Ann-Charlotte Granholm-Bentley

Publications
Public outreach and news

Articles

Article: FASEB JOURNAL. 2019;33(4):5082-5088

Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury.

Goetzl EJ; Elahi FM; Mustapic M; Kapogiannis D; Pryhoda M; Gilmore A; Gorgens KA; Davidson B; Granholm A-C; Ledreux A
Article: ALZHEIMERS & DEMENTIA. 2017;13(5):541-549

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

Hamlett ED; Goetzl EJ; Ledreux A; Vasilevko V; Boger HA; LaRosa A; Clark D; Carroll SL; Carmona-Iragui M; Fortea J; Mufson EJ; Sabbagh M; Mohammed AH; Hartley D; Doran E; Lott IT; Granholm A-C
Article: PLOS ONE. 2017;12(12):e0189821

A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats.

Bharani KL; Derex R; Granholm A-C; Ledreux A
Article: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:284

Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice.

Buhusi M; Etheredge C; Granholm A-C; Buhusi CV
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;55(2):1-13

BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function

Hakansson K; Ledreux A; Daffner K; Terjestam Y; Bergman P; Carlsson R; Kivipelto M; Winblad B; Granholm A-C; Mohammed AKH
Article: BEHAVIOURAL BRAIN RESEARCH. 2016;312:294-304

Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats

Ledreux A; Wang X; Schultzberg M; Granholm A-C; Freeman LR
Article: NEUROSCIENCE LETTERS. 2016;621:68-74

Memory and hippocampal architecture following short-term midazolam in western diet-treated rats.

Rosenberger DS; Falangola MF; Ledreux A; Nie X; Suhre WM; Boger HA; Granholm A-C
Article: MOLECULAR NEUROBIOLOGY. 2016;53(4):2733-2749

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ₄₂ Phagocytosis

Zhu M; Wang X; Hjorth E; Colas RA; Schroeder L; Granholm A-C; Serhan CN; Schultzberg M
Article: BRAIN RESEARCH. 2016;1631:34-45

BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease.

Ledreux A; Boger HA; Hinson VK; Cantwell K; Granholm A-C
Article: CURRENT ALZHEIMER RESEARCH. 2015;13(1):35-52

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

Hamlett ED; Boger HA; Ledreux A; Kelley CM; Mufson EJ; Falangola MF; Guilfoyle DN; Nixon RA; Patterson D; Duval N; Granholm A-CE
Article: NEUROIMAGE. 2015;113:235-245

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue.

Keren NI; Taheri S; Vazey EM; Morgan PS; Granholm A-CE; Aston-Jones GS; Eckert MA
Article: ALZHEIMERS & DEMENTIA. 2015;11(6):700-709

Down syndrome and Alzheimer's disease: Common pathways, common goals.

Hartley D; Blumenthal T; Carrillo M; DiPaolo G; Esralew L; Gardiner K; Granholm A-C; Iqbal K; Krams M; Lemere C; Lott I; Mobley W; Ness S; Nixon R; Potter H; Reeves R; Sabbagh M; Silverman W; Tycko B; Whitten M; Wisniewski T
Article: MAGNETIC RESONANCE IMAGING. 2015;33(4):437-447

Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study.

Nie X; Hamlett ED; Granholm A-C; Hui ES; Helpern JA; Jensen JH; Boger HA; Collins HR; Falangola MF
Article: JOURNAL OF NEUROSCIENCE. 2015;35(4):1343-1353

Designer receptors enhance memory in a mouse model of Down syndrome.

Fortress AM; Hamlett ED; Vazey EM; Aston-Jones G; Cass WA; Boger HA; Granholm A-CE
Article: INT NEUROPSYCHIATR DIS J. 2015;3(1):19-26

Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder.

Spratt EG; Granholm A-C; Carpenter LA; Boger HA; Papa CE; Logan S; Chaudhary H; Boatwright S-W; Brady KT
Article: ALZHEIMERS & DEMENTIA. 2015;11(1):70-98

At the interface of sensory and motor dysfunctions and Alzheimer's disease.

Albers MW; Gilmore GC; Kaye J; Murphy C; Wingfield A; Bennett DA; Boxer AL; Buchman AS; Cruickshanks KJ; Devanand DP; Duffy CJ; Gall CM; Gates GA; Granholm A-C; Hensch T; Holtzer R; Hyman BT; Lin FR; McKee AC; Morris JC; Petersen RC; Silbert LC; Struble RG; Trojanowski JQ; Verghese J; Wilson DA; Xu S; Zhang LI
Article: ALZHEIMERS & DEMENTIA. 2015;11(1):40-50.e1-2-50

Resolution of inflammation is altered in Alzheimer's disease

Wang X; Zhu M; Hjorth E; Cortes-Toro V; Eyjolfsdottir H; Graff C; Nennesmo I; Palmblad J; Eriksdotter M; Sambamurti K; Fitzgerald JM; Serhan CN; Granholm A-C; Schultzberg M
Article: JOURNAL OF NEUROINFLAMMATION. 2014;11:171

Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus.

Cunningham MA; Wirth JR; Freeman LR; Boger HA; Granholm A-C; Gilkeson GS
Article: ATHEROSCLEROSIS. 2014;237(2):460-463

Intracranial atherosclerosis: correlation between in-vivo 3T high resolution MRI and pathology.

Turan TN; Rumboldt Z; Granholm A-C; Columbo L; Welsh CT; Lopes-Virella MF; Spampinato MV; Brown TR
Article: JOURNAL OF NEUROSCIENCE METHODS. 2014;231:31-37

Three-dimensional rodent motion analysis and neurodegenerative disorders.

Karakostas T; Hsiang S; Boger H; Middaugh L; Granholm A-C
Article: BRAIN. 2014;137(Pt 3):860-872

Nerve growth factor metabolic dysfunction in Down's syndrome brains.

Iulita MF; Do Carmo S; Ower AK; Fortress AM; Flores Aguilar L; Hanna M; Wisniewski T; Granholm A-C; Buhusi M; Busciglio J; Cuello AC
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2013;104:10-19

Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF.

Littrell OM; Granholm A-C; Gerhardt GA; Boger HA
Article: BRAIN. 2012;135(Pt 9):2736-2749

PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice

Zhang Y; Granholm A-C; Huh K; Shan L; Diaz-Ruiz O; Malik N; Olson L; Hoffer BJ; Lupica CR; Hoffman AF; Baeckman CM
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32(4):643-653

Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet.

Freeman LR; Granholm A-CE
Article: NEUROBIOLOGY OF AGING. 2012;33(2):427.e1-427.14

Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice.

Littrell OM; Pomerleau F; Huettl P; Surgener S; McGinty JF; Middaugh LD; Granholm A-C; Gerhardt GA; Boger HA
Article: CURRENT GERONTOLOGY AND GERIATRICS RESEARCH. 2012;2012:463909-13

Age-related neurodegeneration and memory loss in down syndrome.

Lockrow JP; Fortress AM; Granholm A-CE
Article: BEHAVIOURAL BRAIN RESEARCH. 2011;221(2):610-622

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome.

Lockrow J; Boger H; Bimonte-Nelson H; Granholm A-C
Article: BRAIN PATHOLOGY. 2011;21(3):330-348

Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice.

Granholm A-C; Zaman V; Godbee J; Smith M; Ramadan R; Umphlet C; Randall P; Bhat NR; Rohrer B; Middaugh LD; Boger HA
Article: GENES BRAIN AND BEHAVIOR. 2011;10(2):186-198

Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging.

Boger HA; Mannangatti P; Samuvel DJ; Saylor AJ; Bender TS; McGinty JF; Fortress AM; Zaman V; Huang P; Middaugh LD; Randall PK; Jayanthi LD; Rohrer B; Helke KL; Granholm A-C; Ramamoorthy S
Article: JOURNAL OF ALZHEIMERS DISEASE. 2011;23(3):471-489

A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model.

Lockrow J; Boger H; Gerhardt G; Aston-Jones G; Bachman D; Granholm A-C
Article: THE JOURNAL OF THE SOUTH CAROLINA MEDICAL ASSOCIATION. 2011;107(1):8-12

Use of seniors as mentors to medical students: a collaboration between the University of South Carolina School of Medicine and the Medical University of South Carolina.

Wiley MK; Granholm A-C; Bachman D; Wieland D; Roberts E; Hardin R; Dever-Bumba M; Eleazer GP
Article: JOURNAL OF AGING RESEARCH. 2011;2011:460543-10

Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats.

Fortress AM; Buhusi M; Helke KL; Granholm A-CE
Article: NUTRITIONAL NEUROSCIENCE. 2011;14(1):32-44

Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus.

Freeman LR; Haley-Zitlin V; Stevens C; Granholm A-C
Article: CELL TRANSPLANTATION. 2011;20(10):1499-1514

A high-fat/high-cholesterol diet inhibits growth of fetal hippocampal transplants via increased inflammation.

Freeman LR; Small BJ; Bickford PC; Umphlet C; Granholm A-C
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2010;45(3):226-233

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin.

Fukuda Y; Berry TL; Nelson M; Hunter CL; Fukuhara K; Imai H; Ito S; Granholm-Bentley A-C; Kaplan AP; Mutoh T
Article: GLIA. 2010;58(6):679-690

Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts.

Willis LM; Freeman L; Bickford PC; Quintero EM; Umphlet CD; Moore AB; Goetzl L; Granholm A-C
Article: EXPERIMENTAL NEUROLOGY. 2009;216(2):278-289

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

Lockrow J; Prakasam A; Huang P; Bimonte-Nelson H; Sambamurti K; Granholm A-C
Article: NEUROBIOLOGY OF DISEASE. 2009;33(3):459-466

Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice.

Boger HA; Middaugh LD; Granholm A-C; McGinty JF
Article: BRAIN RESEARCH. 2008;1241:18-28

Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene.

Boger HA; Middaugh LD; Zaman V; Hoffer B; Granholm A-C
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2008;28(8):1557-1568

The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior.

Zaman V; Boger HA; Granholm A-C; Rohrer B; Moore A; Buhusi M; Gerhardt GA; Hoffer BJ; Middaugh LD
Article: JOURNAL OF ALZHEIMERS DISEASE. 2008;14(2):133-145

Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat.

Granholm A-C; Bimonte-Nelson HA; Moore AB; Nelson ME; Freeman LR; Sambamurti K
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2008;28(6):1150-1164

Dietary blueberry supplementation affects growth but not vascularization of neural transplants.

Willis LM; Small BJ; Bickford PC; Umphlet CD; Moore AB; Granholm A-CE
Article: EXPERIMENTAL AGING RESEARCH. 2007;34(1):13-26

Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: how young is "young" and how old is "old"?

Bimonte-Nelson HA; Granholm A-CE; Nelson ME; Moore AB
Article: JOURNAL OF NEUROSCIENCE. 2007;27(33):8816-8825

Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice.

Boger HA; Middaugh LD; Patrick KS; Ramamoorthy S; Denehy ED; Zhu H; Pacchioni AM; Granholm A-C; McGinty JF
Article: BRAIN RESEARCH. 2007;1141:56-64

Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat.

Paredes D; Granholm A-C; Bickford PC
Article: BRAIN RESEARCH. 2007;1133(1):10-19

Effects of glial cell line-derived neurotrophic factor deletion on ventral mesencephalic organotypic tissue cultures.

af Bjerkén S; Boger HA; Nelson M; Hoffer BJ; Granholm A-C; Strömberg I
Article: NEUROSCIENCE LETTERS. 2007;413(2):110-114

Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation.

Williams B; Granholm A-C; Sambamurti K
Article: EXPERIMENTAL NEUROLOGY. 2006;202(2):336-347

A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra.

Boger HA; Middaugh LD; Huang P; Zaman V; Smith AC; Hoffer BJ; Tomac AC; Granholm A-C
Article: PSYCHOPHARMACOLOGY. 2006;188(4):605-618

ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age.

Williams BJ; Bimonte-Nelson HA; Granholm-Bentley A-C
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2006;24(1):229-242

Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats.

Bimonte-Nelson HA; Francis KR; Umphlet CD; Granholm A-C
Article: BRAIN RESEARCH. 2006;1093(1):198-207

Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease.

Quintero EM; Willis L; Singleton R; Harris N; Huang P; Bhat N; Granholm A-C
Article: BEHAVIOURAL BRAIN RESEARCH. 2006;169(2):256-262

Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats.

French KL; Granholm A-CE; Moore AB; Nelson ME; Bimonte-Nelson HA
Article: BRAIN RESEARCH. 2006;1068(1):257-260

Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations.

Griffin WC; Boger HA; Granholm A-C; Middaugh LD
Article: EXPERIMENTAL NEUROLOGY. 2005;196(1):30-40

Altered NGF response but not release in the aged septo-hippocampal cholinergic system.

Williams B; Nelson M; Granholm A-C; Coultrap S; Browning M; Curtis M
Article: CELL TRANSPLANTATION. 2005;14(1):21-29

Regulation of Trophic Factor Expression by Innervating Target Regions in Intraocular Double Transplants.

Willis L; Quintero EM; Nelson M; Granholm A-C
Article: NEUROREPORT. 2004;15(17):2659-2663

Progesterone counteracts estrogen-induced increases in neurotrophins in the aged female rat brain.

Bimonte-Nelson HA; Nelson ME; Granholm A-CE
Article: ANNALS OF NEUROLOGY. 2004;56(5):675-688

Minocycline prevents cholinergic loss in a mouse model of Down's syndrome.

Hunter CL; Bachman D; Granholm A-C
Article: BEHAVIORAL NEUROSCIENCE. 2004;118(4):707-714

Ovarian hormones and cognition in the aged female rat: II. progesterone supplementation reverses the cognitive enhancing effects of ovariectomy.

Bimonte-Nelson HA; Singleton RS; Williams BJ; Granholm A-CE
Article: NEUROBIOLOGY OF AGING. 2004;25(7):873-884

Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen.

Hunter CL; Bimonte-Nelson HA; Nelson M; Eckman CB; Granholm A-C
Article: NEUROSCIENCE. 2004;124(1):137-146

Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway.

Quintero EM; Willis LM; Zaman V; Lee J; Boger HA; Tomac A; Hoffer BJ; Strömberg I; Granholm A-C
Article: BEHAVIORAL NEUROSCIENCE. 2003;117(6):1395-1406

Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance.

Bimonte-Nelson HA; Singleton RS; Hunter CL; Price KL; Moore AB; Granholm A-CE
Article: PHYSIOLOGY & BEHAVIOR. 2003;80(1):27-36

Age-related sex differences in spatial learning and basal forebrain cholinergic neurons in F344 rats.

Veng LM; Granholm A-C; Rose GM
Article: EXPERIMENTAL NEUROLOGY. 2003;181(2):301-312

Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats.

Bimonte-Nelson HA; Singleton RS; Nelson ME; Eckman CB; Barber J; Scott TY; Granholm A-CE
Article: NEUROSCIENCE RESEARCH. 2003;45(4):437-445

Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome.

Hunter CL; Isacson O; Nelson M; Bimonte-Nelson H; Seo H; Lin L; Ford K; Kindy MS; Granholm A-C
Article: BRAIN RESEARCH. 2003;967(1-2):306-310

Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat.

Albeck D; Mesches MH; Juthberg S; Browning M; Bickford PC; Rose GM; Granholm A-C
Article: BEHAVIOURAL BRAIN RESEARCH. 2003;139(1-2):47-57

Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome.

Bimonte-Nelson HA; Hunter CL; Nelson ME; Granholm A-CE
Article: BEHAVIOURAL BRAIN RESEARCH. 2003;138(2):121-131

Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory.

Hunter CL; Bimonte HA; Granholm ACE
Article: NEUROBIOLOGY OF AGING. 2003;24(1):37-48

Age-related deficits as working memory load increases: relationships with growth factors.

Bimonte HA; Nelson ME; Granholm A-CE
Article: HIPPOCAMPUS. 2003;13(8):905-914

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

Granholm A-C; Sanders L; Seo H; Lin L; Ford K; Isacson O
Article: PHYSIOLOGY & BEHAVIOR. 2002;77(2-3):371-385

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome.

Granholm A-CE; Ford KA; Hyde LA; Bimonte HA; Hunter CL; Nelson M; Albeck D; Sanders LA; Mufson EJ; Crnic LS
Article: NEUROSCIENCE LETTERS. 2002;328(1):50-54

Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats.

Bimonte HA; Granholm A-CE; Seo H; Isacson O
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2002;73(1):167-175

Environmental influences on brain neurotrophins in rats

Pham TM; Winblad B; Granholm AC; Mohammed AH
Article: MICROSCOPY RESEARCH AND TECHNIQUE. 2001;54(5):309-316

GDNF improves cerebellar Purkinje neuron function in aged F344 rats.

Bickford PC; Bowenkamp K; Taglialatela G; Hoertig G; Granholm AC
Article: MICROSCOPY RESEARCH AND TECHNIQUE. 2001;54(5):298-308

Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts.

Granholm AC; Helt C; Srivastava N; Backman C; Gerhardt GA
Article: EXPERIMENTAL NEUROLOGY. 2001;170(2):258-269

Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail.

Helt CE; Hoernig GR; Albeck DS; Gerhardt GA; Ickes B; Reyland ME; Quissell DO; Strömberg I; Granholm AC
Article: BRAIN RESEARCH. 2001;890(1):86-99

Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats.

Palmer MR; Granholm AC; van Horne CG; Giardina KE; Freund RK; Moorhead JW; Gerhardt GA
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2000;427(3):440-454

Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion.

Zuch CL; Nordstroem VK; Briedrick LA; Hoernig GR; Granholm AC; Bickford PC
Article: JOURNAL OF NEUROSCIENCE. 2000;20(9):3182-3190

Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.

Granholm AC; Reyland M; Albeck D; Sanders L; Gerhardt G; Hoernig G; Shen L; Westphal H; Hoffer B
Article: EXPERIMENTAL NEUROLOGY. 2000;161(2):647-663

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome.

Granholm AC; Sanders LA; Crnic LS
Article: CELL AND TISSUE RESEARCH. 1999;297(1):67-79

Anatomical distribution of glycoprotein 93 (gp93) on nerve fibers during rat brain development.

Henry S; Pfenninger KH; Mott JL; Granholm AC
Article: NEUROSCIENCE. 1999;94(1):279-286

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year

Pham TM; Ickes B; Albeck D; Söderström S; Granholm AC; Mohammed AH
Article: NEUROSCIENCE. 1998;86(1):241-255

The hyaluronan receptor RHAMM in noradrenergic fibers contributes to axon growth capacity of locus coeruleus neurons in an intraocular transplant model.

Nagy JI; Price ML; Staines WA; Lynn BD; Granholm AC
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 1997;387(1):1-11

Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors.

Bäckman C; Rose GM; Bartus RT; Hoffer BJ; Mufson EJ; Granholm AC
Article: EXPERIMENTAL BRAIN RESEARCH. 1997;116(1):29-38

Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum.

Granholm AC; Mott JL; Bowenkamp K; Eken S; Henry S; Hoffer BJ; Lapchak PA; Palmer MR; van Horne C; Gerhardt GA
Article: NEUROREPORT. 1997;8(9-10):2293-2298

A non-invasive transport system for GDNF across the blood-brain barrier.

Albeck DS; Hoffer BJ; Quissell D; Sanders LA; Zerbe G; Granholm AC
Article: EXPERIMENTAL NEUROLOGY. 1997;145(2 Pt 1):524-535

Collateral sprouting of central noradrenergic neurons during aging: histochemical and neurochemical studies in intraocular triple transplants.

Srivastava N; Granholm AC; Gerhardt GA
Article: JOURNAL OF NEUROSCIENCE. 1997;17(3):1168-1178

Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies.

Granholm AC; Srivastava N; Mott JL; Henry S; Henry M; Westphal H; Pichel JG; Shen L; Hoffer BJ
Article: EXPERIMENTAL NEUROLOGY. 1996;141(2):181-189

Effects of GDNF on fetal septal forebrain transplants in oculo.

Price ML; Hoffer BJ; Granholm AC
Article: EXPERIMENTAL BRAIN RESEARCH. 1996;111(1):1-7

6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor.

Bowenkamp KE; David D; Lapchak PL; Henry MA; Granholm AC; Hoffer BJ; Mahalik TJ
Article: JOURNAL OF NEUROSCIENCE. 1996;16(17):5437-5442

Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy.

Bäckman C; Rose GM; Hoffer BJ; Henry MA; Bartus RT; Friden P; Granholm AC
Article: NATURE. 1996;382(6586):73-76

Defects in enteric innervation and kidney development in mice lacking GDNF.

Pichel JG; Shen L; Sheng HZ; Granholm AC; Drago J; Grinberg A; Lee EJ; Huang SP; Saarma M; Hoffer BJ; Sariola H; Westphal H
Article: EXPERIMENTAL NEUROLOGY. 1995;136(1):12-21

Characterization of histaminergic H3 receptors in intraocular tuberomammillary transplants containing histaminergic neurons.

Bergman H; Prell GD; Lupica CR; Granholm AC
Article: CELL AND TISSUE RESEARCH. 1995;282(1):49-57

Tyrosine hydroxylase in the cerebral ganglia of the American cockroach (Periplaneta americana L.): an immunohistochemical study.

Granholm AC; Price ML; Owen MD
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 1995;355(4):479-489

Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons.

Bowenkamp KE; Hoffman AF; Gerhardt GA; Henry MA; Biddle PT; Hoffer BJ; Granholm AC
Article: EXPERIMENTAL NEUROLOGY. 1995;132(1):1-15

EFFECTS OF TRANSFERRIN RECEPTOR ANTIBODY-NGF CONJUGATE ON YOUNG AND AGED SEPTAL TRANSPLANTS IN OCULO

BACKMAN C; BIDDLE PT; EBENDAL T; FRIDEN PM; GERHARDT GA; HENRY MA; MACKERLOVA L; SODERSTROM S; STROMBERG I; WALUS L; HOFFER BJ; GRANHOLM AC
Article: BRAIN RESEARCH BULLETIN. 1995;36(5):425-432

Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo.

Hudson J; Granholm AC; Gerhardt GA; Henry MA; Hoffman A; Biddle P; Leela NS; Mackerlova L; Lile JD; Collins F
Article: NEUROSCIENCE. 1995;64(1):61-70

Intracranial transplantation and survival of tuberomammillary histaminergic neurons.

Bergman H; Nagy JI; Granholm AC
Article: HIPPOCAMPUS. 1995;5(6):584-594

Hypothalamic tissue stimulates hippocampal pyramidal neuron survival during development: evidence from intraocular double transplants.

Curtis M; Bergman H; Price ML; Srivastava N; Granholm AC
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All other publications

Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;114:110-121

Exosomal biomarkers in Down syndrome and Alzheimer's disease.

Hamlett ED; Ledreux A; Potter H; Chial HJ; Patterson D; Espinosa JM; Bettcher BM; Granholm A-C
Meeting abstract: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2017;49(5):836

Assessments Of Standing Balance In Division I Athletes With History Of Concussion: A Pilot Study

Powell JJ; Pryhoda MK; Belgasem H; Sanders W; Shelburne KB; Granholm-Bentley A-C; Davidson BS
Meeting abstract: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2017;49(5):835

Concussion History And Kinematics Of Dynamic Balance In Division I Athletes: A Pilot Study

Pryhoda MK; Powell J; Belgasem H; Landusky C; Shelburne KB; Granholm-Bentley A-C; Davidson BS
Review: NUTRITIONAL NEUROSCIENCE. 2014;17(6):241-251

Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms.

Freeman LR; Haley-Zitlin V; Rosenberger DS; Granholm A-C
Editorial comment: JOURNAL OF NEUROSCIENCE METHODS. 2014;231:1-2

Motion capture and associated novel measurement devices for movement function in humans and animal models.

Karakostas T; Granholm A-C
Meeting abstract: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2012;206(1):s197

Adolescent cognitive and anxiety behavior in offspring following in utero exposure to increased trans unsaturated fatty acids through maternal diet

Alanis M; Umphlet C; Boger H; Granholm A-C
Editorial comment: NEUROPSYCHOPHARMACOLOGY. 2010;35(8):1621-1622

Why do we need to use animal models to study cognition and aging?

Granholm A-C
Published conference paper: PROGRESS IN NEUROBIOLOGY. 2010;90(2):217-229

A dual-hit animal model for age-related parkinsonism.

Boger HA; Granholm A-C; McGinty JF; Middaugh LD
Editorial comment: PROGRESS IN NEUROBIOLOGY. 2010;90(2):71-74

Chemical signaling in the nervous system in health and disease: Nils-Ake Hillarp's legacy Introduction

Granholm A-C; Skirboll L; Schultzberg M
Published conference paper: NEUROTOXICOLOGY. 2008;29(5):864-870

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits.

Liu Y; Qin L; Wilson B; Wu X; Qian L; Granholm A-C; Crews FT; Hong J-S
Review: CURRENT AGING SCIENCE. 2008;1(2):133-139

Mood, memory and movement: an age-related neurodegenerative complex?

Granholm A-C; Boger H; Emborg ME
Published conference paper: CELL TRANSPLANTATION. 2007;16(3):197-205

Galantamine effects on memory, spatial cue utilization, and neurotrophic factors in aged female rats.

French KL; Bimonte-Nelson HA; Granholm AC
Review: PROGRESS IN NEUROBIOLOGY. 2006;80(3):114-128

Nerve growth factor in treatment and pathogenesis of Alzheimer's disease

Williams BJ; Eriksdotter-Jonhagen M; Granholm A-C
Meeting abstract: EXPERIMENTAL NEUROLOGY. 2006;198(2):594

Dietary supplementation with blueberry extract attenuates the age-associated increase in microglial activation

Willis LM; Bickford PC; Stromberg I; Granholm AC
Meeting abstract: EXPERIMENTAL NEUROLOGY. 2006;198(2):578

APP accumulation and inflammation in the Ts65dn mouse, a model for Down's syndrome

Lockrow J; Willis L; Granholm AC; Sambamurti K
Other: ALZHEIMERS & DEMENTIA. 2005;1(1):53-54

Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, Luigi Puglielli.

Granholm A-C; Bachman D; Mintzer J; Sambamurti K
Published conference paper: CELL TRANSPLANTATION. 2005;14(4):213-223

Blueberry extract enhances survival of intraocular hippocampal transplants.

Willis L; Bickford P; Zaman V; Moore A; Granholm A-C
Review: CURRENT DRUG TARGETS. 2004;5(6):517-528

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

Sambamurti K; Granholm A-C; Kindy MS; Bhat NR; Greig NH; Lahiri DK; Mintzer JE
Published conference paper: CELL TRANSPLANTATION. 2003;12(3):291-303

The Noradrenergic System of Aged GDNF Heterozygous Mice.

Zaman V; Li Z; Middaugh L; Ramamoorthy S; Rohrer B; Nelson ME; Tomac AC; Hoffer BJ; Gerhardt GA; Granholm AC
Editorial comment: TRENDS IN NEUROSCIENCES. 2002;25(2):79-84

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

Isacson O; Seo H; Lin L; Albeck D; Granholm AC
Published conference paper: CELL TRANSPLANTATION. 2002;11(3):215-227

Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.

McGrath J; Lintz E; Hoffer BJ; Gerhardt GA; Quintero EM; Granholm A-C
Editorial comment: MICROSCOPY RESEARCH AND TECHNIQUE. 2001;54(5):271-272

Introduction:: Factors influencing neurite outgrowth and regeneration

Granholm AC; Strömberg I
Published conference paper: EXPERIMENTAL NEUROLOGY. 2000;164(1):45-52

Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain

Ickes BR; Pham TM; Sanders LA; Albeck DS; Mohammed AH; Granholm AC
Review: EXPERT OPINION ON INVESTIGATIONAL DRUGS. 2000;9(4):685-694

Oestrogen and nerve growth factor - neuroprotection and repair in Alzheimer's disease.

Granholm AC
Editorial comment: CELL TRANSPLANTATION. 1999;8(1):7-9

Fifth Annual Meeting of the American Society for Neural Transplantation and Repair.

Granholm A-C; Emerich D
Published conference paper: CELL TRANSPLANTATION. 1999;8(1):75-85

Effects of osteogenic protein-1 (OP-1) treatment on fetal spinal cord transplants to the anterior chamber of the eye.

Granholm AC; Sanders LA; Ickes B; Albeck D; Hoffer BJ; Young DA; Kaplan PL
Published conference paper: CELL TRANSPLANTATION. 1998;7(2):197-212

Kidney cografts enhance fiber outgrowth from ventral mesencephalic grafts to the 6-OHDA-lesioned striatum, and improve behavioral recovery.

Granholm AC; Henry S; Herbert MA; Eken S; Gerhardt GA; van Horne C
Review: REVIEWS IN THE NEUROSCIENCES. 1998;9(1):31-56

A non-invasive system for delivering neural growth factors across the blood-brain barrier: a review.

Granholm AC; Albeck D; Bäckman C; Curtis M; Ebendal T; Friden P; Henry M; Hoffer B; Kordower J; Rose GM; Söderström S; Bartus RT
Editorial comment: CELL TRANSPLANTATION. 1996;5(2):127-130

Second annual meeting of the American Society for Neural Transplantation.

Granholm AC
Published conference paper: CELL TRANSPLANTATION. 1996;5(2):305-314

Development of an intact blood-brain barrier in brain tissue transplants is dependent on the site of transplantation.

Granholm AC; Curtis M; Diamond DM; Branch BJ; Heman KL; Rose GM
Published conference paper: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 1996;61:445-457

GDNF is required for kidney development and enteric innervation.

Pichel JG; Shen L; Sheng HZ; Granholm AC; Drago J; Grinberg A; Lee EJ; Huang SP; Saarma M; Hoffer BJ; Sariola H; Westphal H
Published conference paper: CELL TRANSPLANTATION. 1995;4(1):3-12

Synapsin I in intraocular hippocampal transplants during maturation and aging: effects of brainstem cografts.

Granholm AC; Bergman H; Dudek E; Browning M
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