Azadeh Karami
Phd Student
E-mail: azadeh.karami@ki.se
Visiting address: Blickagången 16, 14152 Huddinge
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Klinisk geriatrik Eriksdotter, 171 77 Stockholm
About me
- I am a PhD student passionate about pharmacology and the complexity of the
brain. Following the completion of my university studies in pharmacy at
Uppsala University, I gained further experience in Alzheimer´s disease (AD)
research at Novum Science Park. I appreciated the challenges of research and
new discoveries in drug treatment for AD. In order to pursue my strong
interest at the basic science level, I worked as a research assistant for one
year. This experience ultimately inspired me to become a doctoral student
at the Division of Clinical Geriatrics/ Division of Translational Alzheimer
Neurobiology at Karolinska Institutet, a research laboratory internationally
known for leading-edge research on AD.
http://www.sverigesfarmaceuter.se/Aktuellt_och_press/Nyhetsarkiv/Nyheter-2013/Oktober/Azadeh-Karami-far-forskningsanslag-fran-Odd-Fellow/
[1]
2012 Master of Science in Pharmacy, Uppsala University
[1] http://www.sverigesfarmaceuter.se/Aktuellt_och_press/Nyhetsarkiv/Nyheter-2013/Oktober/Azadeh-Karami-far-forskningsanslag-fran-Odd-Fellow/
Research
- My project; To characterize and evaluate the feasibility of ChAT and the
ratio of AChE/BChE as early and longitudinal therapeutic biomarkers of AD
drug therapies targeting the cholinergic system.
We have recently proved that choline acetyltransferase (ChAT) is present in
both plasma and cerebrospinal fluid (CSF) and we have also invented a unique,
simple, non-radioactive and highly sensitive fluorometric/colorimetric assay
of ChAT activity together with a sensitive ELISA assay for determining ChAT
protein levels. This assay will be a useful tool to investigate short- and
long-term effects of drugs aimed at the central cholinergic system.
Articles
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:704583
- Article: MOLECULAR NEUROBIOLOGY. 2019;56(7):4601-4619
- Article: GUT. 2019;68(7):1210-1223
- Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:239
- Article: ALZHEIMERS RESEARCH & THERAPY. 2016;8(1):30
- Article: ALZHEIMERS & DEMENTIA. 2015;11(11):1316-1328
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;43(3):1059-1072