Antonio Gigliotti Rothfuchs
About me
My laboratory works on tuberculosis.
I have more than 15 years of research experience with intracellular
pathogens, primarily Mycobacterium species, under Biosafety Level 2 (BSL2)
and BSL3, and in mouse models. I am Chairman of the Biosafety Committee at
Karolinska Institutet and help oversee KI's regulations on biosafety,
containment work in different biosafety levels and the handling of
genetically-modified microorganisms. I am also Director of the BSL3 core
facility at Biomedicum which supports research on risk group 3 bacteria,
parasites and viruses.
Associate Professor of Immunology (Docent), Karolinska Institutet. 2014
Doctor of Medical Science (PhD) in Immunobiology, Karolinska Institutet. 2004
Master of Medical Science with a Major in Biomedicine, Karolinska Institutet. 1999
Research
My laboratory does basic research on the immunology and infection biology of
mycobacteria. We are particularly interested in the aerobiology of
Mycobacterium tuberculosis and in techniques to capture and analyze
pathogens in the air. We have developed an aerobiology platform in BSL3 where
highly-pathogenic microorganisms can be safely and experimentally
aerosolized, collected using different air samplers and detected by different
analytical methods. We are using this platform to investigate the performance
of an electrostatic air sampler for M. tuberculosis developed in the lab;
to investigate biosafety and sampling performance of commercial samplers; and
to study the effects of aerosol transport on the survival, infectivity and
immune response of M. tuberculosis and SARS-CoV-2.
Teaching
Coordinator, KI Summer School in Medical Research (KISS) https://education.ki.se/ki-summer-school-in-medical-research
Teacher, Basic Laboratory Safety (course 2690)
Teacher, Immunology and Microbiology (course 1BI041)
Articles
- Article: INFECTIOUS DISEASES. 2024;56(11):991-999
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(3):e13342
- Article: MOLECULAR PSYCHIATRY. 2022;27(10):3939-3950
- Article: JOURNAL OF IMMUNOLOGY. 2022;208(11):2549-2557
- Article: INDOOR AIR. 2022;32(3):e13023
- Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267
- Article: JOURNAL OF IMMUNOLOGY. 2021;206(4):776-784
- Article: ANNALS OF WORK EXPOSURES AND HEALTH. 2020;64(8):852-865
- Article: NATURE COMMUNICATIONS. 2020;11(1):4812
- Article: TUBERCULOSIS. 2020;120:101896
- Article: PLOS PATHOGENS. 2018;14(5):e1007008
- Article: SCIENTIFIC REPORTS. 2017;7:43989
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2016;(116):54620
- Article: JOURNAL OF IMMUNOLOGY. 2016;196(5):2262-2271
- Article: PLOS PATHOGENS. 2015;11(10):e1005206
- Article: MICROBES AND INFECTION. 2015;17(5):337-344
- Article: JOURNAL OF IMMUNOLOGY. 2012;188(2):649-660
- Article: PLOS ONE. 2012;7(11):e47835
- Article: IMMUNITY. 2011;34(5):807-819
- Article: MICROBES AND INFECTION. 2011;13(2):198-201
- Article: EXPERIMENTAL PARASITOLOGY. 2010;125(4):315-324
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2010;120(5):1674-1682
- Article: JOURNAL OF IMMUNOLOGY. 2009;182(11):6915-6925
- Article: BLOOD. 2008;112(4):1461-1471
- Article: EUROPEAN RESPIRATORY JOURNAL. 2008;32(2):405-412
- Article: IMMUNITY. 2008;28(2):271-284
- Article: JOURNAL OF IMMUNOLOGY. 2007;179(6):3463-3471
- Article: JOURNAL OF IMMUNOLOGY. 2006;177(10):7086-7093
- Article: JOURNAL OF IMMUNOLOGY. 2006;176(11):6982-6990
- Article: JOURNAL OF IMMUNOLOGY. 2004;172(10):6345-6353
- Article: JOURNAL OF IMMUNOLOGY. 2004;172(4):2407-2415
- Article: INFECTION AND IMMUNITY. 2003;71(7):4102-4111
- Article: JOURNAL OF IMMUNOLOGY. 2001;167(11):6453-6461
- Article: INFECTION AND IMMUNITY. 2001;69(7):4232-4241
- Article: JOURNAL OF IMMUNOLOGY. 2000;164(9):4812-4818
- Article: JOURNAL OF IMMUNOLOGY. 1999;162(5):2829-2836
- Show more
All other publications
- Letter: INDOOR AIR. 2022;32(11):e13169
- Corrigendum: INDOOR AIR. 2022;32(8):e13085
- Doctoral thesis: 2004
- Review: CURRENT OPINION IN IMMUNOLOGY. 2002;14(4):444-451
Grants
- BSL3 Biomedicum-SciLifeLab collaborative platformSciLifeLab
- Advancing environmental virus profiling and risk assessment for public health perspectiveKAW/SciLifeLab
- Kapacitetsuppbyggnad av BSL3 för att utveckla COVID-19 forskning på aktivt virus samt celler och vävnader infekterade med SARS-CoV-2TetraLaval/TetraPak
- Survival and infectiousness of Mycobacterium tuberculosis in aerosolsKarolinska Institutet
- Diagnosing and tracing tuberculosis through electrostatic cough samplingSwedish Heart-Lung Foundation
- Testing BSL3 Biomedicum capabilities and moreSciLifeLab
- Aerosolization of Mycobacterium tuberculosis: establishing its role in the transmission of tuberculosisSwedish Research Council
- BSL3 Biomedicum Core FacilityKarolinska Institutet
- Exploring how aerosol transport and particle size impacts mycobacterial infectionKarolinska Institutet
- EnBiFlu, testing the efficiency of multifaceted enviornmental assessment of avian influenza threats and outbreaksSciLifeLab
- BSL3 capacity for Pandemic Laboratory PreparednessSciLifeLab
- Swedish Environmental Epidemiology Center, a holistic pandemic preparedness capability for health-related environmental research and surveillanceSciLifeLab
Employments
- Principal Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2014
- Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2004
- Master Of Medical Science, Karolinska Institutet, 1999