Antonio Checa Gómez

About me
Publications
Public outreach and news

About me

Analytical chemist with over a decade of LC-MS based small metabolomics experience a focus on biomedical projects and analysis of large clinical cohorts.

At the Small Molecule Mass Spectrometry core facility, we bring to the table over a decade of experience in LC-MS based small metabolomics. Our expertise particularly focuses in biomedical projects, from basic research pre-clinical cell models to the analysis of extensive clinical cohorts.

Our core facility is dedicated to the development and application of liquid chromatography-mass spectrometry methods for small molecule analysis within a biomedical context. However, our support extends beyond mere analytical assistance. We also provide expert guidance in experimental design and data interpretation for metabolomic studies.

Research

Mass Spectrometry

Metabolomics

Immune mediated diseases

Sphingolipids

Articles

Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2024;249:116378
Metabolomic and sphingolipidomic profiling of human hepatoma cells exposed to widely used pharmaceuticals
Perez-Cova M; Bedia C; Checa A; Meister I; Tauler R; Wheelock CE; Jaumot J
Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2024;416(25):5485-5496
Cohort-based strategies as an in-house tool to evaluate and improve phenotyping robustness of LC-MS/MS lipidomics platforms
Zohrer B; Gomez C; Jaumot J; Idborg H; Torekov SS; Wheelock AM; Wheelock CE; Checa A
Article: JOURNAL OF NUTRITION. 2024;154(2):395-402
A Walnut-Enriched Diet for 2 Years Changes the Serum Oxylipin Profile in Healthy Older Persons
Cofan M; Checa A; Serra-Mir M; Roth I; Valls-Pedret C; Lopez-Illamola A; Domenech M; Rajaram S; Lazaro I; Sabate J; Ros E; Wheelock CE; Sala-Vila A
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;79(2):404-418
Sphingolipid classes and the interrelationship with pediatric asthma and asthma risk factors
Chen Y; Checa A; Zhang P; Huang M; Kelly RS; Kim M; Chen Y-CS; Lee-Sarwar KA; Prince N; Mendez KM; Begum S; Kachroo P; Chu SH; Stokholm J; Bonnelykke K; Litonjua AA; Bisgaard H; Weiss ST; Chawes BL; Wheelock CE; Lasky-Su JA
Article: SCIENTIFIC REPORTS. 2023;13(1):20230
Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study
Mahdi A; Zhao A; Fredengren E; Fedorowski A; Braunschweig F; Nygren-Bonnier M; Runold M; Bruchfeld J; Nickander J; Deng Q; Checa A; Desta L; Pernow J; Stahlberg M
Article: ELIFE. 2022;11:e78861
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
Kuo A; Checa A; Niaudet C; Jung B; Fu Z; Wheelock CE; Singh SA; Aikawa M; Smith LE; Proia RL; Hla T
Article: EBIOMEDICINE. 2022;83:104236
Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort
Sevelsted A; Gurdeniz G; Rago D; Pedersen C-ET; Lasky-Su JA; Checa A; Zhang P; Wheelock CE; Normann SS; Kristensen DM; Rasmussen MA; Schullehner J; Sdougkou K; Martin JW; Stokholm J; Bonnelykke K; Bisgaard H; Chawes B
Article: SCIENTIFIC REPORTS. 2022;12(1):6317
Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767).
Koutsouveli V; Balgoma D; Checa A; Hedeland M; Riesgo A; Cárdenas P
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2021;77(20):2494-2513
Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease
Akawi N; Checa A; Antonopoulos AS; Akoumianakis I; Daskalaki E; Kotanidis CP; Kondo H; Lee K; Yesilyurt D; Badi I; Polkinghorne M; Akbar N; Lundgren J; Chuaiphichai S; Choudhury R; Neubauer S; Channon KM; Torekov SS; Wheelock CE; Antoniades C
Article: JOURNAL OF HEPATOLOGY. 2020;73(4):817-828
Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis
Lopez-Vicario C; Checa A; Urdangarin A; Aguilar F; Alcaraz-Quiles J; Caraceni P; Amoros A; Pavesi M; Gomez-Cabrero D; Trebicka J; Oettl K; Moreau R; Planell N; Arroyo V; Wheelock CE; Claria J
Article: NITRIC OXIDE - BIOLOGY AND CHEMISTRY. 2020;98:33-40
"Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury"
Heredia Martinez A; Rosa Diez G; Ferraris V; Coccia PA; Ferraris JR; Checa A; Wheelock CE; Lundberg JO; Weitzberg E; Carlstrom M; Krmar RT
Article: CELL METABOLISM. 2020;31(2):375-390.e11
Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus P; Lecoutre S; Dollet L; Wiel C; Sulen A; Gao H; Tavira B; Laurencikiene J; Rooyackers O; Checa A; Douagi I; Wheelock CE; Arner P; McCarthy M; Bergo MO; Edgar L; Choudhury RP; Aouadi M; Krook A; Ryden M
Article: AMERICAN JOURNAL OF PHYSIOLOGY - RENAL PHYSIOLOGY. 2019;317(3):F529-F539
Effect of spironolactone for 1 yr on endothelial function and vascular inflammation biomarkers in renal transplant recipients
Mortensen LA; Bistrup C; Stubbe J; Carlstrom M; Checa A; Wheelock CE; Palarasah Y; Bladbjerg EM; Thiesson HC; Jensen BL
Article: NATURE COMMUNICATIONS. 2019;10(1):3081
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
Carlstrom KE; Ewing E; Granqvist M; Gyllenberg A; Aeinehband S; Enoksson SL; Checa A; Badam TVS; Huang J; Gomez-Cabrero D; Gustafsson M; Al Nimer F; Wheelock CE; Kockum I; Olsson T; Jagodic M; Piehl F
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:636
Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
Bergqvist F; Ossipova E; Idborg H; Raouf J; Checa A; Englund K; Englund P; Khoonsari PE; Kultima K; Wheelock CE; Larsson K; Korotkova M; Jakobsson P-J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients
Idborg H; Zandian A; Ossipova E; Wigren E; Preger C; Mobarrez F; Checa A; Sohrabian A; Pucholt P; Sandling JK; Fernandes-Cerqueira C; Ronnelid J; Oke V; Grosso G; Kvarnstrom M; Larsson A; Wheelock CE; Syvanen A-C; Ronnblom L; Kultima K; Persson H; Graslund S; Gunnarsson I; Nilsson P; Svenungsson E; Jakobsson P-J
Article: ANALYTICA CHIMICA ACTA. 2018;1037:338-350
The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability
Daskalaki E; Pillon NJ; Krook A; Wheelock CE; Checa A
Article: RESPIRATORY RESEARCH. 2018;19(1):236
Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study
Sjodin MOD; Checa A; Yang M; Dahlen S-E; Wheelock AM; Eklund A; Grunewald J; Wheelock CE
Article: CIRCULATION. 2018;138(16):1693-1705
ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages
Laguna-Fernandez A; Checa A; Carracedo M; Artiach G; Petri MH; Baumgartner R; Forteza MJ; Jiang X; Andonova T; Walker ME; Dalli J; Arnardottir H; Gistera A; Thul S; Wheelock CE; Paulsson-Berne G; Ketelhuth DFJ; Hansson GK; Back M
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):388-398
Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy
Mahdi A; Kovamees O; Checa A; Wheelock CE; von Heijne M; Alvarsson M; Pernow J
Article: PEDIATRIC NEPHROLOGY. 2018;33(4):639-649
Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children
Al-Mashhadi A; Checa A; Wahlin N; Neveus T; Fossum M; Wheelock CE; Karanikas B; Stenberg A; Persson AEG; Carlstrom M
Article: JOURNAL OF PROTEOME RESEARCH. 2018;17(2):870-878
Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics
Kamleh MA; McLeod O; Checa A; Baldassarre D; Veglia F; Gertow K; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Tremoli E; Silveira A; Orvik J; Hamsten A; Wheelock CE
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2018;103(2):710-721
Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance
Petrus P; Bialesova L; Checa A; Kerr A; Naz S; Backdahl J; Gracia A; Toft S; Dahlman-Wright K; Heden P; Dahlman I; Wheelock CE; Arner P; Mejhert N; Gao H; Ryden M
Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2275-2288
Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma
Bowden JA; Heckert A; Ulmer CZ; Jones CM; Koelmel JP; Abdullah L; Ahonen L; Alnouti Y; Armando AM; Asara JM; Bamba T; Barr JR; Bergquist J; Borchers CH; Brandsma J; Breitkopf SB; Cajka T; Cazenave-Gassiot A; Checa A; Cinel MA; Colas RA; Cremers S; Dennis EA; Evans JE; Fauland A; Fiehn O; Gardner MS; Garrett TJ; Gotlinger KH; Han J; Huang Y; Neo AH; Hyotylainen T; Izumi Y; Jiang H; Jiang H; Jiang J; Kachman M; Kiyonami R; Klavins K; Klose C; Kofeler HC; Kolmert J; Koal T; Koster G; Kuklenyik Z; Kurland IJ; Leadley M; Lin K; Maddipati KR; McDougall D; Meikle PJ; Mellett NA; Monnin C; Moseley MA; Nandakumar R; Oresic M; Patterson R; Peake D; Pierce JS; Post M; Postle AD; Pugh R; Qiu Y; Quehenberger O; Ramrup P; Rees J; Rembiesa B; Reynaud D; Roth MR; Sales S; Schuhmann K; Schwartzman ML; Serhan CN; Shevchenko A; Somerville SE; John-Williams LS; Surma MA; Takeda H; Thakare R; Thompson JW; Torta F; Triebl A; Troetzmueller M; Ubhayasekera SJK; Vuckovic D; Weir JM; Welti R; Wenk MR; Wheelock CE; Yao L; Yuan M; Zhao XH; Zhou S
Article: LUPUS. 2017;26(10):1023-1033
Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study
Checa A; Idborg H; Zandian A; Sar DG; Surowiec I; Trygg J; Svenungsson E; Jakobsson P-J; Nilsson P; Gunnarsson I; Wheelock CE
Article: REDOX BIOLOGY. 2017;11:205-212
New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
Gonzalez-Pena D; Checa A; de Ancos B; Wheelock CE; Sanchez-Moreno C
Article: EUROPEAN RESPIRATORY JOURNAL. 2017;49(3):1601740
Metabolomics analysis identifies different metabotypes of asthma severity
Reinke SN; Gallart-Ayala H; Gomez C; Checa A; Fauland A; Naz S; Kamleh MA; Djukanovic R; Hinks TSC; Wheelock CE
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2016;101(11):3952-3958
Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus
Kovamees O; Shemyakin A; Checa A; Wheelock CE; Lundberg JO; Ostenson C-G; Pernow J
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;99:87-98
Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation
Hezel M; Peleli M; Liu M; Zollbrecht C; Jensen BL; Checa A; Giulietti A; Wheelock CE; Lundberg JO; Weitzberg E; Carlstrom M
Article: JOURNAL OF IMMUNOLOGY. 2016;197(5):1843-1851
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion
Paquin-Proulx D; Gibbs A; Bachle SM; Checa A; Introini A; Leeansyah E; Wheelock CE; Nixon DF; Broliden K; Tjernlund A; Moll M; Sandberg JK
Article: NITRIC OXIDE - BIOLOGY AND CHEMISTRY. 2016;58:1-9
Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia
Carlstrom M; Cananau C; Checa A; Wide K; Sartz L; Svensson A; Wheelock CE; Westphal S; Bekassy Z; Barany P; Lundberg JO; Hansson S; Weitzberg E; Krmar RT
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(7):e003868
Genetic Abrogation of Adenosine A₃ Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension
Yang T; Zollbrecht C; Winerdal ME; Zhuge Z; Zhang X-M; Terrando N; Checa A; Sallstrom J; Wheelock CE; Winqvist O; Harris RA; Larsson E; Persson AEG; Fredholm BB; Carlstrom M
Article: JOURNAL OF THE INSTITUTE OF BREWING. 2016;122(3):430-436
Ultra-high-performance liquid chromatography-high-resolution mass spectrometry based metabolomics as a strategy for beer characterization
Gallart-Ayala H; Anas Kamleh M; Hernandez-Cassou S; Saurina J; Checa A
Article: JOURNAL OF CHROMATOGRAPHY A. 2016;1433:90-97
Told through the wine: A liquid chromatography-mass spectrometry interplatform comparison reveals the influence of the global approach on the final annotated metabolites in non-targeted metabolomics
Diaz R; Gallart-Ayala H; Sancho JV; Nunez O; Zamora T; Martins CPB; Hernandez F; Hernandez-Cassou S; Saurina J; Checa A
Article: SCIENTIFIC REPORTS. 2015;5:15740
Lipid mediator profile in vernix caseosa reflects skin barrier development
Checa A; Holm T; Sjodin MOD; Reinke SN; Alm J; Scheynius A; Wheelock CE
Article: MULTIPLE SCLEROSIS JOURNAL. 2015;21(10):1271-1279
Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis
Checa A; Khademi M; Sar DG; Haeggstroem JZ; Lundberg JO; Piehl F; Olsson T; Wheelock CE
Article: REDOX BIOLOGY. 2015;5:234-242
Effects of long-term dietary nitrate supplementation in mice
Hezel MP; Liu M; Schiffer TA; Larsen FJ; Checa A; Wheelock CE; Carlstrom M; Lundberg JO; Weitzberg E
Article: ANALYTICA CHIMICA ACTA. 2015;885:1-16
Lipidomic data analysis: Tutorial, practical guidelines and applications
Checa A; Bedia C; Jaumot J
Article: SCIENTIFIC REPORTS. 2015;5:12017
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
Checa A; Xu N; Sar DG; Haeggstrom JZ; Stahle M; Wheelock CE
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2014;99(4):843-850
Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
Larsen FJ; Schiffer TA; Ekblom B; Mattsson MP; Checa A; Wheelock CE; Nystrom T; Lundberg JO; Weitzberg E
Article: FOOD CHEMISTRY. 2012;135(3):1425-1431
Classification and characterisation of Spanish red wines according to their appellation of origin based on chromatographic profiles and chemometric data analysis
Serrano-Lourido D; Saurina J; Hernandez-Cassou S; Checa A
Article: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2012;60(34):8340-8349
Determination of Polyphenols in Spanish Wines by Capillary Zone Electrophoresis. Application to Wine Characterization by Using Chemometrics
Franquet-Griell H; Checa A; Nunez O; Saurina J; Hernandez-Cassou S; Puignou L
Article: ANALYTICA CHIMICA ACTA. 2012;722:34-42
Combination of chromatographic and chemometric methods to study the interactions between DNA strands
Ruiz-Castelar S; Checa A; Gargallo R; Jaumot J
Article: JOURNAL OF SEPARATION SCIENCE. 2011;34(5):527-535
Determination of polyphenols in wines by liquid chromatography with UV spectrophotometric detection
Aznar O; Checa A; Oliver R; Hernandez-Cassou S; Saurina J
Article: ANALYTICA CHIMICA ACTA. 2008;616(1):85-94
Reversed-phase liquid chromatographic method with spectrophotometric detection for the determination of antiretroviral drugs
Checa A; Oliver R; Hernandez-Cassou S; Saurina J
Article: ANALYTICA CHIMICA ACTA. 2007;592(2):173-180
Flow-injection determination of zidovudine in plasma samples using multivariate curve resolution
Checa A; Oliver R; Hernandez-Cassou S; Saurina J
Article: ANALYTICA CHIMICA ACTA. 2006;572(1):155-164
Flow-injection spectrophotometric determination of reverse transcriptase inhibitors used for acquired immuno deficiency syndrome (AIDS) treatment.: Focus on strategies for dealing with the background components
Checa A; Oliver R; Saurina J; Hernandez-Cassou S
Article: ANALYTICA CHIMICA ACTA. 2005;554(1-2):177-183
Fast determination of pK_a values of reverse transcriptase inhibitor drugs for AIDS treatment by using pH-gradient flow-injection analysis and multivariate curve resolution
Checa A; Soto VG; Hernández-Cassou S; Saurina J
Show more

All other publications

Preprint: BIORXIV. 2024
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers
Horwath O; Cornet L; Strömlind H; Moberg M; Edman S; Söderlund K; Checa A; Ruas JL; Blomstrand E
Published conference paper: SCIENCE OF THE TOTAL ENVIRONMENT. 2018;644:1101-1109
Effect of psychiatric drugs on Daphnia magna oxylipin profiles
Garreta-Lara E; Checa A; Fuchs D; Tauler R; Lacorte S; Wheelock CE; Barata C
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441
Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients
Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Erhardt S; Wheelock CE
Book chapter: DATA ANALYSIS FOR OMIC SCIENCES: METHODS AND APPLICATIONS: COMPREHENSIVE ANALYTICAL CHEMISTRY. 2018;p. 613-641
Data Analysis in Transcriptomics and Metabolomics Clinical Applications
Gallart-Ayala H; Fernández-Navarro J; Checa A
Review: MOLECULAR NUTRITION AND FOOD RESEARCH. 2013;57(8):1359-1377
Quantitative metabolic profiling of lipid mediators
Balgoma D; Checa A; Sar DG; Snowden S; Wheelock CE
Book chapter: COMPREHENSIVE ANALYTICAL CHEMISTRY: COMPREHENSIVE ANALYTICAL CHEMISTRY. 2013;p. 123-143
Metabolomics and PDO
Checa A; Saurina J
Review: ANALYTICA CHIMICA ACTA. 2009;647(1):1-13
Determination of HIV drugs in biological matrices: A review
Checa A; Oliver R; Hernandez-Cassou S; Saurina J

About me

Research

Articles

All other publications

News from KI

Events from KI