Yvonne Freund-Levi

Publications
Grants
CV
Public outreach and news

Articles

Article: ALZHEIMERS & DEMENTIA. 2024;20(10):6682-6698
Blood-based multivariate methylation risk score for cognitive impairment and dementia
Koetsier J; Cavill R; Reijnders R; Harvey J; Homann J; Kouhsar M; Deckers K; Kohler S; Eijssen LMT; van den Hove DLA; Demuth I; Duezel S; Smith RG; Smith AR; Burrage J; Walker EM; Shireby G; Hannon E; Dempster E; Frayling T; Mill J; Dobricic V; Johannsen P; Wittig M; Franke A; Vandenberghe R; Schaeverbeke J; Freund-Levi Y; Froelich L; Scheltens P; Teunissen CE; Frisoni G; Blin O; Richardson JC; Bordet R; Engelborghs S; de Roeck E; Martinez-Lage P; Tainta M; Lleo A; Sala I; Popp J; Peyratout G; Verhey F; Tsolaki M; Andreasson U; Blennow K; Zetterberg H; Streffer J; Vos SJB; Lovestone S; Visser P-J; Lill CM; Bertram L; Lunnon K; Pishva E
Article: ALZHEIMERS & DEMENTIA. 2024;20(10):6722-6739
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study
Smith RG; Pishva E; Kouhsar M; Imm J; Dobricic V; Johannsen P; Wittig M; Franke A; Vandenberghe R; Schaeverbeke J; Freund-Levi Y; Froelich L; Scheltens P; Teunissen CE; Frisoni G; Blin O; Richardson JC; Bordet R; Engelborghs S; de Roeck E; Martinez-Lage P; Altuna M; Tainta M; Lleo A; Sala I; Popp J; Peyratout G; Winchester L; Nevado-Holgado A; Verhey F; Tsolaki M; Andreasson U; Blennow K; Zetterberg H; Streffer J; Vos SJB; Lovestone S; Visser PJ; Bertram L; Lunnon K
Article: RES SQ. 2024
Synaptic protein CSF levels relate to memory scores in individuals without dementia.
Wesenhagen KEJ; de Leeuw DM; Tomassen J; Gobom J; Bos I; Vos SJB; Martinez-Lage P; Tainta M; Popp J; Peyratout G; Tsolaki M; Vandenberghe R; Freund-Levi Y; Verhey F; Lovestone S; Streffer J; Dobricic V; Blennow K; Scheltens P; Smit AB; Bertram L; Teunissen CE; Zetterberg H; Tijms BM; Alzheimer’s Disease Neuroimaging Initiative
Article: FLUIDS AND BARRIERS OF THE CNS. 2024;21(1):58
Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies
Delvenne A; Vandendriessche C; Gobom J; Burgelman M; Dujardin P; De Nolf C; Tijms BM; Teunissen CE; Schindler SE; Verhey F; Ramakers I; Martinez-Lage P; Tainta M; Vandenberghe R; Schaeverbeke J; Engelborghs S; De Roeck E; Popp J; Peyratout G; Tsolaki M; Freund-Levi Y; Lovestone S; Streffer J; Bertram L; Blennow K; Zetterberg H; Visser PJ; Vandenbroucke RE; Vos SJB
Article: ALZHEIMERS & DEMENTIA. 2024;:6205-6220
CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease
Delvenne A; Gobom J; Schindler SE; ten Kate M; Reus LM; Dobricic V; Tijms BM; Benzinger TLS; Cruchaga C; Teunissen CE; Ramakers I; Martinez-Lage P; Tainta M; Vandenberghe R; Schaeverbeke J; Engelborghs S; De Roeck E; Popp J; Peyratout G; Tsolaki M; Freund-Levi Y; Lovestone S; Streffer J; Barkhof F; Bertram L; Blennow K; Zetterberg H; Visser PJ; Vos SJB
Article: JOURNAL OF ALZHEIMERS DISEASE. 2024;98(4):1391-1401
High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer's Disease Using [¹¹C]AZD2184
Mattsson P; Cselenyi Z; Moren AF; Freund-Levi Y; Wahlund L-O; Halldin C; Farde L
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S14)
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD Multimodal Biomarker Discovery study
Smith RG; Imm JL; Dobricic V; Sommerer Y; Bos I; Vos SJB; Verhey FRJ; Scheltens P; Engelborgs S; Frisoni GB; Blin O; Richardson JC; Bordet R; Tsolaki M; Popp J; Martinez‐Lage P; Lleo A; Johannsen P; Freund‐Levi Y; Lutz F; Vandenberghe R; Wittig M; Frank A; Lovestone S; Streffer J; Andreasson U; Blennow K; Visser PJ; Zetterberg H; Bertram L; Lunnon K
Article: ALZHEIMERS & DEMENTIA. 2023;19(6):2317-2331
Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits
Kucukali F; Neumann A; Van Dongen J; De Pooter T; Joris G; De Rijk P; Ohlei O; Dobricic V; Bos I; Vos SJB; Engelborghs S; De Roeck E; Vandenberghe R; Gabel S; Meersmans K; Tsolaki M; Verhey F; Martinez-Lage P; Tainta M; Frisoni G; Blin O; Richardson JC; Bordet R; Scheltens P; Popp J; Peyratout G; Johannsen P; Frolich L; Freund-Levi Y; Streffer J; Lovestone S; Legido-Quigley C; Ten Kate M; Barkhof F; Zetterberg H; Bertram L; Strazisar M; Visser PJ; Van Broeckhoven C; Sleegers K
Article: JOURNAL OF NEUROENDOCRINOLOGY. 2023;35(5):e13272
Higher CSF/serum free-T4 ratio is associated with improvement of quality of life during treatment with L-thyroxine
Funkquist A; Wandt B; Blennow K; Zetterberg H; Svensson J; Bjellerup P; Freund-Levi Y; Sjoberg S
Article: ALZHEIMERS & DEMENTIA. 2023;19(3):807-820
Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology
Delvenne A; Gobom J; Tijms B; Bos I; Reus LM; Dobricic V; Ten Kate M; Verhey F; Ramakers I; Scheltens P; Teunissen CE; Vandenberghe R; Schaeverbeke J; Gabel S; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Tsolaki M; Freund-Levi Y; Lovestone S; Streffer J; Barkhof F; Bertram L; Blennow K; Zetterberg H; Visser PJ; Vos SJB
Article: JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. 2023;10(2):207-211
The Geras Solutions Cognitive Test for Assessing Cognitive Impairment: Normative Data from a Population-Based Cohort
Bloniecki V; Ulfvarson J; Javanshiri K; Hagman G; Freund-Levi Y; Nordstroemg A
Article: BMJ OPEN. 2022;12(11):e066834
Swedish Chronic Pain Biobank: protocol for a multicentre registry and biomarker project
Ghafouri B; Ernberg M; Andrell P; Backryd E; Fisher MR; Freund-Levi Y; Grelz H; Grabel O; Karlsten R; Kosek E; Lofgren M; Ringqvist A; Rudling K; Stalnacke B-M; Sorlen N; Uhlin K; Westergren H; Gerdle B
Article: ALZHEIMERS & DEMENTIA. 2022;18(10):1832-1845
Characteristics of subjective cognitive decline associated with amyloid positivity
Janssen O; Jansen WJ; Vos SJB; Boada M; Parnetti L; Gabryelewicz T; Fladby T; Molinuevo JL; Villeneuve S; Hort J; Epelbaum S; Lleo A; Engelborghs S; van der Flier WM; Landau S; Popp J; Wallin A; Scheltens P; Rikkert MO; Snyder PJ; Rowe C; Chetelat G; Ruiz A; Marquie M; Chipi E; Wolfsgruber S; Heneka M; Boecker H; Peters O; Jarholm J; Rami L; Tort-Merino A; Binette AP; Poirier J; Rosa-Neto P; Cerman J; Dubois B; Teichmann M; Alcolea D; Fortea J; Sanchez-Saudinos MB; Ebenau J; Pocnet C; Eckerstrom M; Thompson L; Villemagne V; Buckley R; Burnham S; Delarue M; Freund-Levi Y; Wallin AK; Ramakers I; Tsolaki M; Soininen H; Hampel H; Spiru L; Tijms B; Ossenkoppele R; Verhey FRJ; Jessen F; Visser PJ
Article: MOLECULAR PSYCHIATRY. 2022;27(4):1990-1999
Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation
Neumann A; Kucukali F; Bos I; Vos SJB; Engelborghs S; De Pooter T; Joris G; De Rijk P; De Roeck E; Tsolaki M; Verhey F; Martinez-Lage P; Tainta M; Frisoni G; Blin O; Richardson J; Bordet R; Scheltens P; Popp J; Peyratout G; Johannsen P; Froelich L; Vandenberghe R; Freund-Levi Y; Streffer J; Lovestone S; Legido-Quigley C; ten Kate M; Barkhof F; Strazisar M; Zetterberg H; Bertram L; Visser PJ; van Broeckhoven C; Sleegers K
Article: MOLECULAR NEURODEGENERATION. 2022;17(1):27
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease
Visser PJ; Reus LM; Gobom J; Jansen I; Dicks E; van der Lee SJ; Tsolaki M; Verhey FRJ; Popp J; Martinez-Lage P; Vandenberghe R; Lleo A; Molinuevo JL; Engelborghs S; Freund-Levi Y; Froelich L; Sleegers K; Dobricic V; Lovestone S; Streffer J; Vos SJB; Bos I; Smit AB; Blennow K; Scheltens P; Teunissen CE; Bertram L; Zetterberg H; Tijms BM
Article: JAMA NEUROLOGY. 2022;79(3):228-243
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
Jansen WJ; Janssen O; Tijms BM; Vos SJB; Ossenkoppele R; Visser PJ
Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2022;14(1):e12286
Effects of age, amyloid, sex, and APOE e4 on the CSF proteome in normal cognition
Wesenhagen KEJ; Gobom J; Bos I; Vos SJB; Martinez-Lage P; Popp J; Tsolaki M; Vandenberghe R; Freund-Levi Y; Verhey F; Lovestone S; Streffer J; Dobricic V; Bertram L; Blennow K; Pikkarainen M; Hallikainen M; Kuusisto J; Laakso M; Soininen H; Scheltens P; Zetterberg H; Teunissen CE; Visser PJ; Tijms BM
Article: JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES. 2022;34(3):214-223
Neuropsychiatric Symptoms in Dementia: Considering a Clinical Role for Electroencephalography
Holmgren S; Andersson T; Berglund A; Aarsland D; Cummings J; Freund-Levi Y
Article: BIOMEDICINES. 2021;9(11):1610
Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort
Xu J; Green R; Kim M; Lord J; Ebshiana A; Westwood S; Baird AL; Nevado-Holgado AJ; Shi L; Hye A; Snowden SG; Bos I; Vos SJB; Vandenberghe R; Teunissen CE; Kate MT; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck EE; Engelborghs S; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey FRJ; Alcolea D; Lleo A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Froelich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Proitsi P; Legido-Quigley C
Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;83(3):1291-1301
Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study
Tofiq A; Zetterberg H; Blennow K; Basun H; Cederholm T; Eriksdotter M; Faxen-Irving G; Hjorth E; Jerneren F; Schultzberg M; Wahlund L-O; Palmblad J; Freund-Levi Y
Article: ALZHEIMERS & DEMENTIA. 2021;17(9):1452-1464
Replication study of plasma proteins relating to Alzheimer's pathology
Shi L; Winchester LM; Westwood S; Baird AL; Anand SN; Buckley NJ; Hye A; Ashton NJ; Bos I; Vos SJB; ten Kate M; Scheltens P; Teunissen CE; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lleo A; Sala I; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Freund-Levi Y; Froeich L; Dobricic V; Legido-Quigley C; Barkhof F; Andreasson U; Blennow K; Zetterberg H; Streffer J; Lill CM; Bertram L; Visser PJ; Kolb HC; Narayan VA; Lovestone S; Nevado-Holgado AJ
Article: PROTEOMES. 2021;9(3):36
CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals
Tijms BM; Gobom J; Teunissen C; Dobricic V; Tsolaki M; Verhey F; Popp J; Martinez-Lage P; Vandenberghe R; Lleo A; Molinuevo JL; Engelborghs S; Freund-Levi Y; Froelich L; Bertram L; Lovestone S; Streffer J; Vos S; Blennow K; Scheltens P; Zetterberg H; Visser PJ
Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):64
Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial
Rosenberg A; Solomon A; Soininen H; Visser PJ; Blennow K; Hartmann T; Kivipelto M
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S3)
CSF proteomic profiling of mild cognitive impairment individuals with suspected non‐Alzheimer’s disease pathophysiology
Delvenne A; Gobom J; Tijms BM; Bos I; Verhey FR; Ramakers IH; Scheltens P; Teunissen CE; Vandenberghe R; Gabel S; Popp J; Peyratout G; Martinez‐Lage P; Tainta M; Tsolaki M; Freund‐Levi Y; Lovestone S; Streffer J; Blennow K; Zetterberg H; Visser PJ; Vos SJ
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S3)
Synaptic proteins relate to memory scores in preclinical Alzheimer’s disease and cognitively healthy controls depending on amyloid
Wesenhagen KEJ; Visser PJ; Gobom J; Bos I; Vos SJB; Martinez‐Lage P; Tainta M; Popp J; Peyratout G; Tsolaki M; Vandenberghe R; Freund‐Levi Y; Verhey FRJ; Lovestone S; Streffer J; Blennow K; Scheltens P; Teunissen CE; Zetterberg H; Tijms BM; Initiative ADN
Article: ALZHEIMERS RESEARCH & THERAPY. 2020;12(1):153
Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?
Bloniecki V; Zetterberg H; Aarsland D; Vannini P; Kvartsberg H; Winblad B; Blennow K; Freund-Levi Y
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;77(3):1353-1368
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
Shi L; Winchester LM; Liu BY; Killick R; Ribe EM; Westwood S; Baird AL; Buckley NJ; Hong S; Dobricic V; Kilpert F; Franke A; Kiddle S; Sattlecker M; Dobson R; Cuadrado A; Hye A; Ashton NJ; Morgan AR; Bos I; Vos SJB; ten Kate M; Scheltens P; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lleo A; Alcolea D; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Teunissen CE; Freund-Levi Y; Frolich L; Legido-Quigley C; Barkhof F; Blennow K; Rasmussen KL; Nordestgaard BG; Frikke-Schmidt R; Nielsen SF; Soininen H; Vellas B; Kloszewska I; Mecocci P; Zetterberg H; Morgan BP; Streffer J; Visser PJ; Bertram L; Nevado-Holgado AJ; Lovestone S
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;74(1):213-225
Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort
Westwood S; Baird AL; Anand SN; Nevado-Holgado AJ; Kormilitzin A; Shi L; Hye A; Ashton NJ; Morgan AR; Bos I; Vos SJB; Baker S; Buckley NJ; Ten Kate M; Scheltens P; Teunissen CE; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lleo A; Sala I; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Freund-Levi Y; Froelich L; Dobricic V; Legido-Quigley C; Bertram L; Barkhof F; Zetterberg H; Morgan BP; Streffer J; Visser PJ; Lovestone S
Article: LANCET NEUROLOGY. 2019;18(11):1034-1044
Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study
van Maurik IS; Vos SJ; Bos I; Bouwman FH; Teunissen CE; Scheitens P; Barkhof F; Frolich L; Kornhuber J; Wiftfang J; Maier W; Peters O; ROther E; Nobili F; Frisoni GB; Spiru L; Freund-Levi Y; Wallin AK; Hampel H; Soininen H; Tsolaki M; Verhey F; Kloszewska I; Mecocci P; Vellas B; Lovestone S; Gailuzzi S; Herukka S-K; Santana I; Baldeiras I; de Mendonca A; Silva D; Chetelat G; Egret S; Palmqvist S; Hansson O; Visser PJ; Berkhof J; van der Flier WM
Article: ALZHEIMERS & DEMENTIA. 2019;15(11):1478-1488
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Shi L; Westwood S; Baird AL; Winchester L; Dobricic V; Kilpert F; Hong S; Franke A; Hye A; Ashton NJ; Morgan AR; Bos I; Vos SJB; Buckley NJ; ten Kate M; Scheltens P; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lleo A; Alcolea D; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Teunissen CE; Freund-Levi Y; Froelich L; Legido-Quigley C; Barkhof F; Blennow K; Zetterberg H; Baker S; Morgan BP; Streffer J; Visser PJ; Bertram L; Lovestone S; Nevado-Holgado AJ
Article: ALZHEIMERS & DEMENTIA. 2019;15(7):888-898
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
Vermunt L; Sikkes SAM; van den Hout A; Handels R; Bos I; van der Flier WM; Kern S; Ousset P-J; Maruff P; Skoog I; Verhey FRJ; Freund-Levi Y; Tsolaki M; Wallin AK; Rikkert MO; Soininen H; Spiru L; Zetterberg H; Blennow K; Scheltens P; Muniz-Terrera G; Visser PJ; Vellas B; Reynish E; Ousset PJ; Andrieu S; Burns A; Pasquier F; Frisoni G; Salmon E; Michel JP; Zekry DS; Boada M; Dartigues JF; Olde-Rikkert MGM; Rigaud AS; Winblad B; Malick A; Sinclair A; Froelich L; Scheltens P; Ribera C; Touchon J; Robert P; Salva A; Waldemar G; Bullock R; Tsolaki M; Rodriguez G; Spiru L; Jones RW; Stiens G; Stoppe G; Jonhagen EM; Cherubini A; Lage PM; Gomezisla T; Camus V; Aguera-Morales E; Lopez F; Savy S; Cantet C; Coley N
Article: ALZHEIMERS & DEMENTIA. 2019;15(6):742-753
Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study
Lleo A; Alcolea D; Martinez-Lage P; Scheltens P; Parnetti L; Poirier J; Simonsen AH; Verbeek MM; Rosa-Neto P; Slot RER; Tainta M; Izaguirre A; Reijs BLR; Farotti L; Tsolaki M; Vandenbergue R; Freund-Levi Y; Verhey FRJ; Clarimon J; Fortea J; Frolich L; Santana I; Luis Molinuevo J; Lehmann S; Visser PJ; Teunissen CE; Zetterberg H; Blennow K
Article: ALZHEIMERS & DEMENTIA. 2019;15(6):817-827
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
Kim M; Snowden S; Suvitaival T; Ali A; Merkler DJ; Ahmad T; Westwood S; Baird A; Proitsi P; Nevado-Holgado A; Hye A; Bos I; Vos S; Vandenberghe R; Teunissen C; ten Kate M; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck E; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey F; Sala I; Lleo A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frolich L; Dobricic V; Engelborghs S; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Barkhof F; Ashton N; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Legido-Quigley C
Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;69(1):189-197
Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study
Jerneren F; Cederholm T; Refsum H; Smith AD; Turner C; Palmblad J; Eriksdotter M; Hjorth E; Faxen-Irving G; Wahlund L-O; Schultzberg M; Basun H; Freund-Levi Y
Article: ALZHEIMERS & DEMENTIA. 2019;15(5):644-654
Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum
Bos I; Vos S; Verhey F; Scheltens P; Teunissen C; Engelborghs S; Sleegers K; Frisoni G; Blin O; Richardson JC; Bordet R; Tsolaki M; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Lleo A; Johannsen P; Freund-Levi Y; Froelich L; Vandenberghe R; Westwood S; Dobricic V; Barkhof F; Legido-Quigley C; Bertram L; Lovestone S; Streffer J; Andreasson U; Blennow K; Zetterberg H; Visser PJ
Article: ALZHEIMER'S AND DEMENTIA: TRANSLATIONAL RESEARCH AND CLINICAL INTERVENTIONS. 2019;5(1):933-938
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
Stamate D; Kim M; Proitsi P; Westwood S; Baird A; Nevado-Holgado A; Hye A; Bos I; Vos SJB; Vandenberghe R; Teunissen CE; Ten Kate M; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck E; Engelborghs S; Sleegers K; Bordet R; Ramit L; Kettunen P; Tsolaki M; Verhey F; Alcolea D; Lleo A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frolich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Legido-Quigley C
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_14):p780-p781
P2‐270: INCREASED CSF AMYLOID‐β 1‐38 AND 1‐40 CONCENTRATIONS IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT WITH TAU BUT WITHOUT AMYLOID PATHOPHYSIOLOGY
Vos SJB; Bos I; Verhey FRJ; Engelborghs S; Lleó A; Johannsen P; Freund-Levi Y; Frölich L; Vandenberghe R; Frisoni GB; Blin O; Richardson J; Bordet R; Scheltens P; Ramakers IHGB; Popp J; Tsolaki M; Martinez-Lage P; Bertram L; Lovestone S; Streffer J; Blennow K; Andreasson U; Zetterberg H; Visser PJ
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_3):p201
F1‐02‐01: RELATING CSF MARKERS NEUROGRANIN, NEUROFILAMENT‐LIGHT AND YKL‐40 TO Aβ, APOE ε4 AND COGNITION: RESULTS FROM THE EMIF‐AD MULTIMODAL BIOMARKER DISCOVERY STUDY
Bos I; Vos SJB; Verhey FRJ; Scheltens P; Engelborghs S; Frisoni GB; Blin O; Richardson J; Bordet R; Tsolaki M; Popp J; Martinez-Lage P; Lleó A; Johannsen P; Freund-Levi Y; Frölich L; Vandenberghe R; Baird AL; Barkhof F; Legido-Quigley C; Bertram L; Lovestone S; Streffer J; Andreasson U; Blennow K; Visser PJ; Zetterberg H
Article: ALZHEIMERS & DEMENTIA. 2018;14(7):913-924
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease
Mattsson N; Groot C; Jansen WJ; Landau SM; Villemagne VL; Engelborghs S; Mintun MM; Lleo A; Molinuevo JL; Jagust WJ; Frisoni GB; Ivanoiu A; Chetelat G; de Oliveira CR; Rodrigue KM; Kornhuber J; Wallin A; Klimkowicz-Mrowiec A; Kandimalla R; Popp J; Aalten PP; Aarsland D; Alcolea D; Almdahl IS; Baldeiras I; van Buchem MA; Cavedo E; Chen K; Cohen AD; Foerster S; Fortea J; Frederiksen KS; Freund-Levi Y; Gill KD; Gkatzima O; Grimmer T; Hampel H; Herukka S-K; Johannsen P; van Laere K; de Leon MJ; Maier W; Marcusson J; Meulenbroek O; Mollergard HM; Morris JC; Mroczko B; Nordlund A; Prabhakar S; Peters O; Rami L; Rodriguez-Rodriguez E; Roe CM; Ruther E; Santana I; Schroder J; Seo SW; Soininen H; Spiru L; Stomrud E; Struyfs H; Teunissen CE; Verhey FRJ; Vos SJB; van Doorn LJCVW; Waldemar G; Wallin AK; Wiltfang J; Vandenberghe R; Brooks DJ; Fladby T; Rowe CC; Drzezga A; Verbeek MM; Sarazin M; Wolk DA; Fleisher AS; Klunk WE; Na DL; Sanchez-Juan P; Lee DY; Nordberg A; Tsolaki M; Camus V; Rinne JO; Fagan AM; Zetterberg H; Blennow K; Rabinovici GD; Hansson O; van Berckel BNM; van der Flier WM; Scheltens P; Visser PJ; Ossenkoppele R
Article: FRONTIERS IN AGING NEUROSCIENCE. 2018;10:193
Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data
Bos I; Vos SJB; Jansen WJ; Vandenberghe R; Gabel S; Estanga A; Ecay-Torres M; Tomassen J; den Braber A; Lleo A; Sala I; Wallin A; Kettunen P; Molinuevo JL; Rami L; Chetelat G; de la Sayette V; Tsolaki M; Freund-Levi Y; Johannsen P; Novak GP; Ramakers I; Verhey FR; Visser PJ
Article: JAMA PSYCHIATRY. 2018;75(1):84-95
Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia
Jansen WJ; Ossenkoppele R; Tijms BM; Fagan AM; Hansson O; Klunk WE; van der Flier WM; Villemagne VL; Frisoni GB; Fleisher AS; Lleo A; Mintun MA; Wallin A; Engelborghs S; Na DL; Chetelat G; Molinuevo JL; Landau SM; Mattsson N; Kornhuber J; Sabri O; Rowe CC; Parnetti L; Popp J; Fladby T; Jagust WJ; Aalten P; Lee DY; Vandenberghe R; de Oliveira CR; Kapaki E; Froelich L; Ivanoiu A; Gabryelewicz T; Verbeek MM; Sanchez-Juan P; Hildebrandt H; Camus V; Zboch M; Brooks DJ; Drzezga A; Rinne JO; Newberg A; de Mendonca A; Sarazin M; Rabinovici GD; Madsen K; Kramberger MG; Nordberg A; Mok V; Mroczko B; Wolk DA; Meyer PT; Tsolaki M; Scheltens P; Verhey FRJ; Visser PJ
Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):101
Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline
Bos I; Verhey FR; Ramakers IHGB; Jacobs HIL; Soininen H; Freund-Levi Y; Hampel H; Tsolaki M; Wallin AK; van Buchem MA; Oleksik A; Verbeek MM; Rikkert MO; van der Flier WM; Scheltens P; Aalten P; Visser PJ; Vos SJB
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;61(2):515-519
Does Fatty Acid Composition in Subcutaneous Adipose Tissue Differ between Patients with Alzheimer's Disease and Cohabiting Proxies?
Faxen-Irving G; Falahati F; Basun H; Eriksdotter M; Vedin I; Wahlund L-O; Schultzberg M; Hjorth E; Palmblad J; Cederholm T; Freund-Levi Y
Article: LANCET NEUROLOGY. 2017;16(12):965-975
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
Soininen H; Solomon A; Visser PJ; Hendrix SB; Blennow K; Kivipelto M; Hartmann T
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;60(4):1387-1395
Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study
Reijs BLR; Vos SJB; Soininen H; Lotjonen J; Koikkalainen J; Pikkarainen M; Hall A; Vanninen R; Liu Y; Herukka S-K; Freund-Levi Y; Frisoni GB; Frolich L; Nobilij F; Rikkert MO; Spiru L; Tsolaki M; Wallinn AK; Scheltens P; Verhey F; Visser PJ
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2017;106(4):1157-1165
DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
Karimi M; Vedin I; Levi YF; Basun H; Irving GF; Eriksdotter M; Wahlund L-O; Schultzberg M; Hjorth E; Cederholm T; Palmblad J
Article: ALZHEIMERS & DEMENTIA. 2017;13(8):903-912
Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers
Handels RLH; Vos SJB; Kramberger MG; Jelic V; Blennow K; van Buchem M; van der Flier W; Freund-Levi Y; Hampel H; Rikkert MO; Oleksik A; Pirtosek Z; Scheltens P; Soininen H; Teunissen C; Tsolaki M; Wallin AK; Winblad B; Verhey FRJ; Visser PJ
Article: NEUROBIOLOGY OF AGING. 2017;56:33-40
The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
Bos I; Vos SJ; Froelich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Ruether E; Engelborghs S; Niemantsverdriet E; De Roeck EE; Tsolaki M; Freund-Levim Y; Johannsen P; Vandenberghe R; Lleo A; Alcolea D; Frisoni GB; Galluzzi S; Nobili F; Morbelli S; Drzezga A; Didic M; van Berckel BN; Salmon E; Bastin C; Dauby S; Santana I; Baldeiras I; de Mendonca A; Silva D; Wallin A; Nordlund A; Coloma PM; Wientzek A; Alexander M; Novak GP; Gordon MF; Wallin AK; Hampel H; Soininen H; Herukka S-K; Scheltens P; Verhey FR; Visser PJ
Journal article: ALZHEIMERS & DEMENTIA. 2017;13(7S_Part_22):p1047-p1048
[P3–273]: EFFECTS OF RISPERIDONE AND GALANTAMINE TREATMENT ON ALZHEIMER BIOMARKER LEVELS IN CEREBROSPINAL FLUID
Bloniecki V; Freund‐Levi Y; Blennow K; Aarsland D; Cummings JL; Winblad B
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;57(2):387-393
Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid
Bloniecki V; Aarsland D; Blennow K; Cummings J; Falahati F; Winblad B; Freund-Levi Y
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;56(2):543-555
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
van Doorn LJCVW; Gispert JD; Kuiperij HB; Claassen JAHR; Arighi A; Baldeiras I; Blennow K; Bozzali M; Castelo-Branco M; Cavedo E; Emek-Savas DD; Eren E; Eusebi P; Farotti L; Fenoglio C; Ormaechea JF; Freund-Levi Y; Frisoni GB; Galimberti D; Genc S; Greco V; Hampel H; Herukka S-K; Liu Y; Llado A; Lleo A; Nobili FM; Oguz KK; Parnetti L; Pereira J; Picco A; Pikkarainen M; de Oliveira CR; Saka E; Salvadori N; Sanchez-Valle R; Santana I; Scarpini E; Scheltens P; Soininen H; Tarducci R; Teunissen C; Tsolaki M; Urbani A; Vilaplana E; Visser PJ; Wallin AK; Yener G; Molinuevo JL; Meulenbroek O; Verbeek MM
Journal article: ALZHEIMERS & DEMENTIA. 2016;12(7S_Part_22):p1059-p1061
P4‐122: Prevalence of Vascular Risk Factors in Different Stages of Prodromal Alzheimer’s Disease and Its Influence on Cognitive Decline
Bos I; Vos SJB; Frölich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Rüther E; Engelborghs S; Niemantsverdriet E; De Roeck EE; Tsolaki M; Freund-Levi Y; Johannsen P; Vandenberghe R; Lleó A; Alcolea D; Frisoni GB; Galluzzi S; Nobili F; Morbelli S; Drzezga A; Didic M; van Berckel BNM; Salmon E; Bastin C; Dauby S; Santana I; Baldeiras I; Mendonça A; Silva D; Wallin A; Nordlund A; Foskett N; Coloma P; Alexander M; Wientzek-Fleischmann A; Nevado-Holgado A; Gungabissoon U; Novak GP; Gordon MF; Wallin ÅK; Hampel H; Soininen H; Scheltens P; Verhey FRJ; Visser PJ
Article: JOURNAL OF ALZHEIMERS DISEASE. 2015;48(3):805-812
Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study
Eriksdotter M; Vedin I; Falahati F; Freund-Levi Y; Hjorth E; Faxen-Irving G; Wahlund L-O; Schultzberg M; Basun H; Cederholm T; Palmblad J
Journal article: CLINICAL NUTRITION. 2015;34:s245-s246
SUN-LB030: Does Fatty Acid Composition in Subcutaneous Fat Differ Between Patients With Alzheimer’s Disease and their Cohabiting Relatives?
Faxen-Irving G; Falahati F; Basun H; Palmblad J; Cederholm T; Vedin I; Eriksdotter M; Wahlund L-O; Schultzberg M; Hjorth E; Freund-Levi Y
Journal article: CLINICAL NUTRITION. 2015;34:s247-s248
SUN-LB035: Does APOE4 Carriership Influence Potential Omega-3 Fatty Acid Treatment Effects on Cognition or Psychiatric Status in Patients With Mild to Moderate Alzheimer’S Disease: The Omegad Study
Freund-Levi Y; Falahati F; Hjorth E; Cederholm T; Eriksdotter M; Vedin I; Faxen-Irving G; Wahlund L-O; Schultzberg M; Basun H; Palmblad J
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2015;313(19):1924-1938
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia A Meta-analysis
Jansen WJ; Ossenkoppele R; Knol DL; Tijms BM; Scheltens P; Verhey FRJ; Visser PJ
Article: BRAIN. 2015;138(Pt 5):1327-1338
Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage
Vos SJB; Verhey F; Froelich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Ruether E; Nobili F; Morbelli S; Frisoni GB; Drzezga A; Didic M; van Berckel BNM; Simmons A; Soininen H; Kloszewska I; Mecocci P; Tsolaki M; Vellas B; Lovestone S; Muscio C; Herukka S-K; Salmon E; Bastin C; Wallin A; Nordlund A; de Mendonca A; Silva D; Santana I; Lemos R; Engelborghs S; Van der Mussele S; Freund-Levi Y; Wallin AK; Hampel H; van der Flier W; Scheltens P; Visser PJ
Article: JOURNAL OF LIPID RESEARCH. 2015;56(3):674-681
Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study
Wang X; Hjorth E; Vedin I; Eriksdotter M; Freund-Levi Y; Wahlund L-O; Cederholm T; Palmblad J; Schultzberg M
Article: CURRENT ALZHEIMER RESEARCH. 2015;12(1):69-79
Predicting Progression from Cognitive Impairment to Alzheimer's Disease with the Disease State Index
Hall A; Mattila J; Koikkalainen J; Loejonen J; Wolz R; Scheltens P; Frisoni G; Tsolaki M; Nobili F; Freund-Levi Y; Minthon L; Froelich L; Hampel H; Visser PJ; Soininen H
Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;42(3):823-831
Effects of Supplementation with Omega-3 Fatty Acids on Oxidative Stress and Inflammation in Patients with Alzheimer's Disease: The OmegAD Study
Freund-Levi Y; Vedin I; Hjorth E; Basun H; Irving GF; Schultzberg M; Eriksdotter M; Palmblad J; Vessby B; Wahlund L-O; Cederholm T; Basu S
Article: BRAIN RESEARCH BULLETIN. 2014;108:88-93
Neuropsychiatric symptoms in dementia-A role for neuroinflammation?
Holmgren S; Hjorth E; Schultzberg M; Larksater M; Frenkel D; Tysen-Backstrom AC; Aarsland D; Freund-Levi Y
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_4):p265
O4‐07‐05: ADDED VALUE OF MRI BIOMARKERS TO NEUROPSYCHOLOGICAL TEST PERFORMANCE FOR PREDICTION OF AD IN SUBJECTS WITH MCI
Clerx L; Dierckx E; van der Pol L; van Rossum I; Verhey FRJ; Aalten P; Barkhof F; Wolz R; Rueckert D; Frisoni G; Tsolaki M; Nobili F; Freund‐Levi Y; Wallin AK; Frolich L; Hampel HJ; Soininen H; Scheltens P; Visser PJ
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_11):p455
P1‐384: EFFECTS OF OMEGA‐3 FATTY ACID SUPPLEMENTATION ON PLASMA FATTY ACIDS, GENDER EFFECTS, AND EFFECTS ON COGNITION IN ALZHEIMER'S PATIENTS: THE OMEGAD STUDY
Eriksdotter M; Falahati F; Vedin I; Freund‐Levi Y; Hjorth E; Faxen‐Irving G; Wahlund L; Schultzberg M; Basun H; Cederholm T; Palmblad J
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA. 2014;4(2):335-343
Agitation in dementia: relation to core cerebrospinal fluid biomarker levels.
Bloniecki V; Aarsland D; Cummings J; Blennow K; Freund-Levi Y
Article: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY. 2014;22(4):341-348
Galantamine Versus Risperidone Treatment of Neuropsychiatric Symptoms in Patients with Probable Dementia: An Open Randomized Trial
Freund-Levi Y; Jedenius E; Tysen-Backstrom AC; Larksater M; Wahlund L-O; Eriksdotter M
Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(4):428-436
Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study
Levi YF; Vedin I; Cederholm T; Basun H; Irving GF; Eriksdotter M; Hjorth E; Schultzberg M; Vessby B; Wahlund L-O; Salem NJ; Palmblad J
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2014;38(3-4):234-244
Galantamine versus Risperidone for Agitation in People with Dementia: A Randomized, Twelve-Week, Single-Center Study
Freund-Levi Y; Bloniecki V; Auestad B; Backstrom ACT; Larksater M; Aarsland D
Journal article: ALZHEIMERS & DEMENTIA. 2013;9(4S_Part_17):p669-p670
P3–306: A randomized controlled trial investigating the effects of Souvenaid in prodromal Alzheimer's disease: Baseline characteristics of the LipiDiDiet study
Visser PJ; Soininen H; Kivipelto M; Freund‐Levi Y; Kamphuis P; Wieggers RL; Hartmann T
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;36(1):1-6
Effects on Transthyretin in Plasma and Cerebrospinal Fluid by DHA-Rich n-3 Fatty Acid Supplementation in Patients with Alzheimer's Disease: The OmegAD Study
Faxen-Irving G; Freund-Levi Y; Eriksdotter-Jonhagen M; Basun H; Hjorth E; Palmblad J; Vedin I; Cederholm T; Wahlund L-O
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;35(4):697-713
Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β₄₂ by Human Microglia and Decrease Inflammatory Markers
Hjorth E; Zhu M; Toro VC; Vedin I; Palmblad J; Cederholm T; Freund-Levi Y; Faxen-Irving G; Wahlund L-O; Basun H; Eriksdotter M; Schultzberg M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(4):580-593
Low background and high contrast PET imaging of amyloid-β with [¹¹C]AZD2995 and [¹¹C]AZD2184 in Alzheimer's disease patients
Forsberg A; Jureus A; Cselenyi Z; Eriksdotter M; Freund-Levi Y; Jeppsson F; Swahn B-M; Sandell J; Julin P; Schou M; Andersson J; Johnstrom P; Varnas K; Halldin C; Farde L; Svensson S
Journal article: ALZHEIMERS & DEMENTIA. 2012;8(4S_Part_16):p602
P3‐419: The LipiDiDiet study: Rationale and study design
Freund‐Levi Y; Visser PJ; Kivipelto M; Wieggers RL; Hartmann T; Soininen H
Article: PLOS ONE. 2012;7(4):e35425
Effects of DHA- Rich n-3 Fatty Acid Supplementation on Gene Expression in Blood Mononuclear Leukocytes: The OmegAD Study
Vedin I; Cederholm T; Freund-Levi Y; Basun H; Garlind A; Irving GF; Eriksdotter-Jonhagen M; Wahlund L-O; Dahlman I; Palmblad J
Journal article: CLINICAL NUTRITION. 2011;6(1):9
OP020 OXIDATIVE STRESS AND COX-MEDIATED INFLAMMATION IN PATIENTS WITH ALZHEIMER'S DISEASE AND EFFECTS OF N-3 FATTY ACID SUPPLEMENTATION – THE OMEGAD STUDY
Freund-Levi Y; Cederholm T; Basu S; group OBOOS
Article: AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS. 2010;25(6):521-526
To Be a Good Food Provider: An Exploratory Study Among Spouses of Persons With Alzheimer's Disease
Fjellstrom C; Starkenberg A; Wesslen A; Licentiate MS; Backstrom A-CT; Faxen-Irving G
Article: JOURNAL OF LIPID RESEARCH. 2010;51(5):1179-1185
Reduced prostaglandin F_2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study
Vedin I; Cederholm T; Freund-Levi Y; Basun H; Hjorth E; Irving GF; Eriksdotter-Jonhagen M; Schultzberg M; Wahlund L-O; Palmblad J
Journal article: EUROPEAN PSYCHIATRY. 2010;25(S1):1595
PW01-263 - Galantamine compared to risperidone in neuropsychiatric and behavioural symptoms in Alzheimer patients: a one-center clinical trial in 100 patients
Freund-Levi Y; Wahlund L-O; Eriksdotter-Jönhagen M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(11):1859-1863
Detection of amyloid in Alzheimer's disease with positron emission tomography using [¹¹C]AZD2184
Nyberg S; Jonhagen ME; Cselenyi Z; Halldin C; Julin P; Olsson H; Freund-Levi Y; Andersson J; Varnas K; Svensson S; Farde L
Journal article: ALZHEIMERS & DEMENTIA. 2009;5(4S_Part_3):p97
F2‐01‐01: Why Alzheimer patients and caregivers participate in randomized clinical trials
Akenine U; Andreasen N; Freund‐Levi Y; Winblad B; Kivipelto M
Article: LANCET NEUROLOGY. 2009;8(7):619-627
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study
Visser PJ; Verhey F; Knol DL; Scheltens P; Wahlund L-O; Freund-Levi Y; Tsolaki M; Minthon L; Wallin AK; Hampel H; Buerger K; Pirttila T; Soininen H; Rikkert MO; Verbeek MM; Spiru L; Blennow K
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2009;57(1):11-17
Omega-3 Fatty Acid Supplementation Effects on Weight and Appetite in Patients with Alzheimer's Disease: The Omega-3 Alzheimer's Disease Study
Irving GF; Freund-Levi Y; Eriksdotter-Joenhagen M; Basun H; Brismar K; Hjorth E; Palmblad J; Vessby B; Vedin I; Wahlund L-O; Cederholm T
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2009;27(5):481-490
Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer's Disease: The OmegAD Study
Freund-Levi Y; Hjorth E; Lindberg C; Cederholm T; Faxen-Irving G; Vedin I; Palmblad J; Wahlund L-O; Schultzberg M; Basun H; Jonhagen ME
Journal article: CLINICAL NUTRITION. 2009;4(2):20
O043 EFFECTS OF A DHA RICH N-3 FATTY ACID SUPPLEMENTATION ON GENE EXPRESSION CHANGES IN BLOOD LEUKOCYTES: THE OMEGAD STUDY
Vedin I; Cederholm T; Freund-Levi Y; Basun H; Garlind A; Faxén-Irving G; Jönhagen ME; Wahlund L; Dahlman I; Palmblad J
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2008;87(6):1616-1622
Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study
Vedin I; Cederholm T; Levi YF; Basun H; Garlind A; Irving GF; Joenhagen ME; Vessby B; Wahlund L-O; Palmblad J
Article: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2008;23(2):161-169
Omega-3 supplementation in mild to moderate Alzheimer's disease:: effects on neuropsychiatric symptoms
Freund-Levi Y; Basun H; Cederholm T; Faxen-Irving G; Garlind A; Grut M; Vedin I; Palmblad J; Wahlund L-O; Eriksdotter-Jonhagen M
Article: ARCHIVES OF NEUROLOGY. 2006;63(10):1402-1408
ω-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease:: OmegAD study -: A randomized double-blind trial
Freund-Levi Y; Eriksdotter-Jonhagen M; Cederholm T; Basun H; Faxen-Irving G; Garlind A; Vedin I; Vessby B; Wahlund L-O; Palmblad J
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_3):s64
O3–05–08: A randomized double–blind trial with omega–3 fatty acid treatment in mild to moderate Alzheimer's disease
Freund-Levi Y; Jonhagen ME; Cederholm T; Basun H; Faxen-Irving G; Garlind A; Vedin I; Vessby B; Wahlund L-O; Palmblad J
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_9):s271-s272
P2–130: Correlation of inflammatory factors with Alzheimer biomarkers
Schultzberg M; Freund-Levi Y; Garlind A; Cederholm T; Palmblad J; Wahlund L-O; Eriksdotter-Jonhagen M; Basun H
Journal article: LAKARTIDNINGEN. 1991;88(5):310-312
[Light therapy of depression].
Wetterberg L; Kjellman B; Thalén BE; Beck-Friis J; Freund-Levi Y; Friberg Y; Nordlund AL; Björkstén KS; Wiberg B; Zettergren M
Journal article: MAGNETIC RESONANCE IMAGING. 1989;7(2):225-230
ULTRA LOW FIELD BRAIN MRI IN HIV TRANSFUSION INFECTED PATIENTS
FREUNDLEVI Y; SAAF J; WAHLUND LO; WETTERBERG L
Show more

All other publications

Preprint: MEDRXIV. 2023
Blood-based multivariate methylation risk score for cognitive impairment and dementia
Koetsier J; Cavill R; Reijnders R; Harvey J; Deckers K; Köhler S; Eijssen L; Smith RG; Smith AR; Burrage J; Walker EM; Shireby G; Hannon E; Dempster E; Frayling T; Mill J; Dobricic V; Sommerer Y; Johannsen P; Wittig M; Franke A; Vandenberghe R; Schaeverbeke J; Freund-Levi Y; Frölich L; Scheltens P; Teunissen C; Frisoni G; Blin O; Richardson J; Bordet R; Engelborghs S; de Roeck E; Martinez-Lage P; Tainta M; Lleó A; Sala I; Popp J; Peyratout G; Verhey F; Tsolaki M; Andreasson U; Blennow K; Zetterberg H; Streffer J; Vos SJB; Lovestone S; Visser P-J; Bertram L; Lunnon K; Pishva E
Corrigendum: MOLECULAR NEURODEGENERATION. 2022;17(1):37
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease (vol 17, pg 1, 2022)
Visser PJ; Reus LM; Gobom J; Jansen I; Dicks E; van der Lee SJ; Tsolaki M; Verhey FRJ; Popp J; Martinez-Lage P; Vandenberghe R; Lleo A; Molinuevo JL; Engelborghs S; Freund-Levi Y; Froelich L; Sleegers K; Dobricic V; Lovestone S; Streffer J; Vos SJB; Bos I; Smit AB; Smit AB; Blennow K; Scheltens P; Teunissen CE; Bertram L; Zetterberg H; Tijms BM; Smit AB; Blennow K; Scheltens P; Teunissen CE; Bertram L; Zetterberg H; Tijms BM
Preprint: MEDRXIV. 2021
Rare variants in IFFO1, DTNB and NLRC3 associate with Alzheimer’s disease CSF profile of neuronal injury and inflammation
Neumann A; Küçükali F; Bos I; Vos SJB; Engelborghs S; De Pooter T; Joris G; De Rijk P; De Roeck E; Tsolaki M; Verhey F; Martinez-Lage P; Tainta M; Frisoni G; Blin O; Richardson J; Bordet R; Scheltens P; Popp J; Peyratout G; Johannsen P; Frölich L; Vandenberghe R; Freund-Levi Y; Streffer J; Lovestone S; Legido-Quigley C; Kate MT; Barkhof F; Strazisar M; Zetterberg H; Bertram L; Visser PJ; van Broeckhoven C; Sleegers K; group E-AS; Initiative ADN
Preprint: MEDRXIV. 2021
Sex-specific metabolic pathways associate with Alzheimer’s Disease (AD) endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery cohort
Xu J; Green R; Kim M; Lord J; Ebshiana A; Westwood S; Baird AL; Nevado-Holgado AJ; Shi L; Hye A; Snowden SG; Bos I; Vos SJB; Vandenberghe R; Teunissen CE; Kate MT; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck EE; Engelborghs S; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey FRJ; Alcolea D; Lleó A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Proitsi P; Legido-Quigley C
Conference publication: EUROPEAN PSYCHIATRY. 2021;64:S690
Physical training for patients with depression and anxiety - a randomized controlled study
Zhai Q; Freund-Levi Y; Horn A; Fridenberger A-C; Lager E; Montgomery S; Persson J
Preprint: MEDRXIV. 2020;MEDRXIV
Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.
Visser PJ; Reus LM; Gobom J; Jansen I; Dicks E; Tsolaki M; Verhey FRJ; Popp J; Martinez-Lage P; Vandenberghe R; Lleó A; Molinuevo JL; Engelborghs S; Freund-Levi Y; Froelich L; Sleegers K; Dobricic V; Hong S; Lovestone S; Streffer J; Vos SJB; Bos I; Smit AB; Blennow K; Scheltens P; Teunissen CE; Bertram L; Zetterberg H; Tijms BM
Review: ALZHEIMER'S AND DEMENTIA: TRANSLATIONAL RESEARCH AND CLINICAL INTERVENTIONS. 2020;6(1):e12016
Agitation and impulsivity in mid and late life as possible risk markers for incident dementia
Bateman DR; Gill S; Hu S; Foster ED; Ruthirakuhan MT; Sellek AF; Mortby ME; Matuskova V; Ng KP; Tarawneh RM; Freund-Levi Y; Kumar S; Gauthier S; Rosenberg PB; de Oliveira FF; Devanand DP; Ballard C; Ismail Z
Preprint: RESEARCH SQUARE. 2019
Antipsychotic Drugs Attenuate Interleukin-6 Secretion by Microglia Via Dopamine Inhibition
Mekori-Domachevsky E; Nash Y; Rabinovich A; Frenkel D; Freund-Levi Y
Preprint: MEDRXIV. 2019
A metabolite-based machine learning approach to diagnose Alzheimer’s-type dementia in blood: Results from the European Medical Information Framework for Alzheimer’s Disease biomarker discovery cohort
Stamate D; Kim M; Proitsi P; Westwood S; Baird A; Nevado-Holgado A; Hye A; Bos I; Vos S; Vandenberghe R; Teunissen CE; Kate MT; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck E; Engelborghs S; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey F; Alcolea D; Lléo A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Legido-Quigley C
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Biomarker Based and Individualized Prognosis for Patients with Mild Cognitive Impairment: Towards a Personalized Medicine Approach for AD
van Maurik I; Bos I; Vos SJ; Bouwman FH; Teunissen CE; Scheltens P; Barkhof F; Frolich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Ruther E; Nobili F; Frisoni G; Spiru L; Freund-Levi Y; Wallin AK; Hampel H; Soininen H; Tsolaki M; Verhey F; Simmons A; Kloszewska I; Mecocci P; Vellas B; Lovestone S; Galluzzi S; Herukka S-K; Santana I; Baldeiras I; de Mendonça A; Silva D; Chetelat G; Egret S; Palmqvist S; Hansson O; Visser P-J; Initiative ADN; Berkhof J; van der Flier WM
Corrigendum: ALZHEIMERS RESEARCH & THERAPY. 2018;10(1):56
Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline (vol 9, 101, 2017)
Bos I; Verhey FR; Ramakers IHGB; Jacobs HIL; Soininen H; Freund-Levi Y; Hampel H; Tsolaki M; Wallin AK; van Buchem MA; Oleksik A; Verbeek MM; Rikkert MO; van der Flier WM; Scheltens P; Aalten P; Visser PJ; Vos SJB
Review: ADVANCES IN NUTRITION. 2017;8(1):17-26
Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease
Shlisky J; Bloom DE; Beaudreault AR; Tucker KL; Keller HH; Freund-Levi Y; Fielding RA; Cheng FW; Jensen GL; Wu D; Meydani SN
Letter: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY. 2014;22(9):951
Galantamine Versus Risperidone Treatment of Neuropsychiatric Symptoms in Patients with Probable Dementia: An Open Randomized Trial Response
Freund-Levi Y; Jedenius E; Wahlund L-O; Eriksdotter M; Tysen-Backstrom AC; Larksater M
Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2012;15(2):134-143
Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid
Hjorth E; Freund-Levi Y
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2012;19:112
Agitation - relation to clinical and dementia biomarkers in cerebrospinal fluid
Bloniecki V; Freund-Levi Y; Aarsland D; Blennow K
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2012;19:112
Baseline characteristics of subjects with prodromal Alzheimer's disease: the LipiDiDiet study
Freund-Levi Y; Visser PJ; Kivipelto M; Kamphuis PJGH; Wieggers RL; Hartmann T; Soininen H
Conference publication: ANNALS OF NEUROLOGY. 2012;72:S53-S54
Baseline Characteristics of Subjects with Prodromal Alzheimer's Disease: The LipiDiDiet Study
Freund-Levi Y; Visser PJ; Kivipelto M; Wieggers RL; Hartmann T; Soininen H
Conference publication: EUROPEAN PSYCHIATRY. 2010;25
GALANTAMINE COMPARED TO RISPERIDONE IN NEUROPSYCHIATRIC AND BEHAVIOURAL SYMPTOMS IN ALZHEIMER PATIENTS: A ONE-CENTER CLINICAL TRIAL IN 100 PATIENTS
Freund-Levi Y; Wahlund L-O; Eriksdotter-Jonhagen M
Conference publication: FASEB JOURNAL. 2009;23:543.10
N-3 fatty acid treatment and plasma transthyretin in patients with Alzheimer's disease
Irving GF; Freund-Levi Y; Eriksdotter-Jonhagen M; Basun H; Palmblad J; Vedin I; Wahlund L-O; Cederholm T
Corrigendum: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2009;57(3):579
Omega Fatty Acid Supplementation Effects on Weight and Appetite in Patients with Alzheimer's Disease: The Omega-3 Alzheimer's Disease Study (vol 57, pg 11, 2009)
Irving GF; Freund-Levi Y
Thesis / dissertation: 2008
Omega-3 fatty acid treatment in mild to moderate Alzheimer's disease : results from the OmegAD study
Freund-Levi, Yvonne
Review: LAKARTIDNINGEN. 2007;104(44):3268-3271
[Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited].
Palmblad J; Eriksdotter-Jönhagen M; Freund-Levi Y; Cederholm T
Review: LAKARTIDNINGEN. 2006;103(6):369-371
[Administration of symptom-relieving drugs in Alzheimer disease is beneficial].
Nordberg A; Eriksdotter-Jönhagen M; Garlind A; Grut M; Freund-Levi Y; Cornelius C; Ekström A; Fastbom J; Sedvall M; Viitanen M
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S471
Safety and tolerability of omega-3 fatty acids in patients with Alzheimers disease
Freund-Levi Y; Jonhagen ME; Wahlund LO; Basun H; Palmblad J; Cederholm T
Conference publication: FASEB JOURNAL. 2004;18(4):A501
Inflammatory gene expression changes by omega-3 fatty acids in patients with Alzheimer's disease
Vedin I; Cederholm T; Lidén J; Freund-Levi Y; Palmblad J
Show more

Grants

Rehabilitation profile for post COVID-19 patients
Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
1 November 2020 - 31 October 2021

Employments

Senior Lecturer/Senior Physician, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2015
Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2008

Articles

All other publications

Grants

Employments

Degrees and Education

News from KI

Events from KI