Bengt Jernström

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Articles

Article: DNA REPAIR. 2011;10(8):877-886

DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells.

Lagerqvist A; Håkansson D; Lundin C; Prochazka G; Dreij K; Segerbäck D; Jernström B; Törnqvist M; Frank H; Seidel A; Erixon K; Jenssen D
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;177(1):40-47

H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides.

Mattsson A; Jernström B; Cotgreave IA; Bajak E
Article: DNA REPAIR. 2008;7(8):1202-1212

Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.

Lagerqvist A; Håkansson D; Prochazka G; Lundin C; Dreij K; Segerbäck D; Jernström B; Törnqvist M; Seidel A; Erixon K; Jenssen D
Article: MOLECULAR CARCINOGENESIS. 2008;47(4):301-309

Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.

Pääjärvi G; Jernström B; Seidel A; Stenius U
Article: BIOCHEMICAL PHARMACOLOGY. 2007;74(3):496-503

Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells.

Ek M; Söderdahl T; Küppers-Munther B; Edsbagge J; Andersson TB; Björquist P; Cotgreave I; Jernström B; Ingelman-Sundberg M; Johansson I
Article: TOXICOLOGY IN VITRO. 2007;21(5):929-937

Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells.

Söderdahl T; Küppers-Munther B; Heins N; Edsbagge J; Björquist P; Cotgreave I; Jernström B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2003;16(5):590-597

Conformations of benzene- and dibenzo[a,l]pyrene diol epoxides studied by density functional theory: ground states, transition states, dynamics, and solvent effects.

Cho K-B; Dreij K; Jernström B; Gräslund A
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(2):170-179

Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.

Sundberg K; Dreij K; Seidel A; Jernström B
Article: BIOCHEMISTRY. 2001;40(19):5622-5632

Influence of bulky polynuclear carcinogen lesions in a TATA promoter sequence on TATA binding protein-DNA complex formation.

Rechkoblit O; Krzeminsky J; Amin S; Jernström B; Louneva N; Geacintov NE
Article: BIOCHEMICAL JOURNAL. 2000;349 Pt 3(Pt 3):693-696

Studies on the differential inhibition of glutathione conjugate formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and 1-chloro-2,4-dinitrobenzene in V79 Chinese hamster cells.

Sundberg K; Jernström B; Swedmark S
Article: POLYCYCLIC AROMATIC COMPOUNDS. 1999;17(1-4):43-51

Catalytic efficiency of glutathione transferase P1-1 variants towards bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons

Sundberg K; Seidel A; Mannervik B; Jernström B
Article: POLYCYCLIC AROMATIC COMPOUNDS. 1999;17(1-4):33-42

Effects of diol epoxide adducts on binding of different transcription factors to DNA

Voskoboinik I; Persson Å; Jernström B
Article: POLYCYCLIC AROMATIC COMPOUNDS. 1999;17(1-4):21-32

Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with the oligonucleotides 5′-d(CCTATCGTTATCC) and 5′-d(CCTATm⁵CGTTATCC)

Pradhan P; Gräslund A; Seidel A; Jernström B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1999;12(5):403-411

Studies on the adduct heterogeneity of benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy.

Pradhan P; Jernström B; Seidel A; Nordén B; Gräslund A
Article: FEBS LETTERS. 1998;438(3):206-210

Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.

Sundberg K; Seidel A; Mannervik B; Jernström B
Article: MOLECULAR PHARMACOLOGY. 1998;54(2):298-304

Overexpression of stably transfected human glutathione S-transferase P1-1 protects against DNA damage by benzo[a]pyrene diol-epoxide in human T47D cells.

Fields WR; Morrow CS; Doss AJ; Sundberg K; Jernström B; Townsend AJ
Article: BIOCHEMISTRY. 1998;37(13):4664-4673

Induced circular dichroism of benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations.

Pradhan P; Jernström B; Seidel A; Nordén B; Gräslund A
Article: CARCINOGENESIS. 1998;19(3):433-436

Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.

Sundberg K; Johansson AS; Stenberg G; Widersten M; Seidel A; Mannervik B; Jernström B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1997;10(11):1221-1227

Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1.

Sundberg K; Widersten M; Seidel A; Mannervik B; Jernström B
Article: BIOCONJUGATE CHEMISTRY. 1997;8(3):310-317

Critical parameters for adduct formation of the carcinogen (+)-anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide with oligonucleotides.

Funk M; Pontén I; Seidel A; Jernström B
Article: CARCINOGENESIS. 1996;17(9):1963-1969

Inhibitory effects on the DNA binding of AP-1 transcription factor to an AP-1 binding site modified by benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide diastereomers.

Persson AE; Pontén I; Cotgreave I; Jernström B
Article: BIOCHEMICAL JOURNAL. 1996;318 ( Pt 2)(Pt 2):533-538

Comparison of the mRNA sequences for Pi class glutathione transferases in different hamster species and the corresponding enzyme activities with anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide.

Swedmark S; Jernström B; Jenssen D
Article: CARCINOGENESIS. 1996;17(7):1491-1498

Glutathione S-transferase A1-1-catalysed conjugation of bay and fjord region diol epoxides or polycyclic aromatic hydrocarbons with glutathione.

Jernstrom B; Funk M; Frank H; Mannervik B; Seidel A
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1996;9(1):188-196

Synthesis and characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the 5'-d(CCTATAGATATCC) oligonucleotide.

Pontén I; Seidel A; Gräslund A; Jernström B
Article: FEBS LETTERS. 1995;368(1):64-68

Fluorescence-detected interactions of oligonucleotides in RecA complexes.

Wittung P; Funk M; Jernström B; Nordén B; Takahashi M
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1995;94(1):73-82

Studies on the effect of sulfite on benzo[a]pyrene-7,8-dihydrodiol activation to reactive intermediates in human polymorphonuclear leukocytes.

Constantin D; Mehrotra K; Wallin A; Moldéus P; Jernström B
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Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2008;28(4-5):392-401

H2AX, MDM2 AND P53 PHOSPHORYLATION ARE DIFFERENTLY AFFECTED BY BAY- AND FJORD-REGION DIOL EPOXIDES DERIVED FROM CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBONS

Mattsson A; Malmlof M; Seidel A; Stenius U; Jernstrom B
Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 2005;18(4):655-664

Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells.

Dreij K; Seidel A; Jernström B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2004;24(4-5):549-566

DNA adducts of benzo[a]pyrene- and dibenzo[a,l]pyrene-diol epoxides in human lung epithelial cells:: Kinetics of adduct removal, effects on cell cycle checkpoints, and gene expression

Dreij K; Bajak E; Sundberg K; Cotgreave I; Jernström B; Seidel A; Gusnanto A
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2004;24(4-5):537-548

Exposure of mammalian cells to diol epoxides from benzo[a]pyrene and dibenzo[a,l]pyrene and effects on Mdm2 and p53

Pääjärvi G; Jernström B; Stenius U; Seidel A
Review: ENVIRONMENTAL HEALTH PERSPECTIVES. 2002;110 Suppl 3(Suppl 3):451-488

Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.

Boström C-E; Gerde P; Hanberg A; Jernström B; Johansson C; Kyrklund T; Rannug A; Törnqvist M; Victorin K; Westerholm R
Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(6):825-831

Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides.

Dreij K; Sundberg K; Johansson A-S; Nordling E; Seidel A; Persson B; Mannervik B; Jernström B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2002;22(3-4):947-953

Detoxification of polycyclic aromatic hydrocarbon diol epoxides by human glutathione transferases:: Efficiency of conjugation in intact cells relative to purified enzymes

Sundberg K; Dreij K; Jernström B; Seidel A
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2002;22(3-4):823-829

Inactivation of carcinogenic diol epoxides of dibenzo[a,l]pyrene (dibenzo[def,p]chrysene) by human alpha class glutathione transferases

Dreij K; Sundberg K; Jernström B; Johansson AS; Mannervik B; Seidel A
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):91-94

Expression of human glutathione transferases in V79 cells and the effect on DNA adduct-formation of diol epoxides derived from polycyclic aromatic hydrocarbons

Sundberg K; Dreij K; Berntsen S; Seidel A; Jernström B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2000;21(1-4):123-133

Glutathione conjugation and DNA adduct formation of diol epoxides in V79 cells expressing human glutathione transferase P1-1

Sundberg K; Townsend AJ; Seidel A; Jernström B
Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 1999;12(9):816-821

Implications of cytosine methylation on (+)-anti-Benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide N(2)-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides.

Pradhan P; Gräslund A; Seidel A; Jernström B
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 1998;111-112:51-67

Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1.

Hayes JD; Pulford DJ; Ellis EM; McLeod R; James RF; Seidegård J; Mosialou E; Jernström B; Neal GE
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 1996;10(1-4):93-100

Spectroscopic studies of oligonucleotide adducts and base sequence preference of adducts formed by the stereoisomers of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

Ponten I; Seidel A; Jernstrom B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 1996;10(1-4):51-57

Glutathione transferase A1-1 catalyzed conjugation of polycyclic aromatic hydrocarbon diol-epoxides with glutathione

Jernstrom B; Mannervik B; Funk M; Seidel A

Employments

Professor Emeritus/Emerita, Institute of Environmental Medicine, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, 1981

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