CBCS - Core Facility at Karolinska Institutet

The CBCS Core Facility at Karolinska Institutet is a national infrastructure at SciLifeLab, established in 2010. Along with the Laboratories for Chemical Biology Umeå (LCBU), it is part of the Chemical Biology Consortium Sweden (CBCS), a national consortium for chemical biology research.

The facility comprises compound handling labs (hosting the SciLifeLab compound collection of about 200 000 molecules), screening labs (microtiter format liquid handling robotics, high content imaging equipment and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis).

The majority of the scientists at CBCS have extensive background from the pharmaceutical industry and solid experience in the development of assay development, assay screening and bioactive molecules.


Main services that the CBCS Core Facility at Karolinska Institutet offers are:

  • Assay development and screen formatting
  • Screening of small-molecule libraries
  • Development and optimisation of biochemical, phenotypic, cellular and high-content assays
  • High-throughput live cell imaging
  • Hit confirmation
  • Computational chemistry & modelling Medicinal chemistry consultation
  • Iterative chemical optimisation (“hit to probe”)
  • Physiochemical and pharmacokinetic profiling of compounds
  • Target deconvolution

Our team

Anna-Lena Gustavsson

Head of Core Facility

Maria Adolfsson

Laboratory technician

Hanna Axelsson

Project manager

Åsa Slevin

Research engineer

Michaela Vallin

Project manager
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