Vijole Ottosson

About me
Publications
CV
Public outreach and news

About me

- Born 1972 in Lithuania, Kaunas
- 1978-1990 Secondary school, Lithuania Kaunas
- 1991-1996 Master degree, Vytautas Magnus University, Lithuania, Kaunas
- 1997-1998 Exchange program, Karolinska Instutute, MTC, Sweden, Stockholm
- 1999-2004 PhD studies, Karolinska Institutet, Gastroenterology, Sweden, Stockholm
- 2005-2006 Post Doc studies, Karolinska Institutet, Rheumatology Unit, Sweden, Stockholm
- 2006- Labmager, Karolinska Institutet, Rheumatology Unit, Sweden, Stockholm

Research

Rheumatology and Autoimmunity

Articles

Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1151-1161
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function
Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Ottosson V; Forsberg D; Thorlacius GE; Biavati L; Strandberg L; Mofors J; Ramskold D; Ruhrmann S; Meneghel L; Nyberg W; Espinosa A; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(2):194-202
Natural killer cells and type II interferon in Ro/SSA and La/SSB autoantibody-exposed newborns at risk of congenital heart block
Ivanchenko M; Thorlacius GE; Hedlund M; Ottosson V; Meneghel L; Bjorkander S; Ossoinak A; Tingstrom J; Bremme K; Sverremark-Ekstrom E; Gemzell-Danielsson K; Sonesson S-E; Chemin K; Wahren-Herlenius M
Article: RMD OPEN. 2020;6(1):e000989
Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
Hedlund M; Thorlacius GE; Ivanchenko M; Ottosson V; Kyriakidis N; Lagnefeldt L; Tingstrom J; Sirsjo A; Bengtsson AA; Aronsson E; Gemzell-Danielsson K; Ronnblom L; Bergman G; Espinosa A; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
Article: EXPERIMENTAL DERMATOLOGY. 2017;26(8):713-720
TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model
Vinter H; Langkilde A; Ottosson V; Espinosa A; Wahren-Herlenius M; Raaby L; Johansen C; Iversen L
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2016;186(3):284-291
Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model
Hoxha A; Ruffatti A; Ambrosi A; Ottosson V; Hedlund M; Ottosson L; Anandapadamanaban M; Sunnerhagen M; Sonesson S-E; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2015;44(2):135-142
Incident cases of primary Sjogren's syndrome during a 5-year period in Stockholm County: a descriptive study of the patients and their characteristics
Kvarnstrom M; Ottosson V; Nordmark B; Wahren-Herlenius M
Article: ACTA PAEDIATRICA. 2014;103(3):275-281
Late development of complete atrioventricular block may be immune mediated and congenital in origin
Bergman G; Skog A; Tingstrom J; Ottosson V; Hoxha A; Ambrosi A; Salomonsson S; Wahren-Herlenius M
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(Suppl 3):a78-A79
OP0084 Cardiopathogenic Role of Human RO/SSA and LA/SSA Antibodies Demonstrated in a Novel Animal Model of Congenital Heart Block
Hoxha A; Ruffatti A; Ottosson V; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(Suppl 3):a256
THU0268 Efficacy and Safety of a Combined Treatment Protocol for 2nd Degree Congenital Heart Block
Hoxha A; Ottosson V; Brauner S; Wahren-Herlenius M; Favaro M; Calligaro A; Facchinetti M; Ruffatti A; Punzi L
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(Suppl 3):a462-A463
FRI0260 Defining the pathogenetic autoantibodies in congenital heart block
Hoxha A; Ruffatti A; Ottosson V; Anandapadmanaban M; Tonello M; Punzi L; Sunnerhagen M; Wahren-Herlenius M
Article: LUPUS. 2013;22(5):477-485
Autoantibodies to the functionally active RING-domain of Ro52/SSA are associated with disease activity in patients with lupus
Kvarnstrom M; Dzikaite-Ottosson V; Ottosson L; Gustafsson JT; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):448-454
Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model
Ambrosi A; Dzikaite V; Park J; Strandberg L; Kuchroo VK; Herlenius E; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):334-340
Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
Ambrosi A; Salomonsson S; Eliasson H; Zeffer E; Skog A; Dzikaite V; Bergman G; Fernlund E; Tingstrom J; Theander E; Rydberg A; Skogh T; Ohman A; Lundstrom U; Mellander M; Winqvist O; Fored M; Ekbom A; Alfredsson L; Kallberg H; Olsson T; Gadler F; Jonzon A; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;74(5):511-517
A Population-based Investigation of the Autoantibody Profile in Mothers of Children with Atrioventricular Block
Salomonsson S; Dzikaite V; Zeffer E; Eliasson H; Ambrosi A; Bergman G; Fernlund E; Theander E; Ohman A; Rydberg A; Skogh T; Wallberg-Jonsson S; Elfving A; Fored M; Ekbom A; Lundstrom U; Mellander M; Winqvist O; Sonesson S-E; Gadler F; Jonzon A; Wahren-Herlenius M
Article: JOURNAL OF IMMUNOLOGY. 2010;185(6):3574-3582
Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Determine Susceptibility in Congenital Heart Block
Strandberg LS; Ambrosi A; Jagodic M; Dzikaite V; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Article: LIVER INTERNATIONAL. 2006;26(8):976-985
Expression of iron regulatory genes in a rat model of hepatocellular carcinoma
Holmstrom P; Gafvels M; Eriksson LC; Dzikaite V; Hultcrantz R; Eggertsen G; Stal P
Article: JOURNAL OF HEPATOLOGY. 2006;44(3):544-551
Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes
Dzikaite V; Holmström P; Stål P; Eckes K; Hagen K; Eggertsen G; Gåfvels M; Melefors Ö; Hultcrantz R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1630(1):19-24
The regulatory effect of heme on erythroid aminolevulinate synthase in natural erythroid cells
Dzikaite V; Hultcrantz R; Melefors Ö
Article: JOURNAL OF HEPATOLOGY. 2003;39(3):308-314
Structure and liver cell expression pattern of the HFE gene in the rat
Holmström P; Dzikaite V; Hultcrantz R; Melefors Ö; Eckes K; Stål P; Kinnman N; Smedsrod B; Gåfvels M; Eggertsen G
Article: BLOOD. 2000;96(2):740-746
A novel endoproteolytic processing activity in mitochondria of erythroid cells and the role in heme synthesis
Dzikaite V; Kanopka A; Brock JH; Kazlauskas A; Melefors Ö

All other publications

Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1069.2-101070
IMMUNE CELLS AND THEIR EFFECTOR FUNCTIONS IN NEONATES BORN TO ANTI-RO/LA POSITIVE WOMEN
Gerstner C; Rudolph L; Thorlacius GE; Ottosson V; Meneghel L; Nordenstam F; Bergman G; Sonesson SE; Hedlund M; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69
Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero
Thorlacius GE; Hedlund M; Ivanchenko M; Ottosson V; Ossoinak A; Lagnefeldt L; Ronnblom L; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69
Ro/SSA Autoantibody Exposed Neonates Have an Expansion of NK Cells and a Discernible Type II IFN Signature with High IFNγ in Peripheral Blood
Ivanchenko M; Hedlund M; Thorlacius GE; Ottosson V; Chemin K; Sonesson S-E; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68
Expression of IFN-Regulated Genes in Autoantibody Exposed Babies in Utero
Hedlund M; Thorlacius G-E; Ivanchenko M; Ottosson V; Ossoinak A; Lagnefeldt L; Tingstrom J; Espinosa A; Ronnblom L; Eloranta M-L; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):455
Cardiopathogenic Role of Human RO/SSA and LA/SSA Antibodies in a Novel Animal Model of Congenital Heart Block
Ottosson V; Hoxha A; Ruffatti A; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:256
EFFICACY AND SAFETY OF A COMBINED TREATMENT PROTOCOL FOR 2ND DEGREE CONGENITAL HEART BLOCK
Hoxha A; Ottosson V; Brauner S; Wahren-Herlenius M; Favaro M; Calligaro A; Facchinetti M; Ruffatti A; Punzi L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:462-463
DEFINING THE PATHOGENETIC AUTOANTIBODIES IN CONGENITAL HEART BLOCK
Hoxha A; Ruffatti A; Ottosson V; Anandapadmanaban M; Tonello M; Punzi L; Sunnerhagen M; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:78-79
CARDIOPATHOGENIC ROLE OF HUMAN RO/SSA AND LA/SSA ANTIBODIES DEMONSTRATED IN A NOVEL ANIMAL MODEL OF CONGENITAL HEART BLOCK
Hoxha A; Ruffatti A; Ottosson V; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Thesis / dissertation: 2004
Studies of proteins in heme and iron metabolism
Dzikaite, Vijole

Employments

Laboratory Manager, Department of Medicine, Karolinska Institutet, 2006-

Degrees and Education

Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2004

About me

Research

Articles

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