin alterations in patients with cocaine and alcohol use disorders during abstinence for cardiovascular risk assessment
Porras-Perales O; Segovia-Reyes J; Crespo-Delgado A; Ruiz-Gonzalez D; Flores-Lopez M; Medina-Vera D; Sanchez-Marin L; Martin-Chaves L; Requena-Ocana N; Molina-Ramos AI; Ruiz-Ruiz JJ; de Fonseca FR; Jimenez-Navarro M; Rodriguez-Capitan J; Pavon-Moron FJ; Serrano A
Article: NUTRIENTS. 2024;16(23):4186
Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5xFAD Humanized Mouse Model of Alzheimer's Amyloidosis
Medina-Vera D; Lopez-Gambero AJ; Verheul-Campos J; Navarro JA; Morelli L; Galeano P; Suarez J; Sanjuan C; Pacheco-Sanchez B; Rivera P; Pavon-Moron FJ; Rosell-Valle C; Fonseca FRD
Article: BIOLOGY OF SEX DIFFERENCES. 2024;15(1):75
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats
Gobbi C; Sanchez-Marin L; Flores-Lopez M; Medina-Vera D; Pavon-Moron FJ; Rodriguez de Fonseca F; Serrano A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(23):17009
The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis
Galeano P; de Ceglia M; Mastrogiovanni M; Campanelli L; Medina-Vera D; Campolo N; Novack GV; Rosell-Valle C; Suarez J; Aicardo A; Campuzano K; Castano EM; Do Carmo S; Cuello AC; Bartesaghi S; Radi R; de Fonseca FR; Morelli L
Article: NEUROBIOLOGY OF DISEASE. 2023;187:106295
Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice
Medina-Vera D; Zambrana-Infantes EN; Lopez-Gambero AJ; Verheul-Campos J; Santin LJ; Baixeras E; Suarez J; Pavon FJ; Rosell-Valle C; Fonseca FRD
Article: ANTIOXIDANTS. 2023;12(8):1643
Multi-Omics Approach Reveals Prebiotic and Potential Antioxidant Effects of Essential Oils from the Mediterranean Diet on Cardiometabolic Disorder Using Humanized Gnotobiotic Mice
Sanchez-Quintero MJ; Delgado J; Chaves LM; Medina-Vera D; Murri M; Becerra-Munoz VM; Estevez M; Crespo-Leiro MG; Lopez GP; Gonzalez-Jimenez A; Ranea JAG; Queipo-Ortuno MI; Plaza-Andrades I; Rodriguez-Capitan J; Pavon-Moron FJ; Jimenez-Navarro MF
Article: BIOLOGY-BASEL. 2023;12(6):805
The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer's Disease in App^NL-G-F Knock-In Mice
Medina-Vera D; Zhao H; Bereczki E; Rosell-Valle C; Shimozawa M; Chen G; de Fonseca FR; Nilsson P; Tambaro S
Journal article: NEUROSCIENCE APPLIED. 2023;2:103779
Insulin signaling and neurological disorders: investigating the therapeutic potential of D-pinitol in Alzheimer's disease and tauopathies
Medina-Vera D; López-Gambero AJ; Sanjuan C; Baixeras E; Decara J; J PF; Rosell-Valle C; de Fonseca FR
Article: BRAIN COMMUNICATIONS. 2022;5(1):fcad001
Translational potential of synaptic alterations in Alzheimer's disease patients and amyloid precursor protein knock-in mice
Medina-Vera D; Enache D; Tambaro S; Abuhashish E; Rosell-Valle C; Winblad B; de Fonseca FR; Bereczki E; Nilsson P
Article: NUTRIENTS. 2022;14(21):4650
Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus
Jose Sanchez-Quintero M; Delgado J; Medina-Vera D; Becerra-Munoz VM; Isabel Queipo-Ortuno M; Estevez M; Plaza-Andrades I; Rodriguez-Capitan J; Sanchez PL; Crespo-Leiro MG; Jimenez-Navarro MF; Pavon-Moron FJ
Article: NUTRIENTS. 2022;14(19):4094
Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers
Navarro JA; Diaz C; Decara J; Medina-Vera D; Lopez-Gambero AJ; Suarez J; Javier Pavon F; Serrano A; Vargas A; Luisa Gavito A; Porras-Perales O; Aranda J; Vicente F; Sanjuan C; Baixeras E; Rodriguez de Fonseca F
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(19):4655-4672
d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
Medina-Vera D; Navarro JA; Rivera P; Rosell-Valle C; Gutierrez-Adan A; Sanjuan C; Lopez-Gambero AJ; Tovar R; Suarez J; Pavon FJ; Baixeras E; Decara J; de Fonseca FR
Article: PHARMACEUTICS. 2022;14(8):1594
Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes
Navarro JA; Decara J; Medina-Vera D; Tovar R; Lopez-Gambero AJ; Suarez J; Pavon FJ; Serrano A; de Ceglia M; Sanjuan C; Baltasar YA; Baixeras E; Rodriguez de Fonseca F
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;150:112994
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer?s disease
Lopez-Gambero AJL; Pacheco-Sanchez B; Rosell-Valle C; Medina-Vera D; Navarro JA; Fernandez-Arjona MDM; de Ceglia M; Sanjuan C; Simon V; Cota D; Rivera P; de Fonseca FR; Suarez J
Article: BMJ OPEN. 2022;12(2):e058042
Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
del Mar Carmona-Segovia A; Victoria Doncel-Abad M; Becerra-Munoz VM; Rodriguez-Capitan J; Sabatel-Perez F; Flores-Lopez M; Jose Sanchez-Quintero M; Medina-Vera D; Isabel Molina-Ramos A; El Bekay R; Miguel Morales-Asencio J; Angullo-Gomez M; Garcia-Rodriguez L; Palma-Marti L; Javier Pavon-Moron F; Jimenez-Navarro MF
Article: NUTRIENTS. 2021;13(7):2268
Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol
Medina-Vera D; Antonio Navarro J; Tovar R; Rosell-Valle C; Gutierrez-Adan A; Carlos Ledesma J; Sanjuan C; Javier Pavon F; Baixeras E; Rodriguez de Fonseca F; Decara J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(10):5365
A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse
Lopez-Gambero AJ; Rosell-Valle C; Medina-Vera D; Navarro JA; Vargas A; Rivera P; Sanjuan C; Rodriguez de Fonseca F; Suarez J
Article: ADDICTION BIOLOGY. 2021;26(1):e12883
Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice
Carlos Ledesma J; Rodriguez-Arias M; Gavito AL; Sanchez-Perez AM; Vina J; Medina Vera D; Rodriguez de Fonseca F; Minarro J
Article: BIOLOGY-BASEL. 2020;9(11):E377-377
Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer's Disease in a Preclinical Model: A Therapeutic Opportunity
Medina-Vera D; Rosell-Valle C; Lopez-Gambero AJ; Navarro JA; Zambrana-Infantes EN; Rivera P; Santin LJ; Suarez J; Rodriguez de Fonseca F
Article: NUTRIENTS. 2020;12(7):E2030-2030
D-Pinitol fromCeratonia siliquaIs an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats
Navarro JA; Decara J; Medina-Vera D; Tovar R; Suarez J; Pavon J; Serrano A; Vida M; Gutierrez-Adan A; Sanjuan C; Baixeras E; de Fonseca FR
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2020;177(14):3309-3326
Differential hepatoprotective role of the cannabinoid CB₁ and CB₂ receptors in paracetamol-induced liver injury
Rivera P; Vargas A; Pastor A; Boronat A; Jesus Lopez-Gambero A; Sanchez-Marin L; Medina-Vera D; Serrano A; Javier Pavon F; de la Torre R; Agirregoitia E; Isabel Lucena M; Rodriguez de Fonseca F; Decara J; Suarez J
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All other publications

Book chapter: ANANDAMIDE IN HEALTH AND DISEASE. 2025;p. 419-443
Chapter 14 Role of anandamide in Alzheimer's disease
Medina-Vera D; Tambaro S
Review: NEURAL REGENERATION RESEARCH. 2024;19(2):289-295
Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance
Medina-Vera D; Lopez-Gambero A; Navarro JA; Sanjuan C; Baixeras E; Decara J; de Fonseca FR
Conference publication: JOURNAL OF NEUROCHEMISTRY. 2023;166:148
Impact of western diet or D-PINITOL in cognitive behavior and hippocampal protein expression of 5XFAD ALZHEIMER mouse model
de Ceglia M; Medina Vera D; Lopez Gambero A; Rosell Valle C; Antonio Navarro J; Suarez J; Rodriguez de Fonseca F
Conference publication: ALCOHOL. 2023;109:96
SEX DIFFERENCES IN PLASMA FRACTALKINE (CX3CL1) LEVELS IN RATS EXPOSED TO EARLY STRESS AND ALCOHAL
Pavon-Moron FJ; Medina-Vera D; Sanchez-Marin L; Martin-Chaves L; Porras-Perales O; Gavito A; Jimenez-Navarro M; Rodriguez-de-Fonseca F; Serrano A
Conference publication: 2020;00:1155-1159
Automatically Navigating Protein Interaction Networks with a Software Product Line Approach
Munoz D-J; Medina-Vera D

Grants

Impact of Type 2 Diabetes on Brain Vulnerability: A Catalyst for Amyloid-Beta Deposition and Cognitive Decline in Elderly Patients with iNPH
Loo and Hans Osterman Foundation [Translated from Swedish by AI.]
1 January 2026 - 31 December 2026
Type 2 Diabetes and Brain Vulnerability in Patients with iNPH: Uncovering Links to Amyloid Pathology and Cognitive Decline
Stiftelsen Maja & J.P. Åhlén
1 January 2026 - 31 December 2026
Type 2 Diabetes and Brain Vulnerability in Patients with iNPH: Uncovering Links to Amyloid Pathology and Cognitive Decline
Stiftelsen För Gamla Tjänarinno
1 January 2026 - 31 December 2026
From Live Brain Cortex Biopsy to a Functional Approach for the Development of Early Alzheimer's Disease Biomarkers
David och Astrid Hageléns stiftelse
1 March 2025 - 1 March 2027
Type 2 Diabetes and Brain Vulnerability in Patients with iNPH: Uncovering Links to Amyloid Pathology and Cognitive Decline
Gun and Bertil Stohne Foundation [Translated from Swedish by AI.]
1 January 2025 - 1 January 2026

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