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About me

I defended my thesis on DNA repair at Stockholm University in 2011. With an increased focus on cancer, I continued as a researcher in the DNA repair field for a few years while moving to SciLifeLab in Solna. I spent 2014 at the Institute of Cancer Research in London, where I came even closer to the clinical setting in my aims to optimise radiotherapy for different tumors. My progression from basic research towards patient care has since May 2017 taken me to the group of Katarina Le Blanc at KI, where we develop cell therapies and produce mesenchymal stem cells intended for clinical use.

Education

  • M.Sc. in Cell- and Molecular Biology at Södertörn University College
  • PhD in Molecular Genetics at Stockholm University

Publications

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014)
Gad H, Koolmeister T, Jemth As, Eshtad S, Jacques Sa, Strom Ce, et al
NATURE 2017;544(7651):508-

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H, Koolmeister T, Jemth As, Eshtad S, Jacques Sa, Ström Ce, et al
Nature 2014;508(7495):215-21

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions
Orta Ml, Höglund A, Calderón-montaño Jm, Domínguez I, Burgos-morón E, Visnes T, et al
Nucleic acids research 2014;42(14):9108-20

Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy
Ström Ce, Helleday T
Biomolecules 2012;2(4):635-49

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair
Segal-raz H, Mass G, Baranes-bachar K, Lerenthal Y, Wang Sy, Chung Ym, et al
EMBO reports 2011;12(7):713-9

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Ström Ce, Mortusewicz O, Finch D, Parsons Jl, Lagerqvist A, Johansson F, et al
DNA repair 2011;10(9):961-9

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
Ström Ce, Johansson F, Uhlén M, Szigyarto Ca, Erixon K, Helleday T
Nucleic acids research 2011;39(8):3166-75

XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair
Parsons Jl, Dianova Ii, Finch D, Tait Ps, Ström Ce, Helleday T, et al
DNA repair 2010;9(7):835-41