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About me

I am a Neuropsychologist and Clinical Psychologist from the University of La Laguna (Spain). I graduated as a PhD in 2012 also at the University of La Laguna (Spain). I have been working at Karolinska Institutet since 2012. Currently I am leading several lines of research and I supervise several PhD students, Master students and Degree students. I also collaborate with other research groups from KI, other centers in Sweden, and other International groups. I am Co-Director of GENIC (Group of Neuropsychological Studies of the Canary Islands, University of La Laguna, Spain).

Research description

My main research interest is Normal Aging and neurodegenerative disorders such as Alzheimer’s disease. The main focus is put in cognition and neuroimaging but genetic factors, CSF biomarkers, and clinical and socio-demographic variables are part of my research as well. 

Projects available for students (Master, Degree, Guests, etc.):

- “Subjective Cognitive Decline”: You will investigate the clinical value of subjective cognitive complaints in cognitively normal people, and their association with neuroimaging, CSF biomarkers, cognition, and emotion.

- “Brain atrophy and subtypes of Alzheimer’s disease”:  You will study brain atrophy by different techniques. You will also study different subtypes of Alzheimer’s disease, looking at prevalence, clinical characterization, and progression over time.

- "Cognitive reserve": You will investigate the fascinating topic of cognitive reserve. We will study the neuroanatomical basis of cognitive reserve but also how this can be used clinically.


A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium
Alzheimer's Disease Neuroimaging Initiative, Oppedal K, Ferreira D, Cavallin L, Lemstra Aw, Ten Kate M, et al
Alzheimer's & dementia : the journal of the Alzheimer's Association 2019;15(3):400-409

Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis
Guo C, Ferreira D, Fink K, Westman E, Granberg T
European radiology 2019;29(3):1355-1364

Subjective Cognitive Decline Below and Above the Age of 60: A Multivariate Study on Neuroimaging, Cognitive, Clinical, and Demographic Measures
Cedres N, Machado A, Molina Y, Diaz-galvan P, Hernández-cabrera Ja, Barroso J, et al
Journal of Alzheimer's disease : JAD 2019;68(1):295-309

Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain
Chiotis K, Stenkrona P, Almkvist O, Stepanov V, Ferreira D, Arakawa R, et al
European journal of nuclear medicine and molecular imaging 2018;45(9):1605-1617

Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data
Velickaite V, Ferreira D, Cavallin L, Lind L, Ahlström H, Kilander L, et al
European radiology 2018;28(4):1739-1747

Proposal for a hierarchical, multidimensional, and multivariate approach to investigate cognitive aging
Machado A, Barroso J, Molina Y, Nieto A, Díaz-flores L, Westman E, et al
Neurobiology of aging 2018;71():179-188

Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study
Thordardottir S, Rodriguez-vieitez E, Almkvist O, Ferreira D, Saint-aubert L, Kinhult-ståhlbom A, et al
Alzheimer's research & therapy 2018;10(1):45-

The A/T/N biomarker scheme and patterns of brain atrophy assessed in mild cognitive impairment
Ekman U, Ferreira D, Westman E

The contribution of small vessel disease to subtypes of Alzheimer's disease: a study on cerebrospinal fluid and imaging biomarkers
Ferreira D, Shams S, Cavallin L, Viitanen M, Martola J, Granberg T, et al
Neurobiology of aging 2018;70():18-29

The heterogeneity within Alzheimer's disease
Ferreira D, Wahlund Lo, Westman E
Aging 2018;10(11):3058-3060

A 'Disease Severity Index' to identify individuals with Subjective Memory Decline who will progress to mild cognitive impairment or dementia
Ferreira D, Falahati F, Linden C, Buckley Rf, Ellis Ka, Savage G, et al
Scientific reports 2017;7():44368-

Cerebrospinal Fluid Biomarkers for the Differential Diagnosis between Alzheimer's Disease and Frontotemporal Lobar Degeneration: Systematic Review, HSROC Analysis, and Confounding Factors
Rivero-santana A, Ferreira D, Perestelo-pérez L, Westman E, Wahlund Lo, Sarría A, et al
Journal of Alzheimer's disease : JAD 2017;55(2):625-644

Cognitive Variability during Middle-Age: Possible Association with Neurodegeneration and Cognitive Reserve
Ferreira D, Machado A, Molina Y, Nieto A, Correia R, Westman E, et al
Frontiers in aging neuroscience 2017;9():188-

Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications
Ferreira D, Verhagen C, Hernández-cabrera Ja, Cavallin L, Guo Cj, Ekman U, et al
Scientific reports 2017;7():46263-

Monitoring disease progression in mild cognitive impairment: Associations between atrophy patterns, cognition, APOE and amyloid
Falahati F, Ferreira D, Muehlboeck Js, Eriksdotter M, Simmons A, Wahlund Lo, et al
NeuroImage. Clinical 2017;16():418-428

MRI-assessed atrophy subtypes in Alzheimer's disease and the cognitive reserve hypothesis
Persson K, Eldholm Rs, Barca Ml, Cavallin L, Ferreira D, Knapskog Ab, et al
PloS one 2017;12(10):e0186595-

The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals
Australian Imaging Biomarkers And Lifestyle Study Of Ageing (aibl) Research Group, The Addneuromed Consortium For The Alzheimer's Disease Neuroimaging Initiative (adni), Ferreira D, Hansson O, Barroso J, Molina Y, et al
Hippocampus 2017;27(6):653-667

Different reserve proxies confer overlapping and unique endurance to cortical thinning in healthy middle-aged adults
Ferreira D, Bartrés-faz D, Nygren L, Rundkvist Lj, Molina Y, Machado A, et al
Behavioural brain research 2016;311():375-383

Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers
Ferreira D, Jelic V, Cavallin L, Oeksengaard Ar, Snaedal J, Høgh P, et al
Dementia and geriatric cognitive disorders 2016;42(1-2):80-92

Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations
Addneuronmed Consortium, Orellana C, Ferreira D, Muehlboeck Js, Mecocci P, Vellas B, et al

Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition
Addneuromed Consortium And For The Alzheimer’s Disease Neuroimaging Initiative*, Ferreira D, Cavallin L, Granberg T, Lindberg O, Aguilar C, et al
European radiology 2016;26(8):2597-610

Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device
Eyjolfsdottir H, Eriksdotter M, Linderoth B, Lind G, Juliusson B, Kusk P, et al
Alzheimer's research & therapy 2016;8(1):30-

The Effect of Age Correction on Multivariate Classification in Alzheimer's Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects
Addneuromed Consortium And The Alzheimer’s Disease Neuroimaging Initiative, Falahati F, Ferreira D, Soininen H, Mecocci P, Vellas B, et al
Brain topography 2016;29(2):296-307

Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor
Ferreira D, Westman E, Eyjolfsdottir H, Almqvist P, Lind G, Linderoth B, et al
Journal of Alzheimer's disease : JAD 2015;43(3):1059-72

Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease
Karami A, Eyjolfsdottir H, Vijayaraghavan S, Lind G, Almqvist P, Kadir A, et al
Alzheimer's & dementia : the journal of the Alzheimer's Association 2015;11(11):1316-28

Cognitive decline before the age of 50 can be detected with sensitive cognitive measures
Ferreira D, Correia R, Nieto A, Machado A, Molina Y, Barroso J
Psicothema 2015;27(3):216-22

Fund of Information is More Strongly Associated with Neuropsychological Functioning Than Education in Older Spanish Adults
Correia R, Nieto A, Ferreira D, Sabucedo M, Barroso J
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2015;30(4):310-21

Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment
Addneuromed Consortium And The Alzheimer's Disease Neuroimaging Initiative, Ferreira D, Cavallin L, Larsson Em, Muehlboeck Js, Mecocci P, et al
Journal of internal medicine 2015;278(3):277-90

Preclinical Cerebrospinal Fluid and Volumetric Magnetic Resonance Imaging Biomarkers in Swedish Familial Alzheimer's Disease
Thordardottir S, Stahlbom Ak, Ferreira D, Almkvist O, Westman E, Zetterberg H, et al

Cognitive decline is mediated by gray matter changes during middle age
Ferreira D, Molina Y, Machado A, Westman E, Wahlund Lo, Nieto A, et al
Neurobiology of aging 2014;35(5):1086-94

Improving CSF Biomarkers' Performance for Predicting Progression from Mild Cognitive Impairment to Alzheimer's Disease by Considering Different Confounding Factors: A Meta-Analysis
Ferreira D, Rivero-santana A, Perestelo-pérez L, Westman E, Wahlund Lo, Sarría A, et al
Frontiers in aging neuroscience 2014;6():287-

Meta-review of CSF core biomarkers in Alzheimer's disease: the state-of-the-art after the new revised diagnostic criteria
Ferreira D, Perestelo-perez L, Westman E, Wahlund Lo, Sarria A, Serrano-aguilar P

Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy
Ferreira D, Voevodskaya O, Imrell K, Stawiarz L, Spulber G, Wahlund Lo, et al
Journal of neuroimmunology 2014;274(1-2):149-54

Evolution of global and local grey matter atrophy on serial MRI scans during the progression from MCI to AD
Spulber G, Niskanen E, Macdonald S, Kivipelto M, Padilla Df, Julkunen V, et al
Current Alzheimer research 2012;9(4):516-24

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers
Schöll M, Wall A, Thordardottir S, Ferreira D, Bogdanovic N, Långström B, et al
Neurology 2012;79(3):229-36

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