Anna Matton

My research focuses on uncovering the biological mechanisms that influence dementia risk and exploring ways to prevent its onset. While Alzheimer’s disease remains a complex and challenging condition, we are committed to advancing understanding through a multidisciplinary approach. We examine early biomarkers of Alzheimer’s and related dementias, including fluid biomarkers, within clinical lifestyle intervention trials. Our goal is to identify new predictors of cognitive decline that could facilitate earlier intervention and better outcomes.

In addition to clinical studies, we utilize preclinical models- specifically, innovative reverse translation of the lifestyle intervention trial FINGER into various mouse models. This allows us to investigate the intricate relationship between neuropathology, lifestyle factors, and dementia risk in a controlled setting. These efforts enable us to deepen our understanding of how lifestyle modifications may influence disease progression at a biological level.

Our vision is rooted in translational research: bridging clinical observations with preclinical models to identify novel targets for prevention and therapy. We aim to generate insights that can be translated into real-world interventions, ultimately contributing to healthier aging trajectories.

Our lab is part of the larger Nordic-UK Brain Network, led by Professor Miia Kivipelto, where we collaborate with a community of dedicated researchers committed to tackling neurodegenerative diseases.