Yunzhang Wang

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Articles

Article: AGING CELL. 2024;23(6):e14135
Epigenome-wide analysis of frailty: Results from two European twin cohorts
Mak JKL; Skovgaard AC; Nygaard M; Kananen L; Reynolds CA; Wang Y; Kuja-Halkola R; Karlsson IK; Pedersen NL; Hagg S; Soerensen M; Jylhava J
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2024;22(1):444
Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality
Zhao Y; Li X; Loscalzo J; Smelik M; Sysoev O; Wang Y; Mahmud AKMF; Mansour Aly D; Benson M
Article: STATISTICS IN MEDICINE. 2024;43(4):731-755
Combining Mendelian randomization with the sibling comparison design
Sjolander A; Frisell T; Oberg S; Wang Y; Hagg S
Article: EPIGENETICS. 2023;18(1):2158285
Leukocyte DNA methylation in Alzheimer′s disease associated genes: replication of findings from neuronal cells
Karlsson IK; Ploner A; Wang Y; Gatz M; Pedersen NL; Haegg S
Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2023;11(12):e2255
Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population
Li X; Ploner A; Wang Y; Mak JKL; Lu Y; Magnusson PKE; Jylhava J; Hagg S
Article: BRAIN. 2023;146(12):4891-4902
Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings
Mcmurran CE; Wang Y; Mak JKL; Karlsson IK; Tang B; Ploner A; Pedersen NL; Hagg S
Article: AGING CELL. 2023;22(8):e13868
Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses
Mak JKL; Kananen L; Qin C; Kuja-Halkola R; Tang B; Lin J; Wang Y; Jaaskelainen T; Koskinen S; Lu Y; Magnusson PKE; Hagg S; Jylhava J
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2023;38(7):809-819
Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study
Qin C; Diaz-Gallo L-M; Tang B; Wang Y; Nguyen T-D; Harder A; Lu Y; Padyukov L; Askling J; Hagg S
Article: NEUROBIOLOGY OF AGING. 2023;126:103-112
Independent role of Alzheimer?s disease genetics and C-reactive protein on cognitive ability in aging
Supiyev A; Karlsson R; Wang Y; Koch E; Hagg S; Kauppi K
Article: GEROSCIENCE. 2023;45(3):2065-2078
Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging
Tang B; Li X; Wang Y; Sjolander A; Johnell K; Thambisetty M; Ferrucci L; Reynolds CA; Finkel D; Jylhava J; Pedersen NL; Hagg S
Article: GEROSCIENCE. 2023;45(3):2051-2064
Can frailty scores predict the incidence of cancer? Results from two large population-based studies
Mak JKL; Kuja-Halkola R; Wang Y; Haegg S; Jylhaevae J
Article: GERONTOLOGY. 2023;69(12):1385-1393
Is Frailty Different in Younger Adults Compared to Old? Prevalence, Characteristics, and Risk Factors of Early-Life and Late-Life Frailty in Samples from Sweden and UK
Bai G; Wang Y; Mak JKL; Ericsson M; Hagg S; Jylhava J
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2022;37(12):1261-1271
Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels
Karlsson IK; Zhan Y; Wang Y; Li X; Jylhava J; Hagg S; Aslan AKD; Gatz M; Pedersen NL; Reynolds CA
Article: CLINICAL EPIGENETICS. 2022;14(1):153
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy
Qin X; Wang Y; Pedersen NL; Tang B; Hagg S
Article: NEUROLOGY. 2022;99(7):e650-e659
Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk A Mendelian Randomization Study
Tang B; Wang Y; Jiang X; Thambisetty M; Ferrucci L; Johnell K; Hagg S
Article: NATURE AGING. 2022;2(7):644-661
A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking
Higgins-Chen AT; Thrush KL; Wang Y; Minteer CJ; Kuo P-L; Wang M; Niimi P; Sturm G; Lin J; Moore AZ; Bandinelli S; Vinkers CH; Vermetten E; Rutten BPF; Geuze E; Okhuijsen-Pfeifer C; van der Horst MZ; Schreiter S; Gutwinski S; Luykx JJ; Picard M; Ferrucci L; Crimmins EM; Boks MP; Haegg S; Hu-Seliger TT; Levine ME
Article: JOURNAL OF NUTRITION. 2022;152(1):269-275
Protein Nutritional Status and Frailty: A Mendelian Randomization Study
Tomata Y; Wang Y; Hagg S; Jylhava J
Article: AGE AND AGEING. 2021;50(6):2174-2182
Frailty trajectories in three longitudinal studies of aging: Is the level or the rate of change more predictive of mortality?
Bai G; Szwajda A; Wang Y; Li X; Bower H; Karlsson IK; Johansson B; Aslan AKD; Pedersen NL; Hagg S; Jylhava J
Article: BMC MEDICINE. 2021;19(1):248
Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?
Bai G; Wang Y; Kuja-Halkola R; Li X; Tomata Y; Karlsson IK; Pedersen NL; Hagg S; Jylhava J
Article: NUTRIENTS. 2021;13(10):3539
Fatty Acids and Frailty: A Mendelian Randomization Study
Tomata Y; Wang Y; Hagg S; Jylhava J
Article: AGING CELL. 2021;20(9):e13459
A genome-wide association study of the frailty index highlights brain pathways in ageing
Atkins JL; Jylhava J; Pedersen NL; Magnusson PK; Lu Y; Wang Y; Hagg S; Melzer D; Williams DM; Pilling LC
Article: CLINICAL EPIGENETICS. 2021;13(1):129
The epigenetic etiology of cardiovascular disease in a longitudinal Swedish twin study
Qin X; Karlsson IK; Wang Y; Li X; Pedersen N; Reynolds CA; Hagg S
Article: MOLECULAR PSYCHIATRY. 2021;26(6):2148-2162
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
van Dongen J; Hagenbeek FA; Suderman M; Roetman PJ; Sugden K; Chiocchetti AG; Ismail K; Mulder RH; Hafferty JD; Adams MJ; Walker RM; Morris SW; Lahti J; Kupers LK; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip HF; Jansen R; Baselmans BML; Parmar P; Lowry E; Streit F; Sirignano L; Send TS; Frank J; Jylhava J; Wang Y; Mishra PP; Colins OF; Corcoran DL; Poulton R; Mill J; Hannon E; Arseneault L; Korhonen T; Vuoksimaa E; Felix JF; Bakermans-Kranenburg MJ; Campbell A; Czamara D; Binder E; Corpeleijn E; Gonzalez JR; Grazuleviciene R; Gutzkow KB; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; Kluft C; Davies GE; Hakulinen C; Keltikangas-Jarvinen L; Franke B; Freitag CM; Konrad K; Hervas A; Fernandez-Rivas A; Vetro A; Raitakari O; Lehtimaki T; Vermeiren R; Strandberg T; Raikkonen K; Snieder H; Witt SH; Deuschle M; Pedersen NL; Hagg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt TE; Tiemeier H; van IJzendoorn MH; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans KL; McIntosh AM; Bartels M; Boomsma DI
Article: HUMAN GENETICS. 2021;140(6):849-861
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Hagg S; Jylhava J; Wang Y; Czene K; Grassmann F
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(5):1128-1139
Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: The effect of sampling
Mak JKL; Kuja-Halkola R; Wang Y; Hagg S; Jylhava J
Article: CLINICAL EPIGENETICS. 2021;13(1):85
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life
Karlsson IK; Ericsson M; Wang Y; Jylhava J; Hagg S; Aslan AKD; Reynolds CA; Pedersen NL
Article: EBIOMEDICINE. 2021;66:103318
Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data
Li X; Ploner A; Wang Y; Zhan Y; Pedersen NL; Magnusson PK; Jylhava J; Hagg S
Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(11):1555-1559.e2
Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care
Hagg S; Jylhava J; Wang Y; Xu H; Metzner C; Annetorp M; Garcia-Ptacek S; Khedri M; Bostrom A-M; Kadir A; Johansson A; Kivipelto M; Eriksdotter M; Cederholm T; Religa D
Article: LIFE SCIENCE ALLIANCE. 2020;3(10):e202000817
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality
Hong M-G; Dodig-Crnkovic T; Chen X; Drobin K; Lee W; Wang Y; Edfors F; Kotol D; Thomas CE; Sjoberg R; Odeberg J; Hamsten A; Silveira A; Hall P; Nilsson P; Pawitan Y; Uhlen M; Pedersen NL; Hagg S; Magnusson PK; Schwenk JM
Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(6):1397-1405
Replicating associations between DNA methylation and body mass index in a longitudinal sample of older twins
Karlsson IK; Ericsson M; Wang Y; Jylhava J; Hagg S; Pedersen NL; Reynolds CA; Dahl Aslan AK
Article: CLINICAL EPIGENETICS. 2020;12(1):49
DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
Seeboth A; McCartney DL; Wang Y; Hillary RF; Stevenson AJ; Walker RM; Campbell A; Evans KL; McIntosh AM; Hagg S; Deary IJ; Marioni RE
Article: ELIFE. 2020;9:e51507
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up
Li X; Ploner A; Wang Y; Magnusson PK; Reynolds C; Finkel D; Pedersen NL; Jylhava J; Hagg S
Article: CLINICAL EPIGENETICS. 2019;11(1):187
Comprehensive longitudinal study of epigenetic mutations in aging
Wang Y; Karlsson R; Jylhava J; Hedman AK; Almqvist C; Karlsson IK; Pedersen NL; Almgren M; Hagg S
Article: EPIGENETICS. 2019;14(10):961-976
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Sturm G; Cardenas A; Bind M-A; Horvath S; Wang S; Wang Y; Hagg S; Hirano M; Picard M
Article: EBIOMEDICINE. 2019;45:487-494
Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank
Wang Q; Wang Y; Lehto K; Pedersen NL; Williams DM; Hagg S
Article: NATURE GENETICS. 2019;51(3):404-413
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Hagg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Braekhus A; Brathen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbaek G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
Article: EPIGENETICS. 2018;13(9):975-987
Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins
Wang Y; Karlsson R; Lampa E; Zhang Q; Hedman AK; Almgren M; Almqvist C; McRae AF; Marioni RE; Ingelsson E; Visscher PM; Deary IJ; Lind L; Morris T; Beck S; Pedersen NL; Hagg S
Article: EPIGENETICS. 2018;13(8):866-874
Implementing a method for studying longitudinal DNA methylation variability in association with age
Wang Y; Pedersen NL; Hagg S
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2018;47(3):899-907
Apolipoprotein E DNA methylation and late-life disease
Karlsson IK; Ploner A; Wang Y; Gatz M; Pedersen NL; Hagg S
Article: GENES. 2018;9(2):E78-78
DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins
Svane AM; Soerensen M; Lund J; Tan Q; Jylhava J; Wang Y; Pedersen NL; Hagg S; Debrabant B; Deary IJ; Christensen K; Christiansen L; Hjelmborg JB
Article: MOLECULAR PSYCHIATRY. 2017;22(12):1680-1690
An epigenome-wide association study meta-analysis of educational attainment
Linner RK; Marioni RE; Rietveld CA; Simpkin AJ; Davies NM; Watanabe K; Armstrong NJ; Auro K; Baumbach C; Bonder MJ; Buchwald J; Fiorito G; Ismail K; Iurato S; Joensuu A; Karell P; Kasela S; Lahti J; Mcrae AF; Mandaviya PR; Seppala I; Wang Y; Baglietto L; Binder EB; Harris SE; Hodge AM; Horvath S; Hurme M; Johannesson M; Latvala A; Mather KA; Medland SE; Metspalu A; Milani L; Milne RL; Pattie A; Pedersen NL; Peters A; Polidoro S; Raikkonen K; Severi G; Starr JM; Stolk L; Waldenberger M; Eriksson JG; Esko T; Franke L; Gieger C; Giles GG; Hagg S; Jousilahti P; Kaprio J; Kahonen M; Lehtimaki T; Martin NG; van Meurs JBC; Ollikainen M; Perola M; Posthuma D; Raitakari OT; Sachdev PS; Taskesen E; Uitterlinden AG; Vineis P; Wijmenga C; Wright MJ; Relton C; Smith GD; Deary IJ; Koellinger PD; Benjamin DJ
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Review: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(10):glad251
Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age
Mak JKL; Karlsson IK; Tang B; Wang Y; Pedersen NL; Hagg S; Jylhava J; Reynolds CA
Corrigendum: HUMAN GENETICS. 2021;140(6):863
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance (Dec, 10.1007/s00439-020-02249-w, 2020)
Hagg S; Jylhava J; Wang Y; Czene K; Grassmann F
Corrigendum: NATURE GENETICS. 2020;52(3):354
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk (vol 51, 404, 2019)
Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Haegg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Braekhus A; Brathen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbaek G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
Thesis / dissertation: 2020
DNA methylation and aging : a longitudinal study of old Swedish twins
Wang, Yunzhang

Employments

Statistician, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2020

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