Charlotte Rolny
Affiliated to Research
E-mail: charlotte.rolny@ki.se
Mobile phone: 0707335006
Visiting address: BioClinicum, Visionsgatan 4, J6, 17164 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Holmgren Östman, 171 77 Stockholm
About me
- Leading a research team that focuses on tumor immunology specifically to understand the underlying mechanisms that regulate the pro-tumoral phenotype of immune cells denoted Tumor-Associated Macrophages (TAMs). By employing state-of-art mouse models, cutting edge molecular biology techniques and patient samples, we have deciphered several mechanisms whereby pro-tumoral TAM phenotypes are regulated. By targeting these controlled pathways, pro-tumoral TAMs can be reprogrammed into an anti-tumoral phenotype leading to activation of cytotoxic immune cells and hampering tumor growth and metastatic dissemination. We work closely to clinicians assuring a bench-to-bedside link. Topics that we address:
i) Identifying novel targets that govern tumor-associated macrophage pro-tumoral functions by single-cell sequencing in, genome wide sequencing of total and ribosome- bound RNA, and proteomics.
ii) Identifying novel tumor microenvironment biomarkers in patient samples including TAM phenotypes and their spatial localization.
iii) Regulation of metastatic dissemination via the hematogenous route to secondary organs
Articles
- Article: CELL REPORTS. 2023;42(12):113507Banerjee K; Kerzel T; Bekkhus T; Ferreira SDS; Wallmann T; Wallerius M; Landwehr L-S; Agardy DA; Schauer N; Malmerfeldt A; Bergh J; Bartish M; Hartman J; Ostman A; Squadrito ML; Rolny C
- Journal article: CANCER RESEARCH. 2023;83(5):p2-20-08-p2-20-08Talkhoncheh MS; Sjolund J; Balbas PB; Kurzejamska E; Larsson S; Cordero E; Oudenaarden CR; Pantaleo J; Jonsson G; Rolny C; Bocci M; Pietras K
- Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
- Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(46):e2117333118Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; Ferreira SDS; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(10):e2017089118Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; Ferreira SDS; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
- Article: GYNECOLOGIC ONCOLOGY. 2020;159(3):860-868Corvigno S; Mezheyeuski A; De La Fuente LM; Westbom-Freme S; Carlson JW; Fernebro J; Avall-Lundqvist E; Kannisto P; Hedenfalk I; Malander S; Rolny C; Dahlstrand H; Ostman A
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(44):27556-27565Bartish M; Tong D; Pan Y; Wallerius M; Liu H; Ristau J; Ferreira SDS; Wallmann T; van Hoef V; Masvidal L; Kerzel T; Joly A-L; Goncalves C; Preston SEJ; Ebrahimian T; Seitz C; Bergh J; Pietras K; Lehoux S; Naldini L; Andersson J; Squadrito ML; del RSV; Larsson O; Rolny C
- Article: CANCERS. 2019;11(10):E1479-1479Zerdes I; Wallerius M; Sifakis EG; Wallmann T; Betts S; Bartish M; Tsesmetzis N; Tobin NP; Coucoravas C; Bergh J; Rassidakis GZ; Rolny C; Foukakis T
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;200(3):348-358Sandri BJ; Masvidal L; Murie C; Bartish M; Avdulov S; Higgins L; Markowski T; Peterson M; Bergh J; Yang P; Rolny C; Limper AH; Griffin TJ; Bitterman PB; Wendt CH; Larsson O
- Article: CLINICAL CANCER RESEARCH. 2019;25(12):3702-3717Sjoberg E; Meyrath M; Milde L; Herrera M; Lovrot J; Hagerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Andy CE; Augsten M; Ostman A
- Journal article: PANCREATOLOGY. 2019;19:s28-s29Li X; Wallmann T; Nania S; Hornung L; Kleiter I; Löhr J-M; Rolny C; Heuchel R
- Journal article: ANNALS OF THE AMERICAN THORACIC SOCIETY. 2018;15(Supplement_4):s290-s291Wendt CH; Sandri BJ; Masvidal L; Murie C; Bartish M; Avdulov S; Higgins L; Markowski T; Peterson M; Bergh J; Yang P; Rolny C; Limper AH; Griffin TJ; Bitterman PB; Larsson O
- Article: ISCIENCE. 2018;9:71-83Wallmann T; Zhang X-M; Wallerius M; Bolin S; Joly A-L; Sobocki C; Leiss L; Jiang Y; Bergh J; Holland EC; Enger PO; Andersson J; Swartling FJ; Miletic H; Uhrbom L; Harris RA; Rolny C
- Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(11):1417-1425Witt K; Ligtenberg MA; Conti L; Lanzardo S; Ruiu R; Wallmann T; Tufvesson-Stiller H; Chambers BJ; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
- Article: ONCOIMMUNOLOGY. 2017;6(8):e1338238Sarhan D; Leijonhufvud C; Murray S; Witt K; Seitz C; Wallerius M; Xie H; Ullen A; Harmenberg U; Lidbrink E; Rolny C; Andersson J; Lundqvist A
- Article: CANCER RESEARCH. 2016;76(11):3166-3178Wallerius M; Wallmann T; Bartish M; Ostling J; Mezheyeuski A; Tobin NP; Nygren E; Pangigadde P; Pellegrini P; Squadrito ML; Ponten F; Hartman J; Bergh J; DeMilito A; De Palma M; Ostman A; Andersson J; Rolny C
- Article: CELL REPORTS. 2016;15(9):2000-2011Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
- Article: SCIENCE. 2015;347(6226):1138-1142Zeisel A; Munoz-Manchado AB; Codeluppi S; Lonnerberg P; La Manno G; Jureus A; Marques S; Munguba H; He L; Betsholtz C; Rolny C; Castelo-Branco G; Hjerling-Leffler J; Linnarsson S
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2013;43(1):249-257Sarhan D; D'Arcy P; Wennerberg E; Lidén M; Hu J; Winqvist O; Rolny C; Lundqvist A
- Article: CANCER RESEARCH. 2012;72(8):1953-1963Tugues S; Honjo S; Konig C; Noguer O; Hedlund M; Botling J; Deschoemaeker S; Wenes M; Rolny C; Jahnen-Dechent W; Mazzone M; Claesson-Welsh L
- Journal article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(7):2945Casazza A; Finisguerra V; Capparuccia L; Camperi A; Swiercz JM; Rizzolio S; Rolny C; Christensen C; Bertotti A; Sarotto I; Risio M; Trusolino L; Weitz J; Schneider M; Mazzone M; Comoglio PM; Tamagnone L
- Journal article: CANCER RESEARCH. 2011;71(8_Supplement):3268Casazza A; Kigel B; Rolny C; Neufeld G; Tamagnone L
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(4):741-749Casazza A; Fu X; Johansson I; Capparuccia L; Andersson F; Giustacchini A; Squadrito ML; Venneri MA; Mazzone M; Larsson E; Carmeliet P; De Palma M; Naldini L; Tamagnone L; Rolny C
- Article: CANCER CELL. 2011;19(1):31-44Rolny C; Mazzone M; Tugues S; Laoui D; Johansson I; Coulon C; Squadrito ML; Segura I; Li X; Knevels E; Costa S; Vinckier S; Dresselaer T; Akerud P; De Mol M; Salomaki H; Phillipson M; Wyns S; Larsson E; Buysschaert I; Botling J; Himmelreich U; Van Ginderachter JA; De Palma M; Dewerchin M; Claesson-Welsh L; Carmeliet P
- Article: DIABETES. 2010;59(10):2569-2578Christoffersson G; Henriksnas J; Johansson L; Rolny C; Ahlstrom H; Caballero-Corbalan J; Segersvard R; Permert J; Korsgren O; Carlsson P-O; Phillipson M
- Article: BLOOD. 2010;116(11):1924-1931Massena S; Christoffersson G; Hjertstrom E; Zcharia E; Vlodavsky I; Ausmees N; Rolny C; Li J-P; Phillipson M
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2010;120(8):2684-2698Casazza A; Finisguerra V; Capparuccia L; Camperi A; Swiercz JM; Rizzolio S; Rolny C; Christensen C; Bertotti A; Sarotto I; Risio M; Trusolino L; Weitz J; Schneider M; Mazzone M; Comoglio PM; Tamagnone L
- Article: CELL. 2010;141(1):178-190Van de Veire S; Stalmans I; Heindryckx F; Oura H; Tijeras-Raballand A; Schmidt T; Loges S; Albrecht I; Jonckx B; Vinckier S; Van Steenkiste C; Tugues S; Rolny C; De Mol M; Dettori D; Hainaud P; Coenegrachts L; Contreres J-O; Van Bergen T; Cuervo H; Xiao W-H; Le Henaff C; Buysschaert I; Masouleh BK; Geerts A; Schomber T; Bonnin P; Lambert V; Haustraete J; Zacchigna S; Rakic J-M; Jimenez W; Noel A; Giacca M; Colle I; Foidart J-M; Tobelem G; Morales-Ruiz M; Vilar J; Maxwell P; Vinores SA; Carmeliet G; Dewerchin M; Claesson-Welsh L; Dupuy E; Van Vlierberghe H; Christofori G; Mazzone M; Detmar M; Collen D; Carmeliet P
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(5):1155-1171Rolny C; Capparuccia L; Casazza A; Mazzone M; Vallario A; Cignetti A; Medico E; Carmeliet P; Comoglio PM; Tamagnone L
- Article: BLOOD. 2006;108(6):1877-1886Rolny C; Nilsson I; Magnusson P; Armulik A; Jakobsson L; Wentzel P; Lindblom P; Norlin J; Betsholtz C; Heuchel R; Welsh M; Claesson-Welsh L
- Article: EXPERIMENTAL CELL RESEARCH. 2005;308(2):381-393Rolny C; Lu LG; Ågren N; Nilsson I; Roe C; Webb GC; Welsh M
- Article: FASEB JOURNAL. 2004;18(13):1507-1515Nilsson I; Rolny C; Wu Y; Pytowski B; Hicklin D; Alitalo K; Claesson-Welsh L; Wennström S
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(21):22267-22275Holmqvist K; Cross MJ; Rolny C; Hägerkvist R; Rahimi N; Matsumoto T; Claesson-Welsh L; Welsh M
- Article: JOURNAL OF CELL SCIENCE. 2004;117(8):1513-1523Magnusson P; Rolny C; Jakobsson L; Wikner C; Wu Y; Hicklin DJ; Claesson-Welsh L
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(22):19315-19321Rolny C; Spillmann D; Lindahl U; Claesson-Welsh L
- Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1998;12(2):309-313Andersson AC; Svensson AC; Rolny C; Andersson G; Larsson E
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All other publications
- Review: NATURE REVIEWS CANCER. 2023;23(6):408-425Bartish M; Abraham MJ; Goncalves C; Larsson O; Rolny C; Del Rincon SV
- Preprint: BIORXIV. 2022Banerjee K; Kerzel T; Bekkhus T; de Souza Ferreira S; Wallmann T; Wallerius M; Landwehr L-S; Agardy DA; Schauer N; Malmerfeldt A; Bergh J; Bartish M; Hartman J; Östman A; Squadrito ML; Rolny C
- Conference publication: CANCER IMMUNOLOGY RESEARCH. 2018;6(9):a77Witt K; Ligtenberg MA; Conti L; Lanzardo S; Ruiu R; Tufvesson-Stiller H; Ostling J; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):314-315Wallerius M; Bartish M; Wallmann T; Andresson J; Rolny C
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):315-316Wallmann T; Wallerius M; Landwehr L; Agardy D; Bartish M; Squadrito M; De Palma M; Rolny C
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):312-313Bartish M; Wallerius M; Wallmann T; Sanz LM; van Hoef V; Joly A-L; Andersson J; Larsson O; Rolny C
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):315Bartish M; Wallerius M; Wallmann T; Sanz LM; Van Hoef V; Joly A-L; Andersson J; Rolny C; Larsson O
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):334Witt K; Ligtenberg MA; Conti L; Lanzardo S; Tufvesson-Stiller H; Ostling J; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
- Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2017;35:e23088Zerdes I; Tsesmetzis N; Lovrot J; Rolny C; Bergh JCS; Rassidakis G; Foukakis T
- Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(12):5411Casazza A; Finisguerra V; Capparuccia L; Camperi A; Swiercz JM; Rizzolio S; Rolny C; Christensen C; Bertotti A; Sarotto I; Risio M; Trusolino L; Weitz J; Schneider M; Mazzone M; Comoglio PM; Tamagnone L
- Review: EXPERIMENTAL CELL RESEARCH. 2013;319(11):1635-1643Eissler N; Rolny C
- Conference publication: DIABETOLOGIA. 2010;53:S60Christoffersson G; Henriksnas J; Johansson L; Rolny C; Ahlstrom H; Caballero-Corbalan J; Segersvard R; Permert J; Korsgren O; Carlsson P-O; Phillipson M
- Book chapter: HANDBOOK OF CELL SIGNALING. 2010;p. 1927-1937Dimberg A; Rolny C; van Meeteren LA; Claesson-Welsh L
Employments
- Affiliated to Research, Department of Oncology-Pathology, Karolinska Institutet, 2025-2026
- Principal Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2022-2024
Degrees and Education
- Docent, Uppsala Universitet, 2011