Jaw Orthopedics

Jaw Orthopedics is the topic within orthodontics dealing with growth and growth adaptation. The largest group of patients have congenital malformations most often cleft lip and/or palate CL/P. Our unit is situated within the Stockholm Craniofacial Team situated at the Karolinska University Hospital in Solna. 

Principal Investigator

  • Agneta Karsten DDS., Spec. Ortho., MSc., PhD., Associate Professor, Head of the Division of Orthodontics and Section for Jaw Orthopedics at the Stockholm Craniofacial Team, KI

Projects

Genetic factors in the ethiology of cleft lip and palate

Which genetic factors regulates the development of a cleft lip and palate defect? We have ongoing studies on patients with van der Woude syndrome where known mutations have been found in the IRF6 and GRHL3 genes.

Members

  • Marie Pegelow, DDS, Spec. Ortho., PhD., Division of Orthodontics and Section for Jaw Orthopedics at the Stockholm Craniofacial Team, KI
  • Malin Vesterbacka DDS., MSc., Spec. Ortho., Research student, Section for Jaw Orthopedics at the Stockholm Craniofacial Team, KI

Collaborators

Section for Jaw Orthopedics at the Stockholm Craniofacial Team, KI, Centre for Molecular Medicine, KI and the Division of Plastic and Reconstructive Surgery, Karolinska Hospital, Solna.

Financing

Karolinska Institutet, Svenska Tandläkare-Sällskapet

Studies on growth of the jaws and the dentition after three different palatoplasties up til 19 years of age

Patients born and treated in the Stockholm craniofacial team, with isolated cleft palate have been operated with three different surgical palatoplasties. The children are divided into six groups depending on length of the cleft and surgery performed. The children have been followed by the CLP team up til 19 years of age. We analyse lateral cephalograms and dental casts at 5, 10, 16 and 19 years of age and compare the three groups statistically.  What matters most, the extension of the cleft or the palatoplasty performed? The results will be compared with children without a cleft and children treated in other centers with other techniques.

Members

  • Konstantinos Parikakis DDS, Spec. Ortho., MSc., PhD., Division of Orthodontics and Section for Jaw Orthopedics at the Stockholm Craniofacial Team, KI

Collaborators

Ola Larson DDS, MD, PhD, Associate Professor, Department for Plastic and Reconstructive Surgery, Karolinska University Hospital, Solna. Co-supervisor for Konstantinos Parikakis.

Financing

Karolinska Institutet, Svenska Tandläkare Sällskapet

Studies on growth of the jaws, positions of teeth in the jaws, reconstruction of alveolar clefts with bonegrafts, speech, communication and self perceived quality of life are studied in patients born with cleft lip and palate

Patients born and treated in the Stockholm Craniofacial Team, with unilateral cleft lip and palate have been operated with three different surgical protocols. The children have been followed by the CLP team up til 19 years of age. We analyse lateral cephalograms with cephalometrics and dental casts with the GOSLON yardstick at 5, 10, 16 and 19 years of age and compare the three groups statistically.  The results will be compared with children without a cleft and children treated in other centers with other techniques. We also evalutate what has happened in the grafted area at 19 years of age. The patients are given a questionnaire at 19 years of age based on self perceived questions on quality of life. The speech will be evaluated by professionals from other centers and peers.

Members

  • Petra Peterson MD, Plastic Surgeon, PhD student,  Department for Plastic and Reconstructive Surgery, Stockholm Craniofacial Team, Karolinska University Hospital, Solna.
  • Mathias Lemberger DDS, Spec. Ortho., PhD-student., Division of Orthodontics and Section for Jaw Orthopedics at the Stockholm Craniofacial Team, KI

Collaborators

Ola Larson DDS, MD, PhD, Associate Professor, Department for Plastic and Reconstructive Surgery, Karolinska University Hospital, Solna. Co-supervisor for Petra Peterson. Anette Lohmander, Speech pathologist, Professor in Speech and language, KI. Co-supervisor for Petra Peterson.

Financing

Karolinska Institutet, Svenska Tandläkare Sällskapet, Stiftelsen Frimurare barnhuset i Stockholm, European Orthodontic Society research funds.

Scandcleft–  a multidisciplinary prospective multicentre study

Three parallel randomized clinical trials with ten participating CLP-teams are performed since 1997 to evaluate four different surgical protocols for the treatment of patients with CLP. The primary outcomes are surgical complications, craniofacial growth, dentolaveolar status and speech. The children have been evaluated up til eight years of age. They will be followed til 19 years of age with various registrations. 450 children are included in the study. 75 in each group.

Evaluation of 450 study casts on five year old patients born with unilateral cleft lip and palate from ten centers  in Manchester 2012. The hostess Gunvor Semb and Agneta Karsten discusses a case.

Collaborators

CLP-teams in Oslo, Bergen, Norway, Copenhagen, Århus, Denmark, Helsinki, Finland, Manchester, Belfast UK, Gothenburg and Linköping, Sweden.

Financing

Karolinska Institutet, NIH, ADSS

Odontology