Visuomotor Circuits in Space and Action
We are a newly established research group exploring the neural mechanisms that link spatial perception to gaze motor action. One main research objective is to obtain a mechanistic understanding of how neural circuits implement computations that link visual inputs to patterns of motor output at the level of the individual neuron and their synaptic interactions within subcortical and neocortical sensorimotor loops.
A basic and evolutionarily conserved sensorimotor behaviour that all animals, including humans, rely on is gaze reorientation for the deployment of visuospatial attention – a task that is executed rapidly, precisely and versatilely, yet involves a complex function of stimulus saliency, goal/task-dependency, motivation and experience-based learning. Critical to this function is the phylogenetically ancient vertebrate midbrain structure, the superior colliculus, which integrates sensory information from the retina (bottom-up) and descending inputs that can modulate visuomotor function from areas of the neocortex and the basal ganglia (top-down).
Our long-term vision is to unmask the role of such circuits by controlling this plethora of diverse inputs by disentangling their synaptic interaction with cell-type specificity during behaviour. We aim to manipulate the core transformations of spatial information used to (re)shape goal-dependent action by employing a wide range of experimental approaches that include in vivo and in vitro electrophysiology, transgenic and viral strategies for circuit mapping, optogenetics combined with behavioural paradigms, computational methods and virtual reality.
|Andreas Kardamakis||Assistant professor|
- Swedish Research Council
- Karolinska Institutet
- Strategic Neuroscience (StratNeuro)
- Hedlunds Stifelse
Direct Dopaminergic Projections from the SNc Modulate Visuomotor Transformation in the Lamprey Tectum.
Neuron 2017 Nov;96(4):910-924.e5
Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
Proc. Natl. Acad. Sci. U.S.A. 2015 Apr;112(15):E1956-65
Neural network simulations of the primate oculomotor system. V. Eye-head gaze shifts.
Biol Cybern 2010 Mar;102(3):209-25
Optimal control of gaze shifts.
Karamakis A, Moschovakis A
J Neurosci, 29(24); 7723-30
Implications of interrupted eye-head gaze shifts for resettable integrator reset.
Brain Res. Bull. 2006 Jun;70(2):171-8