Davide Liborio Vetrano

Davide Liborio Vetrano

Assistant Professor | Docent
Telephone: +46852485836
Visiting address: Tomtebodavägen 18 A, 17165 Solna
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 ARC Medicin Vetrano, 171 77 Stockholm

About me

  • I am a MD specialized in geriatric medicine at the Catholic University of
    Rome, with a PhD in geriatric epidemiology from Karolinska Institutet.
    I am currently an Assistant Professor in Geriatric Medicine at the Aging
    Research Center of Karolinska Institutet.
    - 2019 PhD in Geriatric Epidemiology
    - 2016 Specialization in Geriatrics
    - 2010 Medical Doctor degree


  • My main research interests are:
    *Multimorbidity development and its prognosis.* Multimorbidity, the
    co-occurrence of multiple diseases in the same individual, is the most
    common condition encountered in older people. During the past years, I
    focused my attention on the definition of multimorbidity and its measurement
    in older individuals. Together with a group of colleagues from KI and other
    international Institutions, we refined the concept of multimorbidity
    clusters and that of speed of multimorbidity development. We
    investigate the impact of multimorbidity clusters on several health-related
    outcomes, and we recently started looking at the risk factors and
    determinants (i.e., psychosocial, biological etc.) of fast disease
    *Multidimensional assessment of health and biological age in older
    people.* Aging is a complex and heterogeneous process which greatly departs
    from the linearity of calendar time. We combine clinical, biological,
    functional and socio-demographic information a) to build reliable prognostic
    tools for risk stratification as for example the frailty index
  • b) to build
    measures of biological and phenotypic age
  • c) to identify homogeneous groups
    of individuals with specific needs, that may benefit from given preventive
    and therapeutic interventions. The combination of information on disease
    status with functional parameters (physical and cognitive) and frailty status
    has been investigated in several studies I authored and co-authored.
    /Full publication list/ here [1]
    /Google Scholar profile/ here [2]
    /*Selected publications:*/
    *Vetrano DL*, Triolo F, Maggi S, Malley R, Jackson TA, Poscia A, Bernabei R,
    Ferrucci L, Fratiglioni L. Fostering healthy aging: the interdependency of
    infections, immunity and frailty. *Ageing Res Rev*. 2021 May 7:101351.
    Grande G, Marengoni A, *Vetrano DL*, Roso-Llorach A, Rizzuto D, Zucchelli A,
    Qiu C, Fratiglioni L, Calderón-Larrañaga A. Multimorbidity burden and
    dementia risk in older adults: The role of inflammation and genetics.
    *Alzheimers Dement*. 2021 May
  • 17(5):768-776.
    Calderón-Larrañaga A, Saadeh M, Hooshmand B, Refsum H, Smith AD, Marengoni
    A, *Vetrano DL*. Association of Homocysteine, Methionine, and MTHFR 677C>
  • T
    Polymorphism With Rate of Cardiovascular Multimorbidity Development in Older
    Adults in Sweden. *JAMA Netw Open*. 2020 May 1
  • 3(5):e205316.
    *Vetrano DL*, Roso-Llorach A, Fernández S, Guisado-Clavero M, Violán C,
    Onder G, Fratiglioni L, Calderón-Larrañaga A, Marengoni A. Twelve-year
    clinical trajectories of multimorbidity in a population of older adults. *Nat
    Commun*. 2020 Jun 26
  • 11(1):3223.
    Zucchelli A, Marengoni A, Rizzuto D, Calderón-Larrañaga A, Zucchelli M,
    Bernabei R, Onder G, Fratiglioni L, *Vetrano DL*. Using a genetic algorithm
    to derive a highly predictive and context-specific frailty index. *Aging
    (Albany NY)*. 2020 Apr 28
  • 12(8):7561-7575.
    Zucchelli A, *Vetrano DL (co-first)*, Grande G, Calderón-Larrañaga A,
    Fratiglioni L, Marengoni A, Rizzuto D. Comparing the prognostic value of
    geriatric health indicators: a population-based study. *BMC Med*. 2019 Oct
  • 17(1):185.
    *Vetrano DL*, Rizzuto D, Calderón-Larrañaga A, Onder G, Welmer AK, Qiu C,
    Bernabei R, Marengoni A, Fratiglioni L. Walking Speed Drives the Prognosis of
    Older Adults with Cardiovascular and Neuropsychiatric Multimorbidity. *Am J
    Med*. 2019 May 27. pii: S0002-9343(19)30432-2.
    Dekhtyar S, *Vetrano DL*, Marengoni A, Wang HX, Pan KY, Fratiglioni L,
    Calderón-Larrañaga A. Association Between Speed of Multimorbidity
    Accumulation in Old Age and Life Experiences: A Cohort Study. *Am J
    Epidemiol*. 2019 Sep 1
  • 188(9):1627-1636. doi: 10.1093/aje/kwz101. PMID:
    Calderón-Larrañaga A, *Vetrano DL (co-first)*, Ferrucci L, Mercer SW,
    Marengoni A, Onder G, Eriksdotter M, Fratiglioni L. Multimorbidity and
    functional impairment-bidirectional interplay, synergistic effects and common
    pathways. *J Intern Med*. 2019 Mar
  • 285(3):255-271.
    Grande G, Triolo F, Nuara A, Welmer AK, Fratiglioni L, *Vetrano DL*.
    Measuring gait speed to better identify prodromal dementia. *Exp Gerontol*.
    2019 Sep
  • 124:110625.
    *Vetrano DL*, Palmer K, Marengoni A, Marzetti E, Lattanzio F,
    Roller-Wirnsberger R, Lopez Samaniego L, Rodríguez-Mañas L, Bernabei R,
    Onder G
  • Joint Action ADVANTAGE WP4 group. Frailty and multimorbidity: a
    systematic review and meta-analysis. *J Gerontol A Biol Sci Med Sci*. 2018
    May 3.
    *Vetrano DL*, Rizzuto D, Calderón-Larrañaga A, Onder G, Welmer AK, Bernabei
    R, Marengoni A, Fratiglioni L. Trajectories of functional decline in older
    adults with neuropsychiatric and cardiovascular multimorbidity: A Swedish
    cohort study. *PLoS Med*. 2018 Mar 6
  • 15(3):e1002503.
    Calderón-Larrañaga A, *Vetrano DL* *(co-first)*, Onder G, Gimeno-Feliu LA,
    Coscollar-Santaliestra C, Carfí A, Pisciotta MS, Angleman S, Melis RJ,
    Santoni G, Mangialasche F, Rizzuto D, Welmer AK, Bernabei R, Prados-Torres A,
    Marengoni A, Fratiglioni L. Assessing and Measuring Chronic Multimorbidity in
    the Older Population: A Proposal for Its Operationalization. *J Gerontol A
    Biol Sci Med Sci*. 2016 Dec 21. pii: glw233.
    *Vetrano DL*, Tosato M, Colloca G, Topinkova E, Fialova D, Gindin J, van der
    Roest HG, Landi F, Liperoti R, Bernabei R, Onder G
  • SHELTER Study.
    Polypharmacy in nursing home residents with severe cognitive impairment:
    results from the SHELTER Study. *Alzheimers Dement*. 2013 Sep
  • 9(5):587-93.
    *Vetrano DL*, Landi F, Volpato S, Corsonello A, Meloni E, Bernabei R, Onder
    G. Association of sarcopenia with short- and long-term mortality in older
    adults admitted to acute care wards: results from the CRIME study. *J
    Gerontol A Biol Sci Med Sci*. 2014 Sep
  • 69(9):1154-61.
    [1] https://pubmed.ncbi.nlm.nih.gov/?term=vetrano+dl&
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    [2] https://scholar.google.it/citations?user=V7Zr82UAAAAJ&
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  • As part of my pedagogical activity, I have been lecturing to both masters'
    and PhD students. I have also been a supervisor of several MD students and
    residents in geriatrics. I am currently co-supervising two PhD students
    and supervising several masters' students and research assistants.


All other publications


  • Assistant Professor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2021-2025

Degrees and Education

  • Docent, Karolinska Institutet, 2023
  • Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2019

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