Denna sida på svenska
Loading profile information...


  • PhD in Psychiatric Epidemiology, Karolinska Institutet, 2013
  • MSc in Biomedicine, Karolinska Institutet, 2009
  • BSc in Life Science, Fudan University, 2007

Research description

My main research interest is in the field of pharmacoepidemiology. My current projects include studies of the risks and benefits of psychotropic medications (e.g., antidepressants, ADHD medication) using large-scale population data (e.g., national health registers, medical claim database).

As a separate research interest, I've also participated in a series of studies on the associations between mental and somatic disorders, using various data sources from Sweden, China, and the US.

Selected publications:








Association of Mental Health Conditions and Treatments With Long-term Opioid Analgesic Receipt Among Adolescents
Quinn Pd, Hur K, Chang Z, Scott El, Krebs Ee, Bair Mj, et al
JAMA pediatrics 2018;172(5):423-430

Attention-deficit/hyperactivity disorder medication and seizures
Wiggs Kk, Chang Z, Quinn Pd, Hur K, Gibbons R, Dunn D, et al
Neurology 2018;90(13):e1104-e1110

Epilepsy, antiepileptic drugs, and serious transport accidents: A nationwide cohort study
Sundelin Hek, Chang Z, Larsson H, Lichtenstein P, Almqvist C, Tomson T, et al
Neurology 2018;90(13):e1111-e1118

Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits
Chen X, Kuja-halkola R, Chang Z, Karlsson R, Hägg S, Svensson P, et al
Journal of the American Heart Association 2018;7(9):-

ADHD Medication and Substance-Related Problems
Quinn Pd, Chang Z, Hur K, Gibbons Rd, Lahey Bb, Rickert Me, et al
The American journal of psychiatry 2017;174(9):877-885

Association Between Medication Use for Attention-Deficit/Hyperactivity Disorder and Risk of Motor Vehicle Crashes
Chang Z, Quinn Pd, Hur K, Gibbons Rd, Sjölander A, Larsson H, et al
JAMA psychiatry 2017;74(6):597-603

Incident and long-term opioid therapy among patients with psychiatric conditions and medications: a national study of commercial health care claims
Quinn Pd, Hur K, Chang Z, Krebs Ee, Bair Mj, Scott El, et al
Pain 2017;158(1):140-148

Metabolic and Cardiovascular Complications in Obsessive-Compulsive Disorder: A Total Population, Sibling Comparison Study With Long-Term Follow-up
Isomura K, Brander G, Chang Z, Kuja-halkola R, Rück C, Hellner C, et al
Biological psychiatry 2017;():-

The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder
Viktorin A, Rydén E, Thase Me, Chang Z, Lundholm C, D'onofrio Bm, et al
The American journal of psychiatry 2017;174(4):341-348

Association Between Prescription of Major Psychotropic Medications and Violent Reoffending After Prison Release
Chang Z, Lichtenstein P, Långström N, Larsson H, Fazel S
JAMA 2016;316(17):1798-1807

Genetic and environmental influences on the relationship between ADHD symptoms and internalizing problems: A Chinese twin study
Chen Tj, Ji Cy, Wang Ss, Lichtenstein P, Larsson H, Chang Z
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2016;171(7):931-7

Medication for Attention-Deficit/Hyperactivity Disorder and Risk for Depression: A Nationwide Longitudinal Cohort Study
Chang Z, D'onofrio Bm, Quinn Pd, Lichtenstein P, Larsson H
Biological psychiatry 2016;80(12):916-922

OxRec model for assessing risk of recidivism: ethics - Authors' reply
Fazel S, Chang Z, Långström N, Fanshawe T, Mallett S
The lancet. Psychiatry 2016;3(9):809-10

Prediction of violent reoffending on release from prison: derivation and external validation of a scalable tool
Fazel S, Chang Z, Fanshawe T, Långström N, Lichtenstein P, Larsson H, et al
The lancet. Psychiatry 2016;3(6):535-43

Comparison of heritability of Cystatin C- and creatinine-based estimates of kidney function and their relation to heritability of cardiovascular disease
Arpegård J, Viktorin A, Chang Z, De Faire U, Magnusson Pk, Svensson P
Journal of the American Heart Association 2015;4(1):e001467-

Depression and violence: a Swedish population study
Fazel S, Wolf A, Chang Z, Larsson H, Goodwin Gm, Lichtenstein P
LANCET PSYCHIATRY 2015;2(3):224-32

Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study
Mataix-cols D, Isomura K, Pérez-vigil A, Chang Z, Rück C, Larsson Kj, et al
JAMA psychiatry 2015;72(8):787-93

Psychiatric disorders and violent reoffending: a national cohort study of convicted prisoners in Sweden
Chang Z, Larsson H, Lichtenstein P, Fazel S
The lancet. Psychiatry 2015;2(10):891-900

Substance use disorders, psychiatric disorders, and mortality after release from prison: a nationwide longitudinal cohort study
Chang Z, Lichtenstein P, Larsson H, Fazel S
LANCET PSYCHIATRY 2015;2(5):422-430

Variation in mortality risk of people released from prison - Authors' reply
Chang Z, Lichtenstein P, Larssen H, Fazel S
The lancet. Psychiatry 2015;2(8):681-682

Genetic factors may play a prominent role in the development of coronary heart disease dependent on important environmental factors
Song C, Chang Z, Magnusson Pk, Ingelsson E, Pedersen Nl
Journal of internal medicine 2014;275(6):631-9

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L
Viktorin A, Frankowiack M, Padyukov L, Chang Z, Melén E, Sääf A, et al
Human molecular genetics 2014;23(15):4177-84

Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study
Chang Z, Lichtenstein P, D'onofrio Bm, Almqvist C, Kuja-halkola R, Sjölander A, et al
International journal of epidemiology 2014;43(6):1815-24

Oppositional defiant- and conduct disorder-like problems: neurodevelopmental predictors and genetic background in boys and girls, in a nationwide twin study
Kerekes N, Lundström S, Chang Z, Tajnia A, Jern P, Lichtenstein P, et al
PeerJ 2014;2():e359-

Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study
Chang Z, Lichtenstein P, D'onofrio Bm, Sjölander A, Larsson H
JAMA psychiatry 2014;71(3):319-25

Stimulant ADHD medication and risk for substance abuse
Chang Z, Lichtenstein P, Halldner L, D'onofrio B, Serlachius E, Fazel S, et al
Journal of child psychology and psychiatry, and allied disciplines 2014;55(8):878-85

The heritability of clinically diagnosed attention deficit hyperactivity disorder across the lifespan
Larsson H, Chang Z, D'onofrio Bm, Lichtenstein P

Developmental twin study of attention problems: high heritabilities throughout development
Chang Z, Lichtenstein P, Asherson Pj, Larsson H
JAMA psychiatry 2013;70(3):311-8

Genetic and environmental influences on adult attention deficit hyperactivity disorder symptoms: a large Swedish population-based study of twins
Larsson H, Asherson P, Chang Z, Ljung T, Friedrichs B, Larsson Jo, et al
Psychological medicine 2013;43(1):197-207

Prevalence, comorbidity and heritability of hoarding symptoms in adolescence: a population based twin study in 15-year olds
Ivanov Vz, Mataix-cols D, Serlachius E, Lichtenstein P, Anckarsäter H, Chang Z, et al
PloS one 2013;8(7):e69140-

Autism spectrum disorders and autistic like traits: similar etiology in the extreme end and the normal variation
Lundström S, Chang Z, Råstam M, Gillberg C, Larsson H, Anckarsäter H, et al
Archives of general psychiatry 2012;69(1):46-52

Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs
Larsson H, Anckarsater H, Råstam M, Chang Z, Lichtenstein P
Journal of child psychology and psychiatry, and allied disciplines 2012;53(1):73-80

The effects of childhood ADHD symptoms on early-onset substance use: a Swedish twin study
Chang Z, Lichtenstein P, Larsson H
Journal of abnormal child psychology 2012;40(3):425-35

Autistic-like traits and their association with mental health problems in two nationwide twin cohorts of children and adults
Lundström S, Chang Z, Kerekes N, Gumpert Ch, Råstam M, Gillberg C, et al
Psychological medicine 2011;41(11):2423-33

Show all publications