Brun Ulfhake

Brun Ulfhake

Professor, Senior
Visiting address: Alfred Nobels allé 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klin Fysiologi, 141 52 Huddinge

About me

  • Brun Ulfhake was born in Stockholm in 1952, and received his M.D. from Karolinska Institutet in 1980. He combined his medical studies with researching. In 1982 he received his Ph.D. with a dissertation about electrical characteristics, function and structure in central nerve cells. Thereafter he was active in the clinic as an anesthesiologist and diving physician, while at the same time he carried out neurobiological research at Karolinska Institutet. In 1988 he was appointed Associate Professor, and in 1994 was appointed University Lecturer. For a period in the beginning of the 1990s, Brun Ulfhake was a postdoctor with NIH in USA, and since 1991 has carried out research at Karolinska Institutet on the connection between our genetic material and changes in the function of the nerve system during aging. Brun Ulfhake was appointed Professor in Anatomy at Karolinska Institutet on March 1, 2001. In August 2019 Brun Ulfhake retired from the professorship in Anatomy at the Department of Neuroscience and was re-hired as senior professor at the Department of Laboratory medicine
    Brun Ulfhake has had a number of engagements within both teaching at Karolinska institutet as the Director of Anatomy Education, as well as being engaged in laboratory animal ethical matters. Between January 1, 2013, and March 2018, Brun Ulfhake served as the Director for Comparative Medicine.


  • Aging is inescapable, but at the same time an unequal process where certain persons live well over 100 years, while others have a much shorter life. The deciding factor is the integration of our genetic material and our behavior with random and fixed environmental factors and epigenetic changes. The research aims at creating understanding for which genes and the regulation thereof that lie behind those deficiencies in function that arise with increasing age. This knowledge can then be used to alleviate the negative consequences of aging for the individual.
    Recent publications:
    1. A systematic review of the development and application of home cage monitoring in laboratory mice and rats.
    Kahnau P, Mieske P, Wilzopolski J, Kalliokoski O, Mandillo S, Hölter SM, Voikar V, Amfim A, Badurek S, Bartelik A, Caruso A, Čater M, Ey E, Golini E, Jaap A, Hrncic D, Kiryk A, Lang B, Loncarevic-Vasiljkovic N, Meziane H, Radzevičienė A, Rivalan M, Scattoni ML, Torquet N, Trifkovic J, Ulfhake B, Thöne-Reineke C, Diederich K, Lewejohann L, Hohlbaum K.
    BMC Biol. 2023 Nov 13
  • 21(1):256. doi: 10.1186/s12915-023-01751-7.
    PMID: 37953247
    2. The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods.
    van Beuningen N, Alkema S, Hijlkema N, Ulfhake B, Frias R, Ritskes-Hoitinga M, Alkema W.
    Altern Lab Anim. 2023 Nov
  • 51(6):376-386. doi: 10.1177/02611929231210777. Epub 2023 Oct 21.
    PMID: 37864460
    3. Emergence and Progression of Behavioral Motor Deficits and Skeletal Muscle Atrophy across the Adult Lifespan of the Rat.
    GrönholdtKlein M, Gorzi A, Wang L, Edström E, Rullman E, Altun M, Ulfhake B.
    Biology (Basel). 2023 Aug 28
  • 12(9):1177. doi: 10.3390/biology12091177.
    PMID: 37759577 Free PMC article.
    4. Bouts of rest and physical activity in C57BL/6J mice.
    Pernold K, Rullman E, Ulfhake B.
    PLoS One. 2023 Jun 26
  • 18(6):e0280416. doi: 10.1371/journal.pone.0280416. eCollection 2023.
    PMID: 37363906 Free PMC article.
    5. A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change.
    Ulfhake B, Lerat H, Honetschlager J, Pernold K, Rynekrová M, Escot K, Recordati C, Kuiper RV, Rosati G, Rigamonti M, Zordan S, Prins JB.
    PLoS One. 2022 May 25
  • 17(5):e0267281. doi: 10.1371/journal.pone.0267281. eCollection 2022.
    PMID: 35613182 Free PMC article.
    6. Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms.
    Zhu R, Yan T, Feng Y, Liu Y, Cao H, Peng G, Yang Y, Xu Z, Liu J, Hou W, Wang X, Li Z, Deng L, Wang S, Li J, Han Q, Li H, Shan G, Cao Y, An X, Yan J, Zhang Z, Li H, Qu X, Zhu J, Zhou S, Wang J, Zhang F, Gao J, Jin R, Xu D, Ma YQ, Huang T, Peng S, Zheng Z, Stambler I, Gilson E, Lim LW, Moskalev A, Cano A, Chakrabarti S, Ulfhake B, Su H, Xu H, Xu S, Wei F, Brown-Borg HM, Min KJ, Ellison-Hughes G, Caruso C, Jin K, Zhao RC.
    Cell Res. 2021 Dec
  • 31(12):1244-1262. doi: 10.1038/s41422-021-00573-y. Epub 2021 Oct 26.
    PMID: 34702946 Free PMC article.
    7. Sarcopenia: What Is the Origin of This Aging-Induced Disorder?
    Gustafsson T, Ulfhake B.
    Front Genet. 2021 Jul 2
  • 12:688526. doi: 10.3389/fgene.2021.688526. eCollection 2021.
    PMID: 34276788 Free PMC article. Review.
    8. Major oscillations in spontaneous home-cage activity in C57BL/6 mice housed under constant conditions.
    Pernold K, Rullman E, Ulfhake B.
    Sci Rep. 2021 Mar 2
  • 11(1):4961. doi: 10.1038/s41598-021-84141-9.
    PMID: 33654141 Free PMC article.
    9. Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice.
    Talamonti E, Sasso V, To H, Haslam RP, Napier JA, Ulfhake B, Pernold K, Asadi A, Hessa T, Jacobsson A, Chiurchiù V, Viscomi MT.
    FASEB J. 2020 Feb
  • 34(2):2024-2040. doi: 10.1096/fj.201901890RR. Epub 2019 Dec 11.
    PMID: 31909582 Free PMC article.
    10. Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging-The ULSAM Cohort Revisited.
    Skoglund E, Grönholdt-Klein M, Rullman E, Thornell LE, Strömberg A, Hedman A, Cederholm T, Ulfhake B, Gustafsson T.
    J Gerontol A Biol Sci Med Sci. 2020 Mar 9
  • 75(4):654-663. doi: 10.1093/gerona/glz068.
    PMID: 31002330
    11. Muscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crush.
    Grönholdt-Klein M, Altun M, Becklén M, Dickman Kahm E, Fahlström A, Rullman E, Ulfhake B.
    Acta Physiol (Oxf). 2019 Nov
  • 227(3):e13335. doi: 10.1111/apha.13335. Epub 2019 Jul 2.
    PMID: 31199566
    12. Towards large scale automated cage monitoring - Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique.
    Pernold K, Iannello F, Low BE, Rigamonti M, Rosati G, Scavizzi F, Wang J, Raspa M, Wiles MV, Ulfhake B.
    PLoS One. 2019 Feb 4
  • 14(2):e0211063. doi: 10.1371/journal.pone.0211063. eCollection 2019.
    PMID: 30716111 Free PMC article.


All other publications


News from KI

Events from KI