Bertil Fredholm

About me
Publications
CV
Public outreach and news

About me

Professor Emeritus of Pharmacology at the Department of Physiology and Pharmacology

Research

My research is about Adenosine and its receptors, pathophysiological significance and therapeutic opportunities. For more information se group page.

Articles

Article: PARKINSONISM & RELATED DISORDERS. 2020;80:S3-S6

Why target brain adenosine receptors? A historical perspective

Fredholm BB; Svenningsson P
Article: SCIENTIFIC REPORTS. 2017;7(1):11458

Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth

Yu NY; Bieder A; Raman A; Mileti E; Katayama S; Einarsdottir E; Fredholm BB; Falk A; Tapia-Paez I; Daub CO; Kere J
Article: PLOS ONE. 2017;12(1):e0170545

Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

Winerdal M; Urmaliya V; Winerdal ME; Fredholm BB; Winqvist O; Aden U
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(7):e003868

Genetic Abrogation of Adenosine A₃ Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension

Yang T; Zollbrecht C; Winerdal ME; Zhuge Z; Zhang X-M; Terrando N; Checa A; Sallstrom J; Wheelock CE; Winqvist O; Harris RA; Larsson E; Persson AEG; Fredholm BB; Carlstrom M
Article: PURINERGIC SIGNALLING. 2016;12(1):89-101

Adenosine A₁ receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury

Winerdal M; Winerdal ME; Wang Y-Q; Fredholm BB; Winqvist O; Aden U
Article: DIABETOLOGIA. 2015;58(7):1610-1620

Abrogation of adenosine A₁ receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses

Yang T; Gao X; Sandberg M; Zollbrecht C; Zhang X-M; Hezel M; Liu M; Peleli M; Lai E-Y; Harris RA; Persson AEG; Fredholm BB; Jansson L; Carlstrom M
Article: FRONTIERS IN PHYSIOLOGY. 2015;6:222

In adenosine A_2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver

Peleli M; Hezel M; Zollbrecht C; Persson AEG; Lundberg JO; Weitzberg E; Fredholm BB; Carlstrom M
Article: ACTA PHYSIOLOGICA. 2014;210(3):590-599

Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors

Yang J; Zheng X; Haugen F; Dare E; Lovdahl C; Schulte G; Fredholm BB; Valen G
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2014;92(3):201-206

Adenosine-a physiological or pathophysiological agent?

Fredholm BB
Article: ACTA PHYSIOLOGICA. 2014;210(2):440-445

Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice

Saellstroem J; Eriksson T; Fredholm BB; Persson AEG; Palm F
Article: LAKARTIDNINGEN. 2012;109(49-50):2274-2275

[The Nobel Prize to detailed studies of G protein-coupled receptors. This years Nobel Prize in chemistry provides important knowledge--but it might take a while before it can be practically applied].

Fredholm BB
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;303(2):E180-E190

Improved blood glucose disposal and altered insulin secretion patterns in adenosine A₁ receptor knockout mice

Yang GK; Fredholm BB; Kieffer TJ; Kwok YN
Article: EUROPEAN REVIEW. 2012;20(3):316-323

How Drugs can Stimulate Psychic Functions - Using Caffeine as an Example

Fredholm BB
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2011;301(6):R1669-R1681

Adenosine A₁-receptor deficiency diminishes afferent arteriolar and blood pressure responses during nitric oxide inhibition and angiotensin II treatment

Gao X; Patzak A; Sendeski M; Scheffer PG; Teerlink T; Sallstrom J; Fredholm BB; Persson AEG; Carlstrom M
Article: JOURNAL OF NEUROSCIENCE. 2011;31(45):16327-16335

CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents

Cipriani R; Villa P; Chece G; Lauro C; Paladini A; Micotti E; Perego C; De Simoni M-G; Fredholm BB; Eusebi F; Limatola C
Article: JOURNAL OF NEUROSCIENCE. 2011;31(27):10067-10075

Arousal Effect of Caffeine Depends on Adenosine A_2A Receptors in the Shell of the Nucleus Accumbens

Lazarus M; Shen H-Y; Cherasse Y; Qu W-M; Huang Z-L; Bass CE; Winsky-Sommerer R; Semba K; Fredholm BB; Boison D; Hayaishi O; Urade Y; Chen J-F
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(7):2679-2683

A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors

Masino SA; Li T; Theofilas P; Sandau US; Ruskin DN; Fredholm BB; Geiger JD; Aronica E; Boison D
Article: DIABETES. 2011;60(2):669-679

Links Between Insulin Resistance, Adenosine A_2B Receptors, and Inflammatory Markers in Mice and Humans

Figler RA; Wang G; Srinivasan S; Jung DY; Zhang Z; Pankow JS; Ravid K; Fredholm B; Hedrick CC; Rich SS; Kim JK; LaNoue KF; Linden J
Article: BRAIN RESEARCH. 2011;1367:310-318

Deletion of adenosine A₁ or A_2A receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease

Xiao D; Cassin JJ; Healy B; Burdett TC; Chen J-F; Fredholm BB; Schwarzschild MA
Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2011;(200):1-9

Notes on the history of caffeine use.

Fredholm BB
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2011;336(1):77-86

Involvement of Adenosine Signaling in Controlling the Release of Ghrelin from the Mouse Stomach

Yang GK; Yip L; Fredholm BB; Kieffer TJ; Kwok YN
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2010;299(5):R1263-R1268

High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases

Sallstrom J; Carlstrom M; Olerud J; Fredholm BB; Kouzmine M; Sandler S; Persson AEG
Article: NEUROSCIENCE. 2010;170(3):923-928

PERIPHERAL ADENOSINE A_2A RECEPTORS ARE INVOLVED IN CARRAGEENAN-INDUCED MECHANICAL HYPERALGESIA IN MICE

Li L; Hao JX; Fredholm BB; Schulte G; Wiesenfeld-Hallin Z; Xu XJ
Article: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION. 2010;30(5):284-286

International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?

Kenakin T; Agnati LF; Caron M; Fredholm B; Guidoli D; Kobilka B; Lefkowitz RW; Lohse M; Woods A; Fuxe K
Article: FASEB JOURNAL. 2010;24(7):2325-2333

Adenosine A₁ receptors (A₁Rs) play a critical role in osteoclast formation and function

Kara FM; Chitu V; Sloane J; Axelrod M; Fredholm BB; Stanley ER; Cronstein BN
Article: NEUROPSYCHOPHARMACOLOGY. 2010;35(7):1550-1559

Adenosine A₁ Receptors and Microglial Cells Mediate CX3CL1-Induced Protection of Hippocampal Neurons Against Glu-Induced Death

Lauro C; Cipriani R; Catalano M; Trettel F; Chece G; Brusadin V; Antonilli L; van Rooijen N; Eusebi F; Fredholm BB; Limatola C
Article: ACTA PHYSIOLOGICA. 2010;199(2):211-220

Adenosine A₁ receptors and vascular reactivity

Wang Y; Yang JN; Arner A; Boels PJM; Fredholm BB
Article: ACTA PHYSIOLOGICA. 2010;199(2):221-230

Adenosine A₃ receptors regulate heart rate, motor activity and body temperature

Yang JN; Wang Y; Garcia-Roves PM; Bjornholm M; Fredholm BB
Article: NEUROSCIENCE LETTERS. 2010;473(3):178-181

Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A₁ receptors: Insights using knockout mice

Sawynok J; Reid AR; Fredholm BB
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(2):534-541

Adenosine A₁ Receptors Regulate Bone Resorption in Mice Adenosine A₁ Receptor Blockade or Deletion Increases Bone Density and Prevents Ovariectomy-Induced Bone Loss in Adenosine A₁ Receptor-Knockout Mice

Kara FM; Doty SB; Boskey A; Goldring S; Zaidi M; Fredholm BB; Cronstein BN
Article: AMBIO. 2010;39(Suppl 1):31-35

Fuels for Transportation

Fredholm BB; Norden B
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;215(1-2):36-42

LTP impairment by fractalkine/CX₃CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A₃R)

Maggi L; Trettel F; Scianni M; Bertollini C; Eusebi F; Fredholm BB; Limatola C
Article: LIFE SCIENCES. 2009;85(11-12):470-476

Absence of adenosine A₁ receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin

Salehi A; Parandeh F; Fredholm BB; Grapengiesser E; Hellman B
Article: PHYSIOLOGICAL GENOMICS. 2009;37(3):199-210

Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A_2A receptor knockout mice with microarray profiling

Yu L; Coelho JE; Zhang X; Fu Y; Tillman A; Karaoz U; Fredholm BB; Weng Z; Chen J-F
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2009;296(4):H1141-H1149

Physiological roles of A₁ and A_2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine

Yang J-N; Chen J-F; Fredholm BB
Article: FREE RADICAL RESEARCH. 2009;43(3):304-311

A₁ and A₃ adenosine receptors alter glutathione status in an organ-specific manner and influence the changes after inhibition of γ-glutamylcysteine ligase

Conte C; Grottelli S; Prudenzi E; Bellezza I; Fredholm BB; Minelli A
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2009;106(2):631-639

Mice heterozygous for both A₁ and A_2A adenosine receptor genes show similarities to mice given long-term caffeine

Yang J-N; Bjorklund O; Lindstrom-Tornqvist K; Lindgren E; Eriksson TM; Kahlstrom J; Chen J-F; Schwarzschild MA; Tobler I; Fredholm BB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19992-19997

Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A₁ receptors and promotes non-rapid eye movement sleep

Oishi Y; Huang Z-L; Fredholm BB; Urade Y; Hayaishi O
Article: PHYSIOLOGY & BEHAVIOR. 2008;95(5):668-676

Decreased behavioral activation following caffeine, amphetamine and darkness in A₃ adenosine receptor knock-out mice

Bjorklund O; Halldner-Henriksson L; Yang J; Eriksson TM; Jacobson MA; Dare E; Fredholm BB
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;597(1-3):92-101

Adenosine A₁ receptors regulate lipolysis and lipogenesis in mouse adipose tissue - Interactions with insulin

JohanssonA SM; Lindgren E; Yang J-N; Herling AW; Fredholm BB
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;596(1-3):6-13

Adenosine A₁ and A₃ receptors protect astrocytes from hypoxic damage

Bjorklund O; Shang M; Tonazzini I; Dare E; Fredholm BB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(39):15118-15123

Adenosine receptor antagonists alter the stability of human epileptic GABA_A receptors

Roseti C; Martinello K; Fucile S; Piccari V; Mascia A; Di Gennaro G; Quarato PP; Manfredi M; Esposito V; Cantore G; Arcella A; Simonato M; Fredholm BB; Limatola C; Miledi R; Eusebi F
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;590(1-3):36-42

Adenosine A_2A receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC

Brand F; Klutz AM; Jacobson KA; Fredholm BB; Schulte G
Article: NEUROSCIENCE LETTERS. 2008;440(2):181-184

Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A₁ receptors

Sawynok J; Reid AR; Fredholm BB
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2008;122(1):107-113.e7

Adenosine induces airway hyperresponsiveness through activation of A₃ receptors on mast cells

Hua X; Chason KD; Fredholm BB; Deshpande DA; Penn RB; Tilley SL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(14):5609-5613

Postendocytotic traffic of the galanin R1 receptor:: A lysosomal signal motif on the cytoplasmic terminus

Xia S; Dun X-P; Hu P-S; Kjaer S; Zheng K; Qian Y; Solen C; Xu T; Fredholm B; Hokfelt T; Xu Z-QD
Article: MOLECULAR IMMUNOLOGY. 2008;45(8):2247-2254

Adenosine, through the A₁ receptor, inhibits vesicular MHC class I cross-presentation by resting DC

Chen L; Fredholm BB; Jondal M
Article: BIOCHEMICAL PHARMACOLOGY. 2008;75(4):931-941

Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A₁ receptor signalling in mammalian spermatozoa (Publication with Expression of Concern. See vol. 212, 2023)

Minelli A; Bellezza F; Collodel G; Fredholm BB
Article: PLOS ONE. 2008;3(12):e3977

Perinatal Caffeine, Acting on Maternal Adenosine A₁ Receptors, Causes Long-Lasting Behavioral Changes in Mouse Offspring

Bjorklund O; Kahlstrom J; Salmi P; Fredholm BB
Article: BIOCHEMICAL PHARMACOLOGY. 2007;74(11):1628-1635

A₁ receptor deficiency causes increased insulin and glucagon secretion in mice

Johansson SM; Salehi A; Sandstroem ME; Westerblad H; Lundquist I; Carlsson P-O; Fredholm BB; Katz A
Article: JOURNAL OF IMMUNOLOGY. 2007;179(11):7431-7438

1,3,7-trimethylxanthine (Caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism

Ohta A; Lukashev D; Jackson EK; Fredholm BB; Sitkovsky M
Article: TOXICOLOGY. 2007;241(3):119-133

The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration

Bjoerklund O; Kahlstroem J; Salmi P; Oegren SO; Vahter M; Chen J-F; Fredholm BB; Dare E
Article: NEURON GLIA BIOLOGY. 2007;3(4):353-366

Adenosine dysfunction in astrogliosis: cause for seizure generation?

Li T; Lan JQ; Fredholm BB; Simon RP; Boison D
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):15-20

Modulation of glial cell functions by adenosine receptors

Dare E; Schulte G; Karovic O; Hammarberg C; Fredholm BB
Article: ACTA PHYSIOLOGICA. 2007;190(3):253-259

Diabetes-induced hyperfiltration in adenosine A₁-receptor deficient mice lacking the tubuloglomerular feedback mechanism

Sallstrom J; Carlsson P-O; Fredholm BB; Larsson E; Persson AEG; Palm F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(23):9697-9702

A1 adenosine receptors play an essential role in protecting the embryo against hypoxia

Wendler CC; Amatya S; McClaskey C; Ghatpande S; Fredholm BB; Rivkees SA
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2007;581(2):693-708

G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells

Tabata T; Kawakami D; Hashimoto K; Kassai H; Yoshida T; Hashimotodani Y; Fredholm BB; Sekino Y; Aiba A; Kano M
Article: BIOCHEMICAL PHARMACOLOGY. 2007;73(5):694-708

Toxic effects of cobalt in primary cultures of mouse astrocytes -: Similarities with hypoxia and role of HIF-1α

Karovic O; Tonazzini I; Rebola N; Edstrom E; Lovdahl C; Fredholm BB; Dare E
Article: KIDNEY INTERNATIONAL. 2006;70(4):690-698

Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction

Lai EY; Patzak A; Steege A; Mrowka R; Brown R; Spielmann N; Persson PB; Fredholm BB; Persson AEG
Article: NEUROPHARMACOLOGY. 2006;51(2):272-282

NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A₁ receptors:: Evidence from knockout mice

Schotanus SM; Fredholm BB; Chergui K
Article: NEUROSCIENCE LETTERS. 2006;402(1-2):164-166

Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury

Wu W-P; Hao J-X; Fredholm BB; Wiesenfeld-Hallin Z; Xu X-J
Article: EXPERIMENTAL NEUROLOGY. 2006;200(1):184-190

Adenosine A₁ receptors are crucial in keeping an epileptic focus localized

Fedele DE; Li T; Lan JQ; Fredholm BB; Boison D
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2006;290(5):r1324-r1329

Influence of the adenosine A₁ receptor on blood pressure regulation and renin release

Brown RD; Thorén P; Steege A; Mrowka R; Sällström J; Skott O; Fredholm BB; Persson AEG
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2006;290(4):H1469-H1473

Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioning.

Lankford AR; Yang J-N; Rose'Meyer R; French BA; Matherne GP; Fredholm BB; Yang Z
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16(2):129-136

Combination of adenosine A₁ and A_2A receptor blocking agents induces caffeine-like locomotor stimulation in mice

Kuzmin A; Johansson B; Gimenez L; Ögren SO; Fredholm BB
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2005;82(3):495-505

Differences between A 68930 and SKF 82958 could suggest synergistic roles of D₁ and D₅ receptors

Nergårdh R; Oerther S; Fredholm BB
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2005;289(4):E562-E569

Susceptibility of the developing brain to acute hypoglycemia involving A1 adenosine receptor activation.

Kim M; Yu Z-X; Fredholm BB; Rivkees SA
Article: JOURNAL OF NEUROSCIENCE. 2005;25(37):8432-8438

Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons

Andersson M; Usiello A; Borgkvist A; Pozzi L; Dominguez C; Fienberg AA; Svenningsson P; Fredholm BB; Borrelli E; Greengard P; Fisone G
Article: BIOCHEMICAL PHARMACOLOGY. 2005;70(4):598-605

Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor

Johansson S; Fredholm BB; Hjort C; Morein T; Kull B; Hu PS
Article: NATURE NEUROSCIENCE. 2005;8(7):858-859

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.

Huang Z-L; Qu W-M; Eguchi N; Chen J-F; Schwarzschild MA; Fredholm BB; Urade Y; Hayaishi O
Article: SYNAPSE. 2005;57(1):8-16

Mice lacking the adenosine a, receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly

Giménez-Llort L; Masino SA; Diao LH; Fernández-Teruel A; Tobeña A; Halldner L; Fredholm BB
Article: BEHAVIOURAL BRAIN RESEARCH. 2005;161(1):82-87

Intake inhibition by NPY and CCK-8:: A challenge of the notion of NPY as an "Orexigen"

Ammar AA; Nergårdh R; Fredholm BB; Brodin U; Södersten P
Article: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2005;288(5):G972-G977

Luminal adenosine stimulates chloride secretion through A₁ receptor in mouse jejunum

Ghanem E; Lövdahl C; Daré E; Ledent C; Fredholm BB; Boeynaems JM; Van Driessche W; Beauwens R
Article: JOURNAL OF NEUROSCIENCE. 2005;25(11):2832-2837

The role of extracellular adenosine in regulating mossy fiber synaptic plasticity.

Kukley M; Schwan M; Fredholm BB; Dietrich D
Article: PAIN. 2005;113(3):395-404

Increased nociceptive response in mice lacking the adenosine A₁ receptor

Wu WP; Hao JX; Halldner L; Lövdahl C; DeLander GE; Wiesenfeld-Hallin Z; Fredholm BB; Xu XJ
Article: ACTA PHYSIOLOGICA. 2004;182(2):133-143

Adenosine A₁ receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia

Schulte G; Sommerschild H; Yang J; Tokuno S; Goiny M; Lövdahl C; Johansson B; Fredholm BB; Valen G
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2004;370(4):270-278

Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice:: evidence that CGS 21680 binds to A₁ receptors in hippocampus

Halldner L; Lopes LV; Daré E; Lindström K; Johansson B; Ledent C; Cunha RA; Fredholm BB
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2004;20(5):1197-1204

Deletion of the adenosine A₁ receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro

Olsson T; Cronberg T; Rytter A; Asztély F; Fredholm BB; Smith ML; Wieloch T
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2004;497(2):173-180

Neuromuscular blocking agents block carotid body neuronal nicotinic acetylcholine receptors

Jonsson M; Wyon N; Lindahl SGE; Fredholm BB; Eriksson LI
Article: NEUROPHARMACOLOGY. 2004;46(7):1008-1017

The adenosine A₁ receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion:: a study in mice lacking adenosine A₁ and/or A_2A receptors

Halldner L; Ådén U; Dahlberg V; Johansson B; Ledent C; Fredholm BB
Article: JOURNAL OF ANDROLOGY. 2004;25(2):286-292

Involvement of A₁ adenosine receptors in the acquisition of fertilizing capacity

Minelli A; Liguori L; Bellazza I; Mannucci R; Johansson B; Fredholm BB
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2004;141(6):1006-1014

Binding of the prototypical adenosine A_2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A₁ and A_2A receptor knockout mice

Lopes LV; Halldner L; Rebola N; Johansson B; Ledent C; Chen JF; Fredholm BB; Cunha RA
Article: BIOCHEMICAL PHARMACOLOGY. 2004;67(1):129-134

Adenosine A₃ receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3′-kinase

Hammarberg C; Fredholm BB; Schulte G
Article: JOURNAL OF SLEEP RESEARCH. 2003;12(4):283-290

Sleep and its homeostatic regulation in mice lacking the adenosine A₁ receptor

Stenberg D; Litonius E; Halldner L; Johansson B; Fredholm BB; Porkka-Heiskanen T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(20):11718-11722

A₁ adenosine receptors mediate hypoxia-induced ventriculomegaly

Turner CP; Seli M; Ment L; Stewart W; Yan HL; Johansson B; Fredholm BB; Blackburn M; Rivkees SA
Article: JOURNAL OF NEUROCHEMISTRY. 2003;86(4):1051-1054

Evidence for functional adenosine A₃ receptors in microglia cells

Hammarberg C; Schulte G; Fredholm BB
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;307(1):180-187

Adenosine A_2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells

Lynge J; Schulte G; Nordsborg N; Fredholm BB; Hellsten Y
Article: DRUG NEWS AND PERSPECTIVES. 2003;16(5):283-289

Adenosine receptors as targets for drug development.

Fredholm BB
Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2003;23(3):379-400

Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells.

Fredholm BB; Assender JW; Irenius E; Kodama N; Saito N
Article: STROKE. 2003;34(3):739-744

Aggravated brain damage after hypoxic ischemia in immature adenosine A_2A knockout mice

Ådén U; Halldner L; Lagercrantz H; Dalmau I; Ledent C; Fredholm BB
Article: NEUROSCIENCE. 2003;121(4):907-916

Distribution of antinociceptive adenosine a, receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations

Schulte G; Robertson B; Fredholm BB; Delander GE; Shortland P; Molander C
Article: NATURE. 2002;418(6899):774-778

Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine

Lindskog M; Svenningsson P; Pozzi L; Kim Y; Fienberg AA; Bibb JA; Fredholm BB; Nairn AC; Greengard P; Fisone G
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2002;16(3):547-550

Mice lacking the adenosine A₁ receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rat

Giménez-Llort L; Fernández-Teruel A; Escorihuela RM; Fredholm BB; Tobeña A; Pekny M; Johansson B
Article: STROKE. 2002;33(5):1405-1410

MRI evaluation and functional assessment of brain injury after hypoxic ischemia in neonatal mice

Ådén U; Dahlberg V; Fredholm BB; Lai LJ; Chen ZG; Bjelke B
Article: NATURE REVIEWS DRUG DISCOVERY. 2002;1(3):237-238

The role of pharmacology in drug discovery.

Fredholm BB; Fleming WW; Vanhoutte PM; Godfraind T
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2002;365(2):150-157

Anoxia redistributes adenosine A_2A receptors in PC12 cells and increases receptor-mediated formation of cAMP

Arslan G; Kull B; Fredholm BB
Article: NEUROSCIENCE. 2002;114(3):523-527

Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A₃ receptors

Wu WP; Hao JX; Halldner-Henriksson L; Xu XJ; Jacobson MA; Wiesenfeld-Hallin Z; Fredholm BB
Article: NEUROSCIENCE. 2002;112(2):319-329

Adenosine A_2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A₁ receptor inhibition

Lopes LV; Cunha RA; Kull B; Fredholm BB; Ribeiro JA
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2001;281(5):R1362-R1367

Abolished tubuloglomerular feedback and increased plasma renin in adenosine A₁ receptor-deficient mice

Brown R; Ollerstam A; Johansson B; Skott O; Gebre-Medhin S; Fredholm B; Persson AEG
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2001;426(3):185-192

Adenosine A₁ receptor agonism in the immature rat brain and heart

Ådén U; Leverin AL; Hagberg H; Fredholm BB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(16):9407-9412

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A₁ receptor

Johansson B; Halldner L; Dunwiddie TV; Masino SA; Poelchen W; Giménez-Llort L; Escorihuela RM; Fernández-Teruel A; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Betsholtz C; Herlenius E; Fredholm BB
Article: NEUROREPORT. 2001;12(8):1577-1580

Opposite changes in adenosine A₁ and A_2A receptor mRNA in the rat following sleep deprivation

Basheer R; Halldner L; Alanko L; McCarley RW; Fredholm BB; Porkka-Heiskanen T
Article: BIOCHEMICAL PHARMACOLOGY. 2001;61(4):443-448

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells

Fredholm BB; Irenius E; Kull B; Schulte G
Article: LAKARTIDNINGEN. 2001;98(6):534-539

[Pharmacology at the start of a new millennium. Larger assortment and individual drug dosing are coming].

Fredholm BB; Sjöqvist F
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2000;406(3):345-354

Lack of tolerance to motor stimulant effects of a selective adenosine A_2A receptor antagonist

Halldner L; Lozza G; Lindström K; Fredholm BB
Article: NEUROSCIENCE LETTERS. 2000;292(3):183-186

Stimulatory and inhibitory effects of adenosine A(2A) receptors on nerve growth factor-induced phosphorylation of extracellular regulated kinases 1/2 in PC12 cells.

Arslan G; Fredholm BB
Article: MOLECULAR PHARMACOLOGY. 2000;58(4):771-777

Adenosine A_2A receptors are colocalized with and activate G_olf in rat striatum

Kull B; Svenningsson P; Fredholm BB
Article: NEUROPHARMACOLOGY. 2000;39(12):2374-2380

GTP differentially affects antagonist radioligand binding to adenosine A₁ and A_2A receptors in human brain

Kull B; Svenningsson P; Hall H; Fredholm BB
Article: MOLECULAR PHARMACOLOGY. 2000;58(3):477-482

Human adenosine A₁, A_2A, A_2B, and A₃ receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2

Schulte G; Fredholm BB
Article: JOURNAL OF NEUROSCIENCE. 2000;20(16):5949-5957

Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors.

Zahniser NR; Simosky JK; Mayfield RD; Negri CA; Hanania T; Larson GA; Kelly MA; Grandy DK; Rubinstein M; Low MJ; Fredholm BB
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12(8):3026-3032

Differences in the effect of chronic and acute caffeine on self-administration of cocaine in mice

Kuzmin A; Johansson B; Semenova S; Fredholm BB
Article: PEDIATRIC RESEARCH. 2000;48(2):177-183

Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain

Ådén U; Herlenius E; Tang LQ; Fredholm BB
Article: BRAIN RESEARCH. 2000;872(1-2):44-53

Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats

Berman RF; Fredholm BB; Aden U; O'Connor WT
Article: JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM. 2000;81(1-3):82-86

Nitric oxide interacts with oxygen free radicals to evoke the release of adenosine and adenine nucleotides from rat hippocampal slices.

Broad RM; Fallahi N; Fredholm BB
Article: JOURNAL OF NEUROCHEMISTRY. 2000;75(1):248-257

Dopamine D₁ receptor-induced gene transcription is modulated by DARPP-32

Svenningsson P; Fienberg AA; Allen PB; Le Moine C; Lindskog M; Fisone G; Greengard P; Fredholm BB
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2000;130(2):471-477

Thyrotropin regulates adenosine A(1) receptor expression in rat thyroid FRTL-5 cells.

Vainio M; Fredholm BB; Törnquist K
Article: LAKARTIDNINGEN. 2000;97(17):2046-2048

[The journey from genome structure to cure of diseases is long and winding. Research specialists in molecular biology and physiology should cooperate].

Fredholm BB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(4):1856-1860

Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D₁, dopamine D₂, and adenosine A_2A receptors

Svenningsson P; Lindskog M; Ledent C; Parmentier M; Greengard P; Fredholm BB; Fisone G
Article: NEUROPHARMACOLOGY. 2000;39(3):482-496

P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells

Arslan G; Catalin CM; Irenius E; Kull B; Clementi E; Allgaier C; Erlinge D; Fredholm BB
Article: LIFE SCIENCES. 2000;66(8):PL113-PL118

Genetic evidence that cocaine and caffeine stimulate locomotion in mice via different mechanisms

Kuzmin A; Johansson B; Fredholm BB; Ögren SO
Article: NEUROSCIENCE. 2000;98(4):749-757

Co-stimulation of D₁/D₅ and D₂ dopamine receptors leads to an increase in c-fos messenger RNA in cholinergic interneurons and a redistribution of c-fos messenger RNA in striatal projection neurons

Svenningsson P; Fredholm BB; Bloch B; Le Moine C
Article: BIOCHEMICAL PHARMACOLOGY. 1999;58(6):1035-1045

Reciprocal interactions between adenosine A_2A and dopamine D₂ receptors in Chinese hamster ovary cells co-transfected with the two receptors

Kull B; Ferré S; Arslan G; Svenningsson P; Fuxe K; Owman C; Fredholm BB
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1999;380(2-3):197-202

Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A₁ and A_2A receptors

Fredholm BB; Lindström K
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1999;290(2):535-542

Caffeine, acting on adenosine A₁ receptors, prevents the extinction of cocaine-seeking behavior in mice

Kuzmin A; Johansson B; Zvartau EE; Fredholm BB
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(6):2182-2186

μ- and δ-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons

Lindskog M; Svenningsson P; Fredholm B; Greengard P; Fisone G
Article: JOURNAL OF NEUROSCIENCE. 1999;19(10):4011-4022

The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions

Svenningsson P; Nomikos GG; Fredholm BB
Article: NEUROCHEMISTRY INTERNATIONAL. 1999;34(3):235-244

Adenosine and dopamine receptor antagonist binding in the rat ventral and dorsal striatum:: lack of changes after a neonatal bilateral lesion of the ventral hippocampus

Lillrank SM; Lipska BK; Weinberger DR; Fredholm BB; Fuxe K; Ferré S
Article: NEUROSCIENCE. 1999;89(3):827-837

Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons

Svenningsson P; Fourreau L; Bloch B; Fredholm BB; Gonon F; Le Moine C
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1999;359(1):7-10

Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.

Ongini E; Dionisotti S; Gessi S; Irenius E; Fredholm BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1999;359(1):28-32

Signaling via A_2A adenosine receptor in four PC12 cell clones

Arslan G; Kull B; Fredholm BB
Article: BIOCHEMICAL PHARMACOLOGY. 1999;57(1):65-75

Differences in the order of potency for agonists but not antagonists at human and rat adenosine A_2A receptors

Kull B; Arslan G; Nilsson C; Owman C; Lorenzen A; Schwabe U; Fredholm BB
Article: FEBS LETTERS. 1998;441(1):97-102

Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K⁺-channel activity in insulin-secreting cells

Köhler M; Norgren S; Berggren PO; Fredholm BB; Larsson O; Rhodes CJ; Herbert TP; Luthman H
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 1998;399(2):229-240

Cellular distribution of adenosine A_2A receptor mRNA in the primate striatum

Svenningsson P; Le Moine C; Aubert I; Burbaud P; Fredholm BB; Bloch B
Article: DRUG AND ALCOHOL DEPENDENCE. 1998;51(1-2):199-206

Caffeine--an atypical drug of dependence.

Daly JW; Fredholm BB
Article: NEUROSCIENCE. 1998;84(1):223-228

Activation of adenosine A_2A and dopamine D₁ receptors stimulates cyclic AMP dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons

Svenningsson P; Lindskog M; Rognoni F; Fredholm BB; Greengard P; Fisone G
Article: BRAIN RESEARCH. 1998;791(1-2):177-185

Age-dependent changes in adenosine receptors are not modified by life-long intermittent alcohol administration

Fredholm BB; Johansson B; Lindström K; Wahlström G
Article: JOURNAL OF NEUROCHEMISTRY. 1998;70(3):1210-1216

[³H]SCH 58261, a selective adenosine A_2A receptor antagonist, is a useful ligand in autoradiographic studies

Fredholm BB; Lindström K; Dionisotti S; Ongini E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(8):4718-4724

Adenosine A₁ receptor-mediated modulation of dopamine D₁ receptors in stably cotransfected fibroblast cells

Ferré S; Torvinen M; Antoniou K; Irenius E; Civelli O; Arenas E; Fredholm BB; Fuxe K
Article: LAKARTIDNINGEN. 1998;95(6):534-535

[Thoughts at the start of a new year. What happens to time?].

Fredholm BB
Article: NEUROPHARMACOLOGY. 1998;37(3):331-337

Regional differences in the ability of caffeine to affect haloperidol-induced striatal c-fos mRNA expression in the rat

Svenningsson P; Nergårdh R; Fredholm BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1997;357(1):1-9

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells

Klotz KN; Hessling J; Hegler J; Owman C; Kull B; Fredholm BB; Lohse MJ
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1997;340(2-3):169-175

Glucose deprivation increases basal and electrically evoked transmitter release from rat striatal slices. Role of NMDA and adenosine A1 receptors.

Jin S; Fredholm BB
Article: LAKARTIDNINGEN. 1997;94(49):4650-4651

[Our genetic differences confirm the idea on equal value of all human beings].

Fredholm B
Article: ACTA PHYSIOLOGICA. 1997;161(4):517-525

Spinal expression of mRNA for immediate early genes in a model of chronic pain

DeLander GE; Schott E; Brodin E; Fredholm BB
Article: ACTA PHYSIOLOGICA. 1997;161(4):509-516

Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain

Delander GE; Schött E; Brodin E; Fredholm BB
Article: SYNAPSE. 1997;27(4):322-335

Distribution of adenosine receptors in the postmortem human brain: An extended autoradiographic study

Svenningsson P; Hall H; Sedvall G; Fredholm BB
Article: EXPERIMENTAL EYE RESEARCH. 1997;65(5):595-602

Localization of adenosine receptor messenger RNAs in the rat eye

Kvanta A; Seregard S; Sejersen S; Kull B; Fredholm BB
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(11):2370-2382

Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle

Chergui K; Svenningsson P; Nomikos GG; Gonon F; Fredholm BB; Svennson TH
Article: LAKARTIDNINGEN. 1997;94(42):3711-3712

[New discoveries on adenosis and prostacyclin. Physiological processes are surveyed in genetic elimination trials].

Fredholm BB
Article: JOURNAL OF NEUROSCIENCE. 1997;17(20):8038-8048

Dopamine-adenosine interactions in the striatum and the globus pallidus: Inhibition of striatopallidal neurons through either D-2A receptors enhances D-2 receptor-mediated effects on c-fos expression

LeMoine C; Svenningsson P; Fredholm BB; Bloch B
Article: LAKARTIDNINGEN. 1997;94(40):3474-3477

[Political control of the universities is contra-productive and hazardous. Free universities are important for democracy].

Fredholm B
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(10):2135-2141

Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum

Svenningsson P; Georgieva J; Kontny E; Heilig M; Fredholm BB
Article: NEUROSCIENCE. 1997;80(4):1171-1185

Cellular expression of adenosine A(2A) receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas

Svenningsson P; LeMoine C; Kull B; Sunahara R; Bloch B; Fredholm BB
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1997;121(7):1269-1276

Electrically-evoked dopamine and acetylcholine release from rat striatal slices perfused without magnesium: regulation by glutamate acting on NMDA receptors.

Jin S; Fredholm BB
Article: NEUROSCIENCE. 1997;79(3):753-764

Antagonism of adenosine A(2A) receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens

Svenningsson P; Nomikos GG; Ongini E; Fredholm BB
Article: BRAIN RESEARCH. 1997;762(1-2):153-164

A(1) and A(2A) adenosine receptors and A(1) mRNA in mouse brain: effect of long-term caffeine treatment

Johansson B; Georgiev V; Lindstrom K; Fredholm BB
Article: ACTA PHYSIOLOGICA. 1997;160(3):207-217

5-Hydroxytryptamine, angiotensin and bradykinin transiently increase intracellular calcium concentrations and PKC-alpha activity, but do not induce mitogenesis in human vascular smooth muscle cells.

Assender JW; Irenius E; Fredholm BB
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1997;329(2-3):107-113

Adenosine A1 receptors mediate hypoxia-induced inhibition of electrically evoked transmitter release from rat striatal slices.

Jin S; Fredholm BB
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1997;121(3):353-360

Characterization of human A(2A) adenosine receptors with the antagonist radioligand [H-3]-SCH 58261

Dionisotti S; Ongini E; Zocchi C; Kull B; Arslan G; Fredholm BB
Article: LAKARTIDNINGEN. 1997;94(19):1787-1788

[New series: action mechanisms of drugs].

Fredholm BB
Article: TRENDS IN PHARMACOLOGICAL SCIENCES. 1997;18(3):79-82

Towards a revised nomenclature for P1 and P2 receptors.

Fredholm BB; Abbracchio MP; Burnstock G; Dubyak GR; Harden TK; Jacobson KA; Schwabe U; Williams M
Article: NUCLEAR MEDICINE AND BIOLOGY. 1997;24(2):187-191

In vivo biodistribution of [N-C-11-methyl]KF 17837 using 3-D-PET: Evaluation as a ligand for the study of adenosine A(2A) receptors

StoneElander S; Thorell JO; Eriksson L; Fredholm BB; Ingvar M
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 1997;8(1):29-44

On the role of the low-affinity neurotrophin receptor p75(LNTR) in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells

Kontny E; Ciruela F; Svenningsson P; Ibanez CF; Fredholm BB
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1997;280(2):1094-1101

Glucocorticoids regulate the expression of adenosine A(1) but not A(2A) receptors in rat brain

Svenningsson P; Fredholm BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1996;355(1):48-56

Adenosine A2A receptor stimulation increases release of acetylcholine from rat hippocampus but not striatum, and does not affect catecholamine release.

Jin S; Fredholm BB
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1996;316(2-3):325-331

Adenosine A(2A) receptors modulate the binding characteristics of dopamine D-2 receptors in stably cotransfected fibroblast cells

Dasgupta S; Ferre S; Kull B; Hedlund PB; Finnman UB; Ahlberg S; Arenas E; Fredholm BB; Fuxe K
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1996;8(12):2447-2458

Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding

Johansson B; Georgiev V; Kuosmanen T; Fredholm BB
Article: DRUG DEVELOPMENT RESEARCH. 1996;39(3-4):450-460

Neuropharmacology of the adenosine A(2A) receptors

Ongini E; Dionisotti S; Morelli M; Ferre S; Svenningsson P; Fuxe K; Fredholm BB
Article: DRUG DEVELOPMENT RESEARCH. 1996;39(3-4):262-268

Adenosine (P1) receptor signalling

Fredholm BB; Arslan C; Kull B; Kontny E; Svenningsson P
Article: DRUG DEVELOPMENT RESEARCH. 1996;39(3-4):461-466

Receptor nomenclature

Fredholm BB; Burnstock G; Harden TK; Spedding M
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1996;313(3):237-242

Propentofylline inhibits polymorphonuclear leukocyte recruitment in vivo by a mechanism involving adenosine A(2A) receptors

Zhang Y; Raud J; Hedqvist P; Fredholm BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1996;354(4):539-541

The selective adenosine A(2A) receptor antagonist SCH 58261 discriminates between two different binding sites for [H-3]-CGS 21680 in the rat brain

Lindstrom K; Ongini E; Fredholm BB
Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 1996;79(3):120-123

Effects of ethanol and acetate on adenosine production in rat hippocampal slices.

Fredholm BB; Wallman-Johansson A
Article: ACTA PHYSIOLOGICA. 1996;157(4):451-460

Endothelin-1 causes a prolonged protein kinase C activation and acts as a co-mitogen in vascular smooth muscle cells.

Assender JW; Irenius E; Fredholm BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1996;354(3):262-267

AdenosineA(2A) receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes

Fredholm BB; Zhang Y; vanderPloeg I
Article: JOURNAL OF NEUROCHEMISTRY. 1996;67(1):186-193

Release of adenosine from rat hippocampal slices by nitric oxide donors.

Fallahi N; Broad RM; Jin S; Fredholm BB
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1996;8(7):1545-1553

Dopamine D-1 receptor-mediated facilitation of GABAergic neurotransmission in the rat strioentopeduncular pathway and its modulation by adenosine A(1) receptor-mediated mechanisms

Ferre S; OConnor WT; Svenningsson P; Bjorklund L; Lindberg J; Tinner B; Stromberg I; Goldstein M; Ogren SO; Ungerstedt U; Fredholm BB; Fuxe K
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1996;306(1-3):187-194

Plasma membrane Ca2+ pumping plays a prominent role in adenosine A1 receptor mediated changes in [Ca2+]i in DDT1 MF-2 cells.

Sipma H; Fredholm BB; Den Hertog A; Nelemans A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(10):5161-5165

Oscillations in K-ATP channel activity promote oscillations in cytoplasmic free Ca2+ concentration in the pancreatic beta cell

Larsson O; Kindmark H; Branstrom R; Fredholm B; Berggren PO
Article: BIOCHEMICAL PHARMACOLOGY. 1996;51(7):957-965

Biphasic effect of ATP on neutrophil functions mediated by P-2U and adenosine A(2A) receptors

Zhang Y; Palmblad J; Fredholm BB
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1996;277(1):193-197

A1, but not A2A, adenosine receptors modulate electrically stimulated [14C]acetylcholine release from rat cortex.

Broad RM; Fredholm BB
Article: IMMUNOLOGY LETTERS. 1996;49(3):197-201

P-2X purinoceptor is not important in thymocyte apoptosis

Jiang SN; Kull B; Fredholm BB; Orrenius S
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1996;353(3):250-260

Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists.

van der Ploeg I; Ahlberg S; Parkinson FE; Olsson RA; Fredholm BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1996;353(3):261-271

Evidence for high affinity binding sites for the adenosine A(2A) receptor agonist [H-3] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A(2A) receptors

Cunha RA; Johansson B; Constantino MD; Sebastiao AM; Fredholm BB
Article: ADVANCES IN NEUROLOGY. 1996;71:469-474

Caffeine and ischemia - Effects on immediate early genes and adenosine receptors

Fredholm BB; Aden U; Lindstrom K; Bona E; Hagberg H
Article: BRAIN RESEARCH. 1996;35(1-2):183-189

Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801

Svenningsson P; Johansson B; Fredholm BB
Article: LIFE SCIENCES. 1996;58(9):769-776

Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine

Fernandez M; Svenningsson P; Fredholm BB
Article: NEUROPHARMACOLOGY. 1996;35(1):79-89

Adenosine A(1) and A(2A) receptors and nitrobenzylthioinosine-sensitive transporters in gerbil brain: No changes following long-term treatment with the adenosine transport inhibitor propentofylline

Parkinson FE; Johansson B; Lindstrom K; Fredholm BB
Article: LAKARTIDNINGEN. 1995;92(44):4079-4080

[Should coffee be classified as a doping agent? Caffeine is definitely effective when it comes to performance capacity].

Fredholm BB
Article: JOURNAL OF NEUROSCIENCE. 1995;15(11):7612-7624

BIPHASIC CHANGES IN LOCOMOTOR BEHAVIOR AND IN EXPRESSION OF MESSENGER-RNA FOR NGFI-A AND NGFI-B IN RAT STRIATUM FOLLOWING ACUTE CAFFEINE ADMINISTRATION

SVENNINGSSON P; NOMIKOS GG; FREDHOLM BB
Article: PEDIATRIC RESEARCH. 1995;38(3):312-318

THE EFFECT OF LONG-TERM CAFFEINE TREATMENT ON HYPOXIC-ISCHEMIC BRAIN-DAMAGE IN THE NEONATE

BONA E; ADEN U; FREDHOLM BB; HAGBERG H
Article: NEUROSCIENCE LETTERS. 1995;196(1-2):41-44

ADENOSINE A(2A) RECEPTORS STIMULATE ACETYLCHOLINE-RELEASE FROM NERVE-TERMINALS OF THE RAT HIPPOCAMPUS

CUNHA RA; JOHANSSON B; FREDHOLM BB; RIBEIRO JA; SEBASTIAO AM
Article: ACTA PHYSIOLOGICA. 1995;154(1):17-24

EFFECT OF DIFFERENT XANTHINES AND PHOSPHODIESTERASE INHIBITORS ON C-FOS EXPRESSION IN RAT STRIATUM

SVENNINGSSON P; JOHANSSON B; FREDHOLM BB
Article: JOURNAL OF NEUROSCIENCE. 1995;15(5):3583-3593

INCREASED EXPRESSION OF C-JUN, JUNB, AP-1, AND PREPROENKEPHALIN MESSENGER-RNA IN RAT STRIATUM FOLLOWING A SINGLE INJECTION OF CAFFEINE

SVENNINGSSON P; STROM A; JOHANSSON B; FREDHOLM BB
Article: LAKARTIDNINGEN. 1995;92(14):1454-1457

[A new series: growth factors].

Fredholm BB; Heldin CH
Article: NEUROCHEMISTRY INTERNATIONAL. 1995;26(4):387-395

Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices.

Lloyd HG; Fredholm BB
Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 1995;76(4):228-239

Purinoceptors in the nervous system.

Fredholm BB
Article: NEUROPHARMACOLOGY. 1995;34(4):393-403

FURTHER CHARACTERIZATION OF THE BINDING OF THE ADENOSINE RECEPTOR AGONIST [H-3] CGS-21680 TO RAT-BRAIN USING AUTORADIOGRAPHY

JOHANSSON B; FREDHOLM BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1995;351(2):194-201

Activation of phospholipase C and phospholipase D by stimulation of adenosine A1, bradykinin or P2U receptors does not correlate well with protein kinase C activation.

Gerwins P; Fredholm BB
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1995;351(2):186-193

Activation of adenosine A1 and bradykinin receptors increases protein kinase C and phospholipase D activity in smooth muscle cells.

Gerwins P; Fredholm BB
Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 1995;76(2):93-101

Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine.

Fredholm BB
Article: PHYSIOLOGY. 1995;10:122-128

ADENOSINE RECEPTORS IN THE CENTRAL-NERVOUS-SYSTEM

FREDHOLM BB
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All other publications

Review: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2019;253:359-381

Adenosine and Sleep.

Lazarus M; Chen J-F; Huang Z-L; Urade Y; Fredholm BB
Review: MOLECULAR ASPECTS OF MEDICINE. 2017;55:20-25

Low, but not high, dose caffeine is a readily available probe for adenosine actions

Fredholm BB; Yang J; Wang Y
Review: MOLECULAR ASPECTS OF MEDICINE. 2017;55:4-8

Pharmacological targeting of adenosine receptor signaling

Peleli M; Fredholm BB; Sobrevia L; Carlstrom M
Editorial comment: MOLECULAR ASPECTS OF MEDICINE. 2017;55:1-3

Adenosine - from molecular mechanisms to pathophysiology

Sobrevia L; Fredholm BB
Review: NATURE REVIEWS DRUG DISCOVERY. 2013;12(4):265-286

Adenosine receptors as drug targets - what are the challenges?

Chen J-F; Eltzschig HK; Fredholm BB
Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(16):5913-5914

Rethinking the purinergic neuron-glia connection

Fredholm BB
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2011;11(8):973-1011

Adenosine and ATP Receptors in the Brain

Burnstock G; Fredholm BB; Verkhratsky A
Review: PHARMACOLOGICAL REVIEWS. 2011;63(1):1-34

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors-An Update

Fredholm BB; IJzerman AP; Jacobson KA; Linden J; Mueller CE
Review: SLEEP AND BIOLOGICAL RHYTHMS. 2011;9:24-28

Physiological and pathophysiological roles of adenosine

Fredholm BB
Review: ADVANCES IN PHARMACOLOGY. 2011;61:77-94

Adenosine and the regulation of metabolism and body temperature.

Fredholm BB; Johansson S; Wang Y-Q
Published conference paper: JOURNAL OF NEUROIMMUNOLOGY. 2010;224(1-2):85-92

CX₃CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes

Piccinin S; Di Angelantonio S; Piccioni A; Volpini R; Cristalli G; Fredholm BB; Limatola C; Eusebi F; Ragozzino D
Review: CELL DEATH AND DIFFERENTIATION. 2010;17(7):1071-1082

Adenosine signaling and function in glial cells

Boison D; Chen J-F; Fredholm BB
Review: ACTA PHYSIOLOGICA. 2010;199(2):93-147

The birth and postnatal development of purinergic signalling

Burnstock G; Fredholm BB; North RA; Verkhratsky A
Editorial comment: ACTA PHYSIOLOGICA. 2010;199(2):91-92

Purines-80 years and very much alive

Fredholm B; Verkhratsky A
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1284-1288

Adenosine receptors as drug targets

Fredholm BB
Review: PARKINSONISM & RELATED DISORDERS. 2009;15(6):406-413

Adenosine, adenosine A_2A antagonists, and Parkinson's disease

Jenner P; Mori A; Hauser R; Morelli M; Fredholm BB; Chen JF
Other: HETEROCYCLES. 2009;79(1):73-83

Adenosine Receptors: The Contributions by John W. Daly

Fredholm BB; Jacobson KA
Published conference paper: PROGRESS IN NEUROBIOLOGY. 2007;83(5):263-276

Aspects of the general biology of adenosine A_2A signaling

Fredholm BB; Chern Y; Franco R; Sitkovsky M
Review: CELL DEATH AND DIFFERENTIATION. 2007;14(7):1315-1323

Adenosine, an endogenous distress signal, modulates tissue damage and repair

Fredholm BB
Published conference paper: ACTA PHYSIOLOGICA. 2007;190(1):87-96

Eliminating the antilipolytic adenosine A₁ receptor does not lead to compensatory changes in the antilipolytic actions of PGE₂ and nicotinic acid

Johansson SM; Yang J-N; Lindgren E; Fredholm BB
Published conference paper: ACTA PHYSIOLOGICA. 2007;190(1):63-75

Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A₁ receptors

Yang J-N; Tiselius C; Dare E; Johansson B; Valen G; Fredholm BB
Published conference paper: ACTA PHYSIOLOGICA. 2007;190(1):3-7

G-protein-coupled receptors:: an update

Fredholm BB; Hokfelt T; Milligan G
Editorial comment: ACTA PHYSIOLOGICA. 2007;190(1):1

A Nordic meeting on G-protein-coupled receptors: from molecular aspects to novel therapy

Schulte G; Fredholm B
Editorial comment: CURRENT OPINION IN PHARMACOLOGY. 2007;7(1):1-2

Many ways to Rome - multiple approaches to novel drugs

Chergui K; Fredholm BB; Svenningsson P
Published conference paper: ANESTHESIOLOGY. 2006;104(4):724-733

Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine

Jonsson M; Dabrowski M; Gurley DA; Larsson O; Johnson EC; Fredholm BB; Eriksson LI
Editorial comment: LIFE SCIENCES. 2005;78(1):1

Untitled

Fredholm B; Porreca F
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2005;45:385-412

Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.

Fredholm BB; Chen J-F; Masino SA; Vaugeois J-M
Published conference paper: JOURNAL OF MOLECULAR NEUROSCIENCE. 2005;26(2-3):239-244

Adenosine-dopamine interactions revealed in knockout mice

Salmi P; Chergui K; Fredholm BB
Review: INTERNATIONAL REVIEW OF NEUROBIOLOGY. 2005;63:191-270

Adenosine and brain function

Fredholm BB; Chen JF; Cunha RA; Svenningsson P; Vaugeois JM
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2004;14:S156-S157

Caffeine as an adenosine receptor antagonist

Fredholm BB
Review: LAKARTIDNINGEN. 2004;101(34):2552-2555

[Connection between caffeine, adenosine receptors and dopamine. Coffee reduces the risk of Parkinson disease].

Fredholm BB
Editorial comment: TRENDS IN PHARMACOLOGICAL SCIENCES. 2004;25(4):170-171

Borje Uvnas and the rise of modern pharmacology

Fredholm B
Other: NEUROLOGY. 2003;61(11 Suppl 6):S10-S11

Exciting news about A2A receptors.

Svenningsson P; Fredholm BB
Review: NEUROLOGY. 2003;61(11 Suppl 6):S5-S9

Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities.

Fredholm BB; Svenningsson P
Published conference paper: EXPERIMENTAL CELL RESEARCH. 2003;290(1):168-176

The G_S-coupled adenosine A_2B receptor recruits divergent pathways to regulate ERK1/2 and p38

Schulte G; Fredholm BB
Review: CELLULAR SIGNALLING. 2003;15(9):813-827

Signalling from adenosine receptors to mitogen-activated protein kinases

Schulte G; Fredhohn BB
Published conference paper: DRUG DEVELOPMENT RESEARCH. 2003;58(4):428-438

Adenosine A₃ receptors in the rat hippocampus:: Lack of interaction with A₁ receptors

Lopes LV; Rebola N; Costenla AR; Halldner L; Jacobson MA; Oliveira CR; Richardson PJ; Fredholm BB; Ribeiro JA; Cunha RA
Published conference paper: DRUG DEVELOPMENT RESEARCH. 2003;58(4):350-353

Consequences of eliminating adenosine A₁ receptors in mice

Fredholm BB; Halldner L; Johansson C; Schulte G; Lövdahl C; Thorén P; Dunwiddie TV; Masino SA; Poelchen W; Diao LH; Illes P; Zahniser NR; Valen G; Tokuno S; Sommerschild H; Giménez-Llort L; Fernández-Teruel A; Escorihuela RM; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Herlenius E; Pekny S; Gebré-Medhin S; Brown R; Ollerstam A; Persson AEG; Skott O; Johansson B
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2003;3(4):413-426

Pharmacology of adenosine A_2A receptors and therapeutic applications

Fredholm BB; Cunha RA; Svenningsson P
Published conference paper: MOLECULAR PHARMACOLOGY. 2002;62(5):1137-1146

Signaling pathway from the human adenosine A₃ receptor expressed in chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2

Schulte G; Fredholm BB
Meeting abstract: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2002;34(6):A59

A1 receptors mediate delayed remote preconditioning, possible involvement of MAPK

Sommershild HT; Fredholm BB; Schulte G; Jägerbrink T; Lövdahl C; Tokuno S; Valen G
Review: LAKARTIDNINGEN. 2002;99(14):1604-1608

[The passion concerning behavior of human beings. The intensive sociology debate and some lessons learned from it].

Fredholm BB
Published conference paper: CELLULAR SIGNALLING. 2002;14(2):109-113

Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists

Schulte G; Fredholm BB
Review: PHARMACOLOGICAL REVIEWS. 2001;53(4):527-552

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.

Fredholm BB; IJzerman AP; Jacobson KA; Klotz KN; Linden J
Other: TRENDS IN PHARMACOLOGICAL SCIENCES. 2001;22(11):596

Thomas V. Dunwiddie (1951-2001) - Obituary

Fredholm BB
Published conference paper: DRUG DEVELOPMENT RESEARCH. 2001;52(1-2):274-282

Adenosine receptor signaling in vitro and in vivo

Fredholm BB; Arslan G; Halldner L; Kull B; Schulte G; Ådén U; Svenningsson P
Review: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2000;362(4-5):364-374

Structure and function of adenosine receptors and their genes

Fredholm BB; Arslan G; Halldner L; Kull B; Schulte G; Wasserman W
Review: LAKARTIDNINGEN. 1999;96(50):5639-5644

[Vademecum of a biomedical researcher: from the foundation of science to the threat from post-modern "nonsense"].

Fredholm BB
Review: PROGRESS IN NEUROBIOLOGY. 1999;59(4):355-396

Distribution, biochemistry and function of striatal adenosine A_2A receptors

Svenningsson P; Le Moine C; Fisone G; Fredholm BB
Review: PHARMACOLOGICAL REVIEWS. 1999;51(1):83-133

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

Fredholm BB; Bättig K; Holmén J; Nehlig A; Zvartau EE
Published conference paper: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 1999;120:301-310

Adenosine and P2 receptors in PC12 cells. Genotypic, phenotypic and individual differences.

Arslan G; Fredholm BB
Letter: NEUROSCIENCE. 1999;88(4):1005-1008

Activation of dopamine D₂ receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms

Lindskog M; Svenningsson P; Fredholm BB; Greengard P; Fisone G
Published conference paper: DRUG DEVELOPMENT RESEARCH. 1998;45(3-4):324-328

Locating the neuronal targets for caffeine

Fredholm BB; Arslan G; Kull B; Svenningsson P
Letter: TRENDS IN PHARMACOLOGICAL SCIENCES. 1998;19(2):46-48

Striatal adenosine A_2A receptors -: where are they?: What do they do?

Fredholm BB; Svenningsson P
Review: TRENDS IN NEUROSCIENCES. 1997;20(10):482-487

Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia

Ferre S; Fredholm BB; Morelli M; Popoli P; Fuxe K
Review: NEUROSCIENCE. 1997;80(4):1187-1207

Distribution and postnatal ontogeny of adenosine A(2A) receptors in rat brain: Comparison with dopamine receptors

Johansson B; Georgiev V; Fredholm BB
Published conference paper: NEUROPHARMACOLOGY. 1997;36(9):1319-1326

Down-regulation of adenosine A2A receptors upon NGF-induced differentiation of PC12 cells.

Arslan G; Kontny E; Fredholm BB
Published conference paper: NEUROPHARMACOLOGY. 1997;36(9):1327-1338

Neonatal cerebral hypoxia-ischemia: The effect of adenosine receptor antagonists

Bona E; Aden U; Gilland E; Fredholm BB; Hagberg H
Published conference paper: NEUROPHARMACOLOGY. 1997;36(9):1309-1317

Caffeine mimics the effect of a dopamine D-2/3 receptor agonist on the expression of immediate early genes in globus pallidus

Svenningsson P; Fredholm BB
Review: GENERAL PHARMACOLOGY: THE VASCULAR SYSTEM. 1997;28(3):345-350

Purines and neutrophil leukocytes.

Fredholm BB
Review: INTERNATIONAL REVIEW OF NEUROBIOLOGY. 1997;40:259-280

Adenosine and neuroprotection.

Fredholm BB
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 1996;17(10):364-372

Pharmacology of adenosine A2A receptors.

Ongini E; Fredholm BB
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 1996;17(3):108-113

Adenosine receptor ligands: differences with acute versus chronic treatment.

Jacobson KA; von Lubitz DK; Daly JW; Fredholm BB
Other: BIOCHEMICAL SOCIETY TRANSACTIONS. 1995;23(3):453S

Protein kinase C isoform expression and ATP response change with smooth muscle cell differentiation.

Assender JW; Irenius E; Fredholm BB
Review: LAKARTIDNINGEN. 1995;92(16):1662-1664

[Hirschsprung disease. A receptor defect].

Fredholm BB
Review: LAKARTIDNINGEN. 1995;92(14):1459-1467

[Growth factors--clarification of their mechanism].

Fredholm BB; Heldin CH
Published conference paper: ZOOLOGICAL STUDIES. 1995;34:191-194

A SENSITIVE METHOD FOR MEASUREMENTS OF LUMINESCENCE IN SINGLE CELLS

KOHLER M; NORGREN S; FREDHOLM BB; LARSSON O; LUTHMAN H; BERGGREN PO
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Professor Emeritus/Emerita, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-2024

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Docent, Karolinska Institutet, 1971

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