Luana Naia
Biträdande Lektor
E-postadress: luana.naia@ki.se
Besöksadress: Blickagången 6, 14157 Huddinge
Postadress: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Ankarcrona, 171 77 Stockholm
Om mig
- My scientific career has been grounded on studying mitochondrial function, dynamics and mitotherapeutics with potential to reach clinical studies. I
received my PhD in neuroscience and health sciences in 2017 from Faculty of Medicine, University of Coimbra, Portugal. My post-doctoral work was focused on the study of mitochondria-endoplasmic reticulum contact sites (MERCS) in neurodegeneration and drug discovery to modulate MERCS. This work was done in multidisciplinary team coordinated by Teva Pharma and Prilenia Therapeutics and later at Karolinska Institutet, under the research group of Prof Maria Ankarcrona. In 2023 I was appointed as Assistant Professor at Karolinska Institutet where I develop my research line which is focused on neuro-astrocyte mitochondrial communication with a focus on Alzheimer´s Disease.
Forskningsbeskrivning
- ´ Mitochondria are the clandestine rulers of our world`
My research is focus on mitochondrial function, dynamics and organelle interplay (mitochondria associated membranes) in neurodegeneration,
particularly in Alzheimer’s disease. Therefore, my current goals are to understand the molecular mechanisms leading to deficits in synaptic mitochondria and how neuron-glia crosstalk can influence/modulate those deficits in Alzheimer’s disease models. We are particularly interested in studying mitochondrial transfer between brain cells by tunneling nanotubes and extracellular vesicles (mitovesicles). We also have been developing a pipeline to study mitovesicles metabolic signatures in health and disease.
Undervisning
- 2022-present: Coordinating and lecturing the PhD course Alzheimer’s disease: clinical features and pathogenic mechanisms (Karolinska Institutet)
2019-present: Teaching Cell death mechanisms in the PhD course Protein Mechanisms in Health and Disease, from the Clinical Research School in Molecular Medicine (Karolinska Institutet)
2018-present: Teaching Mechanisms of Neurodegeneration in the Master programme in Biomedicine (Karolinska Institutet)
Artiklar
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Journal article: CELLS. 2023;12(19):2397
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Article: MOLECULAR PSYCHIATRY. 2023;28(9):3966-3981
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Article: JOURNAL OF NEUROINFLAMMATION. 2023;20(1):43
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Article: JOURNAL OF ALZHEIMERS DISEASE. 2022;90(2):565-583
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Article: CELLS. 2022;11(3):514
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Article: SCIENTIFIC REPORTS. 2021;11(1):21975
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Article: NEUROTHERAPEUTICS. 2021;18(2):1017-1038
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Article: FREE RADICAL BIOLOGY AND MEDICINE. 2021;163:163-179
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Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2018;1049:59-83
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Article: METHODS IN MOLECULAR BIOLOGY. 2018;1780:415-442
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Article: HUMAN MOLECULAR GENETICS. 2017;26(21):4105-4117
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Article: MOLECULAR NEUROBIOLOGY. 2017;54(7):5385-5399
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Article: JOURNAL OF NEUROSCIENCE. 2017;37(10):2776-2794
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;483(4):1069-1077
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Article: NEUROPEPTIDES. 2016;58:73-81
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Article: MOLECULAR NEUROBIOLOGY. 2015;51(1):331-348
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Article: NEURODEGENERATIVE DISEASES. 2015;15(4):207-218
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Article: PLOS ONE. 2015;10(10):e0141610
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Article: TOXICOLOGICAL SCIENCES. 2013;136(2):487-499
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Article: REVIEWS IN THE NEUROSCIENCES. 2011;23(1):13-28
- Visa fler
Alla övriga publikationer
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Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:920228
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Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S17
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Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2018;48:55
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Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1852(10 Pt A):2183-2194
Forskningsbidrag
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Mitovesiklar: en ny strategi för att förstå och lindra neurodegeneration av Alzheimers sjukdomVetenskapsrådet1 January 2024 - 31 December 2027
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Nya innovativa vägar mot Alzheimers sjukdom: Vätskebiomarkörer och intracellulära behandlingarPrivate donation from Leif Lundblad Family and others1 October 2023 - 30 September 2026
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Potential för extracellulära mitokondrier för terapi och diagnos vid AlzheimersPetrus och Augusta Hedlunds Stiftelse2 January 2022 - 31 January 2024
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Mitochondria on the road: neuroglial crosstalk in Alzheimer’s diseaseStartNeuro – funding for postdoctoral researchers1 June 2020 - 31 December 2021
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Exploring extracellular mitochondria in Alzheimer's disease: from organelle-based therapy to biomarkersAlzheimerfonden1 January 2020 - 31 December 2023
Anställningar
- Biträdande Lektor, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2022-2028
- Postdoctoral Researcher, Mitochondria and neurodegeneration, Center for Neuroscience and Cell Biology (CNC), 2017-2018
Examina och utbildning
- PhD in Neurosciences, Health Sciences – field Neuroscience, Role of lysine deacetylases on transcription regulation and mitochondrial function in Huntington's disease, Faculty of Medicine, University of Coimbra, 2017
- Master in Biotechnology, Biotechnology in Health Sciences, University of Trás-os-Montes and Alto Douro, 2011
- Bachelor in Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, 2008