Behzad Iravani
About me
I am currently a postdoctoral fellow at the Large-Scale Network Connectivity in the Human Brain Lab, Karolinska Institutet. My research is focused on both invasive and non-invasive brain imaging, using a variety of analytic tools.
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Ph.D. in Medicine - Clinical Neuroscience
M.Sc. in Biomedical - Bioelectric Engineering
B.Sc. in Telecommunication Engineering
Research
I have developed a non-invasive method, the so-called electrobulbogram (EBG), to record from a human olfactory bulb (OB). In this method, we placed 4 active electrodes on the forehead of individuals following the outline of their
- eyebrows. Assessing the spectrogram reveals that EBG can detect the
- characteristics of gamma oscillations of OB. We have further validated this method
- in several experiments. Non-invasive recording from the human olfactory bulb
- [1].
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Our EBG method has shown promising results where we could demonstrate that odor valence processing during the first sniff in humans is a sequential process consisting of early and late processes. The oscillatory behavior of
- these processes is different, and so does their functional role. Specifically,
- we indicated that the early process cues avoidance motor response in
- humans. The human olfactory bulb processes odor valence representation and
- cues motor avoidance behavior [2].
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Moreover, using EBG we further demonstrated that the odor identity can be deciphered from the connectivity between OB and piriform cortex (PC) as
- early as 100ms post odor onset. We also found that the oscillation in
- the OB-PC connectivity evolves from fast gamma oscillations to slower theta
- oscillations during late time points. Additionally, the afferent and efferent
- connections of OB-PC are found to operate in gamma/beta and delta/theta
- respectively. Odor identity can be extracted from the reciprocal
- connectivity between the olfactory bulb and the piriform cortex in humans [3].
Given that OB is the first area of insult in Parkinson's disease (PD), - measuring the OB function seems to be a relevant candidate for early
diagnosis of PD. Yet there was no non-invasive method to measure OB function - in humans until we developed EBG. Using EBG we demonstrated that the
- differences in the oscillator olfactory processes during the first sniff can
- dissociate PD patients from age-matched healthy controls with sensitivity of
- 90% and specificity of 100%, values comparable to clinical odor identification tests. Consequently, this finding puts EBG as a potentially best method for early diagnosis of PD that has to be validated in future works. A
- non-invasive olfactory bulb measure dissociates Parkinson's patients from
- healthy controls and discloses disease duration [4].
[1] https://pubmed.ncbi.nlm.nih.gov/32005822
[2] https://pubmed.ncbi.nlm.nih.gov/34645711
[3] https://pubmed.ncbi.nlm.nih.gov/33951509
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373926
Articles
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Journal article: JOURNAL OF NEUROSCIENCE. 2024;44(11):e1634232024
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Article: BIOLOGICAL PSYCHOLOGY. 2024;187:108770
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Article: PLOS COMPUTATIONAL BIOLOGY. 2023;19(3):e1010958
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Article: BRAIN AND LANGUAGE. 2022;235:105200
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Article: COMMUNICATIONS MEDICINE. 2022;2:34
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Article: NEUROIMAGE-CLINICAL. 2022;36:103266
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Article: CHEMICAL SENSES. 2022;47:bjac022
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(42):e2101209118
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Article: NPJ PARKINSONS DISEASE. 2021;7(1):75
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Article: NEUROIMAGE. 2021;237:118130
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Article: SCIENTIFIC REPORTS. 2021;11(1):16422
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Article: NEUROIMAGE. 2021;231:117844
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Article: I-PERCEPTION. 2021;12(1):2041669520983339-204166952098333
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Article: JOURNAL OF PARKINSONS DISEASE. 2020;10(4):1587-1600
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Journal article: CHEMICAL SENSES. 2020;45(6):491-492
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Article: CHEMICAL SENSES. 2020;:bjaa034-456
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Article: NEUROIMAGE. 2020;207:116347
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Article: NATURE COMMUNICATIONS. 2020;11(1):648
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Article: SCIENTIFIC REPORTS. 2019;9(1):10113
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Journal article: BRAIN STIMULATION. 2019;12(2):590
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Journal article: BRAIN STIMULATION. 2019;12(2):590
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Article: JOURNAL OF NEUROSCIENCE. 2018;38(48):10286-10294
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Article: PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE. 2014;37(4):655-664
- Show more
All other publications
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Preprint: BIORXIV. 2023
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Letter: NPJ PARKINSONS DISEASE. 2023;9(1):95
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Conference publication: CHEMICAL SENSES. 2023;48
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Conference publication: CHEMICAL SENSES. 2023;48
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Editorial comment: NPJ PARKINSONS DISEASE. 2022;8(1):152
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Preprint: MEDRXIV. 2022
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Preprint: SSRN ELECTRONIC JOURNAL. 2022
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Preprint: SSRN ELECTRONIC JOURNAL. 2022
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Thesis / dissertation: 2021
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Preprint: MEDRXIV. 2021
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Preprint: BIORXIV. 2021
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Preprint: BIORXIV. 2019
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Preprint: BIORXIV. 2019
Employments
- Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2022-2025
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2021