Amyotrophic Lateral Sclerosis (ALS)
ALS is a rare disease, as a result, epidemiological research on ALS has been rather scarce previously. We, as the first group in Sweden, started to conduct a series of epidemiological studies on ALS in 2005 .
Our team was constructed in 2005 and has since been focusing on the aetiology as well as prognostic indicators of ALS. We are specifically interested in roles of environmental factors (e.g., metals, infections) and medical conditions (e.g., metabolism, inflammation) on ALS etiopathogenesis. We are actively collaborating with different ALS research groups both from Sweden and internationally. For example, from 2013, our team participated in the newly launched EU Consortium “STRENGTH”, aiming to disentangle specifically the gene-environment interactions on ALS risk and prognosis. Furthermore, since 2008, we have also initiated a PhD student exchange program with the National Institute of Environmental Health Sciences, NIH, USA, on Neuroepidemiology, specifically ALS. Up to date, three students have had the chance to participate this program.
Our research is supported by Vetenskapsrådet (VR), Forskningsrådet för hälsa, arbetsliv och välfärd (Forte), Hjärnfonden, Svenska Sällskapet för Medicinsk Forskning (SSMF), and the Karolinska Institutet.
- Suicide among patients with amyotrophic lateral sclerosis.
Brain 2008 Oct;131(Pt 10):2729-33
- Amyotrophic lateral sclerosis in Sweden, 1991-2005.
Arch. Neurol. 2009 Apr;66(4):515-9
- Familial aggregation of amyotrophic lateral sclerosis.
Ann. Neurol. 2009 Jul;66(1):94-9
- Association between blood lead and the risk of amyotrophic lateral sclerosis.
Am. J. Epidemiol. 2010 May;171(10):1126-33
- An estimate of amyotrophic lateral sclerosis heritability using twin data.
J. Neurol. Neurosurg. Psychiatr. 2010 Dec;81(12):1324-6