Åsa Katarina Hedman

Publications
Public outreach and news

Articles

Article: EBIOMEDICINE. 2024;105:105168
Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics
Desai TA; Hedman AK; Dimitriou M; Koprulu M; Figiel S; Yin W; Johansson M; Watts EL; Atkins JR; Sokolov AV; Schioeth HB; Gunter MJ; Tsilidis KK; Martin RM; Pietzner M; Langenberg C; Mills IG; Lamb AD; Maelarstig A; Key TJ; Travis RC; Smith-Byrne K
Article: NATURE COMMUNICATIONS. 2024;15(1):3621
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
Smith-Byrne K; Hedman A; Dimitriou M; Desai T; Sokolov AV; Schioth HB; Koprulu M; Pietzner M; Langenberg C; Atkins J; Penha RC; Mckay J; Brennan P; Zhou S; Richards BJ; Yarmolinsky J; Martin RM; Borlido J; Mu XJ; Butterworth A; Shen X; Wilson J; Assimes TL; Hung RJ; Amos C; Purdue M; Rothman N; Chanock S; Travis RC; Johansson M; Maelarstig A
Article: BRITISH JOURNAL OF CANCER. 2024;130(4):620-627
The impact of circulating protein levels identified by affinity proteomics on short-term, overall breast cancer risk
Grassmann F; Maelarstig A; Dahl L; Bendes A; Dale M; Thomas CE; Gabrielsson M; Hedman AK; Eriksson M; Margolin S; Huang T-H; Ulfstedt M; Forsberg S; Eriksson P; Johansson M; Hall P; Schwenk JM; Czene K
Article: NATURE COMMUNICATIONS. 2023;14(1):7680
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation
Malarstig A; Grassmann F; Dahl L; Dimitriou M; McLeod D; Gabrielson M; Smith-Byrne K; Thomas CE; Huang T-H; Forsberg SKG; Eriksson P; Ulfstedt M; Johansson M; Sokolov AV; Schioth HB; Hall P; Schwenk JM; Czene K; Hedman AK
Article: NATURE. 2023;622(7982):329-338
Plasma proteomic associations with genetics and health in the UK Biobank.
Sun BB; Chiou J; Traylor M; Benner C; Hsu Y-H; Richardson TG; Surendran P; Mahajan A; Robins C; Vasquez-Grinnell SG; Hou L; Kvikstad EM; Burren OS; Davitte J; Ferber KL; Gillies CE; Hedman ÅK; Hu S; Lin T; Mikkilineni R; Pendergrass RK; Pickering C; Prins B; Baird D; Chen C-Y; Ward LD; Deaton AM; Welsh S; Willis CM; Lehner N; Arnold M; Wörheide MA; Suhre K; Kastenmüller G; Sethi A; Cule M; Raj A; Alnylam Human Genetics; AstraZeneca Genomics Initiative; Biogen Biobank Team; Bristol Myers Squibb; Genentech Human Genetics; GlaxoSmithKline Genomic Sciences; Pfizer Integrative Biology; Population Analytics of Janssen Data Sciences; Regeneron Genetics Center; Burkitt-Gray L; Melamud E; Black MH; Fauman EB; Howson JMM; Kang HM; McCarthy MI; Nioi P; Petrovski S; Scott RA; Smith EN; Szalma S; Waterworth DM; Mitnaul LJ; Szustakowski JD; Gibson BW; Miller MR; Whelan CD
Article: NATURE IMMUNOLOGY. 2023;24(9):1540-1551
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
Zhao JH; Stacey D; Eriksson N; Macdonald-Dunlop E; Hedman AK; Kalnapenkis A; Enroth S; Cozzetto D; Digby-Bell J; Marten J; Folkersen L; Herder C; Jonsson L; Bergen SE; Gieger C; Needham EJ; Surendran P; Metspalu A; Milani L; Magi R; Nelis M; Hudjasov G; Paul DS; Polasek O; Thorand B; Grallert H; Roden M; Vosa U; Esko T; Hayward C; Johansson A; Gyllensten U; Powell N; Hansson O; Mattsson-Carlgren N; Joshi PK; Danesh J; Padyukov L; Klareskog L; Landen M; Wilson JF; Siegbahn A; Wallentin L; Malarstig A; Butterworth AS; Peters JE
Article: SCIENTIFIC REPORTS. 2023;13(1):10058
Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs
Hedman AK; Winter E; Yoosuf N; Benita Y; Berg L; Brynedal B; Folkersen L; Klareskog L; Maciejewski M; Sirota-Madi A; Spector Y; Ziemek D; Padyukov L; Shen-Orr SS; Jelinsky SA
Article: NATURE. 2023;613(7944):508-518
FinnGen provides genetic insights from a well-phenotyped isolated population
Kurki MI; Karjalainen J; Palta P; Sipila TP; Kristiansson K; Donner KM; Reeve MP; Laivuori H; Aavikko M; Kaunisto MA; Loukola A; Lahtela E; Mattsson H; Laiho P; Parolo PDB; Lehisto AA; Kanai M; Mars N; Ramo J; Kiiskinen T; Heyne HO; Veerapen K; Rueger S; Lemmela S; Zhou W; Ruotsalainen S; Parn K; Hiekkalinna T; Koskelainen S; Paajanen T; Llorens V; Gracia-Tabuenca J; Siirtola H; Reis K; Elnahas AG; Sun B; Foley CN; Aalto-Setala K; Alasoo K; Arvas M; Auro K; Biswas S; Bizaki-Vallaskangas A; Carpen O; Chen C-Y; Dada OA; Ding Z; Ehm MG; Eklund K; Farkkila M; Finucane H; Ganna A; Ghazal A; Graham RR; Green EM; Hakanen A; Hautalahti M; Hedman AK; Hiltunen M; Hinttala R; Hovatta I; Hu X; Huertas-Vazquez A; Huilaja L; Hunkapiller J; Jacob H; Jensen J-N; Joensuu H; John S; Julkunen V; Jung M; Junttila J; Kaarniranta K; Kahonen M; Kajanne R; Kallio L; Kalviainen R; Kaprio J; Kerimov N; Kettunen J; Kilpelainen E; Kilpi T; Klinger K; Kosma V-M; Kuopio T; Kurra V; Laisk T; Laukkanen J; Lawless N; Liu A; Longerich S; Magi R; Makela J; Makitie A; Malarstig A; Mannermaa A; Maranville J; Matakidou A; Meretoja T; Mozaffari SV; Niemi MEK; Niemi M; Niiranen T; Okafo G; Ollila HM; Palomaki A; Palotie T; Partanen J; Paul DS; Pelkonen M; Pendergrass RK; Petrovski S; Pitkaranta A; Platt A; Pulford D; Punkka E; Pussinen P; Raghavan N; Rahimov F; Rajpal D; Renaud NA; Riley-Gillis B; Rodosthenous R; Saarentaus E; Salminen A; Salminen E; Salomaa V; Schleutker J; Serpi R; Shen H-Y; Siegel R; Silander K; Siltanen S; Soini S; Soininen H; Sul JH; Tachmazidou I; Tasanen K; Tienari P; Toppila-Salmi S; Tukiainen T; Tuomi T; Turunen JA; Ulirsch JC; Vaura F; Virolainen P; Waring J; Waterworth D; Yang R; Nelis M; Reigo A; Metspalu A; Milani L; Esko T; Fox C; Havulinna AS; Perola M; Ripatti S; Jalanko A; Laitinen T; Makela TP; Plenge R; McCarthy M; Runz H; Daly MJ; Palotie A
Article: EMBO MOLECULAR MEDICINE. 2023;15(1):e16359
The genetic regulation of protein expression in cerebrospinal fluid
Hansson O; Kumar A; Janelidze S; Stomrud E; Insel PS; Blennow K; Zetterberg H; Fauman E; Hedman AK; Nagle MW; Whelan CD; Baird D; Malarstig A; Mattsson-Carlgren N
Article: ESC HEART FAILURE. 2021;8(6):5531-5541
The genomics of heart failure: design and rationale of the HERMES consortium
Lumbers RT; Shah S; Lin H; Czuba T; Henry A; Swerdlow DI; Malarstig A; Andersson C; Verweij N; Holmes MV; Arnlov J; Svensson P; Hemingway H; Sallah N; Almgren P; Aragam KG; Asselin G; Backman JD; Biggs ML; Bloom HL; Boersma E; Brandimarto J; Brown MR; Brunner-La Rocca H-P; Carey DJ; Chaffin MD; Chasman DI; Chazara O; Chen X; Chen X; Chung JH; Chutkow W; Cleland JGF; Cook JP; de Denus S; Dehghan A; Delgado GE; Denaxas S; Doney AS; Doerr M; Dudley SC; Engstrom G; Esko T; Fatemifar G; Felix SB; Finan C; Ford I; Fougerousse F; Fouodjio R; Ghanbari M; Ghasemi S; Giedraitis V; Giulianini F; Gottdiener JS; Gross S; Guobjartsson DF; Gui H; Gutmann R; Haggerty CM; van der Harst P; Hedman AK; Helgadottir A; Hillege H; Hyde CL; Jacob J; Jukema JW; Kamanu F; Kardys I; Kavousi M; Khaw K-T; Kleber ME; Kober L; Koekemoer A; Kraus B; Kuchenbaecker K; Langenberg C; Lind L; Lindgren CM; London B; Lotta LA; Lovering RC; Luan J; Magnusson P; Mahajan A; Mann D; Margulies KB; Marston NA; Maerz W; McMurray JJV; Melander O; Melloni G; Mordi IR; Morley MP; Morris AD; Morris AP; Morrison AC; Nagle MW; Nelson CP; Newton-Cheh C; Niessner A; Niiranen T; Nowak C; O'Donoghue ML; Owens AT; Palmer CNA; Pare G; Perola M; Perreault L-PL; Portilla-Fernandez E; Psaty BM; Rice KM; Ridker PM; Romaine SPR; Roselli C; Rotter JI; Ruff CT; Sabatine MS; Salo P; Salomaa V; van Setten J; Shalaby AA; Smelser DT; Smith NL; Stefansson K; Stender S; Stott DJ; Sveinbjornsson G; Tammesoo M-L; Tardif J-C; Taylor KD; Teder-Laving M; Teumer A; Thorgeirsson G; Thorsteinsdottir U; Torp-Pedersen C; Trompet S; Tuckwell D; Tyl B; Uitterlinden AG; Vaura F; Veluchamy A; Visscher PM; Voelker U; Voors AA; Wang X; Wareham NJ; Weeke PE; Weiss R; White HD; Wiggins KL; Xing H; Yang J; Yang Y; Yerges-Armstrong LM; Yu B; Zannad F; Zhao F; Wilk JB; Holm H; Sattar N; Lubitz SA; Lanfear DE; Shah S; Dunn ME; Wells QS; Asselbergs FW; Hingorani AD; Dube M-P; Samani NJ; Lang CC; Cappola TP; Ellinor PT; Vasan RS; Smith JG
Article: NATURE COMMUNICATIONS. 2021;12(1):3987
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Jhun M-A; Mendelson M; Wilson R; Gondalia R; Joehanes R; Salfati E; Zhao X; Braun KVE; Do AN; Hedman AK; Zhang T; Carnero-Montoro E; Shen J; Bartz TM; Brody JA; Montasser ME; O'Connell JR; Yao C; Xia R; Boerwinkle E; Grove M; Guan W; Liliane P; Singmann P; Mueller-Nurasyid M; Meitinger T; Gieger C; Peters A; Zhao W; Ware EB; Smith JA; Dhana K; van Meurs J; Uitterlinden A; Ikram MA; Ghanbari M; Zhi D; Gustafsson S; Lind L; Li S; Sun D; Spector TD; Chen Y-DI; Damcott C; Shuldiner AR; Absher DM; Horvath S; Tsao PS; Kardia S; Psaty BM; Sotoodehnia N; Bell JT; Ingelsson E; Chen W; Dehghan A; Arnett DK; Waldenberger M; Hou L; Whitsel EA; Baccarelli A; Levy D; Fornage M; Irvin MR; Assimes TL
Article: NATURE METABOLISM. 2020;2(10):1135-1148
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen L; Gustafsson S; Wang Q; Hansen DH; Hedman AK; Schork A; Page K; Zhernakova DV; Wu Y; Peters J; Eriksson N; Bergen SE; Boutin TS; Bretherick AD; Enroth S; Kalnapenkis A; Gadin JR; Suur BE; Chen Y; Matic L; Gale JD; Lee J; Zhang W; Quazi A; Ala-Korpela M; Choi SH; Claringbould A; Danesh J; Smith GD; de Masi F; Elmstahl S; Engstrom G; Fauman E; Fernandez C; Franke L; Franks PW; Giedraitis V; Haley C; Hamsten A; Ingason A; Johansson A; Joshi PK; Lind L; Lindgren CM; Lubitz S; Palmer T; Macdonald-Dunlop E; Magnusson M; Melander O; Michaelsson K; Morris AP; Magi R; Nagle MW; Nilsson PM; Nilsson J; Orho-Melander M; Polasek O; Prins B; Palsson E; Qi T; Sjogren M; Sundstrom J; Surendran P; Vosa U; Werge T; Wernersson R; Westra H-J; Yang J; Zhernakova A; Arnlov J; Fu J; Smith JG; Esko T; Hayward C; Gyllensten U; Landen M; Siegbahn A; Wilson JF; Wallentin L; Butterworth AS; Holmes MV; Ingelsson E; Malarstig A
Article: HEART. 2020;106(5):342-349
Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning
Hedman AK; Hage C; Sharma A; Brosnan MJ; Buckbinder L; Gan L-M; Shah SJ; Linde CM; Donal E; Daubert J-C; Malarstig A; Ziemek D; Lund L
Article: NATURE COMMUNICATIONS. 2020;11(1):163
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Shah S; Henry A; Roselli C; Lin H; Sveinbjornsson G; Fatemifar G; Hedman AK; Wilk JB; Morley MP; Chaffin MD; Helgadottir A; Verweij N; Dehghan A; Almgren P; Andersson C; Aragam KG; Arnlov J; Backman JD; Biggs ML; Bloom HL; Brandimarto J; Brown MR; Buckbinder L; Carey DJ; Chasman DI; Chen X; Chen X; Chung J; Chutkow W; Cook JP; Delgado GE; Denaxas S; Doney AS; Doerr M; Dudley SC; Dunn ME; Engstrom G; Esko T; Felix SB; Finan C; Ford I; Ghanbari M; Ghasemi S; Giedraitis V; Giulianini F; Gottdiener JS; Gross S; Gudbjartsson DF; Gutmann R; Haggerty CM; van der Harst P; Hyde CL; Ingelsson E; Jukema JW; Kavousi M; Khaw K-T; Kleber ME; Kober L; Koekemoer A; Langenberg C; Lind L; Lindgren CM; London B; Lotta LA; Lovering RC; Luan J; Magnusson P; Mahajan A; Margulies KB; Maerz W; Melander O; Mordi IR; Morgan T; Morris AD; Morris AP; Morrison AC; Nagle MW; Nelson CP; Niessner A; Niiranen T; O'Donoghue ML; Owens AT; Palmer CNA; Parry HM; Perola M; Portilla-Fernandez E; Psaty BM; Rice KM; Ridker PM; Romaine SPR; Rotter JI; Salo P; Salomaa V; van Setten J; Shalaby AA; Smelser DT; Smith NL; Stender S; Stott DJ; Svensson P; Tammesoo M-L; Taylor KD; Teder-Laving M; Teumer A; Thorgeirsson G; Thorsteinsdottir U; Torp-Pedersen C; Trompet S; Tyl B; Uitterlinden AG; Veluchamy A; Voelker U; Voors AA; Wang X; Wareham NJ; Waterworth D; Weeke PE; Weiss R; Wiggins KL; Xing H; Yerges-Armstrong LM; Yu B; Zannad F; Zhao JH; Hemingway H; Samani NJ; McMurray JJV; Yang J; Visscher PM; Newton-Cheh C; Malarstig A; Holm H; Lubitz SA; Sattar N; Holmes MV; Cappola TP; Asselbergs FW; Hingorani AD; Kuchenbaecker K; Ellinor PT; Lang CC; Stefansson K; Smith JG; Vasan RS; Swerdlow DI; Lumbers RT; Abecasis G; Backman J; Bai X; Balasubramanian S; Banerjee N; Baras A; Barnard L; Beechert C; Blumenfeld A; Cantor M; Chai Y; Chung J; Coppola G; Damask A; Dewey F; Economides A; Eom G; Forsythe C; Fuller ED; Gu Z; Gurski L; Guzzardo PM; Habegger L; Hahn Y; Hawes A; van Hout C; Jones MB; Khalid S; Lattari M; Li A; Lin N; Liu D; Lopez A; Manoochehri K; Marchini J; Marcketta A; Maxwell EK; McCarthy S; Mitnaul LJ; O'Dushlaine C; Overton JD; Padilla MS; Paulding C; Penn J; Pradhan M; Reid JG; Schleicher TD; Schurmann C; Shuldiner A; Staples JC; Sun D; Toledo K; Ulloa RH; Widom L; Wolf SE; Yadav A; Ye B
Article: CLINICAL EPIGENETICS. 2019;11(1):187
Comprehensive longitudinal study of epigenetic mutations in aging
Wang Y; Karlsson R; Jylhava J; Hedman AK; Almqvist C; Karlsson IK; Pedersen NL; Almgren M; Hagg S
Article: SCIENCE ADVANCES. 2019;5(9):eaaw3095
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Alves AC; De Silva NMG; Karhunen V; Sovio U; Das S; Taal HR; Warrington NM; Lewin AM; Kaakinen M; Cousminer DL; Thiering E; Timpson NJ; Bond TA; Lowry E; Brown CD; Estivill X; Lindi V; Bradfield JP; Geller F; Speed D; Coin LJM; Loh M; Barton SJ; Beilin LJ; Bisgaard H; Bonnelykke K; Alili R; Hatoum IJ; Schramm K; Cartwright R; Charles M-A; Salerno V; Clement K; Claringbould AAJ; van Duijn CM; Moltchanova E; Eriksson JG; Elks C; Feenstra B; Flexeder C; Franks S; Frayling TM; Freathy RM; Elliott P; Widen E; Hakonarson H; Hattersley AT; Rodriguez A; Banterle M; Heinrich J; Heude B; Holloway JW; Hofman A; Hypponen E; Inskip H; Kaplan LM; Hedman AK; Laara E; Prokisch H; Grallert H; Lakka TA; Lawlor DA; Melbye M; Ahluwalia TS; Marinelli M; Millwood IY; Palmer LJ; Pennell CE; Perry JR; Ring SM; Savolainen MJ; Rivadeneira F; Standl M; Sunyer J; Tiesler CMT; Uitterlinden AG; Schierding W; O'Sullivan JM; Prokopenko I; Herzig K-H; Smith GD; O'Reilly P; Felix JF; Buxton JL; Blakemore AIF; Ong KK; Jaddoe VWV; Grant SFA; Sebert S; McCarthy MI; Jarvelin M-R
Article: NATURE COMMUNICATIONS. 2019;10(1):1209
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements.
Allum F; Hedman ÅK; Shao X; Cheung WA; Vijay J; Guénard F; Kwan T; Simon M-M; Ge B; Moura C; Boulier E; Rönnblom L; Bernatsky S; Lathrop M; McCarthy MI; Deloukas P; Tchernof A; Pastinen T; Vohl M-C; Grundberg E
Article: EPIGENETICS. 2018;13(9):975-987
Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins
Wang Y; Karlsson R; Lampa E; Zhang Q; Hedman AK; Almgren M; Almqvist C; McRae AF; Marioni RE; Ingelsson E; Visscher PM; Deary IJ; Lind L; Morris T; Beck S; Pedersen NL; Hagg S
Article: MOLECULAR PSYCHIATRY. 2018;23(2):422-433
A DNA methylation biomarker of alcohol consumption
Liu C; Marioni RE; Hedman AK; Pfeiffer L; Tsai P-C; Reynolds LM; Just AC; Duan Q; Boer CG; Tanaka T; Elks CE; Aslibekyan S; Brody JA; Kuehnel B; Herder C; Almli LM; Zhi D; Wang Y; Huan T; Yao C; Mendelson MM; Joehanes R; Liang L; Love S-A; Guan W; Shah S; Mcrae AF; Kretschmer A; Prokisch H; Strauch K; Peters A; Visscher PM; Wray NR; Guo X; Wiggins KL; Smith AK; Binder EB; Ressler KJ; Irvin MR; Absher DM; Hernandez D; Ferrucci L; Bandinelli S; Lohman K; Ding J; Trevisi L; Gustafsson S; Sandling JH; Stolk L; Uitterlinden AG; Yet I; Castillo-Fernandez JE; Spector TD; Schwartz JD; Vokonas P; Lind L; Li Y; Fornage M; Arnett DK; Wareham NJ; Sotoodehnia N; Ong KK; van Meurs JBJ; Conneely KN; Baccarelli AA; Deary IJ; Bell JT; North KE; Liu Y; Waldenberger M; London SJ; Ingelsson E; Levy D
Article: HUMAN MOLECULAR GENETICS. 2017;26(16):3221-3231
Tea and coffee consumption in relation to DNA methylation in four European cohorts.
Ek WE; Tobi EW; Ahsan M; Lampa E; Ponzi E; Kyrtopoulos SA; Georgiadis P; Lumey LH; Heijmans BT; Botsivali M; Bergdahl IA; Karlsson T; Rask-Andersen M; Palli D; Ingelsson E; Hedman ÅK; Nilsson LM; Vineis P; Lind L; Flanagan JM; Johansson Å; Epigenome-Wide Association Study
Article: PLOS MEDICINE. 2017;14(1):e1002215
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach
Mendelson MM; Marioni RE; Joehanes R; Liu C; Hedman AK; Aslibekyan S; Demerath EW; Guan W; Zhi D; Yao C; Huan T; Willinger C; Chen B; Courchesne P; Multhaup M; Lrvin MR; Cohain A; Schadt EE; Grove ML; Bressler J; North K; Sundstrom J; Gustafsson S; Shah S; McRae AF; Harris SE; Gibson J; Redmond P; Coriey J; Murphy L; Starr JM; Kleinbrink E; Lipovich L; Visscher PM; Wray NR; Krauss RM; Fallin D; Feinberg A; Absher DM; Fornage M; Pankow JS; Lind L; Fox C; Ingelsson E; Arnett DK; Boerwinkle E; Liang L; Levy D; Deary LJ
Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2017;10(1):e001487
Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies
Hedman AK; Mendelson MM; Marioni RE; Gustafsson S; Joehanes R; Irvin MR; Zhi D; Sandling JK; Yao C; Liu C; Liang L; Huan T; McRae AF; Demissie S; Shah S; Starr JM; Cupples LA; Deloukas P; Spector TD; Sundstrom J; Krauss RM; Arnett DK; Deary IJ; Lind L; Levy D; Ingelsson E
Article: JOURNAL OF LIPID RESEARCH. 2016;57(12):2176-2184
Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36
Love-Gregory L; Kraja AT; Allum F; Aslibekyan S; Hedman AK; Duan Y; Borecki IB; Arnett DK; McCarthy MI; Deloukas P; Ordovas JM; Hopkins PN; Grundberg E; Abumrad NA
Article: BMC MEDICAL GENOMICS. 2016;9(1):72
DNA methylation patterns associated with oxidative stress in an ageing population
Hedman AK; Zilmer M; Sundstrom J; Lind L; Ingelsson E
Article: HUMAN MOLECULAR GENETICS. 2016;25(4):817-827
Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15
Ek WE; Hedman AK; Enroth S; Morris AP; Lindgren CM; Mahajan A; Gustafsson S; Gyllensten U; Lind L; Johansson A
Article: NATURE COMMUNICATIONS. 2016;7:10495
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu Y; Day FR; Gustafsson S; Buchkovich ML; Na J; Bataille V; Cousminer DL; Dastani Z; Drong AW; Esko T; Evans DM; Falchi M; Feitosa MF; Ferreira T; Hedman AK; Haring R; Hysi PG; Iles MM; Justice AE; Kanoni S; Lagou V; Li R; Li X; Locke A; Lu C; Magi R; Perry JRB; Pers TH; Qi Q; Sanna M; Schmidt EM; Scott WR; Shungin D; Teumer A; Vinkhuyzen AAE; Walker RW; Westra H-J; Zhang M; Zhang W; Zhao JH; Zhu Z; Afzal U; Ahluwalia TS; Bakker SJL; Bellis C; Bonnefond A; Borodulin K; Buchman AS; Cederholm T; Choh AC; Choi HJ; Curran JE; de Groot LCPGM; De Jager PL; Dhonukshe-Rutten RAM; Enneman AW; Eury E; Evans DS; Forsen T; Friedrich N; Fumeron F; Garcia ME; Gartner S; Han B-G; Havulinna AS; Hayward C; Hernandez D; Hillege H; Ittermann T; Kent JW; Kolcic I; Laatikainen T; Lahti J; Leach IM; Lee CG; Lee J-Y; Liu T; Liu Y; Lobbens S; Loh M; Lyytikainen L-P; Medina-Gomez C; Michaelsson K; Nalls MA; Nielson CM; Oozageer L; Pascoe L; Paternoster L; Polasek O; Ripatti S; Sarzynski MA; Shin CS; Narancic NS; Spira D; Srikanth P; Steinhagen-Thiessen E; Sung YJ; Swart KMA; Taittonen L; Tanaka T; Tikkanen E; van der Velde N; van Schoor NM; Verweij N; Wright AF; Yu L; Zmuda JM; Eklund N; Forrester T; Grarup N; Jackson AU; Kristiansson K; Kuulasmaa T; Kuusisto J; Lichtner P; Luan J; Mahajan A; Mannisto S; Palmer CD; Ried JS; Scott RA; Stancakova A; Wagner PJ; Demirkan A; Doring A; Gudnason V; Kiel DP; Kuhnel B; Mangino M; Mcknight B; Menni C; O'Connell JR; Oostra BA; Shuldiner AR; Song K; Vandenput L; van Duijn CM; Vollenweider P; White CC; Boehnke M; Boettcher Y; Cooper RS; Forouhi NG; Gieger C; Grallert H; Hingorani A; Jorgensen T; Jousilahti P; Kivimaki M; Kumari M; Laakso M; Langenberg C; Linneberg A; Luke A; Mckenzie CA; Palotie A; Pedersen O; Peters A; Strauch K; Tayo BO; Wareham NJ; Bennett DA; Bertram L; Blangero J; Bluher M; Bouchard C; Campbell H; Cho NH; Cummings SR; Czerwinski SA; Demuth I; Eckardt R; Eriksson JG; Ferrucci L; Franco OH; Froguel P; Gansevoort RT; Hansen T; Harris TB; Hastie N; Heliovaara M; Hofman A; Jordan JM; Jula A; Kahonen M; Kajantie E; Knekt PB; Koskinen S; Kovacs P; Lehtimaki T; Lind L; Liu Y; Orwoll ES; Osmond C; Perola M; Perusse L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Rivadeneira F; Rudan I; Salomaa V; Sorensen TIA; Stumvoll M; Tonjes A; Towne B; Tranah GJ; Tremblay A; Uitterlinden AG; van der Harst P; Vartiainen E; Viikari JS; Vitart V; Vohl M-C; Volzke H; Walker M; Wallaschofski H; Wild S; Wilson JF; Yengo L; Bishop DT; Borecki IB; Chambers JC; Cupples LA; Dehghan A; Deloukas P; Fatemifar G; Fox C; Furey TS; Franke L; Han J; Hunter DJ; Karjalainen J; Karpe F; Kaplan RC; Kooner JS; McCarthy MI; Murabito JM; Morris AP; Bishop JAN; North KE; Ohlsson C; Ong KK; Prokopenko I; Richards JB; Schadt EE; Spector TD; Widen E; Willer CJ; Yang J; Ingelsson E; Mohlke KL; Hirschhorn JN; Pospisilik JA; Zillikens MC; Lindgren C; Kilpelainen TO; Loos RJF
Article: NATURE COMMUNICATIONS. 2016;7:10494
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
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Grundberg E; Small KS; Hedman AK; Nica AC; Buil A; Keildson S; Bell JT; Yang T-P; Meduri E; Barrett A; Nisbett J; Sekowska M; Wilk A; Shin S-Y; Glass D; Travers M; Min JL; Ring S; Ho K; Thorleifsson G; Kong A; Thorsteindottir U; Ainali C; Dimas AS; Hassanali N; Ingle C; Knowles D; Krestyaninova M; Lowe CE; Di Meglio P; Montgomery SB; Parts L; Potter S; Surdulescu G; Tsaprouni L; Tsoka S; Bataille V; Durbin R; Nestle FO; O'Rahilly S; Soranzo N; Lindgren CM; Zondervan KT; Ahmadi KR; Schadt EE; Stefansson K; Smith GD; McCarthy MI; Deloukas P; Dermitzakis ET; Spector TD
Article: PLOS ONE. 2012;7(6):e39718
Transcriptional Profiling of Serogroup B Neisseria meningitidis Growing in Human Blood: An Approach to Vaccine Antigen Discovery
Hedman AK; Li M-S; Langford PR; Kroll JS
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Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
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Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue
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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
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Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
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Article: PLOS GENETICS. 2011;7(4):e1002025
Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms
Zhai G; Teumer A; Stolk L; Perry JRB; Vandenput L; Coviello AD; Koster A; Bell JT; Bhasin S; Eriksson J; Eriksson A; Ernst F; Ferrucci L; Frayling TM; Glass D; Grundberg E; Haring R; Hedman AK; Hofman A; Kiel DP; Kroemer HK; Liu Y; Lunetta KL; Maggio M; Lorentzon M; Mangino M; Melzer D; Miljkovic I; Nica A; Penninx BWJH; Vasan RS; Rivadeneira F; Small KS; Soranzo N; Uitterlinden AG; Voelzke H; Wilson SG; Xi L; Zhuang WV; Harris TB; Murabito JM; Ohlsson C; Murray A; de Jong FH; Spector TD; Wallaschofski H
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The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study
Nica AC; Parts L; Glass D; Nisbet J; Barrett A; Sekowska M; Travers M; Potter S; Grundberg E; Small K; Hedman AK; Bataille V; Bell JT; Surdulescu G; Dimas AS; Ingle C; Nestle FO; di Meglio P; Min JL; Wilk A; Hammond CJ; Hassanali N; Yang T-P; Montgomery SB; O'Rahilly S; Lindgren CM; Zondervan KT; Soranzo N; Barroso I; Durbin R; Ahmadi K; Deloukas P; McCarthy MI; Dermitzakis ET; Spector TD
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SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data
Price TS; Regan R; Mott R; Hedman A; Honey B; Daniels RJ; Smith L; Greenfield A; Tiganescu A; Buckle V; Ventress N; Ayyub H; Salhan A; Pedraza-Diaz S; Broxholme J; Ragoussis J; Higgs DR; Flint J; Knight SJL
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Desai TA; Hedman ÅK; Dimitriou M; Koprulu M; Figiel S; Yin W; Johansson M; Watts EL; Atkins JR; Sokolov AV; Schiöth HB; Gunter MJ; Tsilidis KK; Martin RM; Pietzner M; Langenberg C; Mills IG; Lamb AD; Mälarstig A; Key TJ; PRACTICAL Consortium; Travis RC; Smith-Byrne K
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Jhun M-A; Mendelson M; Wilson R; Gondalia R; Joehanes R; Salfati E; Zhao X; Braun KVE; Do AN; Hedman AK; Zhang T; Carnero-Montoro E; Shen J; Bartz TM; Brody JA; Montasser ME; O'Connell JR; Yao C; Xia R; Boerwinkle E; Grove M; Guan W; Liliane P; Singmann P; Mueller-Nurasyid M; Meitinger T; Gieger C; Peters A; Zhao W; Ware EB; Smith JA; Dhana K; van Meurs J; Uitterlinden A; Ikram MA; Ghanbari M; Zhi D; Gustafsson S; Lind L; Li S; Sun D; Spector TD; Chen Y-DI; Damcott C; Shuldiner AR; Absher DM; Horvath S; Tsao PS; Kardia S; Psaty BM; Sotoodehnia N; Bell JT; Ingelsson E; Chen W; Dehghan A; Arnett DK; Waldenberger M; Hou L; Whitsel EA; Baccarelli A; Levy D; Fornage M; Irvin MR; Assimes TL
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Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19.
Klaric L; Gisby JS; Papadaki A; Muckian MD; Macdonald-Dunlop E; Zhao JH; Tokolyi A; Persyn E; Pairo-Castineira E; Morris AP; Kalnapenkis A; Richmond A; Landini A; Hedman ÅK; Prins B; Zanetti D; Wheeler E; Kooperberg C; Yao C; Petrie JR; Fu J; Folkersen L; Walker M; Magnusson M; Eriksson N; Mattsson-Carlgren N; Timmers PRHJ; Hwang S-J; Enroth S; Gustafsson S; Vosa U; Chen Y; Siegbahn A; Reiner A; Johansson Å; Thorand B; Gigante B; Hayward C; Herder C; Gieger C; Langenberg C; Levy D; Zhernakova DV; Smith JG; Campbell H; Sundstrom J; Danesh J; Michaëlsson K; Suhre K; Lind L; Wallentin L; Padyukov L; Landén M; Wareham NJ; Göteson A; Hansson O; Eriksson P; Strawbridge RJ; Assimes TL; Esko T; Gyllensten U; Baillie JK; Paul DS; Joshi PK; Butterworth AS; Mälarstig A; Pirastu N; Wilson JF; Peters JE
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Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.
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