Antonio Gigliotti Rothfuchs
About me
My laboratory works on tuberculosis.
I have more than 15 years of research experience with intracellular
pathogens, primarily Mycobacterium species, under Biosafety Level 2 (BSL2)
and BSL3, and in mouse models. I am Chairman of the Biosafety Committee at
Karolinska Institutet and help oversee KI's regulations on biosafety,
containment work in different biosafety levels and the handling of
genetically-modified microorganisms. I am also Director of the BSL3 core
facility at Biomedicum which supports research on risk group 3 bacteria,
parasites and viruses.
Associate Professor of Immunology (Docent), Karolinska Institutet. 2014
Doctor of Medical Science (PhD) in Immunobiology, Karolinska Institutet. 2004
Master of Medical Science with a Major in Biomedicine, Karolinska Institutet. 1999
Research
My laboratory does basic research on the immunology and infection biology of
mycobacteria. We are particularly interested in the aerobiology of
Mycobacterium tuberculosis and in techniques to capture and analyze
pathogens in the air. We have developed an aerobiology platform in BSL3 where
highly-pathogenic microorganisms can be safely and experimentally
aerosolized, collected using different air samplers and detected by different
analytical methods. We are using this platform to investigate the performance
of an electrostatic air sampler for M. tuberculosis developed in the lab;
to investigate biosafety and sampling performance of commercial samplers; and
to study the effects of aerosol transport on the survival, infectivity and
immune response of M. tuberculosis and SARS-CoV-2.
Teaching
Coordinator, KI Summer School in Medical Research (KISS) https://education.ki.se/ki-summer-school-in-medical-research
Teacher, Basic Laboratory Safety (course 2690)
Teacher, Immunology and Microbiology (course 1BI041)
Articles
- Article: INFECTIOUS DISEASES. 2024;56(11):991-999de Sousa NR; Margerie L; Steponaviciute L; Roux J; Kinahan MW; Olsson D; Asgeirsson H; Udekwu KI; Rothfuchs AG
- Journal article: BIOSENSORS AND BIOELECTRONICS: X. 2024;19:100488Du H; Bruno S; Overholt KJ; Palacios S; Huang H-H; Barajas C; Gross B; Lee C; Evile HK; de Sousa NR; Rothfuchs AG; Del Vecchio D
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(3):e13342Krmeska V; Shen L; Nylen S; Wowk PF; Rothfuchs AG
- Article: MOLECULAR PSYCHIATRY. 2022;27(10):3939-3950Samudyata; Oliveira AO; Malwade S; de Sousa NR; Goparaju SK; Gracias J; Orhan F; Steponaviciute L; Schalling M; Sheridan SD; Perlis RH; Rothfuchs AG; Sellgren CM
- Article: JOURNAL OF IMMUNOLOGY. 2022;208(11):2549-2557Krmeska V; Aggio JB; Nylen S; Wowk PF; Rothfuchs AG
- Article: INDOOR AIR. 2022;32(3):e13023de Sousa NR; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
- Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267Classon CH; Li M; Clavero AL; Ma J; Feng X; Tibbitt CA; Stark JM; Cardoso R; Ringqvist E; Boon L; Villablanca EJ; Rothfuchs AG; Eidsmo L; Coquet JM; Nylen S
- Article: JOURNAL OF IMMUNOLOGY. 2021;206(4):776-784Aggio JB; Krmeska V; Ferguson BJ; Wowk PF; Rothfuchs AG
- Article: ANNALS OF WORK EXPOSURES AND HEALTH. 2020;64(8):852-865de Sousa NR; Shen L; Silcott D; Call CJ; Rothfuchs AG
- Article: NATURE COMMUNICATIONS. 2020;11(1):4812Smyrlaki I; Ekman M; Lentini A; de Sousa NR; Papanicolaou N; Vondracek M; Aarum J; Safari H; Muradrasoli S; Rothfuchs AG; Albert J; Hoegberg B; Reinius B
- Article: TUBERCULOSIS. 2020;120:101896de Sousa NR; Sandstrom N; Shen L; Hakansson K; Vezozzo R; Udekwu KI; Croda J; Rothfuchs AG
- Article: PLOS PATHOGENS. 2018;14(5):e1007008Feng X; Classon C; Teran G; Yang Y; Li L; Chan S; Ribacke U; Rothfuchs AG; Coquet JM; Nylen S
- Article: SCIENTIFIC REPORTS. 2017;7:43989Nasi A; Bollampalli VP; Sun M; Chen Y; Amu S; Nylen S; Eidsmo L; Rothfuchs AG; Rethi B
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2016;(116):54620Bollampalli VP; Nylen S; Rothfuchs AG
- Article: JOURNAL OF IMMUNOLOGY. 2016;196(5):2262-2271Obieglo K; Feng X; Bollampalli VP; Dellacasa-Lindberg I; Classon C; Oesterblad M; Helmby H; Hewitson JP; Maizels RM; Rothfuchs AG; Nylen S
- Article: PLOS PATHOGENS. 2015;11(10):e1005206Bollampalli VP; Yamashiro LH; Feng X; Bierschenk D; Gao Y; Blom H; Henriques-Normark B; Nylen S; Rothfuchs AG
- Article: MICROBES AND INFECTION. 2015;17(5):337-344Carvalho NB; Oliveira FS; Marinho FAV; de Almeida LA; Fahel JS; Bafica A; Rothfuchs AG; Zamboni DS; Caliari MV; Oliveira SC
- Article: PLOS ONE. 2012;7(11):e47835Rothfuchs AG; Roffe E; Gibson A; Cheever AW; Ezekowitz RAB; Takahashi K; Steindel M; Sher A; Bafica A
- Article: JOURNAL OF IMMUNOLOGY. 2012;188(2):649-660Roffe E; Rothfuchs AG; Santiago HC; Marino APMP; Ribeiro-Gomes FL; Eckhaus M; Antonelli LRV; Murphy PM
- Article: IMMUNITY. 2011;34(5):807-819Egen JG; Rothfuchs AG; Feng CG; Horwitz MA; Sher A; Germain RN
- Article: MICROBES AND INFECTION. 2011;13(2):198-201Marakalala MJ; Guler R; Matika L; Murray G; Jacobs M; Brombacher F; Rothfuchs AG; Sher A; Brown GD
- Article: EXPERIMENTAL PARASITOLOGY. 2010;125(4):315-324Min-Oo G; Ayi K; Bongfen SE; Tam M; Radovanovic I; Gauthier S; Santiago H; Rothfuchs AG; Roffe E; Sher A; Mullick A; Fortin A; Stevenson MM; Kain KC; Gros P
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2010;120(5):1674-1682Antonelli LRV; Rothfuchs AG; Goncalves R; Roffe E; Cheever AW; Bafica A; Salazar AM; Feng CG; Sher A
- Article: JOURNAL OF IMMUNOLOGY. 2009;182(11):6915-6925Rothfuchs AG; Egen JG; Feng CG; Antonelli LRV; Bafica A; Winter N; Locksley RM; Sher A
- Article: BLOOD. 2008;112(4):1461-1471Soehnlein O; Zernecke A; Eriksson EE; Rothfuchs AG; Pham CT; Herwald H; Bidzhekov K; Rottenberg ME; Weber C; Lindbom L
- Article: EUROPEAN RESPIRATORY JOURNAL. 2008;32(2):405-412Soehnlein O; Oehmcke S; Ma X; Rothfuchs AG; Frithiof R; van Rooijen N; Morgelin M; Herwald H; Lindbom L
- Article: IMMUNITY. 2008;28(2):271-284Macrophage and T cell dynamics during the development and disintegration of mycobacterial GranulomasEgen JG; Rothfuchs AG; Feng CG; Winter N; Sher A; Germain RN
- Article: JOURNAL OF IMMUNOLOGY. 2007;179(6):3463-3471Rothfuchs AG; Bafica A; Feng CG; Egen JG; Williams DL; Brown GD; Sher A
- Article: JOURNAL OF IMMUNOLOGY. 2006;177(10):7086-7093Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A
- Article: JOURNAL OF IMMUNOLOGY. 2006;176(11):6982-6990Rothfuchs AG; Trumstedt C; Mattei F; Schiavoni G; Hidmark A; Wigzell H; Rottenberg ME
- Article: JOURNAL OF IMMUNOLOGY. 2004;172(10):6345-6353Rothfuchs AG; Trumstedt C; Wigzell H; Rottenberg ME
- Article: JOURNAL OF IMMUNOLOGY. 2004;172(4):2407-2415Rothfuchs AG; Kreuger MR; Wigzell H; Rottenberg ME
- Article: INFECTION AND IMMUNITY. 2003;71(7):4102-4111Eriksson E; Dons L; Rothfuchs AG; Heldin P; Wigzell H; Rottenberg ME
- Article: JOURNAL OF IMMUNOLOGY. 2001;167(11):6453-6461Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME
- Article: INFECTION AND IMMUNITY. 2001;69(7):4232-4241Kullberg MC; Rothfuchs AG; Jankovic D; Caspar P; Wynn TA; Gorelick PL; Cheever AW; Sher A
- Article: JOURNAL OF IMMUNOLOGY. 2000;164(9):4812-4818Rottenberg ME; Rothfuchs AG; Gigliotti D; Ceausu M; Une C; Levitsky V; Wigzell H
- Article: JOURNAL OF IMMUNOLOGY. 1999;162(5):2829-2836Rottenberg ME; Rothfuchs ACG; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H
- Show more
All other publications
- Letter: INDOOR AIR. 2022;32(11):e13169Rufino de Sousa N; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
- Review: CURRENT OPINION IN IMMUNOLOGY. 2002;14(4):444-451Rottenberg ME; Gigliotti-Rothfuchs A; Wigzell H
Grants
- Aerosolization of Mycobacterium tuberculosis: establishing its role in the transmission of tuberculosisSwedish Research Council
- BSL3 Biomedicum Core FacilityKarolinska Institutet
- Exploring how aerosol transport and particle size impacts mycobacterial infectionKarolinska Institutet
- Survival and infectiousness of Mycobacterium tuberculosis in aerosolsKarolinska Institutet
- Diagnosing and tracing tuberculosis through electrostatic cough samplingSwedish Heart-Lung Foundation
- Testing BSL3 Biomedicum capabilities and moreSciLifeLab
- EnBiFlu, testing the efficiency of multifaceted enviornmental assessment of avian influenza threats and outbreaksSciLifeLab
- BSL3 capacity for Pandemic Laboratory PreparednessSciLifeLab
- Swedish Environmental Epidemiology Center, a holistic pandemic preparedness capability for health-related environmental research and surveillanceSciLifeLab
- BSL3 Biomedicum-SciLifeLab collaborative platformSciLifeLab
- Advancing environmental virus profiling and risk assessment for public health perspectiveKAW/SciLifeLab
- Kapacitetsuppbyggnad av BSL3 för att utveckla COVID-19 forskning på aktivt virus samt celler och vävnader infekterade med SARS-CoV-2TetraLaval/TetraPak
Employments
- Principal Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2014
- Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2004
- Master Of Medical Science, Karolinska Institutet, 1999
Visiting research fellowships
- Fogarty Visiting Fellow, National Institute of Allergy and Infectious Diseases, 2004-2009