Bengt Jernström

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Articles

Article: DNA REPAIR. 2011;10(8):877-886
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells
Lagerqvist A; Hakansson D; Lundin C; Prochazka G; Dreij K; Segerback D; Jernstrom B; Tornqvist M; Franke H; Seidel A; Erixon K; Jenssen D
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;177(1):40-47
H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides
Mattsson A; Jernstrom B; Cotgreave IA; Bajak E
Article: DNA REPAIR. 2008;7(8):1202-1212
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a,]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide
Lagerqvist A; Hakansson D; Prochazka G; Lundin C; Dreij K; Segerback D; Jernstrom B; Tornqvist M; Seidel A; Erixon K; Jenssen D
Article: MOLECULAR CARCINOGENESIS. 2008;47(4):301-309
Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 ser15 phosphorylation
Paajarvi G; Jernstrom B; Seidel A; Stenius U
Article: BIOCHEMICAL PHARMACOLOGY. 2007;74(3):496-503
Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells
Ek M; Soderdahl T; Kuppers-Munther B; Edsbagge J; Andersson TB; Bjorquist P; Cotgreave I; Jernstrom B; Ingelman-Sundberg M; Johansson I
Article: TOXICOLOGY IN VITRO. 2007;21(5):929-937
Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells
Soderdahl T; Kuppers-Munther B; Heins N; Edsbagge J; Bjorquist P; Cotgreave I; Jernstrom B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2003;16(5):590-597
Conformations of benzene- and dibenzo[a,l]pyrene diol Epoxides studied by density functional theory: Ground states, transition states, dynamics, and solvent effects
Cho KB; Dreij K; Jernström B; Gräslund A
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(2):170-179
Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases
Sundberg K; Dreij K; Seidel A; Jernström B
Article: BIOCHEMISTRY. 2001;40(19):5622-5632
Influence of bulky polynuclear carcinogen lesions in a TATA promoter sequence on TATA binding protein-DNA complex formation
Rechkoblit O; Krzeminsky J; Amin S; Jernström B; Louneva N; Geacintov NE
Article: BIOCHEMICAL JOURNAL. 2000;349(Pt 3):693-696
Studies on the differential inhibition of glutathione conjugate formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and 1-chloro-2,4-dinitrobenzene in V79 Chinese hamster cells
Sundberg K; Jernström B; Swedmark S
Article: POLYCYCLIC AROMATIC COMPOUNDS. 1999;17(1-4):43-51
Catalytic efficiency of glutathione transferase P1-1 variants towards bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons
Sundberg K; Seidel A; Mannervik B; Jernström B
Article: POLYCYCLIC AROMATIC COMPOUNDS. 1999;17(1-4):33-42
Effects of diol epoxide adducts on binding of different transcription factors to DNA
Voskoboinik I; Persson Å; Jernström B
Article: POLYCYCLIC AROMATIC COMPOUNDS. 1999;17(1-4):21-32
Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with the oligonucleotides 5′-d(CCTATCGTTATCC) and 5′-d(CCTATm⁵CGTTATCC)
Pradhan P; Gräslund A; Seidel A; Jernström B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1999;12(5):403-411
Studies on the adduct heterogeneity of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy
Pradhan P; Jernström B; Seidel A; Nordén B; Gräslund A
Article: FEBS LETTERS. 1998;438(3):206-210
Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione
Sundberg K; Seidel A; Mannervik B; Jernström B
Article: MOLECULAR PHARMACOLOGY. 1998;54(2):298-304
Overexpression of stably transfected human glutathione S-Transferase p1-1 protects against DNA damage by benzo[a]pyrene diol-epoxide in human T47D cells
Fields WR; Morrow CS; Doss AJ; Sundberg K; Jernström B; Townsend AJ
Article: BIOCHEMISTRY. 1998;37(13):4664-4673
Induced circular dichroism of benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations
Pradhan P; Jernström B; Seidel A; Nordén B; Gräslund A
Article: CARCINOGENESIS. 1998;19(3):433-436
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons
Sundberg K; Johansson AS; Stenberg G; Widersten M; Seidel A; Mannervik B; Jernström B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1997;10(11):1221-1227
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1
Sundberg K; Widersten M; Seidel A; Mannervik B; Jernstrom B
Article: BIOCONJUGATE CHEMISTRY. 1997;8(3):310-317
Critical parameters for adduct formation of the carcinogen (+)-anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide with oligonucleotides
Funk M; Ponten I; Seidel A; Jernstrom B
Article: CARCINOGENESIS. 1996;17(9):1963-1969
Inhibitory effects on the DNA binding of AP-1 transcription factor to an AP-1 binding site modified by benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide diastereomers
Persson AE; Ponten I; Cotgreave I; Jernstrom B
Article: BIOCHEMICAL JOURNAL. 1996;318(Pt 2):533-538
Comparison of the mRNA sequences for Pi class glutathione transferases in different hamster species and the corresponding enzyme activities with anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide
Swedmark S; Jernstrom B; Jenssen D
Article: CARCINOGENESIS. 1996;17(7):1491-1498
Glutathione S-transferase A1-1-catalysed conjugation of bay and fjord region diol epoxides of polycyclic aromatic hydrocarbons with glutathione
Jernstrom B; Funk M; Frank H; Mannervik B; Seidel A
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1996;9(1):188-196
Synthesis and characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the 5'-d(CCTATAGATATCC) oligonucleotide
Ponten I; Seidel A; Graslund A; Jernstrom B
Article: FEBS LETTERS. 1995;368(1):64-68
FLUORESCENCE-DETECTED INTERACTIONS OF OLIGONUCLEOTIDES IN RECA COMPLEXES
WITTUNG P; FUNK M; JERNSTROM B; NORDEN B; TAKAHASHI M
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1995;94(1):73-82
STUDIES ON THE EFFECT OF SULFITE ON BENZO[A]PYRENE-7,8-DIHYDRODIOL ACTIVATION TO REACTIVE INTERMEDIATES IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES
CONSTANTIN D; MEHROTRA K; WALLIN A; MOLDEUS P; JERNSTROM B
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All other publications

Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2008;28(4-5):392-401
H2AX, MDM2 AND P53 PHOSPHORYLATION ARE DIFFERENTLY AFFECTED BY BAY- AND FJORD-REGION DIOL EPOXIDES DERIVED FROM CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBONS
Mattsson A; Malmlof M; Seidel A; Stenius U; Jernstrom B
Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 2005;18(4):655-664
Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[α]pyrene in human cells
Dreij K; Seidel A; Jernström B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2004;24(4-5):549-566
DNA adducts of benzo[a]pyrene- and dibenzo[a,l]pyrene-diol epoxides in human lung epithelial cells:: Kinetics of adduct removal, effects on cell cycle checkpoints, and gene expression
Dreij K; Bajak E; Sundberg K; Cotgreave I; Jernström B; Seidel A; Gusnanto A
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2004;24(4-5):537-548
Exposure of mammalian cells to diol epoxides from benzo[a]pyrene and dibenzo[a,l]pyrene and effects on Mdm2 and p53
Pääjärvi G; Jernström B; Stenius U; Seidel A
Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(6):825-831
Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides
Dreij K; Sundberg K; Johansson AS; Nordling E; Seidel A; Persson B; Mannervik B; Jernström B
Review: ENVIRONMENTAL HEALTH PERSPECTIVES. 2002;110(Suppl 3):451-488
Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air
Boström CE; Gerde P; Hanberg A; Jernström B; Johansson C; Kyrklund T; Rannug A; Törnqvist M; Victorin K; Westerholm R
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2002;22(3-4):947-953
Detoxification of polycyclic aromatic hydrocarbon diol epoxides by human glutathione transferases:: Efficiency of conjugation in intact cells relative to purified enzymes
Sundberg K; Dreij K; Jernström B; Seidel A
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2002;22(3-4):823-829
Inactivation of carcinogenic diol epoxides of dibenzo[a,l]pyrene (dibenzo[def,p]chrysene) by human alpha class glutathione transferases
Dreij K; Sundberg K; Jernström B; Johansson AS; Mannervik B; Seidel A
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):91-94
Expression of human glutathione transferases in V79 cells and the effect on DNA adduct-formation of diol epoxides derived from polycyclic aromatic hydrocarbons
Sundberg K; Dreij K; Berntsen S; Seidel A; Jernström B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2000;21(1-4):123-133
Glutathione conjugation and DNA adduct formation of diol epoxides in V79 cells expressing human glutathione transferase P1-1
Sundberg K; Townsend AJ; Seidel A; Jernström B
Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 1999;12(9):816-821
Implications of cytosine methylation on (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide N²-dG adduct formation in 5′-d(CGT), 5′-d(CGA), and 5′-d(CGC) sequence contexts of single- and double-stranded oligonucleotides
Pradhan P; Gräslund A; Seidel A; Jernström B
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 1998;112:51-67
Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents:: Mechanisms of inducible resistance to aflatoxin B₁
Hayes JD; Pulford DJ; Ellis EM; McLeod R; James RFL; Seidegård J; Mosialou E; Jernström B; Neal GE
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 1996;10(1-4):93-100
Spectroscopic studies of oligonucleotide adducts and base sequence preference of adducts formed by the stereoisomers of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
Ponten I; Seidel A; Jernstrom B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 1996;10(1-4):51-57
Glutathione transferase A1-1 catalyzed conjugation of polycyclic aromatic hydrocarbon diol-epoxides with glutathione
Jernstrom B; Mannervik B; Funk M; Seidel A

Employments

Professor Emeritus/Emerita, Institute of Environmental Medicine, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, 1981

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