Zongli Zheng

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Articles

Article: CLINICAL CANCER RESEARCH. 2024;30(13):2772-2779
Monitoring Hepatocellular Carcinoma Using Tumor Content in Circulating Cell-Free DNA
Lian S; Lu C; Li F; Yu X; Ai L; Wu B; Gong X; Zhou W; Liang X; Zhan J; Yuan Y; Fang F; Liu Z; Ji M; Zheng Z
Article: ISCIENCE. 2024;27(5):109701
Article Circulating DNA genome-wide fragmentation in early detection and disease monitoring of hepatocellular carcinoma
Lian S; Lu C; Li F; Yu X; Ai L; Wu B; Gong X; Zhou W; Xie Y; Du Y; Quan W; Wang P; Deng L; Liang X; Zhan J; Yuan Y; Fang F; Liu Z; Ji M; Zheng Z
Article: MOLECULAR NEUROBIOLOGY. 2023;60(12):7346-7361
Sex Differences in Long-term Outcome of Prenatal Exposure to Excess Glucocorticoids-Implications for Development of Psychiatric Disorders
Elberling F; Spulber S; Bose R; Keung HY; Ahola V; Zheng Z; Ceccatelli S
Article: ISCIENCE. 2023;26(4):106302
Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues
Cheng S; Breniere-Letuffe D; Ahola V; Wong AOT; Keung HY; Gurung B; Zheng Z; Costa KD; Lieu DK; Keung W; Li RA
Article: NATURE COMMUNICATIONS. 2022;13(1):2219
Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities
Thean DGL; Chu HY; Fong JHC; Chan BKC; Zhou P; Kwok CCS; Chan YM; Mak SYL; Choi GCG; Ho JWK; Zheng Z; Wong ASL
Article: NUCLEIC ACIDS RESEARCH (NAR). 2022;50(3):1650-1660
High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination
Yuen CTL; Thean DGL; Chan BKC; Zhou P; Kwok CCS; Chu HY; Cheung MSH; Wang B; Chan YM; Mak SYL; Leung AY; Choi GCG; Zheng Z; Wong ASL
Article: JOURNAL OF THORACIC ONCOLOGY. 2022;17(2):264-276
Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC
Song Z; Lian S; Mak S; Chow MZ-Y; Xu C; Wang W; Keung HY; Lu C; Kebede FT; Gao Y; Cheuk W; Cho WCS; Yang M; Zheng Z
Article: DIAGNOSTICS. 2021;11(9):1538
Efficacy of Loop-Mediated Isothermal Amplification for H. pylori Detection as Point-of-Care Testing by Noninvasive Sampling
Sohrabi A; Franzen J; Tertipis N; Zagai U; Li W; Zheng Z; Ye W
Article: CELL REPORTS. 2020;32(6):108020
A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets
Zhou P; Chan BKC; Wan YK; Yuen CTL; Choi GCG; Li X; Tong CSW; Zhong SSW; Sun J; Bao Y; Mak SYL; Chow MZY; Khaw JV; Leung SY; Zheng Z; Cheung LWT; Tan K; Wong KH; Chan HYE; Wong ASL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(42):20969-20976
Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity
Tan Y; Chu AHY; Bao S; Duc AH; Kebede FT; Xiong W; Ji M; Shi J; Zheng Z
Article: NATURE METHODS. 2019;16(8):722-730
Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9
Choi GCG; Zhou P; Yuen CTL; Chan BKC; Xu F; Bao S; Chu HY; Thean D; Tan K; Wong KH; Zheng Z; Wong ASL
Article: CANCER DISCOVERY. 2018;8(3):336-353
Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor-Positive Breast Cancer
Matissek KJ; Onozato ML; Sun S; Zheng Z; Schultz A; Lee J; Patel K; Jerevall P-L; Saladi SV; Macleay A; Tavallai M; Badovinac-Crnjevic T; Barrios C; Bese N; Chan A; Chavarri-Guerra Y; Debiasi M; Demirdogen E; Egeli U; Gokgoz S; Gomez H; Liedke P; Tasdelen I; Tolunay S; Werutsky G; St Louis J; Horick N; Finkelstein DM; Le LP; Bardia A; Goss PE; Sgroi DC; Iafrate AJ; Ellisen LW
Article: NATURE. 2017;547(7661):55-60
Recurrent and functional regulatory mutations in breast cancer.
Rheinbay E; Parasuraman P; Grimsby J; Tiao G; Engreitz JM; Kim J; Lawrence MS; Taylor-Weiner A; Rodriguez-Cuevas S; Rosenberg M; Hess J; Stewart C; Maruvka YE; Stojanov P; Cortes ML; Seepo S; Cibulskis C; Tracy A; Pugh TJ; Lee J; Zheng Z; Ellisen LW; Iafrate AJ; Boehm JS; Gabriel SB; Meyerson M; Golub TR; Baselga J; Hidalgo-Miranda A; Shioda T; Bernards A; Lander ES; Getz G
Article: WORLD JOURNAL OF SURGERY. 2016;40(5):1060-1067
Severity of Acute Cholecystitis and Risk of Iatrogenic Bile Duct Injury During Cholecystectomy, a Population-Based Case-Control Study
Tornqvist B; Waage A; Zheng Z; Ye W; Nilsson M
Article: ONCOLOGIST. 2016;21(4):481-486
MET Exon 14 Skipping in Non-Small Cell Lung Cancer
Heist RS; Shim HS; Gingipally S; Mino-Kenudson M; Le L; Gainor JF; Zheng Z; Aryee M; Xia J; Jia P; Jin H; Zhao Z; Pao G; Engelman JA; Iafrate AJ
Article: NATURE. 2016;529(7587):490-495
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Kleinstiver BP; Pattanayak V; Prew MS; Tsai SQ; Nguyen NT; Zheng Z; Joung JK
Article: JOURNAL OF MOLECULAR DIAGNOSTICS. 2016;18(1):124-130
Next-Generation Sequencing and Fluorescence in Situ Hybridization Have Comparable Performance Characteristics in the Analysis of Pancreaticobiliary Brushings for Malignancy.
Dudley JC; Zheng Z; McDonald T; Le LP; Dias-Santagata D; Borger D; Batten J; Vernovsky K; Sweeney B; Arpin RN; Brugge WR; Forcione DG; Pitman MB; Iafrate AJ
Article: GASTROINTESTINAL ENDOSCOPY. 2016;83(1):140-148
Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts
Jones M; Zheng Z; Wang J; Dudley J; Albanese E; Kadayifci A; Dias-Santagata D; Le L; Brugge WR; Fernandez-del Castillo C; Mino-Kenudson M; Iafrate AJ; Pitman MB
Article: NATURE BIOTECHNOLOGY. 2015;33(12):1293-1298
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
Kleinstiver BP; Prew MS; Tsai SQ; Nguyen NT; Topkar VV; Zheng Z; Joung JK
Article: JOURNAL OF THORACIC ONCOLOGY. 2015;10(12):1670-1674
Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer
Farago AF; Le LP; Zheng Z; Muzikansky A; Drilon A; Patel M; Bauer TM; Liu SV; Ou S-HI; Jackman D; Costa DB; Multani PS; Li GG; Hornby Z; Chow-Maneval E; Luo D; Lim JE; Iafrate AJ; Shaw AT
Article: JOURNAL OF MOLECULAR DIAGNOSTICS. 2015;17(6):661-668
Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Platt MY; Fathi AT; Borger DR; Brunner AM; Hassejian RP; Balaj L; Lum A; Yip S; Dias-Santagata D; Zheng Z; Le LP; Graubert TA; Iafrate AJ; Nardi V
Article: CLINICAL CHEMISTRY. 2015;61(11):1408-1416
Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma
Huang J; Lohr J-M; Nilsson M; Segersvard R; Matsson H; Verbeke C; Heuchel R; Kere J; Iafrate AJ; Zheng Z; Ye W
Article: JOURNAL OF THORACIC ONCOLOGY. 2015;10(8):1156-1162
Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung
Shim HS; Mari-Kenudson; Zheng Z; Liebers M; Cha YJ; Ho QH; Onozato M; Le LP; Heist RS; Iafrate AJ
Article: THE BMJ. 2015;351:h3867
Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population
Song H; Ekheden IG; Zheng Z; Ericsson J; Nyren O; Ye W
Article: NATURE. 2015;523(7561):481-485
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Kleinstiver BP; Prew MS; Tsai SQ; Topkar VV; Nguyen NT; Zheng Z; Gonzales APW; Li Z; Peterson RT; Yeh J-RJ; Aryee MJ; Joung JK
Article: MODERN PATHOLOGY. 2015;28(4):552-563
High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome
Cleven AHG; Nardi V; Ok CY; Goswami M; Dal Cin P; Zheng Z; Lafrate AJ; Hamid MAA; Wang SA; Hasserjian RP
Article: NATURE BIOTECHNOLOGY. 2015;33(2):187-197
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Tsai SQ; Zheng Z; Nguyen NT; Liebers M; Topkar VV; Thapar V; Wyvekens N; Khayter C; Iafrate AJ; Le LP; Aryee MJ; Joung JK
Article: NATURE MEDICINE. 2014;20(12):1479-1484
Anchored multiplex FOR for targeted next-generation sequencing
Zheng Z; Liebers M; Zhelyazkova B; Cao Y; Panditi D; Lynch KD; Chen J; Robinson HE; Shim HS; Chmielecki J; Pao W; Engelman JA; Iafrate AJ; Le LP
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2014;371(21):1963-1971
Crizotinib in ROS1-Rearranged Non-Small-Cell Lung Cancer
Shaw AT; Ou S-HI; Bang Y-J; Camidge DR; Solomon BJ; Salgia R; Riely GJ; Varella-Garcia M; Shapiro GI; Costa DB; Doebele RC; Long PL; Zheng Z; Tan W; Stephenson P; Shreeve SM; Tye LM; Christensen JG; Wilner KD; Clark JW; Iafrate AJ
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2014;99(11):E2457-E2462
Identification of Oncogenic Mutations and Gene Fusions in the Follicular Variant of Papillary Thyroid Carcinoma
McFadden DG; Dias-Santagata D; Sadow PM; Lynch KD; Lubitz C; Donovan SE; Zheng Z; Le L; Iafrate AJ; Daniels GH
Article: SCIENCE. 2014;345(6193):216-220
Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
Yu M; Bardia A; Aceto N; Bersani F; Madden MW; Donaldson MC; Desai R; Zhu H; Comaills V; Zheng Z; Wittner BS; Stojanov P; Brachtel E; Sgroi D; Kapur R; Shioda T; Ting DT; Ramaswamy S; Getz G; Iafrate AJ; Benes C; Toner M; Maheswaran S; Haber DA
Article: JOURNAL OF THORACIC ONCOLOGY. 2014;9(4):563-566
A Novel Fusion of TPR and ALK in Lung Adenocarcinoma
Choi Y-L; Lira ME; Hong M; Kim RN; Choi S-J; Song J-Y; Pandy K; Mann DL; Stahl JA; Peckham HE; Zheng Z; Han J; Mao M; Kim J
Article: PLOS ONE. 2014;9(1):e86446
LIN28 Is Involved in Glioma Carcinogenesis and Predicts Outcomes of Glioblastoma Multiforme Patients
Qin R; Zhou J; Chen C; Xu T; Yan Y; Ma Y; Zheng Z; Shen Y; Lu Y; Fu D; Chen J
Article: MBIO. 2013;4(3):e00569-e00512
Metagenomic De Novo Assembly of an Aquatic Representative of the Verrucomicrobial Class Spartobacteria
Herlemann DPR; Lundin D; Labrenz M; Juergens K; Zheng Z; Aspeborg H; Andersson AF
Article: NATURE PROTOCOLS. 2011;6(9):1367-1376
Titration-free 454 sequencing using Y adapters
Zheng Z; Advani A; Melefors O; Glavas S; Nordstrom H; Ye W; Engstrand L; Andersson AF
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2011;33(5):578-584
Hospitalisation of and mortality from bleeding peptic ulcer in Sweden: a nationwide time-trend analysis
Ahsberg K; Ye W; Lu Y; Zheng Z; von Holstein CS
Article: PLOS ONE. 2011;6(5):e19723
Rapid Screening of Complex DNA Samples by Single-Molecule Amplification and Sequencing
Huang J; Zheng Z; Andersson AF; Engstrand L; Ye W
Article: PLOS ONE. 2011;6(10):e26442
A Method for Metagenomics of Helicobacter pylori from Archived Formalin-Fixed Gastric Biopsies Permitting Longitudinal Studies of Carcinogenic Risk
Zheng Z; Andersson AF; Ye W; Nyren O; Normark S; Engstrand L
Article: GASTROENTEROLOGY. 2010;139(6):1844-1854.e1
A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes
Willing BP; Dicksved J; Halfvarson J; Andersson AF; Lucio M; Zheng Z; Jarnerot G; Tysk C; Jansson JK; Engstrand L
Article: NUCLEIC ACIDS RESEARCH (NAR). 2010;38(13):e137
Titration-free massively parallel pyrosequencing using trace amounts of starting material
Zheng Z; Advani A; Melefors O; Glavas S; Nordstrom H; Ye W; Engstrand L; Andersson AF
Article: CANCER CAUSES AND CONTROL. 2010;21(2):313-321
A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer
Jia Y; Persson C; Hou L; Zheng Z; Yeager M; Lissowska J; Chanock SJ; Chow W-H; Ye W
Article: PLOS ONE. 2009;4(10):e7297
Is There a Link between the Lipopolysaccharide of Helicobacter pylori Gastric MALT Lymphoma Associated Strains and Lymphoma Pathogenesis?
Lehours P; Zheng Z; Skoglund A; Megraud F; Engstrand L
Article: HELICOBACTER. 2009;14(5):120-125
Genetic Variation in a4GnT in Relation to Helicobacter pylori Serology and Gastric Cancer Risk
Zheng Z; Jia Y; Hou L; Persson C; Yeager M; Lissowska J; Chanock SJ; Blaser M; Chow W-H; Ye W
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2009;7(9):1013-1018
Long-Term Effects of Iatrogenic Bile Duct Injury During Cholecystectomy
Tornqvist B; Zheng Z; Ye W; Waage A; Nilsson M
Article: GASTROENTEROLOGY. 2008;135(1):72-81
Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal reflux
Zheng Z; Margolis KL; Liu S; Tinker LF; Ye W
Article: GASTROENTEROLOGY. 2008;134(4):921-928
Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins
Nordenstedt H; Zheng Z; Cameron AJ; Ye W; Pedersen NL; Lagergren J
Article: GASTROENTEROLOGY. 2007;132(1):87-95
Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins
Zheng Z; Nordenstedt H; Pedersen NL; Lagergren J; Ye W
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2005;11(12):1867-1871
Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer
Cai L; Zheng Z-L; Zhang Z-F
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2003;9(2):214-218
Risk factors for the gastric cardia cancer: a case-control study in Fujian Province
Cai L; Zheng ZL; Zhang ZF
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All other publications

Letter: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):100
Mutation-independent gene knock-in therapy targeting 5′UTR for autosomal dominant retinitis pigmentosa
Hoang DA; Liao B; Zheng Z; Xiong W
Editorial comment: JOURNAL OF THORACIC ONCOLOGY. 2021;16(3):344-348
Noncanonical Gene Fusions Detected at the DNA Level Necessitate Orthogonal Diagnosis Methods Before Targeted Therapy
Song Z; Lu C; Xu C-W; Zheng Z
Letter: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2020;5(1):27
Cancer-associated histone mutation H2BG53D disrupts DNA-histone octamer interaction and promotes oncogenic phenotypes
Wan YCE; Leung TCS; Ding D; Sun X; Liu J; Zhu L; Kang TZE; Yang D; Zhang Y; Zhang J; Qian C; Huen MSY; Li Q; Chow MZY; Zheng Z; Han J; Goel A; Wang X; Ishibashi T; Chan KM
Letter: ENDOCRINE-RELATED CANCER. 2015;22(6):L23-L28
Identification of insertions in PTEN and TP53 in anaplastic thyroid carcinoma with angiogenic brain metastasis
Sadow PM; Dias-Santagata D; Zheng Z; Lin DT; Long PL; Nucera C
Thesis / dissertation: 2011
Molecular epidemiologic studies on helicobacter pylori infection and stomach cancer risk
Zheng, Zongli

Employments

Affiliated to Research, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2024-2027
Affiliated to Research, Department of Neuroscience, Karolinska Institutet, 2024-2026

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2011

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