Publications

Here are some of our most recent publications at the Center. 
You can also see selected publications from the research groups at each group's own website.

Selected publications 2016

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69(-)CD56(dim) cells.
Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson J, Ivarsson M, et al
J. Allergy Clin. Immunol. 2016 Sep;():

A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains.
Mairpady Shambat S, Siemens N, Monk I, Mohan D, Mukundan S, Krishnan K, et al
Sci Rep 2016 Aug;6():31360

Siemens N, Chakrakodi B, Mairpady Shambat S, Morgan M,  Bergsten H, Hyldegaard O, Skrede S, Arnell P, Madsen M B, Johansson L, INFECT study group, Juarez J, L Bosnjak, Mörgelin M, Svensson M*, and Norrby-Teglund A*. 2016. Biofilm in group A streptococcal necrotizing soft tissue infections.  J Clin Invest INSIGHT. 1(10):e87882. Doi:11.1172/jci.insight.87882. * equal contribution

The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing.
Björklund , Forkel M, Picelli S, Konya V, Theorell J, Friberg D, et al
Nat. Immunol. 2016 Apr;17(4):451-60

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation.
Gibbs A, Leeansyah E, Introini A, Paquin-Proulx D, Hasselrot K, Andersson E, et al
Mucosal Immunol 2016 Apr;():

Emerging insights into natural killer cells in human peripheral tissues.
Björkström N, Ljunggren H, Michaëlsson J
Nat. Rev. Immunol. 2016 Apr;16(5):310-20

Selected publications 2015

Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection.
Blom K, Braun M, Pakalniene J, Dailidyte L, Béziat V, Lampen M, et al
PLoS Pathog. 2015 Jan;11(1):e1004622

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes T, et al
Immunity 2015 Mar;42(3):443-56

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
Leeansyah E, Svärd J, Dias J, Buggert M, Nyström J, Quigley M, et al
PLoS Pathog. 2015 Aug;11(8):e1005072

HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.
Eller M, Opollo M, Liu M, Redd A, Eller L, Kityo C, et al
J. Infect. Dis. 2015 May;211(10):1574-84

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.
Larsson P, Lakshmikanth T, Laitinen O, Utorova R, Jacobson S, Oikarinen M, et al
Diabetologia 2015 Feb;58(2):346-54

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al
J. Immunol. 2015 Mar;194(6):2467-71

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals.
Lunemann S, Malone D, Grabowski J, Port K, Béziat V, Bremer B, et al
Gut 2015 Mar;64(3):469-82

Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.
Willinger T, Staron M, Ferguson S, De Camilli P, Flavell R
Proc. Natl. Acad. Sci. U.S.A. 2015 Apr;112(14):4423-8

Selected publications 2014

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
Edlund A, Esguerra J, Wendt A, Flodström-Tullberg M, Eliasson L
BMC Med 2014 May;12():87

Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients.
Lourda M, Olsson-Åkefeldt S, Gavhed D, Björnfot S, Clausen N, Hjalmars U, et al
Clin. Immunol. 2014 Jul;153(1):112-22

Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.
Nguyen Hoang A, Chen P, Björnfot S, Högstrand K, Lock J, Grandien A, et al
J. Leukoc. Biol. 2014 Sep;96(3):481-9

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.
Leeansyah E, Loh L, Nixon D, Sandberg J
Nat Commun 2014 ;5():3143

Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.
Tittarelli A, Mendoza-Naranjo A, Farías M, Guerrero I, Ihara F, Wennerberg E, et al
J. Immunol. 2014 Feb;192(3):1313-9

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals.
Lunemann S, Malone D, Grabowski J, Port K, Béziat V, Bremer B, et al
Gut 2015 Mar;64(3):469-82

Compromised function of natural killer cells in acute and chronic viral hepatitis.
Lunemann S, Malone D, Hengst J, Port K, Grabowski J, Deterding K, et al
J. Infect. Dis. 2014 May;209(9):1362-73

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes.
Johansson L, Snäll J, Sendi P, Linnér A, Thulin P, Linder A, et al
Front Cell Infect Microbiol 2014 ;4():4

Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community-associated Staphylococcus aureus isolates.
Mairpady Shambat S, Haggar A, Vandenesch F, Lina G, van Wamel W, Arakere G, et al
PLoS ONE 2014 ;9(8):e106107

Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study.
Linnér A, Darenberg J, Sjölin J, Henriques-Normark B, Norrby-Teglund A
Clin. Infect. Dis. 2014 Sep;59(6):851-7

Tightly regulated migratory subversion of immune cells promotes the dissemination of Toxoplasma gondii.
Weidner J, Barragan A
Int. J. Parasitol. 2014 Feb;44(2):85-90

Selected publications 2013

Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.
Larsson P, Lakshmikanth T, Svedin E, King C, Flodström-Tullberg M
Diabetologia 2013 Apr;56(4):867-74

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.
Leeansyah E, Ganesh A, Quigley M, Sönnerborg A, Andersson J, Hunt P, et al
Blood 2013 Feb;121(7):1124-35

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.
Carow B, Reuschl A, Gavier-Widén D, Jenkins B, Ernst M, Yoshimura A, et al
PLoS Pathog. 2013 ;9(7):e1003442    

Differentiation and functional regulation of human fetal NK cells.
Ivarsson M, Loh L, Marquardt N, Kekäläinen E, Berglin L, Björkström N, et al
J. Clin. Invest. 2013 Sep;123(9):3889-901 

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.
Béziat V, Liu L, Malmberg J, Ivarsson M, Sohlberg E, Björklund A, et al
Blood 2013 Apr;121(14):2678-88 

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
Gupta S, Braun M, Tischler N, Stoltz M, Sundström K, Björkström N, et al
PLoS Pathog. 2013 Mar;9(3):e1003272 

Rapid cytoskeleton remodelling in dendritic cells following invasion by Toxoplasma gondii coincides with the onset of a hypermigratory phenotype.
Weidner J, Kanatani S, Hernández-Castañeda M, Fuks J, Rethi B, Wallin R, et al
Cell. Microbiol. 2013 Oct;15(10):1735-52 

 

Doctoral theses from CIM

2014  

Jonas Fuks

Host molecular determinants of toxoplasma gondii dissemination
Katharina Lind  A battle between host and pathogen: the innate immune response and enterovirus evasion strategies

Anna Linnér

Clinical and pathophysiological aspects of sepsis

Pär Larsson

Interactions Between Enteroviruses and the Host - Implications for Type 1 Diabetes

Martin Ivarsson

The Ontogeny and Regulation of Human Natural Killer Cells

Eva Allerbring

Molecular basis for enhanced T-cell recognition and cross-reactivity
2013  

Senait Ashenafi Betemariam

Studies of immune responses in human tuberculosis

Anh Thu Nguyen Hoang

Tissue Regulation of Dendritic Cells: with focus on chemokines, function and migration

Sanna Nyström

Roles of Innate Immune Receptors: Host - Pathogen Interactions and Strengthening Vaccines

Sayma Rahman Local immune responses in tuberculosis: cytolytic effector functions at the site of mycobacterium tuberculosis Infection
Sofia Andersson Invariant NKT cells and CD1d in HIV-1 infection
2012  
Emily Bond Studies of human dendritic cells in the skin after antigen exposure
Hannes Uchtenhagen Elicitation and enhancement of T and B cell responses
Adil Doganay Duru MHC-class I restricted peptidebasedimmunomodulation of CD8+T and NK cells
Annette Sköld Strategies for modulation of dendritic cell responses
Sandra Andersson

Formation of the inhibitory KIR repertoire in human natural killer cells

Venkatramanan Mohanram On HIV-1 restriction in human dendritic cells and peripheral blood mononuclear cells
2011  
William C Adams Regulation of human dendritic cells and T cells by adenovirus vectors types 5 and 35: Implications for vaccine design
Niklas Björkström Human natural killer cell activation and differentiation in health and viral infection
Michael Alan Eller Role of cellular immune functions through the course of HIV-1 natural infection in Ugandans
Cornelia Gujer Regulation of B cell function by plasmacytoid dendritic cells
Oscar Hammarfjord

Toll-like receptor activation induced changes in dendritic cells

Erika Hertzén Streptococcus pyogenes: life within the macrophage
2010    
Mattias Carlsten Molecular specificities of NK cell-mediated recognition of human tumor cells  
Michael Hühn Host-microbe interactions in coxsackievirus infection: Focus on innate immunity  
Stella Jacobson Type 1 diabetes: The autoimmune process and islet transplantation  
Ulrika Johansson Dendritic cell responses to apoptotic cells : Is there life after death?  
Carlotta Kuylenstierna Modulation of invariant NKT cell activity by cytokines and receptors in human disease  
2009    
Veronica D. Gonzalez Innate and adaptive cellular immunity in chronic HCV and HIV-1 infection  
Henrik Lambert Immune evasion and dissemination of Toxoplasma gondii  
Catrine M. Persson NK cell and dendritic cell interactions in innate immune responses  
2008    
Yenan Bryceson

Triggering and mechanisms of natural killer cell mediated cytotoxicity

 
Monica Hultcrantz Interferons in antiviral defense and autoimmunity : Focus on type 1 diabetes  
Pontus Thulin Host-pathogen interactions in severe group A streptococcal infections  
2006  
Anna Cederholm Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease
Jessica Darenberg Streptococcus pyogenes infections and toxic shock syndrome: Molecular epidemiology and immunotherapy
Máire Quigley Characterisation of CD8 T cells in mucosa associated lymphoid tissue : Implications for immune control of HIV-1 infection
Annelie Tjernlund Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection
Hong Xu The role of TPPII in apoptosis control and treatment of malignant disease
2005  
Hayrettin Guven The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer
2004  
Anna Smed Sörensen On the role of dendritic cells in HIV-1 infection
2003  
Nahla Ihendyane Pathogenesis and immunotherapy of streptococcal septicemia and shock
2002  
Homira Behbahani Immune dysregulation in HIV-1 infected lymphoid tissue

Scientific report 2009-2012

Here you can download the latest Scientific report 2009-2012 from CIM

Translational Medical Research