Claes Frostell

Publications
CV
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Articles

Article: LAKARTIDNINGEN. 2025;122:25067
[All cause 30-day mortality and perioperative mortality rate, associated with appendectomy in Sweden? A SPOR-based study between 2017 and 2021].
Larsson E; Albert J; Frostell C; Jakobsson J
Article: LAKARTIDNINGEN. 2024;121:23197
[SPOR covers 100 percent of publicly run surgical care].
Holmström B; Enlund G; Frostell C; Cederlund B
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2024;19(1):295
Difference in early all-cause mortality among patients having hip arthroplasty a Swedish perioperative registry study 2013-2022
Magnusson J; Karlsson J; Skoldenberg O; Albert J; Frostell C; Jakobsson JG
Article: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. 2024;72(1):20240011
Abnormalities of Coagulation and Fibrinolysis Assessed by Thromboelastometry in an Endotoxic Shock Model in Piglets Treated with Nitric Oxide and Hydrocortisone
Adamik B; Frostell C; Dragan B; Paslawska U; Zielinski S; Paslawski R; Janiszewski A; Zielinska M; Ryniak S; Albert J; Gozdzik W
Article: SCIENTIFIC REPORTS. 2023;13(1):11369
Effect of low-dose hydrocortisone and inhaled nitric oxide on inflammatory mediators and local pulmonary metalloproteinases activity in LPS-induced sepsis in piglets
Kiczak L; Paslawska U; Gozdzik W; Adamik B; Zielinska M; Zielinski S; Nowak K; Plociennik M; Bania J; Tabis A; Nowak M; Paslawski R; Frostell C
Article: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE. 2023;32(6):667-676
Fluid resuscitation, but not inhaled nitric oxide, improves microcirculation in septic pigs
Grotowska M; Harbut P; Frostell C; Gozdzik W
Article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2023;11(1):18
A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury
Hurtsen AS; McGreevy DT; Karlsson C; Frostell CG; Horer TM; Nilsson KF
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2023;67(2):233-239
The Swedish Perioperative Register: Description, validation of data mapping and utility
Holmstrom B; Enlund G; Spetz P; Frostell C
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2023;67(2):206-212
Severe Covid-19 and acute pulmonary hypertension: 24-month follow-up regarding mortality and relationship to initial echocardiographic findings and biomarkers
Norderfeldt J; Liliequist A; Eksborg S; Frostell C; Eriksson MJ; Adding C; Agvald P; Lonnqvist P-A
Article: JOURNAL OF CLINICAL MEDICINE. 2022;11(9):2641
Compartment-Specific Differences in the Activation of Monocyte Subpopulations Are Not Affected by Nitric Oxide and Glucocorticoid Treatment in a Model of Resuscitated Porcine Endotoxemic Shock
Skirecki T; Adamik B; Frostell C; Paslawska U; Zielinski S; Glatzel-Plucinska N; Olbromski M; Dziegiel P; Gozdzik W
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2021;65(6):761-769
Acute pulmonary hypertension and short-term outcomes in severe Covid-19 patients needing intensive care
Norderfeldt J; Liliequist A; Frostell C; Adding C; Agvald P; Eriksson M; Lonnqvist P-A
Article: NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2021;108:20-27
Platelet dysfunction in a large-animal model of endotoxic shock; effects of inhaled nitric oxide and low-dose steroid.
Adamik B; Frostell C; Paslawska U; Dragan B; Zielinski S; Paslawski R; Janiszewski A; Zielinska M; Ryniak S; Ledin G; Gozdzik W
Article: SHOCK. 2018;50(4):377-380
MINIMUM QUALITY THRESHOLD IN PRE-CLINICAL SEPSIS STUDIES (MQTiPSS): AN INTERNATIONAL EXPERT CONSENSUS INITIATIVE FOR IMPROVEMENT OF ANIMAL MODELING IN SEPSIS
Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman CS; Drechsler S; Efron P; Frostell C; Fritsch G; Gozdzik W; Hellman J; Huber-Lang M; Inoue S; Knapp S; Kozlov AV; Libert C; Marshall JC; Moldawer LL; Radermacher P; Redl H; Remick DG; Singer M; Thiemermann C; Wang P; Wiersinga WJ; Xiao X; Zingarelli B
Article: INFECTION. 2018;46(5):687-691
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman C; Drechsler S; Efron P; Frostell C; Fritsch G; Gozdzik W; Hellman J; Huber-Lang M; Inoue S; Knapp S; Kozlov AV; Libert C; Marshall JC; Moldawer LL; Radermacher P; Redl H; Remick DG; Singer M; Thiemermann C; Wang P; Wiersinga WJ; Xiao X; Zingarelli B
Article: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 2018;106(6):2337-2344
Evaluation of central venous catheters coated with a noble metal alloy-A randomized clinical pilot study of coating durability, performance and tolerability
Bjorling G; Johansson D; Bergstrom L; Strekalovsky A; Sanchez J; Frostell C; Kalman S
Article: PLOS ONE. 2018;13(4):e0193294
Survival after PICU admission: The impact of multiple admissions and complex chronic conditions
Kalzen H; Larsson B; Eksborg S; Lindberg L; Edberg KE; Frostell C
Article: DRUG DESIGN DEVELOPMENT AND THERAPY. 2018;12:685-694
Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs
Nilsson KF; Gozdzik W; Frostell C; Zielinski S; Zielinska M; Ratajczak K; Skrzypczak P; Rodziewicz S; Albert J; Gustafsson LE
Article: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. 2018;31:394632017751486
Beneficial effects of inhaled nitric oxide with intravenous steroid in an ischemia-reperfusion model involving aortic clamping
Gozdzik W; Zielinski S; Zielinska M; Ratajczak K; Skrzypczak P; Rodziewicz S; Kubler A; Lofstrom K; Dziegiel P; Olbromski M; Adamik B; Ryniak S; Harbut P; Albert J; Frostell C
Article: PLOS ONE. 2017;12(8):e0183073
Septic shock and the use of norepinephrine in an intermediate care unit: Mortality and adverse events
Hallengren M; Astrand P; Eksborg S; Barle H; Frostell C
Article: BMC ANESTHESIOLOGY. 2015;15:174
Tolerability and performance of BIP endotracheal tubes with noble metal alloy coating - a randomized clinical evaluation study
Bjorling G; Johansson D; Bergstrom L; Jalal S; Kohn I; Frostell C; Kalman S
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All other publications

Editorial: ANESTHESIOLOGY. 2026;144(3):518-520
Whither Inhaled Nitric Oxide
Frostell C; Weitzberg E
Editorial: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2021;65(5):576-577
Nitric oxide and COVID-19: Dose, timing and how to administer it might be crucial
Frostell CG; Hedenstierna G
Review: SHOCK. 2019;51(1):23-32
PART II: MINIMUM QUALITY THRESHOLD IN PRECLINICAL SEPSIS STUDIES (MQTiPSS) FOR TYPES OF INFECTIONS AND ORGAN DYSFUNCTION ENDPOINTS
Libert C; Ayala A; Bauer M; Cavaillon J-M; Deutschman C; Frostell C; Knapp S; Kozlov AV; Wang P; Osuchowski MF; Remick DG
Corrigendum: INFECTION. 2018;46(5):745-747
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (vol 46, pg 745, 2018)
Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman C; Drechsler S; Efron P; Frostell C; Fritsch G; Gozdzik W; Hellman J; Huber-Lang M; Inoue S; Knapp S; Kozlov AV; Libert C; Marshall JC; Moldawer LL; Radermacher P; Redl H; Remick DG; Singer M; Thiemermann C; Wang P; Wiersinga WJ; Xiao X; Zingarelli B
Review: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2018;6(1):26
Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
Osuchowski MF; Ayala A; Bahrami S; Bauer M; Boros M; Cavaillon J-M; Chaudry IH; Coopersmith CM; Deutschman C; Drechsler S; Efron P; Frostell C; Fritsch G; Gozdzik W; Hellman J; Huber-Lang M; Inoue S; Knapp S; Kozlov AV; Libert C; Marshall JC; Moldawer LL; Radermacher P; Redl H; Remick DG; Singer M; Thiemermann C; Wang P; Wiersinga WJ; Xiao X; Zingarelli B
Letter: LANCET. 2017;389(10075):1191
Tracheal implants revisited
Frostell C; Bjorling G; Stromberg E; Karlsson S; Aune RE
Editorial: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2016;60(6):693-696
Pharmacological treatment versus acute lung injury/acute respiratory distress syndrome - reflections from the clinical perspective and yacht racing (and more)
Frostell C; Lonnqvist P-A
Editorial: CRITICAL CARE MEDICINE. 2011;39(11):2581-2582
Daily critical assessment of need for mechanical ventilation may shorten time on the ventilator in the pediatric intensive care unit
Frostell C; Larsson B
Other: ANESTHESIOLOGY. 2010;113(6):1437-1438
Torsten Gordh (1907-2010) In Memoriam
Eriksson LI; Frostell C; Irestedt L; Lindahl S; Weitzberg E
Published conference paper: AMERICAN JOURNAL OF VETERINARY RESEARCH. 2008;69(3):423-430
Physiologic responses and plasma endothelin-1 concentrations associated with abrupt cessation of nitric oxide inhalation in isoflurane-anesthetized horses
Grubb TL; Hogman M; Edner A; Frendin JHM; Heinonen E; Malavasi LM; Frostell CG; Ryden A; Alving K; Nyman GC
Other: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2007;51(9):1136-1137
Torsten Gordh celebrates his 100th anniversary
Lindahl SGE; Eriksson LI; Frostell C; Irestedt L; Weitzberg E
Review: INTENSIVE CARE MEDICINE. 2005;31(8):1029-1041
Inhaled nitric oxide therapy in adults: European expert recommendations
Germann P; Braschi A; Della Rocca G; Dinh-Xuan AT; Falke K; Frostell C; Gustafsson LE; Hervé P; Jolliet P; Kaisers U; Litvan H; Macrae DJ; Maggiorini M; Marczin N; Mueller B; Payen D; Ranucci M; Schranz D; Zimmermann R; Ullrich R
Published conference paper: ACTA PHARMACOLOGICA SINICA. 2003;24(12):1314-1315
Reassessment of inhaled nitric oxide in acute lung injury
Frostell C
Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;162(1):332-333
Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland
Luhr O; Antonsen K; Bonde J; Thorsteinsson A; Frostell C
Published conference paper: ZHONGGUO YAO LI XUE BAO = ACTA PHARMACOLOGICA SINICA. 1997;18(6):539-541
Update on clinical trials with inhaled nitric oxide.
Frostell CG
Published conference paper: NEONATOLOGY. 1997;71 Suppl 1:39-43
Clinical aspects of nitric oxide and surfactant replacement.
Frostell CG
Review: MONALDI ARCHIVES FOR CHEST DISEASE. 1996;51(6):538-542
Nitric oxide and acute respiratory failure.
Frostell CG
Published conference paper: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 1995;39:58-59
BACKGROUND OF NITRIC-OXIDE INHALATION
FROSTELL CG
Review: ADVANCES IN PHARMACOLOGY. 1995;34:439-456
Inhaled nitric oxide, clinical rationale and applications.
Frostell CG; Zapol WM

Employments

Professor, Senior, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2025-2026
Professor, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2020-2024
Professor, Senior, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2019-2020
Professor/Senior Physician, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2012-2019
Professor/Senior Physician, Department of Physiology and Pharmacology, Karolinska Institutet, 2005-2011
Professor/Senior Physician, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2005-2005
Professor/Senior Physician, Center for Surgical Sciences, Karolinska Institutet, 2004-2005
Professor/Senior Physician, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2001-2005

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