Weili Xu

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About me

Professor in Geriatric Epidemiology
I have a bachelor’s degree in medicine and a master's in Epidemiology. In 2008, I earned a PhD degree in Geriatric Epidemiology. After that, I worked as a postdoc, Research Associate, Senior researcher and Senior lecturer for 14 years till 2023. As a main supervisor, I have supervised 7 PhD students with 5 defended at KI.

Research

My research has been focusing on cardio- and metabolic-disorder, nutrition, brain/cognitive aging and dementing disorders. Specific research lines of major interest are (1) the impact of cardio-metabolic disorders on brain aging and cognitive phenotypes from cognitive aging, and cognitive impairment to dementia, (2) the role of nutrition and diet in cognitive aging, (3) the influences of poor sensory function on cognitive decline and brain MRI changes, (4) the exploration of compensatory factors for dementia risk in cardio-metabolic diseases, and (5) dementia and care utilization.

Group memebers:
Abigail Dove, PhD student
Sakura Sakakibara, PhD student
Michelle Dunk, Postdoc
Johan Fastbom, Professor
Jie Guo, Postdoc (affiliated)
Anders Sköldunger, Associate Professor (affiliated)

Research funding:
FORTE
Swedish Research Council
Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
Alzheimerfonden

Articles

Article: PSYCHOLOGY HEALTH & MEDICINE. 2024;29(3):574-588

Association between psychosocial working conditions and well-being before retirement: a community-based study.

Zhang Y; Yang W; Xu W; Pan K-Y
Article: CLINICAL NUTRITION. 2024;43(4):943-950

Association of a low-inflammatory diet with survival among adults: The role of cardiometabolic diseases and lifestyle.

Da H; Yang R; Liang J; Wang J; Yang W; Dunk MM; Qi X; Xu W
Article: BRITISH JOURNAL OF PSYCHIATRY. 2024;:1-8

Association of cognitive reserve with the risk of dementia in the UK Biobank: role of polygenic factors.

Yang W; Wang J; Dove A; Dunk MM; Qi X; Bennett DA; Xu W
Article: ALZHEIMERS & DEMENTIA. 2024;20(2):1190-1200

Associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay diet with brain structural markers and their changes.

Chen H; Dunk MM; Wang B; Zhao M; Shen J; Zong G; Pan Y; Tong L; Xu W; Yuan C
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(1):glad111

Associations Between Mid- to Late-Life Body Mass Index and Chronic Disease-Free Survival: A Nationwide Twin Study.

Guo J; Dove A; Shang Y; Marseglia A; Johnell K; Rizzuto D; Xu W
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(1):glad192

Association of Kidney Function With Dementia and Structural Brain Differences: A Large Population-Based Cohort Study.

Wang S; Wang J; Guo J; Dove A; Xu H; Qi X; Xu W
Article: BMC MEDICINE. 2023;21(1):483

A low-inflammatory diet is associated with a lower incidence of diabetes: role of diabetes-related genetic risk.

Yang R; Lin J; Yang H; Dunk MM; Wang J; Xu W; Wang Y
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S17)

Influence of lung function on macro‐ and micro‐structural brain changes in mid‐ and late‐ life: a large population‐based cohort study in the UK Biobank

Wang J; Dove A; Yang W; Bennett DAA; Xu W
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S22)

Cardiometabolic disease, cognitive decline, and structural brain differences in mid‐ and late‐life: a large population‐based cohort study

Dove A; Guo J; Wang J; Sakakibara S; Xu W
Article: EBIOMEDICINE. 2023;98:104862

Trajectories of olfactory identification preceding incident mild cognitive impairment and dementia: a longitudinal study.

Guo J; Dove A; Wang J; Laukka EJ; Ekström I; Dunk MM; Bennett DA; Xu W
Article: NEUROLOGY. 2023;101(17):e1718-e1728

Association of Motor Function With Cognitive Trajectories and Structural Brain Differences: A Community-Based Cohort Study.

Wang Z; Wang J; Guo J; Dove A; Arfanakis K; Qi X; Bennett DA; Xu W
Article: JOURNAL OF ALZHEIMERS DISEASE. 2023;96(1):125-134

Association of Anemia with Cognitive Function and Dementia Among Older Adults: The Role of Inflammation.

Wang J; Wang C; Li X; Guo J; Dove A; Cui Z; Xu W
Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2023;888:164253

Association of time spent in outdoor light and genetic susceptibility with the risk of type 2 diabetes.

Lin J; Yang H; Zhang Y; Zhou L; Chen Y; Xu W; Wang Y
Article: JOURNAL OF ALZHEIMERS DISEASE. 2023;94(s1):S141-S158

Acupuncture Therapy on Dementia: Explained with an Integrated Analysis on Therapeutic Targets and Associated Mechanisms.

Li D; Yang H; Lyu M; Wang J; Xu W; Wang Y
Article: JOURNAL OF ALZHEIMERS DISEASE. 2023;94(2):585-595

Association Between Sensory Impairment and Dementia: The Roles of Social Network and Leisure Activity.

Dintica CS; Calderón-Larrañaga A; Vetrano DL; Xu W
Article: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS. 2023;162(1):309-316

Association of lifespan reproductive duration with depression in Swedish twins: The role of hormone replacement therapy.

Wang S; Yang W; Li X; Wang Z; Zhang L; Wang J; Qi X; Dove A; Xu W
Article: ALZHEIMERS & DEMENTIA. 2023;19(7):2765-2773

Association of impaired kidney function with dementia and brain pathologies: A community-based cohort study.

Wang S; Wang J; Dove A; Guo J; Yang W; Qi X; Bennett DA; Xu W
Article: INNOVATION IN AGING. 2023;7(2):igad006

Assessing Healthy Aging Score and Its Association With All-Cause Mortality: Findings From the China Health and Retirement Longitudinal Study.

Zeng Z; Li X; Yang W; Wang J; Zhu Y; Qi X; Xu W
Article: EUROPEAN HEART JOURNAL. 2023;44(7):573-582

Cardiometabolic multimorbidity and incident dementia: the Swedish twin registry.

Dove A; Guo J; Marseglia A; Fastbom J; Vetrano DL; Fratiglioni L; Pedersen NL; Xu W
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(1):143-150

Association Between Late-Life Weight Change and Dementia: A Population-based Cohort Study.

Guo J; Marseglia A; Shang Y; Dove A; Grande G; Fratiglioni L; Xu W
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2023;38(1):83-93

Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank.

Chen H; Cao Y; Ma Y; Xu W; Zong G; Yuan C
Article: ALZHEIMERS & DEMENTIA. 2023;19(1):217-225

Association of life-course traumatic brain injury with dementia risk: A nationwide twin study.

Zhang L; Yang W; Li X; Dove A; Qi X; Pan K-Y; Xu W
Article: ALZHEIMERS & DEMENTIA. 2023;19(1):208-216

High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function.

Li X; Yang W; Wang J; Dove A; Qi X; Bennett DA; Xu W
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(12):2524-2531

Association of Pulmonary Function With Motor Function Trajectories and Disability Progression Among Older Adults: A Long-Term Community-Based Cohort Study.

Wang J; Wang J; Li X; Wang Z; Qi X; Dove A; Bennett DA; Xu W
Article: AGE AND AGEING. 2022;51(12):afac299

Injurious falls before, during and after dementia diagnosis: a population-based study.

Zhang L; Wang J; Dove A; Yang W; Qi X; Xu W
Article: ALZHEIMERS & DEMENTIA. 2022;18(12):2551-2559

Poor pulmonary function is associated with mild cognitive impairment, its progression to dementia, and brain pathologies: A community-based cohort study.

Wang J; Dove A; Song R; Qi X; Ma J; Bennett DA; Xu W
Article: JAMA PSYCHIATRY. 2022;79(12):1180-1187

Body Mass Index Trajectories Preceding Incident Mild Cognitive Impairment and Dementia.

Guo J; Wang J; Dove A; Chen H; Yuan C; Bennett DA; Xu W
Article: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2022;227(5):748.e1-748.e13

Association of life-course reproductive duration with mortality: a population-based twin cohort study.

Li X; Wang S; Dunk M; Yang W; Qi X; Sun Z; Xu W
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(10):2116-2122

Association of Long-Term Body Weight Variability With Dementia: A Prospective Study.

Chen H; Zhou T; Guo J; Ji JS; Huang L; Xu W; Zuo G; Lv X; Zheng Y; Hofman A; Ma Y; Yuan C
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(10):2093-2101

Healthy Behaviors, Leisure Activities, and Social Network Prolong Disability-Free Survival in Older Adults With Diabetes.

Shang Y; Wu W; Dove A; Guo J; Welmer A-K; Rizzuto D; Fratiglioni L; Xu W
Article: EUROPEAN PSYCHIATRY. 2022;65(1):e63

Association of depression with mortality in nationwide twins: The mediating role of dementia.

Yang W; Wang Z; Li X; Qi X; Zhang L; Pan K-Y; Xu W
Article: AGING-US. 2022;14(15):6081-6093

Influence of cardiovascular risk burden on pulmonary function trajectory: role of physical and social activities.

Bai Y; Wang J; Song R; Wang Z; Qi X; Buchman AS; Bennett DA; Xu W
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2022;11(15):e025969

Association of Sleep Duration, Napping, and Sleep Patterns With Risk of Cardiovascular Diseases: A Nationwide Twin Study.

Wang Z; Yang W; Li X; Qi X; Pan K-Y; Xu W
Article: AGING-US. 2022;14(15):5984-6005

Profiles of behavioral, social and psychological well-being in old age and their association with mobility-limitation-free survival.

Saadeh M; Hu X; Dekhtyar S; Welmer A-K; Vetrano DL; Xu W; Fratiglioni L; Calderón-Larrañaga A
Article: ALZHEIMERS & DEMENTIA. 2022;18(7):1335-1344

Pulmonary function is associated with cognitive decline and structural brain differences.

Wang J; Song R; Dove A; Qi X; Ma J; Laukka EJ; Bennett DA; Xu W
Article: ALZHEIMERS & DEMENTIA. 2022;:821-830

Cardiometabolic multimorbidity accelerates cognitive decline and dementia progression.

Dove A; Marseglia A; Shang Y; Grande G; Vetrano DL; Laukka EJ; Fratiglioni L; Xu W
Article: BMC MEDICINE. 2022;20(1):138

Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study.

Zhang Y; Yang R; Dove A; Li X; Yang H; Li S; Wang J; Li W-D; Zhao H; Xu W; Wang Y
Article: AGING-US. 2022;14(6):2462-2474

Association between social isolation and reduced mental well-being in Swedish older adults during the first wave of the COVID-19 pandemic: the role of cardiometabolic diseases.

Dove A; Guo J; Calderón-Larrañaga A; Vetrano DL; Fratiglioni L; Xu W
Article: DIABETOLOGY & METABOLIC SYNDROME. 2022;14(1):11

Association between life-course cigarette smoking and metabolic syndrome: a discovery-replication strategy.

Wang J; Bai Y; Zeng Z; Wang J; Wang P; Zhao Y; Xu W; Zhu Y; Qi X
Article: JOURNAL OF ALZHEIMERS DISEASE. 2022;85(1):295-308

Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts.

Freak-Poli R; Wagemaker N; Wang R; Lysen TS; Ikram MA; Vernooij MW; Dintica CS; Vernooij-Dassen M; Melis RJF; Laukka EJ; Fratiglioni L; Xu W; Tiemeier H
Article: FRONTIERS IN MEDICINE. 2022;9:856260

Influence of Cardiovascular Risk Burden on Motor Function Among Older Adults: Mediating Role of Cardiovascular Diseases Accumulation and Cognitive Decline.

Wang Z; Cui K; Song R; Li X; Qi X; Buchman AS; Bennett DA; Xu W
Article: ALZHEIMERS & DEMENTIA. 2021;17(12):1914-1922

Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study.

Song R; Pan K-Y; Xu H; Qi X; Buchman AS; Bennett DA; Xu W
Article: CLINICAL NUTRITION. 2021;40(12):5764-5770

Body mass trajectories and multimorbidity in old age: 12-year results from a population-based study.

Calderón-Larrañaga A; Hu X; Guo J; Ferrucci L; Xu W; Vetrano DL
Article: CLINICAL NUTRITION. 2021;40(11):5467-5474

Association of body mass index and its long-term changes with cardiometabolic diseases: A nationwide twin study.

Guo J; Li X; Yang R; Marseglia A; Dove A; Johnell K; Xu W
Article: ALZHEIMERS & DEMENTIA. 2021;17(11):1769-1778

The impact of diabetes on cognitive impairment and its progression to dementia.

Dove A; Shang Y; Xu W; Grande G; Laukka EJ; Fratiglioni L; Marseglia A
Article: NEUROLOGY. 2021;97(17):e1695-e1706

Influence of Cognitive Reserve on Cognitive Trajectories: Role of Brain Pathologies.

Li X; Song R; Qi X; Xu H; Yang W; Kivipelto M; Bennett DA; Xu W
Article: AGE AND AGEING. 2021;50(5):1657-1665

Association of life satisfaction with disability-free survival: role of chronic diseases and healthy lifestyle.

Wu W; Shang Y; Calderón-Larrañaga A; Rizzuto D; Saadeh M; Dove A; Pan K-Y; Xu W
Article: AGE AND AGEING. 2021;50(5):1666-1674

Individual changes in anthropometric measures after age 60 years: a 15-year longitudinal population-based study.

Guo J; Shang Y; Fratiglioni L; Johnell K; Welmer A-K; Marseglia A; Xu W
Article: INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY. 2021;18(1):120

Mobility and muscle strength trajectories in old age: the beneficial effect of Mediterranean diet in combination with physical activity and social support.

Saadeh M; Prinelli F; Vetrano DL; Xu W; Welmer A-K; Dekhtyar S; Fratiglioni L; Calderón-Larrañaga A
Article: CLINICAL NUTRITION. 2021;40(8):4838-4844

The Nordic prudent diet prolongs survival with good mental and physical functioning among older adults: The role of healthy lifestyle.

Wu W; Shang Y; Dove A; Guo J; Calderón-Larrañaga A; Rizzuto D; Xu W
Article: ALZHEIMERS & DEMENTIA. 2021;17(8):1383-1390

Association of life-course depression with the risk of dementia in late life: A nationwide twin study.

Yang W; Li X; Pan K-Y; Yang R; Song R; Qi X; Pedersen NL; Xu W
Article: AGING CLINICAL AND EXPERIMENTAL RESEARCH. 2021;33(8):2183-2190

Predictors for functional decline after an injurious fall: a population-based cohort study.

Ek S; Rizzuto D; Xu W; Calderón-Larrañaga A; Welmer A-K
Article: AGING-US. 2021;13(13):17080-17096

Joint trajectories of episodic memory and odor identification in older adults: patterns and predictors.

Dintica CS; Haaksma ML; Olofsson JK; Bennett DA; Xu W
Article: GYNECOLOGIC ONCOLOGY. 2021;162(1):142-147

Gestational diabetes mellitus and risks of gynecologic cancers: Results from a nationwide Swedish twin study.

Sun Z; Wang S; Yang R; Li X; Yang Y; Qi X; Ma Y; Xu W
Article: BMJ OPEN. 2021;11(6):e048030

Association of low birth weight with cardiometabolic diseases in Swedish twins: a population-based cohort study.

Li X; Yang R; Yang W; Xu H; Song R; Qi X; Xu W
Article: DIABETES CARE. 2021;44(3):690-698

Not Only Diabetes but Also Prediabetes Leads to Functional Decline and Disability in Older Adults.

Shang Y; Fratiglioni L; Vetrano DL; Dove A; Welmer A-K; Xu W
Article: DIABETOLOGIA. 2021;64(3):530-539

A healthy lifestyle mitigates the risk of heart disease related to type 2 diabetes: a prospective nested case-control study in a nationwide Swedish twin cohort.

Yang R; Xu H; Pedersen NL; Li X; Yu J; Bao C; Qi X; Xu W
Article: AGE AND AGEING. 2021;50(2):480-487

Can health behaviours prolong survival and compress the period of survival with the disability? A population-based cohort study.

Wu W; Xu W; Englund S; Shang Y; Pan K-Y; Rizzuto D
Article: ALZHEIMERS & DEMENTIA. 2021;17(2):191-204

Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population-based longitudinal study.

Wang R; Qiu C; Dintica CS; Shang Y; Calderón Larrañaga A; Wang H-X; Xu W
Article: ALZHEIMERS & DEMENTIA. 2020;16(11):1534-1543

Can active life mitigate the impact of diabetes on dementia and brain aging?

Marseglia A; Darin-Mattsson A; Kalpouzos G; Grande G; Fratiglioni L; Dekhtyar S; Xu W
Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(10):1458-1463.e2

The Role of Cognitive Impairment, Physical Disability, and Chronic Conditions in the Association of Sleep Duration With All-Cause Mortality Among Very Old Adults.

Cao Z; Dintica C; Shang Y; Cheng Y; Li S; Yang H; Sun L; Xu W; Wang Y
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2020;9(18):e017346

Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline.

Cui K; Song R; Xu H; Shang Y; Qi X; Buchman AS; Bennett DA; Xu W
Article: ALZHEIMERS & DEMENTIA. 2020;16(7):1003-1012

Association of diabetes with stroke and post-stroke dementia: A population-based cohort study.

Shang Y; Fratiglioni L; Marseglia A; Plym A; Welmer A-K; Wang H-X; Wang R; Xu W
Article: ALZHEIMERS & DEMENTIA. 2020;16(6):873-882

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia.

Xu H; Yang R; Dintica C; Qi X; Song R; Bennett DA; Xu W
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2020;75(20):2525-2534

Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline.

Song R; Xu H; Dintica CS; Pan K-Y; Qi X; Buchman AS; Bennett DA; Xu W
Article: AGING-US. 2020;12(9):8536-8548

The relation of poor mastication with cognition and dementia risk: a population-based longitudinal study.

Dintica CS; Marseglia A; Wårdh I; Stjernfeldt Elgestad P; Rizzuto D; Shang Y; Xu W; Pedersen NL
Article: AGING-US. 2020;12(4):3730-3746

The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia.

Pan K-Y; Xu W; Mangialasche F; Grande G; Fratiglioni L; Wang H-X
Article: ALZHEIMERS & DEMENTIA. 2020;16(2):316-325

Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population-based longitudinal study.

Wang Z; Marseglia A; Shang Y; Dintica C; Patrone C; Xu W
Article: JOURNAL OF CLINICAL DENSITOMETRY. 2020;23(1):29-36

Osteoporosis and Osteopenia Among Patients With Type 2 Diabetes Aged ≥50: Role of Sex and Clinical Characteristics.

Xu H; Wang Z; Li X; Fan M; Bao C; Yang R; Song F; Xu W; Qi X
Article: CLINICAL NUTRITION. 2019;38(6):2813-2820

The impact of nutrient-based dietary patterns on cognitive decline in older adults.

Prinelli F; Fratiglioni L; Musicco M; Johansson I; Adorni F; Shakersain B; Rizzuto D; Xu W
Article: NEUROIMAGE. 2019;199:281-288

Specific nutrient patterns are associated with higher structural brain integrity in dementia-free older adults.

Prinelli F; Fratiglioni L; Kalpouzos G; Musicco M; Adorni F; Johansson I; Marseglia A; Xu W
Article: JAMA NEUROLOGY. 2019;76(10):1184-1191

Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain Pathologies.

Xu H; Yang R; Qi X; Dintica C; Song R; Bennett DA; Xu W
Article: AGING-US. 2019;11(18):7605-7619

Adherence to a healthy lifestyle counteracts the negative effects of risk factors on all-cause mortality in the oldest-old.

Cao Z; Wang R; Cheng Y; Yang H; Li S; Sun L; Xu W; Wang Y
Article: CURRENT ALZHEIMER RESEARCH. 2019;16(7):622-632

Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.

Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G
Article: JOURNAL OF INTERNAL MEDICINE. 2019;286(3):326-340

Natural history of prediabetes in older adults from a population-based longitudinal study.

Shang Y; Marseglia A; Fratiglioni L; Welmer A-K; Wang R; Wang H-X; Xu W
Article: PLOS MEDICINE. 2019;16(9):e1002899

Psychosocial working conditions, trajectories of disability, and the mediating role of cognitive decline and chronic diseases: A population-based cohort study.

Pan K-Y; Xu W; Mangialasche F; Wang R; Dekhtyar S; Calderón-Larrañaga A; Fratiglioni L; Wang H-X
Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2019;20(9):1163-1168.e3

Predicting First-Time Injurious Falls in Older Men and Women Living in the Community: Development of the First Injurious Fall Screening Tool.

Ek S; Rizzuto D; Calderón-Larrañaga A; Franzén E; Xu W; Welmer A-K
Article: DIABETOLOGIA. 2019;62(8):1403-1411

Type 2 diabetes in midlife and risk of cerebrovascular disease in late life: a prospective nested case-control study in a nationwide Swedish twin cohort.

Yang R; Pedersen NL; Bao C; Xu W; Xu H; Song R; Qi X; Xu W
Article: ANNALS OF NEUROLOGY. 2019;86(1):68-78

Genetic risk of dementia mitigated by cognitive reserve: A cohort study.

Dekhtyar S; Marseglia A; Xu W; Darin-Mattsson A; Wang H-X; Fratiglioni L
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(9):2128-2134

Overweight in midlife and risk of cancer in late life: A nationwide Swedish twin study.

Bao C; Yang R; Pedersen NL; Xu W; Xu H; Song R; Qi X; Xu W
Article: NEUROLOGY. 2019;92(7):e700-e709

Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain.

Dintica CS; Marseglia A; Rizzuto D; Wang R; Seubert J; Arfanakis K; Bennett DA; Xu W
Article: DIABETES CARE. 2019;42(2):232-239

Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults.

Marseglia A; Wang H-X; Rizzuto D; Fratiglioni L; Xu W
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2019;67(2):246-253

Risk Factors for Injurious Falls in Older Adults: The Role of Sex and Length of Follow-Up.

Ek S; Rizzuto D; Fratiglioni L; Calderón-Larrañaga A; Johnell K; Sjöberg L; Xu W; Welmer A-K
Article: EUROPEAN JOURNAL OF NUTRITION. 2019;58(1):345-356

Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial.

Ma F; Li Q; Zhou X; Zhao J; Song A; Li W; Liu H; Xu W; Huang G
Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;67(1):315-325

Working Life Psychosocial Conditions in Relation to Late-Life Cognitive Decline: A Population-Based Cohort Study.

Pan K-Y; Xu W; Mangialasche F; Dekhtyar S; Fratiglioni L; Wang H-X
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2019;48(1-2):56-67

Association of Leukocyte Telomere Length with Mild Cognitive Impairment and Alzheimer's Disease: Role of Folate and Homocysteine.

Ma F; Lv X; Du Y; Chen H; Liu S; Zhao J; Gao Y; An P; Zhou X; Song A; Sun C; Wang G; Ji Y; Wang X; Xu W; Huang G
Article: ALZHEIMERS & DEMENTIA. 2019;15(1):25-33

Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study.

Marseglia A; Fratiglioni L; Kalpouzos G; Wang R; Bäckman L; Xu W
Article: NUTRIENTS. 2018;10(9):E1297-1297

An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study.

Shakersain B; Rizzuto D; Wang H-X; Faxén-Irving G; Prinelli F; Fratiglioni L; Xu W
Article: INTERNATIONAL JOURNAL OF CANCER. 2018;143(4):793-800

Diabetes in midlife and risk of cancer in late life: A nationwide Swedish twin study.

Bao C; Pedersen NL; Yang R; Marseglia A; Xu W; Wang Y; Qi X; Xu W
Article: NEUROBIOLOGY OF AGING. 2018;67:23-30

Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study.

Dintica CS; Rizzuto D; Marseglia A; Kalpouzos G; Welmer A-K; Wårdh I; Bäckman L; Xu W
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2018;73(3):400-406

Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study.

Marseglia A; Dahl Aslan AK; Fratiglioni L; Santoni G; Pedersen NL; Xu W
Article: NUTRIENTS. 2018;10(2):E229-229

The Nordic Prudent Diet Reduces Risk of Cognitive Decline in the Swedish Older Adults: A Population-Based Cohort Study.

Shakersain B; Rizzuto D; Larsson SC; Faxén-Irving G; Fratiglioni L; Xu W-L
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2018;73(2):233-239

Risk Profiles for Injurious Falls in People Over 60: A Population-Based Cohort Study.

Ek S; Rizzuto D; Fratiglioni L; Johnell K; Xu W; Welmer A-K
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:349

Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial.

Marseglia A; Xu W; Fratiglioni L; Fabbri C; Berendsen AAM; Bialecka-Debek A; Jennings A; Gillings R; Meunier N; Caumon E; Fairweather-Tait S; Pietruszka B; De Groot LCPGM; Santoro A; Franceschi C
Article: ANNALS OF HUMAN BIOLOGY. 2017;44(6):495-501

Relation of socioeconomic status to overweight and obesity: a large population-based study of Chinese adults.

Zhang H; Xu H; Song F; Xu W; Pallard-Borg S; Qi X
Article: AGING CLINICAL AND EXPERIMENTAL RESEARCH. 2017;29(4):793-800

Impact of tooth loss on walking speed decline over time in older adults: a population-based cohort study.

Welmer A-K; Rizzuto D; Parker MG; Xu W
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):601-610

Work-related psychosocial stress and the risk of type 2 diabetes in later life.

Pan K-Y; Xu W; Mangialasche F; Fratiglioni L; Wang H-X
Article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2017;27(2):251-256

Living alone and unplanned hospitalizations among older adults: a population-based longitudinal study.

Pimouguet C; Rizzuto D; Lagergren M; Fratiglioni L; Xu W
Article: JOURNAL OF HUMAN HYPERTENSION. 2017;31(4):263-269

Pre- and undiagnosed-hypertension in urban Chinese adults: a population-based cross-sectional study.

Zhang H; Deng M; Xu H; Wang H; Song F; Bao C; Paillard-Borg S; Xu W; Qi X
Article: ENDOCRINE. 2017;55(1):179-185

The prevalence and determinants of hypothyroidism in hospitalized patients with type 2 diabetes mellitus.

Song F; Bao C; Deng M; Xu H; Fan M; Paillard-Borg S; Xu W; Qi X
Article: SCIENTIFIC REPORTS. 2016;6:37486

Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI.

Ma F; Wu T; Zhao J; Song A; Liu H; Xu W; Huang G
Article: SCIENTIFIC REPORTS. 2016;6:33082

Comparative efficacy and safety of urate-lowering therapy for the treatment of hyperuricemia: a systematic review and network meta-analysis.

Li S; Yang H; Guo Y; Wei F; Yang X; Li D; Li M; Xu W; Li W; Sun L; Gao Y; Wang Y
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(3):1069-1078

Early Cognitive Deficits in Type 2 Diabetes: A Population-Based Study.

Marseglia A; Fratiglioni L; Laukka EJ; Santoni G; Pedersen NL; Bäckman L; Xu W
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2016;14(1):110

Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study.

Wei F; Sun N; Cai C; Feng S; Tian J; Shi W; Xu W; Wang Y; Yang X; Li W-D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;52(1):213-222

Influence of Incipient Dementia on Hospitalization for Primary Care Sensitive Conditions: A Population-Based Cohort Study.

Pimouguet C; Rizzuto D; Fastbom J; Lagergren M; Fratiglioni L; Xu W
Article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2016;70(3):320-325

Nutritional status and survival among old adults: an 11-year population-based longitudinal study.

Shakersain B; Santoni G; Faxén-Irving G; Rizzuto D; Fratiglioni L; Xu W
Article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2016;26(1):182-187

Impact of living alone on institutionalization and mortality: a population-based longitudinal study.

Pimouguet C; Rizzuto D; Schön P; Shakersain B; Angleman S; Lagergren M; Fratiglioni L; Xu W
Article: ALZHEIMERS & DEMENTIA. 2016;12(2):100-109

Prudent diet may attenuate the adverse effects of Western diet on cognitive decline.

Shakersain B; Santoni G; Larsson SC; Faxén-Irving G; Fastbom J; Fratiglioni L; Xu W
Article: DIABETES CARE. 2016;39(2):300-307

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia.

Chatterjee S; Peters SAE; Woodward M; Mejia Arango S; Batty GD; Beckett N; Beiser A; Borenstein AR; Crane PK; Haan M; Hassing LB; Hayden KM; Kiyohara Y; Larson EB; Li C-Y; Ninomiya T; Ohara T; Peters R; Russ TC; Seshadri S; Strand BH; Walker R; Xu W; Huxley RR
Article: OBESITY FACTS. 2016;9(1):17-28

Prevalence of Overweight and Obesity among Chinese Adults: Role of Adiposity Indicators and Age.

Xu W; Zhang H; Paillard-Borg S; Zhu H; Qi X; Rizzuto D
Article: MEDIATORS OF INFLAMMATION. 2016;2016:5912146-10

Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial.

Chen H; Liu S; Ji L; Wu T; Ji Y; Zhou Y; Zheng M; Zhang M; Xu W; Huang G
Article: PLOS MEDICINE. 2015;12(7):e1001853

HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.

Xu W-L; Pedersen NL; Keller L; Kalpouzos G; Wang H-X; Graff C; Winblad B; Bäckman L; Fratiglioni L
Article: PLOS ONE. 2015;10(3):e0119582

Prevalence, pharmacological treatment, and control of cardiometabolic risk factors among older people in central Stockholm: a population-based study.

Wang R; Fratiglioni L; Liang Y; Welmer A-K; Xu W; Mangialasche F; Johnell K; Qiu C
Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2014;28(6):863-868

Cognitive functioning among patients with diabetic foot.

Marseglia A; Xu W; Rizzuto D; Ferrari C; Whisstock C; Brocco E; Fratiglioni L; Crepaldi G; Maggi S
Article: PUBLIC HEALTH NUTRITION. 2014;17(5):1177-1189

Sociodemographic determinants of diet quality of the EU elderly: a comparative analysis in four countries.

Irz X; Fratiglioni L; Kuosmanen N; Mazzocchi M; Modugno L; Nocella G; Shakersain B; Traill WB; Xu W; Zanello G
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2014;136-137:3-13

Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project's conceptual framework and design.

Santoro A; Pini E; Scurti M; Palmas G; Berendsen A; Brzozowska A; Pietruszka B; Szczecinska A; Cano N; Meunier N; de Groot CPGM; Feskens E; Fairweather-Tait S; Salvioli S; Capri M; Brigidi P; Franceschi C; NU-AGE Consortium
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2014;136-137:59-69

Cognitive decline, dietary factors and gut-brain interactions.

Caracciolo B; Xu W; Collins S; Fratiglioni L
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;37(2):357-365

Natural progression model of cognition and physical functioning among people with mild cognitive impairment and alzheimer's disease.

Handels RLH; Xu W; Rizzuto D; Caracciolo B; Wang R; Winblad B; Verhey FRJ; Severens JL; Fratiglioni L; Joore MA; Wimo A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;36(2):275-284

Relationship of subjective cognitive impairment and cognitive impairment no dementia to chronic disease and multimorbidity in a nation-wide twin study.

Caracciolo B; Gatz M; Xu W; Marengoni A; Pedersen NL; Fratiglioni L
Article: DIABETIC MEDICINE. 2013;30(6):E201-E207

Waist-to-height ratio is the best indicator for undiagnosed type 2 diabetes.

Xu Z; Qi X; Dahl AK; Xu W
Article: DIABETIC MEDICINE. 2013;30(5):E157-E162

Relation of socio-economic status to impaired fasting glucose and Type 2 diabetes: findings based on a large population-based cross-sectional study in Tianjin, China.

Zhang H; Xu W; Dahl AK; Xu Z; Wang H-X; Qi X
Article: NEUROBIOLOGY OF AGING. 2013;34(1):13-21

How can elderly apolipoprotein E ε4 carriers remain free from dementia?

Ferrari C; Xu W-L; Wang H-X; Winblad B; Sorbi S; Qiu C; Fratiglioni L
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;33(2):507-515

Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers.

Xu W-L; Caracciolo B; Wang H-X; Santoni G; Winblad B; Fratiglioni L
Article: NEUROBIOLOGY OF AGING. 2012;33(10):2282-2290

Tocopherols and tocotrienols plasma levels are associated with cognitive impairment.

Mangialasche F; Xu W; Kivipelto M; Costanzi E; Ercolani S; Pigliautile M; Cecchetti R; Baglioni M; Simmons A; Soininen H; Tsolaki M; Kloszewska I; Vellas B; Lovestone S; Mecocci P; AddNeuroMed Consortium
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;31(4):835-842

An active lifestyle postpones dementia onset by more than one year in very old adults.

Paillard-Borg S; Fratiglioni L; Xu W; Winblad B; Wang H-X
Article: CANADIAN JOURNAL OF DIABETES. 2012;36(3):108-113

Detection of Prediabetes and Undiagnosed Type 2 Diabetes: A Large Population-Based Study

Xu W; Xu Z; Jia J; Xie Y; Wang H-X; Qi X
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;29(2):393-403

Differential distribution of subjective and objective cognitive impairment in the population: a nation-wide twin-study.

Caracciolo B; Gatz M; Xu W; Pedersen NL; Fratiglioni L
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2012;19(1):155-162

The economic cost of brain disorders in Europe.

Olesen J; Gustavsson A; Svensson M; Wittchen H-U; Jönsson B; CDBE2010 study group; European Brain Council
Article: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY. 2012;58(5):339-345

Major dietary patterns and risk of asymptomatic hyperuricemia in Chinese adults.

Zhang M; Chang H; Gao Y; Wang X; Xu W; Liu D; Li G; Huang G
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21(10):718-779

Cost of disorders of the brain in Europe 2010.

Gustavsson A; Svensson M; Jacobi F; Allgulander C; Alonso J; Beghi E; Dodel R; Ekman M; Faravelli C; Fratiglioni L; Gannon B; Jones DH; Jennum P; Jordanova A; Jönsson L; Karampampa K; Knapp M; Kobelt G; Kurth T; Lieb R; Linde M; Ljungcrantz C; Maercker A; Melin B; Moscarelli M; Musayev A; Norwood F; Preisig M; Pugliatti M; Rehm J; Salvador-Carulla L; Schlehofer B; Simon R; Steinhausen H-C; Stovner LJ; Vallat J-M; Van den Bergh P; van Os J; Vos P; Xu W; Wittchen H-U; Jönsson B; Olesen J; CDBE2010Study Group
Article: NEUROLOGY. 2011;76(18):1568-1574

Midlife overweight and obesity increase late-life dementia risk: a population-based twin study.

Xu WL; Atti AR; Gatz M; Pedersen NL; Johansson B; Fratiglioni L
Article: JOURNAL OF ALZHEIMERS DISEASE. 2011;23(3):461-469

The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study.

Keller L; Xu W; Wang H-X; Winblad B; Fratiglioni L; Graff C
Article: DIABETES CARE. 2011;34(1):66-70

Prevalence and correlates of latent autoimmune diabetes in adults in Tianjin, China: a population-based cross-sectional study.

Qi X; Sun J; Wang J; Wang PP; Xu Z; Murphy M; Jia J; Wang J; Xie Y; Xu W
Article: DIABETES. 2010;59(11):2928-2935

Accelerated progression from mild cognitive impairment to dementia in people with diabetes.

Xu W; Caracciolo B; Wang H-X; Winblad B; Bäckman L; Qiu C; Fratiglioni L
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;20(1):293-300

Vascular risk profiles for dementia and Alzheimer's disease in very old people: a population-based longitudinal study.

Qiu C; Xu W; Winblad B; Fratiglioni L
Article: DIABETOLOGIA. 2009;52(6):1031-1039

Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study.

Xu WL; von Strauss E; Qiu CX; Winblad B; Fratiglioni L
Article: DIABETES. 2009;58(1):71-77

Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study.

Xu W; Qiu C; Gatz M; Pedersen NL; Johansson B; Fratiglioni L
Article: DIABETES. 2007;56(1):211-216

The effect of borderline diabetes on the risk of dementia and Alzheimer's disease.

Xu W; Qiu C; Winblad B; Fratiglioni L
Article: NEUROLOGY. 2004;63(7):1181-1186

Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study.

Xu WL; Qiu CX; Wahlin A; Winblad B; Fratiglioni L
Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2000;9(3):245-246

Safety of hormonal steroid contraceptive use for hepatitis B virus carrier women.

Wang P; Lai Z; Tang J; Xu W; Mi X; Ma F
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All other publications

Review: AGEING RESEARCH REVIEWS. 2024;95:102254

Associations of environmental factors with neurodegeneration: An exposome-wide Mendelian randomization investigation.

Li D; Zhou L; Cao Z; Wang J; Yang H; Lyu M; Zhang Y; Yang R; Wang J; Bian Y; Xu W; Wang Y
Editorial comment: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2023;118(2):347-348

Could dietary nitrate affect dementia development?

Carballo-Casla A; Dunk MM; Donat-Vargas C; Xu W
Other: THE LANCET HEALTHY LONGEVITY. 2023;4(6):e241-e242

Cardiometabolic multimorbidity and cognitive decline.

Dove A; Xu W
Review: JOURNAL OF NUTRITION HEALTH & AGING. 2021;25(10):1190-1204

Effect of Polyphenols on Cognitive Function: Evidence from Population-Based Studies and Clinical Trials.

Yang W; Cui K; Li X; Zhao J; Zeng Z; Song R; Qi X; Xu W
Letter: JOURNAL OF INTERNAL MEDICINE. 2019;286(6):728-729

Clarifications on blood pressure measurements and the validity of the conclusions.

Shang Y; Xu W
Review: ALZHEIMERS & DEMENTIA. 2015;11(9):1098-1109

Guidelines for reporting methodological challenges and evaluating potential bias in dementia research.

Weuve J; Proust-Lima C; Power MC; Gross AL; Hofer SM; Thiébaut R; Chêne G; Glymour MM; Dufouil C; MELODEM Initiative
Letter: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;173(3):544-545

Relation of socioeconomic status to hypertension occurrence.

Wang Z; Yue X; Wang H; Bao C; Xu W; Chen L; Qi X
Review: CURRENT OPINION IN PSYCHIATRY. 2013;26(3):239-243

Lifestyle change and the prevention of cognitive decline and dementia: what is the evidence?

Lövdén M; Xu W; Wang H-X
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1822(3):482-491

Leisure activities, cognition and dementia.

Wang H-X; Xu W; Pei J-J
Corrigendum: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2012;22(3):237-238

Cost of disorders of the brain in Europe 2010 (vol 21, pg 718, 2011)

Gustavsson A; Svensson M; Jacobi F; Allgulander C; Alonso J; Beghi E; Dodel R; Ekman M; Faravelli C; Fratiglioni L; Gannon B; Jones DH; Jennum P; Jordanova A; Jonsson L; Karampampa K; Knapp M; Kobelt G; Kurth T; Lieb R; Linde M; Ljungcrantz C; Maercker A; Melin B; Moscarelli M; Musayev A; Norwood F; Preisig M; Pugliatti M; Rehm J; Salvador-Carulla L; Schlehofer B; Simon R; Steinhausen H-C; Stovner LJ; Vallat J-M; Van den Bergh P; van Os J; Vos PE; Xu W; Wittchen H-U; Jonsson B; Olesen J
Review: JOURNAL OF ALZHEIMERS DISEASE. 2010;20(3):689-697

Vascular and psychosocial factors in Alzheimer's disease: epidemiological evidence toward intervention.

Qiu C; Xu W; Fratiglioni L

Grants

Reducing Dementia Risk in Older Adults Affected by Cardio-Metabolic Disease

Swedish Research Council

1 January 2022 - 31 December 2024

Employments

Professor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2023-
Senior Lecturer, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2022-2023

Degrees and Education

Docent, Karolinska Institutet, 2013
Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2008

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