SfoEpi Seminars and Workshops

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Seminars and Workshops 2016

Advanced survival models for correlated data

Dates: October 24-25, 2016
Time:  9.00-12.00 13.00-16.00
Location: Karolina. Tomtebodavägen 18A, Widerströmska huset

Invited Lecturer: Virginie Rondeau, INSERM (Bordeaux, France).

1. Standard frailty models for recurrent and clustered data (models, estimation, dynamic prediction and illustrations)
2. Extensions with nested and additive frailty models (models, estimation and illustrations)
3. Extensions with joint frailty models for recurrent events and a longitudinal biomarker (models, estimation, dynamic prediction and illustrations)
4. Extensions with multivariate frailty models (models, estimation and illustrations) 
Simple shared frailty models have been largely developed and applied for recurrent or clustered survival data in the literature. However extensions of frailty models are less common in publications and are not well developed in classical softwares. We are aiming at filling this gap by considering extension of frailty models (as additive frailty models, nested frailty models or joint frailty models) and by presenting an implementation of these models using also the R package frailtypack. A particular interest will be devoted to joint frailty models in order to analysis jointly recurrent events such as cancer relapses and a dependent terminal event (death or lost to follow-up). Prediction tools associated with this package will be presented also.
The first part of this course will introduce general frailty models, the estimation methods and the research questions they may address. The second part of this course will be dedicated to the joint frailty models with illustration on real data. The estimation and the predictive dynamic tools that can be derived from them will be exposed, with methods to evaluate their performance.
Emphasis is given, via examples on real data, of the ability of extended frailty models to describe a very broad range of practical situations. Each concept will be illustrated through implementation of these models using the R package frailtypack.

How to apply
Please send an email to: maria.berner.holmstrom@ki.se by October 10th , 2016.

For more information please contact Nicola Orsini at nicola.orsini@ki.se


Seminars and Workshops 2015

Current Status Data: Epidemiology, Avalanches and Screening

Speaker: Nicholas P. Jewell, Professor of Biostatistics & Statistics,University of California, Berkeley

Date/Time: December 10 14:00-15:00

Place: Lecture Hall Atrium, Nobels Väg 12A, Solna Campus

AbstractMore than 800 people died from avalanches in Europe and North America over the six winters from 2003--2009. Avalanche survival curves describe the probability of survival as a function of burial time. These curves provide the basis for international recommendations for rescue and resuscitation and for the design of safety and rescue devices.  However, estimation of such curves is complicated by the fact that the time of death is unknown for individuals who are not alive when rescued. Such data is formally referred to as current status data. I will review current status data analysis techniques, statistical ideas that have broad application to a variety of other data structures that arise naturally in epidemiology, demography, and economics. I will briefly discuss some new estimation problems related to current status measurements associated with grouped screening.

Hosts: Rino Bellocco (MEB), Nicola Orsini (IMM)

 Supported by the Strategic Research Program in Epidemiology (SFO-EPI)

Consensus formation from observation of complex systems with limited intervention: Why statistics needs to be absorbed into epistemology

Aim: Experienced epidemiologists recognize that current statistical formalisms are inadequate for inference in risk assessment and health policy; astute social scientists recognize analogously that those formalism are inadequate for inference in economic and social policy. The inference problems in these fields are examples of consensus formation from observation of complex systems with limited intervention (CFOCLI). CFOCLI is a conceptually hard problem being addressed only slowly the statistics profession, in part because addressing it requires an epistemology both far more broad and more detailed than found in conventional statistical theory. There are alternative inference systems under development in computer science which claim to address at least some of the more severe limits of current statistical formalisms; their ability to address CFOCLI is intriguing but as yet far from demonstrated. Some crucial elements for CFOCLI absent from most formalisms include coalescing inferences from multiple agents that each have severe cognitive biases. These biases may be viewed as priors that down-weight large regions of the parameter space to the point of no influence. Shared biases develop and can lead to disastrous loss when all agents severely down-weight a region that contains reality in its interior. Examples include the history of diet and health recommendations by academically-based societies, as well as the collapse of hedge funds run by econometric theories. Such examples underscore the need to incorporate concepts from antifragility as well as information and cognitive sciences into the core of CFOCLI.

Date and Time: Thursday, April 2, 2015 at 13.00-14.00 pm

Where: Samuelssonsalen, Tomtebodavägen 6, Karolinska Institutet

Speaker: Sander Greenland,
Department of Epidemiology and Department of Statistics, University of California, Los Angeles, California

Hosted by: Nicola Orsini, Institute of Environmental Medicine, Karolinska Institutet. Supported by SfoEpi

Seminars and workshops 2014

Three New SfoEpi Awardees present their projects

Aim: To introduce our three new SfoEpi aawardees and their projcets

Place: Karolinska Institutet/MEB. Lecture hall Wargentin


Date and Time: December 15th 2014 at 12.00-13.00

PhD course 2790: How to conduct systematic reviews and meta-analyses (3hp)

Organizer: Nele Brusselaers, post-doc (Dept. Molecular Medicine and Surgery)

Background:This course falls within the second SFO theme“Molecular, genetic and clinicalepidemiology”.The interactive lectures and seminars will be given by the 3 lecturers mentioned above who are allepidemiologists, coming from 3 different epidemiology units (and departments) within KarolinskaInstitutet. One afternoon will be organised by the library of Karolinska Institutet (Klas Moberg, CarlGornitzki), to learn practical skills on how to perform a proper systematic literature search.

Scientific Aim:This epidemiology course aims to provide students with the basic skills and knowledge to performsystematic reviews and meta-analyses. The exams mainly consists of writing a study protocol for anown systematic review/meta-analyses, including a detailed description of the systematic search ofthe literature.

and meta-analyses.

Number of enrolled students (without cancellations): 27 + 4 people on waiting list

Planned schedule: 01-05 December 2014: interactive lectures and seminars- Wednesday 10th of December 2014: Feedback seminar on study protocol- Wednesday 17th of December 2014: Examination

Epidemiological designs in a statistical framework (short course)

Organizer: Anna Johansson (biostatistician/phd student), Cecilia Lundholm (head of the applied biostatistics group at MEB), Caroline Weibull (biostatistician/phd student), Therese Andersson (post-doc)

Background: The lecturer will be Professor Esa Läärä from the Department of Mathematical Sciences at Oulu University, Finland (http://stat.oulu.fi/laara/). He has agreed to deliver this one-week course, where epidemiological concepts will be derived and discussed from a general methodological view combining statistics with epidemiology. Professor Läärä gave a similar, much appreciated course at our department in 2011 and has since developed the material further. Furthermore, Professor Läärä teaches at the highly-regarded course “Statistical Practice in Epidemiology using R” in Tartu.

Scientific Aim: We aim to host a one-week advanced course on epidemiology theory aimed at participants with a strong epidemiological and statistical background working at Karolinska Institutet. The scientific aims are:

To give students a deep understanding of epidemiological theory and concepts
To discuss around implications of epidemiological designs for different study questions
To encourage interaction between epidemiology and statistics

Planned Schedule:  November 3-7. The planned course will consist  of lectures and interactive sessions, combined with practical work and group discussions among participants. The course covers the main types of epidemiologic designs and discusses their setup from a statistical sampling perspective. It builds on the distinctions concerning the concepts of study population, study base, and sampling strategy. Study populations can be closed or open, and the study base may be cross-sectional or longitudinal. Measurement of risk factor data can be based on full census of the study base, or on some outcome-selective sampling strategy, such as traditional case-control study, density sampling including nested case-control design, and case-cohort sampling. The properties of various designs are compared in terms of their statistical validity and efficiency in estimating the target parameters as well as their practicality in concrete research settings.

Registration: Registration to the course will open in September with registration details.

Target Group: The course is aimed at participants from any department or research group at Karolinska Institutet, with a strong background in epidemiological methods and biostatistics, e.g. persons with either a degree in statistics or who otherwise have a good knowledge of statistics within epidemiology (e.g., have completed biostat 3, and preferably also advanced doctoral courses such as a causal inference course and longitudinal data analysis). We have informed potential participants at MEB about the planned course, and have had expressions of interest from students and staff at MEB, but we expect there to be interest from other epidemiology departments at KI, such as IMM, KEP and PHS, as well. If the high level of interest should result in the course being over-subscribed, we will prioritise the applications based on the participant’s previous training, area of work and the visiting lecturer’s advice concerning level.

Neuroepidemiology Workshop July 16-17, 2014

Organizer: : Fang Fang, M.D. Ph.D., Assistant Professor, MEB

Background:Neuroepidemiology is a relatively young member of the entire epidemiological research field at KI. Although it has been under vivid development during the last years at MEB for example, a strengthened collaboration within KI and with research entities outside KI is largely needed. To fulfill this aim, in 2012, we organized the first Neuroepidemiology workshop including participants from MEB, IMM and Department of Clinical Neurosciences. This workshop resulted in several important collaborations afterwards. Furthermore, already in 2008, we initiated a collaborative PhD program on ALS between MEB and NIEHS where the PhD student spent one-year research sojourn as a predoctoral fellow at NIEHS. The student was jointly supported by KI and NIEHS. During the following years, this initiative was supported by the KI-NIH joint PhD program in Neuroscience and we have to date enrolled another 3 PhD students (2 in ALS and 1 in PD) of the same training track. Many collaborative works have been carried out through these years, leading to ~20 publications. Now we aim to hold another Neuroepidemiology workshop, aiming to further the development of Neuroepidemiology research at KI

Scientific Aim: To organize a workshop on Neuroepidemiology, focusing on amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD), and to foster collaboration between different epidemiology units at KI as well as between KI and the Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIEHS/NIH), on epidemiological research of neurodegenerative diseases

Schedule: 16-17 July

Target group: Researchers interested in Neuroepidemiology from MEB, IMM, KEP, Department of Public Health Sciences, Department of Clinical Neurosciences, etc.

Registration: Please contact Anna Berglund (Anna.Berglund@ki.se)

Advanced Regression Methods for Large Register Studies

Organizer: Marie Reilly


This will be a hands-on course emphasizing both general concepts and application of the methods (using Stata). The instructor is David V. Glidden, from University of California at San Francisco, co-author of the text book Regression Methods in Biostatistics, Vittinghoff, et al. Second Edition, which will be used as the course text.

Scientific Aims:

The scientific aims are to enhance the methodological tools in use for register-based research to enable researchers to conduct meaningful analyses of health and disease over the life course using real observational data with recurrent events, competing risks, missingness and confounding. A second aim is to present a range of epidemiological designs for sampling from a cohort for a more efficient study, which is of relevance for pursuing genetic and molecular studies within register cohorts.

Target Group

The target group is participants from any department or research group in Karolinska who work with data from national, regional and quality registers of health and disease. Collaborating epidemiologists and biostatisticians will be encouraged to attend together and to apply the methods to their current research work.

Schedule: April 14-16, 2014

Application for two 2.5-days advanced courses in epidemiology

Organizer: Nicola Orsini, Anita Berglund (IMM)

 Course 1: Time-varying exposures and confounders

Professor of Epidemiology, Miguel Hernan, Harvard School of Public Health

 Course 2: Sensitivity and Bayesian analysis for biases  

Professor of Epidemiology and Professor of Statistics, Sander Greenland, UCLA

Scientific aims

Course 1 will provide an in depth investigation of statistical methods for drawing causal inferences from observational studies with time-varying exposures.

Course 2 will explain and illustrate how to perform a sensitivity and Bayesian analysis for common biases in epidemiological research.

The overall aim of these two short courses is to provide in-depth knowledge and understanding of modern epidemiological methods.

Brief background

Course 1. Epidemiologic concepts such as time-varying exposures/confounders and selection bias, intermediate variables, overall effects and direct effects are formally defined within the context of a counterfactual causal model. Methods for the analysis of the causal effects of time-varying exposures in the presence of time-varying covariates that are simultaneously confounders and intermediate variables are emphasized. These methods include g-estimation of structural nested models, inverse probability weighting of marginal structural models, and the g-formula.

Course 2. In the analysis of observational studies different types of biases or errors (selection, participation, measurement, confounding) arise from the fact that is often not possible or feasible to observe exactly one would like to observe. Only few papers, however, investigate the role of bias on the observed findings. Bias analysis is about quantifying the direction and magnitude of potential sources bias on the results.  

Planned schedule: 

April 2-4, 2014.  Time-varying exposures and confounders

April 2-4, 2014.  Sensitivity and Bayesian analysis for biases  

 Target Group:The target group is any epidemiologists, biostatisticians (doctoral students, postdocs, junior and senior researchers) at KI. 

Application instructions to any of the two courses

Post graduate course in Molecular Epidemiology at KI .

Organizer: Bruna Gigante

Background: Molecular Epidemiology is a growing field of research in epidemiology where basic concepts and methods of molecular biology are applied to understand the determinants of a disease using an epidemiological approach. The aim of this application is to get support from the SFO to organize a course in Molecular Epidemiology for doctoral students  during the autumn term 2013. Such a course is given regularly at the Imperial College in London does not exist at Karolinska Institutet and is indeed of importance for the next generation of epidemiologists to approach critically these novel methods, understand their potential and limitations and how to use them to answer their research questions.

Scientific Aims:

- to give the students an overview of the different –omics (transcriptomics, metabolomics and proteomics) platforms available

- to discuss the differences among the different –omics approaches

- to analyse how to interpreter the results in the different study designs

-ethical issue related to occasional findings

Schedule: May 5-9, 2014 

Practical GWAS analysis course

Organizer: Boel Brynedal, IMM

Aim:The course follows a classical GWAS analysis of a complex trait, from receiving the data to processed and illustrated association results. During the course the student will use multiple different tools and computer languages. Each step of the analysis will be discussed and assessed within the group to reach critical understanding.

Background: The latest decade of years have brought a genomic revolution, in large mediated through the ever decreasing cost, and increasing feasibility and range of genomic assays. The problem is no longer the production of data, but the handling and analysis. Very few individuals have the biological understanding as well as the technical expertise in programming to perform the analytical tasks needed. This course is intended for students with an epidemiological/biological/biostatistical background who are or will perform analysis of genome wide association study (GWAS) data. The focus is on understanding and hands on knowledge, and experience, of each step of a standard GWAS analysis. This course is unique at KI, and will enable large-scale projects in genetic epidemiology. This course will be given for the first time this autumn within the PhD program for epidemiology. During January a pilot course was conducted for 5 students, which was given a very good evaluation.

Schedule: November 6-12, 2014

Completed Activities

The Strategic Research Program in epidemiology supported and financed during 2012-2013 a number of interesting seminars and workshops that have either been carried out in their own management or by individuals who filed in and applied for funding through the Small Grants Application.
The interest in these events has been great, and we want to present a short summary of each event.
You are always welcome to contact us if you are interested in a more detailed summary at maria.berner.holmstrom @ ki.se

Activities and seminars 2013

1) Lifespan approach to health and disease

Organizer: Dr Marita Södergren and Centre of Family medicine at NVS

Aim: The aims of the visit are to stimulate collaboration between researchers and academic staff

at the Departments of NVS and of Public Health Sciences (PHS), and initiate and foster collaboration between Karolinska Institutet and Deakin University. The fields of family medicine and social medicine are concerned with peoples health and disease in interaction with surrounding society. The work involved in conducting education or research within the field of nutrition and physical activity at NVS/PHS encompasses epidemiology, healthcare research, health promotion and preventive work, focusing on risk groups and risk factors in their social and gender-related aspects. Benefits with collaboration are likely to be largest when it involves partners from more divergent scientific backgrounds, like in this visit. An international collaboration is a source of stimulation, creativity, intellectual companionship, and a cross-fertilisation of ideas which may in turn generate new insights or perspectives. Thus, collaboration ensures a more effective transfer of knowledge, skills and techniques.

2) Epidemiologic research on inflammatory diseases

Organizer: Erik Melén, IMM, Julia Simard and Johan Askling, KEP

Aim: The aim of this full-day workshop is therefore to bring together active epidemiology researchers from these different fields to present their work and thoughts on the study of inflammation and inflammatory diseases through an epidemiologic lens, and thereby to foster important discussions and knowledge transfer. We hope to increase collaboration and awareness of methodologies and to provide a platform to further support translational research.

Brief background: Inflammation underlies a myriad of diseases and is the subject of scientific investigations in countless areas. Whether the target is the skin, the airway, the vascular system, the brain, the gut, or the joint, chronic inflammatory processes are pivotal. Karolinska Institutet has a strong track record of translational research, including epidemiology, in the field of chronic inflammatory diseases. Yet, despite a highly translational setting for epidemiology within each inflammatory field (respiratory, gastrointestinal, rheumatic diseases, et cetera), there is little cross-fertilization between the epidemiology research groups across these fields, which are further physically dispersed all over Karolinska Institutet. In fact, we are convinced that many, like us, lack an overview of ongoing activities, upcoming methodologies, and emerging data here at KI.

3) Prediction Models in Medicine

Organizer: Hatef Darabi, Andrea Ganna, Marie Reilly

Aim: With this application we aim to host a short course focused on the development, evaluation and implementation of prediction models in medicine.

Short Background: Prediction models are used in clinical practice to guide the decision-making regarding further intervention strategies for preventing diseases or adverse treatment responses. These models use several risk factors or marker of diseases to calculate the individual’s chances of illness. Predictors may range from subject characteristics (e.g. age and sex), history and physical examinations to biological or genetic markers. With the development of new technologies and opportunities for large-scale analysis of different omics profiles, sophisticated modelling to develop a truly individualised risk assessment is increasingly important. Together with the ability to build efficient prediction models, biostatisticians and epidemiologists should be able to make an accurate evaluation of the usefulness of a prediction model in clinical practice

4) Registry-based research in Sweden - past, present and future

Organizer: Rickard Ljung, MMK, KI

Aim: To deepen the understanding of opportunities and limitations of registry-based research.

Short Background: The excellent opportunities for registry-based research in Sweden can improve health, but this ’goldmine of data’ is underused and there are also methodological limitations and funding issues requiring attention.

5) Two-day course in Competing risks

Organizer: Sandra Eloranta, MEB, Therese Andersson, MEB and Karin Ekström Smedby KEP

Aim: Conceptual understanding of central topics for competing risks analyses.

Short Background: Competing risks is an increasingly recognized problem in follow-up studies. However, the existing literature is often very technical and sometimes even contradictory, which has led to a lot of confusion on this topic. At the same time, many studies investigating prognosis and survival do not recognize potential implications of competing risks neither in their analyses or interpretation of results. We propose a two-day seminar/course with the aim to clarify the definition of competing risks and to help identify study designs, settings and research questions where competing risks need to be addressed versus when competing risks do not need to be taken into account, and a shorter session on methods to deal with competing risks. The overarching goal is to increase the analytical quality in this field at KI. The proposed activity mainly supports SFO theme II Molecular, genetic and clinical epidemiology, but also supports other themes to the extent that study questions involve follow-up analyses. The course will be organized in collaboration between two epi units, namely MEB and KEP. Involvement of other epi centers/departments at KI will be ensured by reserving a defined number of course slots for each center (IMM, MEB, KEP, IARC, other) until up to two weeks before the start of the course.

6) “Psychiatric Genetic Epidemiology:  Process and Progress”

Organizer: Sarah Bergen, MEB

Aim: 1) Allow leading experts in conducting, analyzing, and overseeing psychiatric genetic epidemiology research from the Medical Epidemiology and Biostatistics (MEB) department the Theme Center for Inflammatory Diseases, and the Broad Institute to share their knowledge and experience at the forefront of this field with the Swedish research community.

2) Maintain and strengthen ties between MEB and the Theme Center for Inflammatory Diseases at Karolinska and the Broad Institute and foster communication between researchers at these institutes.

3) Facilitate new collaborations between these departments and institutes to enhance academic excellence in the field of psychiatric genetic epidemiology at Karolinska Institutet.

Short Background: Large, international collaborations have formed to unravel the genetics of many complex genetic diseases and traits including psychiatric disorders.  The Broad Institute of MIT and Harvard has been a world leader in the genotyping and analysis for many of these studies and has close ties to the Karolinska Institute.  Talks explaining the formation and management of very large-scale international projects, the data and analyses used for them, the recent explosion of breakthroughs in this field, and the future of psychiatric genetic epidemiology will all be given by experts on these topics.

7) Data Management and Graphics using STATA

Organizer:Debora Rizzuto, Giola Santoni and Weili Xu, Aging Research Center (ARC), NVS, Karolinska Institutet

Aim:This workshop aims to discuss key issues on data management and preparation for data analysis, and to introduce methods on making simple and complicate graphs as well as better Log storage using Stata based on the practical issues raised by researchers.

Short Background: ARC regularly organizes statistical workshops, where PhD students, postdocs and researchers congregate to review key issues on statistics in their data analysis and management, and discuss these issues with the experts in statistics. As Stata has been commonly used, this workshop focuses on practical issues about data cleaning and conversions between formats, preparation for analysis and making graphs using Stata. During this activity, participants may share experiences and views on data quality, collection, and analysis. The Statisticians may provide a review and comments on methodologies and concepts of statistics/indicators. Such workshop is an important platform to ensure proper methods and interpretation that are applied in data analysis. Although many participants participated in many statistical courses previously, practical issues are often encountered and their knowledge on statistics needs to be updated. This workshop also promotes cooperation and collaboration among different epidemiological units within KI.

Organizer: with Dr Anastasia Nyman Iliadou, MEB, Prof Sven Cnattingius, and Dr Olof Stefansson, MedS

Aim: The aim of the course is to first lay the foundations - the basic principles of reproductive physiology, demography, infectious diseases, and genetics as they apply to human reproduction. In parallel it will deal with the endpoints of reproductive epidemiology - a spectrum ranging from infertility and fetal loss to birth defects and the delayed effects of fetal exposures. The course will end with discussions of unsolved problems, suggesting possible research projects for a new generation of epidemiologists.

Short Background: There is no regular course in reproductive epidemiology at Karolinska Institutet today. Nevertheless reproductive epidemiology is  a large scientific field in which several departments are involved both epidemiological and clinical, but also involving basic science. Hnce the need for a course in reproductive epidemiology is warranted.

8) Bayesian methods and bias analysis in epidemiologic research

Organizer: Nicola Orsini, IMM

Aim: Bayesian methods and bias analysis have become common in advanced training and research in epidemiology. Unfortunately there is no elementary training available at KI on these specific topics. Therefore, aim of this short course is to provide the knowledge and understanding of these modern epidemiological methods.

Short Background: It is unlikely that an epidemiologist collects and analyzes its own data without any prior knowledge on the topic. Nevertheless, standard analysis (logistic, Cox) disregards the scientific evidence accumulated in the field and focus on the data at hand.  A Bayesian approach is about incorporating (e.g. averaging) prior knowledge or expert judgments with study-specific results.

In the analysis of observational studies different types of biases or errors (selection, participation, measurement, confounding) arise from the fact that is often not possible or feasible to observe exactly one would like to observe. Only few papers, however, investigate the role of bias on the observed findings. Bias analysis is about quantifying the direction and magnitude of potential sources bias on the results.

Professor Sander Greenland is considered a leading authority on quantitative methods and statistical theory in epidemiology.

Activities and seminars 2012

1) Activities Aiming to Increase Scientific Collaboration between Epidemiology Units at Karolinska Institutet

Organizer: Yang Cao, Ph.D., Assistant Professor, Unit of Biostatistics, Division of Epidemiology, IMM

Aim: To hold a full-day workshop on research and data resources of Shanghai Municipal Center for Disease Control and Prevention (SCDC) and Shanghai Institutes of Preventive Medicine (SIPM), and to foster collaboration between KI epidemiology units and between KI and SCDC/SIPM .

Brief background: Shanghai is the largest city in China and in the world. The 2010 census put Shanghai's total population at 23,019,148, which is more than double of Swedish national population. The diversity and complexity of disease model in Shanghai provides a unique opportunity for global epidemiologists to conduct research on cause and mechanism of diseases. SCDC is the first and one of the largest provincial CDCs in China, which was based on the example of the US CDC and marked a significant step forward in improving public health in China. SCDC owns abundant and high quality data on birth and death, cancers, chronic diseases and communicable diseases and has a well-known reputation for scientific works. On the international level, SCDC collaborates with WHO, World Bank, UNICEF, EU, US CDC, US NIH, the Department of Health Services of California, and University of Toronto. Now, it is looking for research collaborators in Nordic countries.

2) Applied statistical workshop

Organizer: Weili Xu, Neda Agahi and Anna-Karin Welmer

Aging Research Center (ARC), NVS, Karolinska Institutet

Aim:This workshop aims to discuss key issues and review updated statistical methods for data analysis on quantitative measurements, and to solve practical problems that researchers commonly encountered in the data analysis.

Brief background: ARC regularly organizes statistical workshops, where PhD students, postdocs and researchers congregate to review key issues on statistics in their data analysis, and discuss these issues with the experts in statistics. This workshop focuses on a selected set of estimation issues that we generally encounter for quantitative measurements in data analysis. During this activity, participants may share experiences and views on data quality, collection, and analysis. The experts may provide a review and comments on new statistical tools, methodologies and concepts of statistics/indicators. Such workshop is an important platform to ensure proper methods and interpretation that are applied in data analysis. Although many participants participated in many statistical courses previously, practical issues are often encountered and their knowledge on statistics needs to be updated. This workshop also promotes cooperation and collaboration among different epidemiological units within KI.

3) Early life seminar with invited speakers

Organizer: Catarina Almqvist Malmros and Anastasia Nyman Iliadou on behalf of the Strategic Research Program (SFO) in Epidemiology

Aim: To visualize current knowledge on the effect of conception, IVF and early perinatal factors on subsequent health

Brief background: The importance of early life effects such as IVF, intrauterine growth restriction, preterm birth as well as growth patterns in childhood has been assessed in contemporary cohorts. Fetal growth has been found to have a profound effect on subsequent diseases across the lifespan in a plethora of studies. Further, differing growth patterns have also been associated to later adult diseases. IVF is related to low birth weight and preterm birth with an unknown etiology. Epigenetics has been suggested as a possible mechanism. Epigenetic programming may operate through manipulations of the gametes and embryos in early stages or through maternal characteristics during pregnancy. It has also been shown to be related to mode of delive