Anna Marseglia

Anna Marseglia

Assistant Professor
Visiting address: Blickagången 16, 14152 Huddinge
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Klinisk geriatrik Westman, 171 77 Stockholm
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About me

  • Anna Marseglia is an Assistant Professor at Karolinska Institutet within the NVS Department, Division of Clinical Geriatrics. She is a Neuropsychologist and holds a PhD in aging epidemiology. Her reserach is located in the Westman Neuroimaging Group, with a multidisciplinary focus on cognitive disorders arising from neurodegenerative and cerebrovascular disorders. 



  • Anna Marseglia welcomes applications for research internships, exchanges, and student thesis on an ongoing basis. If you are interested, please reach out via email.

    EDUCATION
    2018, Ph.D. in medical science - aging epidemiology, Aging Research Center (ARC), NVS, KI. Thesis “The impact of diabetes on cognitive aging and dementia”.
    2012-present, Licensed psychologist - Register of Psychologists of Puglia, Italy (No. 4473).
    2011, Residency training in neuropsychology, Department of Neurology, Padua University Hospital, Italy
    2009, M.Sc. in Psychology (clinical psychology), Padua University, Italy.

     

  • RESEARCH APPOINTMENTS

    2024-present, Research Collaborator at Mayo Clinic, Rochester, MN, USA.

    2024-present, Assistant Professor, Division of Clinical Geriatrics, NVS, KI.


    POSTDOCTORAL ASSIGNMENTS 


  • 2020-2024, Postdoctoral researcher, Division of Clinical Geriatrics, NVS, KI.
    2019-2020, Postdoctoral researcher, ARC, NVS.

     

  • OTHER PROFESSIONAL APPOINTMENTS

    2024-present, Associate Editor for Aging Clinical and Experimental Research. 

  • 2018-2019, Postdoctoral research assistent (doktorandanställning), ARC, NVS, KI. 


  • 2010-2013, Researcher, Italian Research Council, Institute of Neuroscience, Aging branch, Padua (Italy).

Research

  • In her work, Anna Marseglia harnesses multi-dimensional data from diverse population- and clinical-based cohorts including but not limited to the Gothenburg H70-85 Birth Cohort Studies, the UK Biobank, the Mayo Clinic Study of Aging, the Betula Project, and the Rush Alzheimer's Disease Center Cohorts. These datasets are instrumental in advancing projects within her areas of interest outlined below.

    1) Mechanisms of Vascular Cognitive Impairment and Dementia (VCID).

    These projects aim to deepen our understanding of how vascular risk factors and disorders affect cognitive and brain health. We focus on identifying neuroimaging and molecular biomarkers of inflammation, insulin resistance, and lipid dysregulation that contribute to small vessel disease and clinical transitions across the VCID spectrum, while also exploring intersections with Alzheimer's disease co-pathology.


    2) Key determinants of resilience mechanisms in aging. 


  • These projects aim to uncover how life exposures from early to late life (e.g., education, work complexity, social health) influence cognition and biological markers of resilience. Brain maintenance and cognitive resilience are assessed by the gap between biological 'brain age' and chronological age. We also investigate how life exposures, degenerative and cerebrovascular diseases, and processes like inflammation interact to shape brain resilience and cognitive outcomes.

     

  • 3) Sex-related differences in VCID and resilience. 


  • These projects explore the impact of sex differences on cognitive disorders and resilience, focusing on biological factors like hormones, and socio-cultural determinants. They aim to determine how these factors drive cognitive health disparities between sexes in VCID and identify potential compensatory pathways.

    All projects involve collaborations with national and internation experts across diverse aging research fields. Anna Marseglia's active roles in organizations like VasCog (International Society of Vascular Behavioral and Cognitive Disorders), ISTAART (Alzheimer's Association), and the SAIN-SWEAH Alumni Interdisciplinary Network further facilitate collaborations.


    RESEARCH GRANTS
    Anna Marseglia's reserach is funded by the Swedish Research Council for Health, Working Life and Welfare (FORTE), Center for Innovative Medicine (CIMED), Demensfonde, Karolinska Institutet’s Research Foundation Grant 2024-2025,  
  • Strategic Research Area Neuroscience (StratNeuro), David och Astrid Hageléns Stiftelsen, the Collaboratory on Research Definitions for Cognitive Reserve and Resilience, Loo och Hans Ostermans stiftelse, Foundation for Geriatric Diseases at Karolinska Institute, Stiftelsen för Gamla Tjänarinnor, and Kvinnor och Hälsa Stiftelsen.


    LEADERSHIP AND COLLABORATIONS
    Anna Marseglia has an extensive network of active collaborations in Sweden and internationally (e.g. Umeå University, Gothenburg University, USA-Rush Alzheimer’s Disease Center and Mayo Clinic Rochester, Australia-University of New South Wales, Netherlands-Radboud University Medical Center and Erasmus MC Rotterdam, UK-University College London). She co-led a work package within the JPND’s SHARED consortium and serves as principal investigator for a 3-year UK-Biobank project (KI-Dnr: 4-352/2023), coordinator of the H70-88 MRI cohorts (KI side), and co-led the VasCog Early Career Investigator group with Hilde van den Brink. She regularly organizes seminars and workshops within NVS and at the Center for Alzheimer Research at KI, and StratNeuro. 



  • COMMISSIONS OF TRUST
    (1) Member of Executive Committee, VasCog Society (2018-ongoing)
    (2) Member of Organizing Committee, KI South Distinguished Lecture Series (2023-ongoing)

    (3) Chair Postdoc member, NVS Institutionsråd (2020-2024)

    (4) Member of the Alzheimer’s Association’s ISTAART PIAs: Vascular, Sex and Gender, Reserve and Resilience, Design and data analytics, Nutrition metabolism (2018-ongoing).

Teaching

  • Anna Marseglia actively contributes to a variety of teaching activities including lectures, seminars, workshops, hands-on at both master's and doctoral levels.

    She regularly supervises master's and PhD students as well as guest researchers from diverse backgrounds such as medicine, psychology, public health and epidemiology, radiology, and neuroscience. Moreover, She organizes seminars and workshops, whether they are topic-specific or focused on methodologies, within our Division and the Center for Alzheimer Research (CAR), which acts as a hub for Swedish dementia researchers. If you have any ideas for potential events or workshops, please feel free to reach out.

Articles

All other publications

Grants

  • Sex disparities in social health, resilience, and cognition across the life course: the interplay between biological and sociocultural aspects
    Swedish Research Council for Health, Working Life and Welfare
    1 January 2025 - 31 December 2027
  • Cardiometabolic Burden and Brain Health—Interactions Between Markers of Brain Pathology, Resilience, and Sex Differences
    Center for Innovative Medicine (CIMED)
    1 January 2024 - 31 December 2026
  • Swedish Research Council
    1 January 2022 - 31 December 2024

Employments

  • Assistant Professor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2024-2030
  • Postdoctoral researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2020-2024

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2018
  • Master's degree in Clinical Psychology, University of Padua, 2009
  • Bachelor's degree in Psychology, University of Padua, 2007

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