Carolyn Cesta
About me
I am a pharmacoepidemiologist with a research focus on generating high-quality evidence on the benefits and consequences of medication use during pregnancy for both the mother and child. My work aims to leverage the strengths of the Swedish population-based registers in Nordic and International collaborative studies. I have been a researcher at the Centre for Pharmacoepidemiology [1] at Karolinska Institutet since 2017 and lead the Reproduction research area [2]. Currently, I am the chair of the Nordic Pharmacoepidemiological Network executive committee [3].
Education
2013-2017 PhD, Medical Sciences, Epidemiology, Karolinska Institutet, Sweden
2007-2009 MSc, Medical Sciences, Physiology&Pharmacology, McMaster University, Canada
2001-2006 BSc, Biology and Pharmacology, McMaster University, Canada
Postdoctoral research
2020-2022 Postdoctoral fellow, Harvard T.H. Chan School of Public Health, Boston, USA
2017-2020 Postdoctoral research, Centre for Pharmacoepidemiology, Karolinska Institutet, Sweden
[1] https://ki.se/en/meds/centre-for-pharmacoepidemiology
[2] https://ki.se/en/meds/reproduction
[3] https://www.norpen.org/
Research
My primary research field is within reproductive pharmacoepidemiology, with my largest focus on the benefits and consequences of medication use in pregnancy for the health of the mother and child. Much of my work is conducted in collaboration with Nordic and international researchers within the NorPreSS/InPreSS consortium.[1] Current projects include studying the utilization and safety of medications used to treat type 2 diabetes, bipolar disorder, depression and anxiety, epilepsy, and sleeping problems in pregnant women.
I am the main supervisor for two doctoral students with research projects in this field:
·Felix Wittström
·Silvia Segovia ChacónAs well as two postdoctoral researchers:
My secondary interests include how psychiatric health influences reproductive health and vice versa, and in particular, the role of androgens in the etiology of mood disorders. I address these topics through studies on the comorbidity of psychiatric illness in women and their children with polycystic ovary syndrome, in collaboration with researchers at KI.[2]
Additionally, I am co-PI of UppStART – the "Uppsala-Stockholm Assisted Reproductive Techniques study", a prospective cohort study of couples who underwent infertility treatment in the greater Stockholm and Uppsala municipalities in 2011-2013.
My research is, or has been, funded by:
·Marie Skłodowska-Curie Actions Global Fellowship, European Commission, Horizon 2020
·Stiftelsen Söderström-Königska Sjukhemmet·Karolinska Institutet Research Foundation Grants
·Swedish Research Council for Health, Working Life and Welfare (FORTE)
·Swedish Research Council (Vetenskapsrådet)
[1] PMID: 38079178, 37343541, 36477338, 32870289, 39680408[2] PMID: 31792459, 33441551, 30857571, 27513883, 40036632
Teaching
I have over 300 hours of teaching including supervision, lecturing, and seminar leading at bachelor, masters, and doctoral level at KI:
·2014–2022, Group leader, Medical Program, Scientific Development and Scientific Methodology courses
·2017-2021, Seminar leader, Research School for Clinicians in Epidemiology
·2019, 2020, Seminar leader and examiner, Global Masters Programme in Global Health
·2019, Teaching assistant and examiner, Register-based research: Pharmacoepidemiology - drug use and safety
·2019, 2021, 2023, Lecturer, Basic Pharmacoepidemiology in a Global Context
·2019, 2021, 2022, 2024, Lecturer, Epidemiology I: Introduction to EpidemiologyI am the course director for the new KI doctoral course: K2F6033 Pharmacoepidemiology: Drug Exposure Definitions and Study Design Approaches in Register-Based Data held for the first time in VT2025.
Additionally, I have supervised 4 students for their Term 8 Degree Project in Medicine, Medical Programme, and 3 students for their Degree Project in the Masters Programme in Public Health Sciences - Epidemiology.
Selected publications
- Article: PAEDIATRIC AND PERINATAL EPIDEMIOLOGY. 2024;38(6):521-531Chacon SS; Karlsson P; Cesta CE
- Article: JAMA INTERNAL MEDICINE. 2024;184(2):144-152Cesta CE; Rotem R; Bateman BT; Chodick G; Cohen JM; Furu K; Gissler M; Huybrechts KF; Kjerpeseth LJ; Leinonen MK; Pazzagli L; Zoega H; Seely EW; Patorno E; Hernandez-Diaz S
- Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2023;32(12):1350-1359Cesta CE; Hernandez-Diaz S; Huybrechts KF; Bateman BT; Vine S; Seely EW; Patorno E
- Article: DIABETES CARE. 2023;46(8):1556-1564Kjerpeseth LJ; Cesta CE; Furu K; Engeland A; Gissler M; Gulseth HL; Karlstad O; Leinonen MK; Pazzagli L; Zoega H; Cohen JM
- Journal article: NORSK EPIDEMIOLOGI. 2021;29(1-2)Cohen JM; Cesta CE; Kjerpeseth L; Leinonen MK; Hálfdánarson Ó; Karlstad Ø; Karlsson P; Andersen M; Furu K; Hjellvik V
Articles
- Article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2025;79(8):571-579Joneus P; Pasternak B; Odsbu I; Cesta CE; Bellocco R; Lagerros YT; Pazzagli L
- Article: ANESTHESIOLOGY. 2025;142(6):1100-1113Brett J; Cesta CE; Gillies MB; Bateman BT; Chan AYL; Cheng MC-Y; Cho Y; Choi E; Cohen JM; Donald S; Furu K; Gissler M; Gomes T; Havard A; Hernandez-Diaz S; Hsieh MHC; Huybrechts KF; Karlsson P; Kelty E; Lai ECC; Ledlie S; Wang T; Leinonen MK; Parkin L; Reutfors J; Shin J-Y; Su CTT; Varney B; Wong ICK; Man KKC; Zoega H
- Article: JAMA INTERNAL MEDICINE. 2025;185(6):656-667Tran DT; Cohen JM; Donald S; Cesta CE; Furu K; Parkin L; Pearson S-A; Reutfors J; Robijn AL; Zoega H; Zwar N; Havard A
- Journal article: PAEDIATRIC AND PERINATAL EPIDEMIOLOGY. 2025Srinivas C; Karlstad O; Stigum H; Furu K; Cesta CE; Reutfors J; Hutcheon JA; Cohen JM
- Article: CTS-CLINICAL AND TRANSLATIONAL SCIENCE. 2025;18(3):e70174Pazzagli L; Odsbu I; Cesta CE; Bellocco R; Lagerros YT; Pasternak B
- Journal article: ECLINICALMEDICINE. 2025;81:103139Bruno C; Cesta CE; Hjellvik SV; Ulrichsen P; Bjork M-H; Esen BO; Gillies MB; Gissler M; Havard A; Karlstad O; Leinonen MK; Norgaard M; Pearson S-A; Reutfors J; Furu K; Cohen JM; Zoega H
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2025;:dgaf121Kanina A; Stener-Victorin E; Butwicka A; Oberg AS; Rosenqvist MA; Cesta CE
- Article: THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS. 2025;18:17562864241310996Hellwig K; Magyari M; Macdonald TM; Cesta CE; Wergeland S; Leinonen MK; Ornoy A; Vukusic S; Lauer A; Zhou X; Kawai A; Weinrib R; Arana A; Boumenna T
- Journal article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2025;34(1)Cesta CE; Broms G; Furu K; Hernandez-Diaz S; Huybrechts KF; Stephansson O; Zoega H
- Journal article: DEPRESSION AND ANXIETY. 2025;2025(1):8226088Opatowski M; Deng J; Yang Q; Oberg AS; Cesta CE; Lu D
- Article: JAMA NETWORK OPEN. 2024;7(12):e2451117Wittstroem F; Cesta CE; Bateman BT; Bendix M; Bliddal M; Chan AYL; Cho Y; Choi E-Y; Cohen JM; Donald S; Gissler M; Havard A; Hernandez-Diaz S; Huybrechts KF; Kollhorst B; Lai EC-C; Leinonen MK; Li BMH; Man KKC; Ng VWS; Parkin L; Pazzagli L; Rasmussen L; Rotem RS; Schink T; Shin J-Y; Tran DT; Wong ICK; Zoega H; Reutfors J
- Article: MULTIPLE SCLEROSIS JOURNAL. 2024;30(14):1765-1774Jiang Y; Cesta CE; Liu Q; Kingwell E; Stridh P; Shchetynsky K; Olsson T; Kockum I; Stener-Victorin E; Jiang X; Manouchehrinia A
- Article: JAMA NETWORK OPEN. 2024;7(11):e2445055Nakitanda AO; Odsbu I; Cesta CE; Pazzagli L; Pasternak B
- Article: JAMA NETWORK OPEN. 2024;7(10):e2438269Cesta CE; Reutfors J; Cohen JM; Eriksson J; Furu K; Zoega H; Pazzagli L
- Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2024;33(8):e5878Karlsson P; Gembert K; Esslinger S; Geldhof A; Gissler M; Leinonen MK; Otero-Lobato M; Pedersen L; Cesta CE
- Article: ANNALS OF INTERNAL MEDICINE. 2024;177(7):862-870Chiu Y-H; Huybrechts KF; Patorno E; Yland JJ; Cesta CE; Bateman BT; Seely EW; Hernan MA; Hernandez-Diaz S
- Article: JAMA NETWORK OPEN. 2024;7(6):e2419245Robijn AL; Tran DT; Cohen JM; Donald S; Cesta CE; Furu K; Parkin L; Pearson S-A; Reutfors J; Zoega H; Zwar N; Havard A
- Article: NATURE MEDICINE. 2024;30(5):1416-1423Chan AYL; Gao L; Hsieh MH-C; Kjerpeseth LJ; Avelar R; Banaschewski T; Chan AHY; Coghill D; Cohen JM; Gissler M; Harrison J; Ip P; Karlstad O; Lau WCY; Leinonen MK; Leung WC; Liao T-C; Reutfors J; Shao S-C; Simonoff E; Tan KCB; Taxis K; Tomlin A; Cesta CE; Lai EC-C; Zoega H; Man KKC; Wong ICK
- Article: ECLINICALMEDICINE. 2024;70:102531Bruno C; Cesta CE; Hjellvik V; Ulrichsen SP; Bjork M-H; Esen BO; Gillies MB; Gissler M; Havard A; Karlstad O; Leinonen MK; Norgaard M; Pearson S-A; Reutfors J; Furu K; Cohen JM; Zoega H
- Article: CONTRACEPTION. 2024;131:110309Linder M; Schoendorf J; Pisa F; Schulze-Rath R; Cesta CE
- Article: NEUROLOGY. 2024;102(2):e207996Cohen JM; Alvestad S; Suarez EA; Schaffer A; Selmer RM; Havard A; Bateman BT; Cesta CE; Zoega H; Odsbu I; Huybrechts KF; Kjerpeseth LJ; Straub L; Leinonen MK; Bjork M-H; Norgaard M; Gissler M; Ulrichsen SP; Hernandez-Diaz S; Tomson T; Furu K
- Article: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2023;32(10):2049-2056Sorensen AMS; Wesselhoft R; Andersen JH; Reutfors J; Cesta CE; Furu K; Hartz I; Rasmussen L
- Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2023;32(10):1152-1160Srinivas C; Karlstad O; Stigum H; Furu K; Cesta CE; Reutfors J; Cohen JM
- Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2023;79(9):1261-1269Asplund AB; Skold PD; Lind LK; Cesta CE; Dahl ML; Jonsson EW; Andersson ML
- Article: ANNALS OF NEUROLOGY. 2023;93(3):551-562Cohen JM; Alvestad S; Cesta CE; Bjork M-H; Leinonen MK; Norgaard M; Einarsdottir K; Engeland A; Gissler M; Karlstad O; Klungsoyr K; Odsbu I; Reutfors J; Selmer RM; Tomson T; Ulrichsen SP; Zoega H; Furu K
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2023;323:292-298Tiger M; Wesselhoeft R; Karlsson P; Handal M; Bliddal M; Cesta CE; Skurtveit S; Reutfors J
- Article: JAMA PSYCHIATRY. 2023;80(2):156-166Huybrechts KF; Straub L; Karlsson P; Pazzagli L; Furu K; Gissler M; Hernandez-Diaz S; Norgaard M; Zoega H; Bateman BT; Cesta CE; Cohen JM; Leinonen MK; Reutfors J; Selmer RM; Suarez EA; Ulrichsen SP; Kieler H
- Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2023;79(1):173-180Cohen JM; Srinivas C; Furu K; Cesta CE; Reutfors J; Karlstad O
- Article: PLOS ONE. 2022;17(8):e0272046Pazzagli L; Chacon SS; Karampelias C; Cohen JM; Broms G; Kieler H; Odsbu I; Selmer R; Andersson O; Cesta CE
- Article: BMC INFECTIOUS DISEASES. 2022;22(1):492Nakitanda AO; Karlsson P; Lofling L; Cesta CE; Odsbu I
- Article: OBSTETRICS AND GYNECOLOGY. 2022;139(5):764-770Kopp-Kallner H; Linder M; Cesta CE; Chacon SS; Kieler H; Graner S
- Article: EVIDENCE-BASED MENTAL HEALTH. 2022;25(2):54-62Halfdanarson O; Cohen JM; Karlstad O; Cesta CE; Bjork M-H; Haberg SE; Einarsdottir K; Furu K; Gissler M; Hjellvik V; Kieler H; Leinonen MK; Norgaard M; Essen BO; Ulrichsen SP; Reutfors J; Zoega H
- Journal article: ZEITSCHRIFT FUR GESUNDHEITSWISSENSCHAFTEN. 2022;30(4):911-912Zhao L; Cesta CE; Pazzagli L
- Article: PEDIATRIC DIABETES. 2021;22(7):969-973Pazzagli L; Karampelias C; Selmer R; Andersson O; Cesta CE
- Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2021;100(11):2111-2118Cesta CE; Chacon SS; Engeland A; Broe A; Damkier P; Furu K; Kieler H; Karlsson P
- Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2021;87(11):4470-4475Jensen HK; Rasmussen L; Furu K; Karlstad O; Linder M; Cesta CE; Pottegard A
- Article: NATURE COMMUNICATIONS. 2021;12(1):3362Karampelias C; Rezanejad H; Rosko M; Duan L; Lu J; Pazzagli L; Bertolino P; Cesta CE; Liu X; Korbutt GS; Andersson O
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):45Risal S; Manti M; Lu H; Fornes R; Larsson H; Benrick A; Deng Q; Cesta CE; Rosenqvist MA; Stener-Victorin E
- Article: PLOS ONE. 2021;16(8):e0253944Karlsson P; Nakitanda AO; Lofling L; Cesta CE
- Article: CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE. 2020;65(12):845-853Wall-Wieler E; Robakis TK; Cesta CE; Masarwa R; Lyell DJ; Liu C; Platt RW; Carmichael SL
- Article: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2020;254:271-276Pazzagli L; Abdi L; Kieler H; Cesta CE
- Journal article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2020;324(9):895-897Cesta CE; Engeland A; Karlsson P; Kieler H; Reutfors J; Furu K
- Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2020;29(8):913-922Cohen JM; Cesta CE; Furu K; Einarsdottir K; Gissler M; Havard A; Hernandez-Diaz S; Huybrechts KF; Kieler H; Leinonen MK; Li J; Reutfors J; Schaffer A; Selmer R; Yu Y; Zoega H; Karlstad O
- Article: SCHIZOPHRENIA RESEARCH. 2020;220:106-115Reutfors J; Cesta CE; Cohen JM; Bateman BT; Brauer R; Einarsdottir K; Engeland A; Furu K; Gissler M; Havard A; Hernandez-Diaz S; Huybrechts KF; Karlstad O; Leinonen MK; Li J; Man KKC; Pazzagli L; Schaffer A; Schink T; Wang Z; Yu Y; Zoega H; Broms G
- Article: PSYCHOLOGICAL MEDICINE. 2020;50(4):616-624Cesta CE; Oberg AS; Ibrahimson A; Yusuf I; Larsson H; Almqvist C; D'Onofrio BM; Bulik CM; Fernandez de la Cruz L; Mataix-Cols D; Landen M; Rosenqvist MA
- Article: NATURE MEDICINE. 2019;25(12):1894-1904Risal S; Pei Y; Lu H; Manti M; Fornes R; Pui H-P; Zhao Z; Massart J; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; de Guevara AL; Sir-Petermann T; Larsson H; Rosenqvist MA; Cesta CE; Benrick A; Deng Q; Stener-Victorin E
- Article: BMJ OPEN. 2019;9(8):e028866Iliadou AN; Oberg AS; Pege J; Rodriguez-Wallberg KA; Olofsson JI; Holte J; Wramsby H; Wramsby M; Cnattingius S; Cesta CE
- Article: PLOS ONE. 2019;14(8):e0221015Joelsson LS; Elenis E; Wanggren K; Berglund A; Iliadou AN; Cesta CE; Mumford SL; White R; Tyden T; Skalkidou A
- Article: BMJ OPEN DIABETES RESEARCH & CARE. 2019;7(1):e000759Cesta CE; Cohen JM; Pazzagli L; Bateman BT; Broms G; Einarsdottir K; Furu K; Havard A; Heino A; Hernandez--Diaz S; Huybrechts KF; Karlstad O; Kieler H; Li J; Leinonen MK; Gulseth HL; Duong T; Yu Y; Zoega H; Odsbu I
- Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2018;97(3):258-268Cesta CE; Johansson ALV; Hreinsson J; Rodriguez-Wallberg KA; Olofsson JI; Holte J; Wramsby H; Wramsby M; Cnattingius S; Skalkidou A; Iliadou AN
- Article: PSYCHONEUROENDOCRINOLOGY. 2017;85:63-68Cesta CE; Kuja-Halkola R; Lehto K; Iliadou AN; Landen M
- Article: PSYCHONEUROENDOCRINOLOGY. 2016;73:196-203Cesta CE; Mansson M; Palm C; Lichtenstein P; Iliadou AN; Landen M
- Article: FERTILITY AND STERILITY. 2016;105(6):1594-1602.e3Cesta CE; Viktorin A; Olsson H; Johansson V; Sjolander A; Bergh C; Skalkidou A; Nygren K-G; Cnattingius S; Iliadou AN
- Article: ENDOCRINE. 2009;36(2):281-290Petrik JJ; Gerstein HC; Cesta CE; Kellenberger LD; Alfaidy N; Holloway AC
- Article: REPRODUCTIVE SCIENCES. 2009;16(9):875-882Gruslin A; Cesta CE; Bell M; Qiu Q; Petre MA; Holloway AC
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All other publications
- Preprint: MEDRXIV. 2025de Bruin O; Maisonneuve E; Hurley E; Nordeng HM; Bérard A; Sheehy O; Kaul P; Shinde MU; Cosgrove A; Lyons JG; Messenger-Jones E; Kempner ME; Toh S; Hua W; Hernández-Muñoz JJ; Sahin L; Cesta CE; Hägg D; Gini R; Paoletti O; Poblador-Plou B; Jordan S; Thayer D; Rodríguez-Bernal CL; Sánchez-Sáez F; Lassalle R; Bernard M-A; Alsina E; Ahmadizar F; Favre G; Panchaud A; Bloemenkamp KW; Plueschke K; de Vries C; Siiskonen SJ; Sturkenboom MC
Grants
- Swedish Research Council1 January 2025 - 31 December 2028Semaglutide and other GLP-1 receptor agonists (GLP-1 RA) have revolutionized the treatment of type 2 diabetes and obesity and their use in Sweden and globally has increased dramatically since 2020. Women are more likely to be overweight or obese which is associated with infertility and adverse pregnancy outcomes. GLP-1 RA may be an effective tool to lose weight before pregnancy and while it is advised that they are discontinued two months prior to conception, up to 50% of pregnancies are unplanned. Unintended GLP-1 RA exposure in early pregnancy is a real possibility and it is unknown if they increase the risk of malformations in infants. Additionally, even if GLP-1 RA are discontinued as recommended, there is a chance of excessive weight gain in pregnancy which is associated with adverse pregnancy outcomes, such as gestational diabetes.This project aims to fill this knowledge gap through observational studies using a common protocol in data from Swedish population health registers and from other Nordic and international collaborators. First, utilization patterns and characteristics of women using GLP-1 RA will be described. Then the risk for adverse pregnancy outcomes will be compared between exposed and unexposed pregnancies from women with similar body mass index. High quality evidence will be generated in a timely manner to help avoid unnecessary harm. Results may also provide reassurance to those who can benefit from these new pharmacotherapies.
- Swedish Research Council for Health Working Life and Welfare1 January 2022 - 31 December 2024
- InPreSS – International Pregnancy Safety StudyMarie Skłodowska-Curie Actions Global Fellowship, , European Commission, Horizon 20201 September 2020 - 4 March 2023
Employments
- Assistant Professor, Department of Medicine, Karolinska Institutet, 2023-2029
Degrees and Education
- Docent, Karolinska Institutet, 2024
- Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2017