Lars Tjernberg
Lektor/Funktionsenhetschef
| Docent
E-postadress: lars.tjernberg@ki.se
Telefon: +46852483408
Besöksadress: BioClinicum J9:20, Visionsgatan 4, 17164 Huddinge
Postadress: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Tjernberg, 171 77 Stockholm
Om mig
- Group leader at NVS. Research on Alzheimer disease using cutting edge
techniques including mass spectrometry and nanoscopy.
I have dedicated my 24 years in scientific research to understand how the
amyloid β-peptide (Aβ) is formed and how it polymerizes into fibrils, and
how these processes can be studied and targeted. I have expertise in
analytical chemistry with focus on chromatography and spectrometry and long
track record as a project and group leader at Karolinska Institutet. Under my
leadership, we have had a long-lasting industrial collaboration with a
Japanese pharmaceutical company, resulting in several patent applications on
Aβ related discoveries. Importantly, I have shown the motif most critical
for Aβ polymerization (residues 16-20 in Aβ, also called the Tjernberg
peptide), and that ligands binding to this motif can inhibit Aβ
polymerization. Furthermore, I have developed strategies for single plaque
core analysis, proteomics of selected cells, and studying Aβ polymerization
at nanomolar concentrations. I use several different systems including in
vitro, cell lines, primary neurons, mouse as well as human brain. I have been
in the forefront of introducing and setting up new technology at the
department, including nanoscale liquid chromatography, isotope-labeling
proteomics, laser capture microdissection and proximity ligation interacting
studies in neurons. More recently, my group have developed expertise in
super-resolution microscopy and reported on the synaptic localization of the
Aβ producing enzyme γ-secretase.
Artiklar
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7):3622
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Article: BMC PUBLIC HEALTH. 2024;24(1):823
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Article: ALZHEIMERS & DEMENTIA. 2023;19(7):3244-3249
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Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):196
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Article: GLYCOBIOLOGY. 2022;32(6):506-517
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Article: BMC GERIATRICS. 2022;22(1):365
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Article: SCIENTIFIC DATA. 2021;8(1):312
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Article: CHEMBIOCHEM. 2021;22(22):3208-3213
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Article: JOURNAL OF NEUROCHEMISTRY. 2021;159(2):292-304
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Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;83(2):833-852
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4530
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Article: BRAIN COMMUNICATIONS. 2021;3(2):fcab079
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Article: CURRENT ALZHEIMER RESEARCH. 2021;17(9):858-867
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Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:735334
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Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2020;1867(9):118737
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Article: FEBS JOURNAL. 2020;287(15):3221-3234
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Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;75(1):321-335
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Article: BMC NEUROSCIENCE. 2020;21(1):6
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Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(1):128-141
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Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;72(2):537-548
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Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;71(4):1163-1174
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Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2019;95:86-95
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Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(3):2103-2114
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Article: FRONTIERS IN AGING NEUROSCIENCE. 2019;11:273
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Article: EXPERIMENTAL CELL RESEARCH. 2018;371(1):175-184
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Article: LIFE SCIENCE ALLIANCE. 2018;1(3):e201800028
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Article: PROTEIN SCIENCE. 2017;26(11):2312-2318
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Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):57
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;483(1):352-358
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Article: LANCET NEUROLOGY. 2016;15(5):455-532
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Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2016;4:29
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Article: MOLECULAR NEUROBIOLOGY. 2015;52(3):1077-1092
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Article: ANALYTICAL CHEMISTRY. 2015;87(23):11700-11705
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Article: JOURNAL OF NEUROCHEMISTRY. 2015;135(3):606-615
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Article: PROTEOMICS. 2015;15(19):3349-3355
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Article: FEBS JOURNAL. 2015;282(17):3438-3451
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Article: FEBS JOURNAL. 2015;282(14):2587-2599
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Article: NEUROSCIENCE LETTERS. 2014;566:125-130
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Article: PLOS ONE. 2013;8(2):e55847
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Article: PLOS ONE. 2013;8(5):e63962
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;424(3):476-481
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Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(8):1686-1700
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Article: NEUROCHEMISTRY INTERNATIONAL. 2012;61(1):108-118
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Article: NEUROBIOLOGY OF AGING. 2012;33(5):1010.e1-1010.e13
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Article: JOURNAL OF NEUROSCIENCE METHODS. 2012;205(2):364-367
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(15):11991-12005
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Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2011;15(10):2150-2163
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(36):31153-31158
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Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2010;18(11):1202-1208
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Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2010;14(11):2675-2686
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Article: ACTA NEUROPATHOLOGICA. 2010;119(5):543-554
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Article: PLOS ONE. 2010;5(3):e9772
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Article: PLOS ONE. 2010;5(1):e8948
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Article: NEUROCHEMISTRY INTERNATIONAL. 2010;56(1):67-76
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Article: JOURNAL OF NEUROCHEMISTRY. 2009;110(2):697-706
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Article: NEUROREPORT. 2008;19(11):1085-1089
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Article: FEBS JOURNAL. 2008;275(6):1174-1187
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;361(4):822-828
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Article: BIOCHEMISTRY. 2007;46(25):7647-7654
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(39):29096-29104
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Article: BIOCHEMISTRY. 2006;45(32):9849-9856
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Article: BIOCHEMISTRY. 2005;44(47):15602-15609
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Article: JOURNAL OF CELL BIOLOGY. 2005;171(1):87-98
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Article: FEBS JOURNAL. 2005;272(9):2231-2236
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(2):1007-1015
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(49):51654-51660
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Article: BIOCHEMISTRY. 2004;43(16):4655-4661
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(27):24277-24284
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Article: NEUROSCIENCE LETTERS. 2003;337(2):111-113
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(45):43243-43246
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Article: BIOCHEMICAL JOURNAL. 2002;366(Pt 1):343-351
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(3):1673-1678
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(15):8669-8674
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(23):15990-15995
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(18):12619-12625
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Article: CHEMISTRY AND BIOLOGY. 1999;6(1):53-62
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(19):12601-12605
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(3):1870-1875
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Article: JOURNAL OF NEUROCHEMISTRY. 1996;67(1):294-301
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(15):8545-8548
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Article: NEURON. 1995;15(1):219-228
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Article: LAKARTIDNINGEN. 1995;92(18):1899-1900
- Visa fler
Alla övriga publikationer
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Review: BIOMEDICINES. 2021;9(7):801
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Review: BIOMOLECULES. 2021;11(6):858
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Review: JOURNAL OF INTERNAL MEDICINE. 2016;280(2):153-163
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Review: FEBS JOURNAL. 2014;281(1):46-62
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Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2010;14(4):741-757
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Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s549
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Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s148
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Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(3):326-335
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Thesis / dissertation: 1997
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Review: LAKARTIDNINGEN. 1995;92(42):3881-3884
Anställningar
- Lektor/Funktionsenhetschef, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2018-
Examina och utbildning
- Docent, Neurobiologi, Karolinska Institutet, 2008