Publications Gastroenterology and Nutrition Unit (GUT)

Here you find a list of selected papers from the Gastroenterology and Nutrition Unit (GUT).

In addition to this list, publications are also listed on each research group page.

2026

Opportunities and Challenges for Precision Nutrition in Gestational Obesity Management.
Söderström Shields E, Kaegi-Braun N, Sandborg J, Lilliecreutz C, Löf M
Curr Obes Rep 2026 Apr;15(1):

Primary sclerosing cholangitis.
von Seth E, Karlsen TH, Tanaka A, Ponsioen C, Bergquist A
Lancet 2026 Apr;407(10538):1549-1569

Investigating Children's Exposure to Outdoor Food Marketing in 2 Swedish Cities Using a Smartphone App: Cross-Sectional Study.
Spolander S, Fagerberg P, Langlet B, Sarafis I, Ioakimidis I
JMIR Mhealth Uhealth 2026 Mar;14():e70192

Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations.
Cornillet M, Båve AL, Sun D, Nouairia G, Villard C, Grigoriadis A, von Seth E, Jansson H, Álvez MB, Bergström S, Nilsson P, Uhlén M, Edfors F, Stål P, , Sparrelid E, Björkström NK, Halfvarson J, Bergquist A
JHEP Rep 2026 Mar;8(3):101719

Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes.
Chen L, Kang Z, Härdfeldt J, Li Z, Pedrelli M, Li Q, Lyu R, Valina Allo P, Sych T, Zheng X, Lin P, Zeng J, Huang Z, Garcia-Irigoyen O, Sukhanava S, Parini P, Bonnefond A, Sezgin E, Angelin B, Treuter E, Fan R
Nat Commun 2026 Mar;17(1):

Monitoring cancer-related fatigue and quality of life in breast and prostate cancer patients after primary treatment: a study protocol for the REBECCA trials in Norway.
Stensland M, Bru KF, Austdal M, Dahl IH, Jonsdottir K, Lende TH, Heimvik C, Elve I, Omdal R, van der Giezen M, Kvivik I, Tangeland B, Davidsen L, Hashemi M, Cais A, van Dijk KJ, Seyoum Y, Blåfjelldal V, Sola ST, Papadopoulos A, Kiriakidou N, Ioakeimidis I, Diou C, Sarafis I, Delopoulos A, Janssen EAM, Gilje B, Tjensvoll K
Clin Exp Med 2026 Feb;26(1):133

Cirrhosis and age are key determinants of HCC risk in individuals with primary sclerosing cholangitis: A multicenter longitudinal cohort study.
Holmer M, Ingre M, Färkkilä M, Ponsioen C, Mol B, Schramm C, Folseraas T, Wiencke K, Cazzagon N, Catanzaro E, Molinaro A, Nilsson E, Vessby J, Kechagias S, Nyhlin N, Werner M, Bergquist A
Hepatology 2026 Jan;83(1):21-29

Higher Sedentary Behaviour and Not Following Screen Time Guidelines Were Associated With Unfavourable Cardiometabolic Outcomes in Childhood.
Nilsson E, Migueles JH, Henriksson P, Nyström CD, Löf M
Acta Paediatr 2026 Jan;115(1):89-99

2025

Phosphatidylethanol levels distinguish steatotic liver disease subgroups and are associated with risk of major liver outcomes.
Vaz J, Nasr P, Helander A, Shang Y, Wester A, Strandberg R, Grip ET, Hagström H
J Hepatol 2025 Nov;83(5):1011-1022

Adherence to United European Gastroenterology Guidelines on Diagnosis and Therapy of Immunoglobulin-G4-Related Digestive Disease.
Vujasinovic M, Lanzillotta M, Culver EL, Rebours V, Drenth JPH, Stojkovic Lalosevic M, Vikse J, Gubergrits N, Hirth M, Cardinale V, Motta RV, Della-Torre E, Sciberras N, Maida M, Trikola A, Lammert F, Descourvières C, Ponsioen C, Frøkjær JB, Schneider A, Alvaro D, Capurso G, Löhr JM
United European Gastroenterol J 2025 Oct;13(8):1583-1592

Physical Activity and Screen Time Trends in Swedish Youth: The Generation Pep Study 2018-2023.
Kägi-Braun N, Hedin L, Cassel S, Carlander A, J-Son Höök M, Löf M
Acta Paediatr 2025 Oct;114(10):2589-2602

Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans.
Jonk SM, Nicol A, Chrysostomou V, Lardner E, Yu SC, Stålhammar G, Crowston JG, Tribble JR, Swoboda P, Williams PA
Redox Biol 2025 Sep;85():103732

SMRT anchors the HDAC3 corepressor complex to chromatin to regulate inflammatory and metabolic pathways in macrophages.
Efthymiadou A, Gu C, Wang C, Wang H, Li Z, Garcia-Irigoyen O, Fan R, Treuter E, Huang Z
Nucleic Acids Res 2025 Sep;53(17):

Use of new CORE risk score to predict 10 year risk of liver cirrhosis in general population: population based cohort study.
Strandberg R, Åberg F, Asteljoki JV, Luukkonen PK, Salomaa V, Jula A, Lundqvist A, Männistö S, Perola M, Talbäck M, Hammar N, Hagström H
BMJ 2025 Sep;390():e083182

Intestinal estrogen receptor beta modulates the murine colon tumor immune microenvironment.
Birgersson M, Holm M, Gallardo-Dodd CJ, Chen B, Stepanauskaitė L, Hases L, Kutter C, Archer A, Williams C
Cancer Lett 2025 Jul;622():217661

Implementing digital health to support self-care of chronic diseases.
Löf M, Maddison R
Nat Med 2025 Jul;31(7):2093-2094

Pediatric Autoimmune Pancreatitis: Clinical Findings and Outcomes in Sweden.
Vujasinovic M, Lindgren F, Kartalis N, Pozzi Mucelli R, Rutkowski D, Waldthaler A, Ghorbani P, Moro CF, Casswall T, Löhr JM
United European Gastroenterol J 2025 Jun;13(5):819-830

YCharOS protocol for antibody validation.
Monteiro FL, Voskuil JLA, Williams C
Nat Protoc 2025 Jun;20(6):1389-1390

Towards precision medicine strategies using plasma proteomic profiling for suspected gallbladder cancer: A pilot study.
Nouairia G, Cornillet M, Jansson H, Bergquist A, Sparrelid E
JHEP Rep 2025 Jun;7(6):101365

Recommendations from the European guidelines for the diagnosis and therapy of pancreatic exocrine insufficiency.
Vujasinovic M, Iglesia D, Dominguez-Muñoz JE, Löhr JM,
Pancreatology 2025 May;25(3):293-300

Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders.
Yoshihara M, Coschiera A, Bachmann JA, Pucci M, Li H, Bhagat S, Murakawa Y, Weltner J, Jouhilahti EM, Swoboda P, Sahlén P, Kere J
EMBO Rep 2025 Mar;26(5):1212-1237

SPARK: an mHealth intervention for self-management and treatment of gestational diabetes mellitus in Sweden - protocol for a randomised controlled trial.
Lilliecreutz C, Söderström E, Ersson M, Bendtsen M, Brown V, Kaegi-Braun N, Linder R, Maddison R, Chisalita SI, Löf M
BMJ Open 2025 Mar;15(3):e089355

Metabolic Dysfunction-Associated Steatotic Liver Disease and Pancreatic Disease-A Population-Based Nationwide Cohort and Sibling-Controlled Study.
Vujasinovic M, Ebrahimi F, Roelstraete B, Bergman D, Sun J, Sadr-Azodi O, Löhr JM, Ludvigsson JF
United European Gastroenterol J 2025 Mar;13(2):247-256

Screening for advanced liver fibrosis due to metabolic dysfunction-associated steatotic liver disease alongside retina scanning in people with type 2 diabetes: a cross-sectional study.
Lindfors A, Strandberg R, Hagström H
Lancet Gastroenterol Hepatol 2025 Feb;10(2):125-137

2024

Natural history and progression of metabolic dysfunction-associated steatotic liver disease.
Hagström H, Shang Y, Hegmar H, Nasr P
Lancet Gastroenterol Hepatol 2024 Oct;9(10):944-956

The DoGA consortium expression atlas of promoters and genes in 100 canine tissues.
Hörtenhuber M, Hytönen MK, Mukarram AK, Arumilli M, Araujo CL, Quintero I, Syrjä P, Airas N, Kaukonen M, Kyöstilä K, Niskanen J, Jokinen TS, Mottaghitalab F, Takan I, Salokorpi N, Raman A, Stevens I, Iivanainen A, Yoshihara M, Gusev O, Bannasch D, Sukura A, Schoenebeck JJ, , Ezer S, Katayama S, Daub CO, Kere J, Lohi H
Nat Commun 2024 Oct;15(1):9082

IL-1β promotes adipogenesis by directly targeting adipocyte precursors.
Hofwimmer K, de Paula Souza J, Subramanian N, Vujičić M, Rachid L, Méreau H, Zhao C, Dror E, Barreby E, Björkström NK, Wernstedt Asterholm I, Böni-Schnetzler M, Meier DT, Donath MY, Laurencikiene J
Nat Commun 2024 Sep;15(1):7957

Enhancers regulate genes linked to severe and mild childhood asthma.
Akhter T, Mileti E, Kere MM, Kolmert J, Konradsen JR, Hedlin G, Melén E, Daub CO
Heliyon 2024 Jul;10(14):e34386

The Swedish initiative for the study of Primary sclerosing cholangitis (SUPRIM).
Cornillet M, Villard C, Rorsman F, Molinaro A, Nilsson E, Kechagias S, von Seth E, Bergquist A
EClinicalMedicine 2024 Apr;70():102526

Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes.
Wester A, Shang Y, Toresson Grip E, Matthews AA, Hagström H
Gut 2024 Apr;73(5):835-843

Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
Sommerauer C, Gallardo-Dodd CJ, Savva C, Hases L, Birgersson M, Indukuri R, Shen JX, Carravilla P, Geng K, Nørskov Søndergaard J, Ferrer-Aumatell C, Mercier G, Sezgin E, Korach-André M, Petersson C, Hagström H, Lauschke VM, Archer A, Williams C, Kutter C
Mol Syst Biol 2024 Apr;20(4):374-402

Interaction network of human early embryonic transcription factors.
Gawriyski L, Tan Z, Liu X, Chowdhury I, Malaymar Pinar D, Zhang Q, Weltner J, Jouhilahti EM, Wei GH, Kere J, Varjosalo M
EMBO Rep 2024 Mar;25(3):1589-1622

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway.
Coschiera A, Yoshihara M, Lauter G, Ezer S, Pucci M, Li H, Kavšek A, Riedel CG, Kere J, Swoboda P
BMC Biol 2024 Feb;22(1):48

2023

Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1.
Birgersson M, Indukuri R, Lindquist L, Stepanauskaite L, Luo Q, Deng Q, Archer A, Williams C
BMC Biol 2023 Nov;21(1):277

Transcriptomic differences between human 8-cell-like cells reprogrammed with different methods.
Yoshihara M, Kere J
Stem Cell Reports 2023 Aug;18(8):1621-1628

Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4+ T cells.
Subramanian N, Hofwimmer K, Tavira B, Massier L, Andersson DP, Arner P, Laurencikiene J
Cardiovasc Diabetol 2023 Apr;22(1):84

Prospective surveillance for cholangiocarcinoma in unselected individuals with primary sclerosing cholangitis.
Villard C, Friis-Liby I, Rorsman F, Said K, Warnqvist A, Cornillet M, Kechagias S, Nyhlin N, Werner M, Janczewska I, Hagström T, Nilsson E, Bergquist A
J Hepatol 2023 Mar;78(3):604-613

Effectiveness of a Smartphone App (MINISTOP 2.0) integrated in primary child health care to promote healthy diet and physical activity behaviors and prevent obesity in preschool-aged children: randomized controlled trial.
Alexandrou C, Henriksson H, Henström M, Henriksson P, Delisle Nyström C, Bendtsen M, Löf M
Int J Behav Nutr Phys Act 2023 Feb;20(1):22

Post-pancreatitis diabetes mellitus is common in chronic pancreatitis and is associated with adverse outcomes.
Dugic A, Hagström H, Dahlman I, Rutkowski W, Daou D, Kulinski P, Löhr JM, Vujasinovic M
United European Gastroenterol J 2023 Feb;11(1):79-91

High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice.
Hases L, Stepanauskaite L, Birgersson M, Brusselaers N, Schuppe-Koistinen I, Archer A, Engstrand L, Williams C
Commun Biol 2023 Jan;6(1):20