Azadeh Karami

Azadeh Karami

Phd Student
Visiting address: Blickagången 16, 14152 Huddinge
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Klinisk geriatrik Eriksdotter, 171 77 Stockholm

About me

  • I am a PhD student passionate about pharmacology and the complexity of the
    brain. Following the completion of my university studies in pharmacy at
    Uppsala University, I gained further experience in Alzheimer´s disease (AD)
    research at Novum Science Park. I appreciated the challenges of research and
    new discoveries in drug treatment for AD. In order to pursue my strong
    interest at the basic science level, I worked as a research assistant for one
    year. This experience ultimately inspired me to become a doctoral student
    at the Division of Clinical Geriatrics/ Division of Translational Alzheimer
    Neurobiology at Karolinska Institutet, a research laboratory internationally
    known for leading-edge research on AD.
    2012 Master of Science in Pharmacy, Uppsala University


  • My project
  • To characterize and evaluate the feasibility of ChAT and the
    ratio of AChE/BChE as early and longitudinal therapeutic biomarkers of AD
    drug therapies targeting the cholinergic system.
    We have recently proved that choline acetyltransferase (ChAT) is present in
    both plasma and cerebrospinal fluid (CSF) and we have also invented a unique,
    simple, non-radioactive and highly sensitive fluorometric/colorimetric assay
    of ChAT activity together with a sensitive ELISA assay for determining ChAT
    protein levels. This assay will be a useful tool to investigate short- and
    long-term effects of drugs aimed at the central cholinergic system.


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