Publications related to PRECISE

A selection of key publications from the PRECISE team.

Development and validation of a novel prediction model for hypertensive disorders of pregnancy based on maternal cardiovascular function and placental blood flow metrics at 22 to 24 gestational weeks using machine learning. 
Sci Rep. 2025 Dec 9;15(1):43488

Optical super-resolution histology of formalin-fixed paraffin-embedded tissue samples: challenges and opportunities. 
Nat Commun. 2025 Nov 5;16(1):9760

A comprehensive human embryo reference tool using single-cell RNA-sequencing data.
Nat Methods 2025 Jan;22(1):193-206

Clinical-grade whole genome sequencing-based haplarithmisis enables all forms of preimplantation genetic testing.
Nat Commun 2024 Sep;15(1):7164

BinDel: Detecting Clinically Relevant Fetal Genomic Microdeletions Using Low-Coverage Whole-Genome Sequencing-Based NIPT.
Prenat Diagn 2025 Mar;45(3):352-361

Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss.
Nat Med 2023 Dec;29(12):3233-3242

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
N Engl J Med 2024 Aug;391(6):526-537

An exploratory open-label multicentre phase I/II trial evaluating the safety and efficacy of postnatal or prenatal and postnatal administration of allogeneic expanded fetal mesenchymal stem cells for the treatment of severe osteogenesis imperfecta in infants and fetuses: the BOOSTB4 trial protocol.
BMJ Open 2024 Jun;14(6):e079767

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation. 
Stem Cell Reports.2022;17(6):1458–1475

Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation. 
Nat Cell Biol. 2022;24(6):845–857

Amnion signals are essential for mesoderm formation in primates. 
Nat Commun. 2021;12(1):5126

Evaluating totipotency using criteria of increasing stringency. 
Nat Cell Biol. 2021;23(1):49–60

Karolinska Institutet Human Embryonic Stem Cell Bank. 
Stem Cell Res. 2020;45:101810

Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells. 
Nat Commun.2020;11(1):1609

In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages.
Nat Med 2019 Nov;25(11):1699-1705

Comprehensive cell surface protein profiling identifies specific markers of human naive and primed pluripotent states. 
Cell Stem Cell.2017;20(6):874–890.e7

Xeno-free and defined human embryonic stem cell-derived retinal pigment epithelial cells functionally integrate in a large-eyed preclinical model. Stem Cell Reports. 2016;6(1):9–17

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos.
Cell 2016 May;165(4):1012-26

Content reviewer:
02-10-2026